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Search Results: 1 - 10 of 191347 matches for " D. Autiero "
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MicroTCA implementation of synchronous Ethernet-Based DAQ systems for large scale experiments
C. Girerd,D. Autiero,B. Carlus,S. Gardien,J. Marteau,W. Tromeur
Physics , 2009,
Abstract: Large LAr TPCs are among the most powerful detectors to address open problems in particle and astro-particle physics, such as CP violation in leptonic sector, neutrino properties and their astrophysical implications, proton decay search etc. The scale of such detector implies severe constraints on their readout and DAQ system. In this article we describe a data acquisition scheme for this new generation of large detectors. The main challenge is to propose a scalable and easy to use solution able to manage a large number of channels at the lowest cost. It is interesting to note that these constraints are very similar to those existing in Network Telecommunication Industry. We propose to study how emerging technologies like ATCA and $\mu$TCA could be used in neutrino experiments. We describe the design of an Advanced Mezzanine Board (AMC) including 32 ADC channels. This board receives 32 analogical channels at the front panel and sends the formatted data through the $\mu$TCA backplane using a Gigabit Ethernet link. The gigabit switch of the MCH is used to centralize and to send the data to the event building computer. The core of this card is a FPGA (ARIA-GX from ALTERA) including the whole system except the memories. A hardware accelerator has been implemented using a NIOS II $\mu$P and a Gigabit MAC IP. Obviously, in order to be able to reconstruct the tracks from the events a time synchronisation system is mandatory. We decided to implement the IEEE1588 standard also called Precision Timing Protocol, another emerging and promising technology in Telecommunication Industry. In this article we describe a Gigabit PTP implementation using the recovered clock of the gigabit link. By doing so the drift is directly cancelled and the PTP will be used only to evaluate and to correct the offset.
Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein
Ida Autiero, Susan Costantini, Giovanni Colonna
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0007350
Abstract: Background Sirt-1 is a NAD+-dependent nuclear deacetylase of 747 residues that in mammals is involved in various important metabolic pathways, such as glucose metabolism and insulin secretion, and often works on many different metabolic substrates as a multifunctional protein. Sirt-1 down-regulates p53 activity, rising lifespan, and cell survival; it also deacetylases peroxisome proliferator-activated receptor-gamma (PPAR-γ) and its coactivator 1 alpha (PGC-1α), promoting lipid mobilization, positively regulating insulin secretion, and increasing mitochondrial dimension and number. Therefore, it has been implicated in diseases such as diabetes and the metabolic syndrome and, also, in the mechanisms of longevity induced by calorie restriction. Its whole structure is not yet experimentally determined and the structural features of its allosteric site are unknown, and no information is known about the structural changes determined by the binding of its allosteric effectors. Methodology In this study, we modelled the whole three-dimensional structure of Sirt-1 and that of its endogenous activator, the nuclear protein AROS. Moreover, we modelled the Sirt-1/AROS complex in order to study the structural basis of its activation and regulation. Conclusions Amazingly, the structural data show that Sirt-1 is an unordered protein with a globular core and two large unordered structural regions at both termini, which play an important role in the protein-protein interaction. Moreover, we have found on Sirt-1 a conserved pharmacophore pocket of which we have discussed the implication.
Modeling of the Bacterial Mechanism of Methicillin-Resistance by a Systems Biology Approach
Ida Autiero, Susan Costantini, Giovanni Colonna
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006226
Abstract: Background A microorganism is a complex biological system able to preserve its functional features against external perturbations and the ability of the living systems to oppose to these external perturbations is defined “robustness”. The antibiotic resistance, developed by different bacteria strains, is a clear example of robustness and of ability of the bacterial system to acquire a particular functional behaviour in response to environmental changes. In this work we have modeled the whole mechanism essential to the methicillin-resistance through a systems biology approach. The methicillin is a β-lactamic antibiotic that act by inhibiting the penicillin-binding proteins (PBPs). These PBPs are involved in the synthesis of peptidoglycans, essential mesh-like polymers that surround cellular enzymes and are crucial for the bacterium survival. Methodology The network of genes, mRNA, proteins and metabolites was created using CellDesigner program and the data of molecular interactions are stored in Systems Biology Markup Language (SBML). To simulate the dynamic behaviour of this biochemical network, the kinetic equations were associated with each reaction. Conclusions Our model simulates the mechanism of the inactivation of the PBP by methicillin, as well as the expression of PBP2a isoform, the regulation of the SCCmec elements (SCC: staphylococcal cassette chromosome) and the synthesis of peptidoglycan by PBP2a. The obtained results by our integrated approach show that the model describes correctly the whole phenomenon of the methicillin resistance and is able to respond to the external perturbations in the same way of the real cell. Therefore, this model can be useful to develop new therapeutic approaches for the methicillin control and to understand the general mechanism regarding the cellular resistance to some antibiotics.
On new challenge for the Bioinformatics
Susan Costantini,Ida Autiero,Giovanni Colonna
Bioinformation , 2008,
Abstract: The living organisms may be studied as a whole complex system. The “omics sciences” tend at understanding and describing the global information of genes, mRNA, proteins, and metabolites. The aim of the Bioinformatics should be that of developing methods not only able to study the individual components of a system, but also to represent and simulate the relationships between all these components.
The CAST Time Projection Chamber
D. Autiero,B. Beltran,J. M. Carmona,S. Cébrian,E. Chesi,M. Davenport,M. Delattre,L. Di Lella,F. Formenti,I. G. Irastorza,H. Gomez,M. Hasinoff,B. Laki?,G. Luzón,J. Morales,L. Musa,A. Ortiz,A. Placci,A. Rodriguez,J. Ruz,J. A. Villar,K. Zioutas
Physics , 2007, DOI: 10.1088/1367-2630/9/6/171
Abstract: One of the three X-ray detectors of the CAST experiment searching for solar axions is a Time Projection Chamber (TPC) with a multi-wire proportional counter (MWPC) as a readout structure. Its design has been optimized to provide high sensitivity to the detection of the low intensity X-ray signal expected in the CAST experiment. A low hardware threshold of 0.8 keV is safely set during normal data taking periods, and the overall efficiency for the detection of photons coming from conversion of solar axions is 62 %. Shielding has been installed around the detector, lowering the background level to 4.10 x 10^-5 counts/cm^2/s/keV between 1 and 10 keV. During phase I of the CAST experiment the TPC has provided robust and stable operation, thus contributing with a competitive result to the overall CAST limit on axion-photon coupling and mass.
Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis
Mieke Delvaeye, Astrid De Vriese, Femke Zwerts, Inge Betz, Michael Moons, Monica Autiero, Edward M Conway
BMC Developmental Biology , 2009, DOI: 10.1186/1471-213x-9-25
Abstract: To gain further insights into the properties of survivin, we used the zebrafish model. There are 2 zebrafish survivin genes (Birc5a and Birc5b) with overlapping expression patterns during early development, prominently in neural and vascular structures. Morpholino-induced depletion of Birc5a causes profound neuro-developmental, hematopoietic, cardiogenic, vasculogenic and angiogenic defects. Similar abnormalities, all less severe except for hematopoiesis, were evident with suppression of Birc5b. The phenotypes induced by morpholino knockdown of one survivin gene, were rescued by overexpression of the other, indicating that the Birc5 paralogs may compensate for each. The potent vascular endothelial growth factor (VEGF) also entirely rescues the phenotypes induced by depletion of either Birc5a and Birc5b, highlighting its multi-functional properties, as well as the power of the model in characterizing the activities of growth factors.Overall, with the zebrafish model, we identify survivin as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis. These properties of survivin, which are consistent with those identified in mice, indicate that its functions are highly conserved across species, and point to the value of the zebrafish model in understanding the role of this IAP in the pathogenesis of human disease, and for exploring its potential as a therapeutic target.For normal homeostasis in multicellular organisms, there exists a delicate balance between cell proliferation and cell death, maintenance of which is required to prevent pathological outcomes including developmental abnormalities, cancer, autoimmune diseases, degenerative disorders and poor outcome following wounds and ischemic injury. The major physiologic means by which cell death is achieved in an organism is via apoptosis, a tightly regulated and highly conserved process. In spite of major gains in characterizing the apoptotic pathways in vitro, a better understanding of
Search for spontaneous muon emission from lead nuclei
L. Arrabito,D. Autiero,E. Barbuto,C. Bozza,S. Cecchini,L. Consiglio,M. Cozzi,N. D'Ambrosio,Y. Declais,G. De Lellis,G. De Rosa,M. De Serio,D. Di Ferdinando,A. Di Giovanni,N. Di Marco,L. S. Esposito,G. Giacomelli,M. Giorgini,G. Grella,M. Hauger,M. Ieva,D. B. Ion,I. Janicsko,F. Juget,I. Laktineh,G. Mandrioli,S. Manzoor,A. Margiotta,P. Migliozzi,P. Monacelli,M. T. Muciaccia,L. Patrizii,C. Pistillo,V. Popa,G. Romano,G. Rosa,P. Royole-Degieux,S. Simone,M. Sioli,C. Sirignano,G. Sirri,G. Sorrentino,M. Spurio,V. Tioukov
Physics , 2005,
Abstract: We describe a possible search for muonic radioactivity from lead nuclei using the base elements ("bricks" composed by lead and nuclear emulsion sheets) of the long-baseline OPERA neutrino experiment. We present the results of a Monte Carlo simulation concerning the expected event topologies and estimates of the background events. Using few bricks, we could reach a good sensitivity level.
Electron/pion separation with an Emulsion Cloud Chamber by using a Neural Network
L. Arrabito,D. Autiero,C. Bozza,S. Buontempo,Y. Caffari,L. Consiglio,M. Cozzi,N. D'Ambrosio,G. De Lellis,M. De Serio,F. Di Capua,D. Di Ferdinando,N. Di Marco,A. Ereditato,L. S. Esposito,S. Gagnebin,G. Giacomelli,M. Giorgini,G. Grella,M. Hauger,M. Ieva,J. Janicsko Csathy,F. Juget,I. Kreslo,I. Laktineh,A. Longhin,G. Mandrioli,A. Marotta,J. Marteau,P. Migliozzi,P. Monacelli,U. Moser,M. T. Muciaccia,A. Pastore,L. Patrizii,C. Pistillo,M. Pozzato,G. Romano,G. Rosa,A. Russo,N. Savvinov,A. Schembri,L. Scotto Lavina,S. Simone,M. Sioli,C. Sirignano,G. Sirri,P. Strolin,V. Tioukov
Physics , 2007, DOI: 10.1088/1748-0221/2/02/P02001
Abstract: We have studied the performance of a new algorithm for electron/pion separation in an Emulsion Cloud Chamber (ECC) made of lead and nuclear emulsion films. The software for separation consists of two parts: a shower reconstruction algorithm and a Neural Network that assigns to each reconstructed shower the probability to be an electron or a pion. The performance has been studied for the ECC of the OPERA experiment [1]. The $e/\pi$ separation algorithm has been optimized by using a detailed Monte Carlo simulation of the ECC and tested on real data taken at CERN (pion beams) and at DESY (electron beams). The algorithm allows to achieve a 90% electron identification efficiency with a pion misidentification smaller than 1% for energies higher than 2 GeV.
Search for solar axion emission from 7Li and D(p,gamma)3He nuclear decays with the CAST gamma-ray calorimeter
CAST Collaboration,S. Andriamonje,S. Aune,D. Autiero,K. Barth,A. Belov,B. Beltran,H. Brauninger,J. M. Carmona,S. Cebrian,J. I. Collar,T. Dafni,M. Davenport,L. Di. Lella,C. Eleftheriadis,J. Englhauser,G. Fanourakis,E. Ferrer. Ribas,H. Fischer,J. Franz,P. Friedrich,T. Geralis,I. Giomataris,S. Gninenko,H. Gomez,M. Hasinoff,F. H. Heinsius,D. H. H. Hoffmann,I. G. Irastorza,J. Jacoby,K. Jakovcic,D. Kang,K. Konigsmann,R. Kotthaus,M. Krcmar,K. Kousouris,M. Kuster,B. Lakic,C. Lasseur,A. Liolios,A. Ljubicic,G. Lutz,G. Luzon,D. W. Miller,J. Morales,A. Ortiz,T. Papaevangelou,A. Placci,G. Raffelt,H. Riege,A. Rodriguez,J. Ruz,I. Savvidis,Y. Semertzidis,P. Serpico,L. Stewart,J. D. Vieira,J. Villar,J. Vogel,L. Walckiers,K. Zioutas
Physics , 2009, DOI: 10.1088/1475-7516/2010/03/032
Abstract: We present the results of a search for a high-energy axion emission signal from 7Li (0.478 MeV) and D(p,gamma)3He (5.5 MeV) nuclear transitions using a low-background gamma-ray calorimeter during Phase I of the CAST experiment. These so-called "hadronic axions" could provide a solution to the long-standing strong-CP problem and can be emitted from the solar core from nuclear M1 transitions. This is the first such search for high-energy pseudoscalar bosons with couplings to nucleons conducted using a helioscope approach. No excess signal above background was found.
Síntese, caracteriza??o e propriedades espectroscópicas de criptatos de lantanídeo do tipo [Lnì(bipy)2py(CO2Et) 2(3+)]
Nova, Suzana P. Vila;Pereira, Giovannia A. de L.;Sá, Gilberto F. de;Alves Júnior, Severino;Bazin, Hervé;Autiero, Hervé;Mathis, Gérard;
Química Nova , 2004, DOI: 10.1590/S0100-40422004000500006
Abstract: this work reports on the synthesis, characterization (infrared and hidrogen nmr spectra) and photophysical properties (luminescence spectra and emission quantum yield) of the lanthanide cryptates [lnì(bipy)2py(co2et) 2]3+ with ln = eu3+, tb3+ or gd3+, which can be applied as efficient light-conversion-molecular-devices. from emission spectra of [euì(bipy)2py(co2et) 2]3+ it was possible to assign c3 symmetry to the metal ion. the spectroscopic studies show a higher emission quantum yield (q=25%) for [tbì(bipy)2py(co2et) 2]3+ in aqueous solution, whereas the europium cryptate presents q=14%. this is justified by a more efficient energy transfer between triplet and emission levels of terbium (t?5d4).
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