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Search Results: 1 - 10 of 433042 matches for " D?bereiner Jürgen "
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Are alveolar bone changes a determinant factor for "cara inchada" in cattle?
Dbereiner, Jürgen;D?mmrich, Klaus;
Pesquisa Veterinária Brasileira , 1997, DOI: 10.1590/S0100-736X1997000200001
Abstract: in order to study possible alterations of the skeleton which might play a role in the pathogenesis of the periodontitis of "cara inchada" in young cattle, ribs from 20 affected calves, 2 to 10 months old, were examined. electrolytically decalcified longitudinal sections of the costochondral junction and cross sections through the corpus costae, stained with haematoxylin-eosin, were studied. in five calves, longitudinal sections of the proximal humerus were examined as well. the status of mineralization was checked by microradiograms. systemic alteration of the skeleton due to disturbances of mineral metabolism could not be shown in any of the animals. in seven 2 to 4 months old calves, no bone changes were found. the reduced osteogenesis in six 3 to 5 months old calves and the reduced osteogenesis and diminished chondral growth in seven 5 to 10 months old calves are therefore a consequence of the disease. the results show that the development of the alveolar bone was not defective, so this cannot be a determinant factor for the development of the periodontitis of "cara inchada" in cattle.
Are alveolar bone changes a determinant factor for "cara inchada" in cattle?
Dbereiner Jürgen,D?mmrich Klaus
Pesquisa Veterinária Brasileira , 1997,
Abstract: In order to study possible alterations of the skeleton which might play a role in the pathogenesis of the periodontitis of "cara inchada" in young cattle, ribs from 20 affected calves, 2 to 10 months old, were examined. Electrolytically decalcified longitudinal sections of the costochondral junction and cross sections through the corpus costae, stained with Haematoxylin-Eosin, were studied. In five calves, longitudinal sections of the proximal humerus were examined as well. The status of mineralization was checked by microradiograms. Systemic alteration of the skeleton due to disturbances of mineral metabolism could not be shown in any of the animals. In seven 2 to 4 months old calves, no bone changes were found. The reduced osteogenesis in six 3 to 5 months old calves and the reduced osteogenesis and diminished chondral growth in seven 5 to 10 months old calves are therefore a consequence of the disease. The results show that the development of the alveolar bone was not defective, so this cannot be a determinant factor for the development of the periodontitis of "cara inchada" in cattle.
Sobre o "ronca", doen?a de etiologia obscura em bovinos, caracterizada por respira??o ruidosa
Tokarnia, Carlos Hubinger;Dbereiner, Jürgen;
Pesquisa Veterinária Brasileira , 1998, DOI: 10.1590/S0100-736X1998000300001
Abstract: "ronca", a disease of cattle occurring in the states of piauí, rio de janeiro and mato grosso do sul, is also known by the popular names "roncadeira" or "ronqueira", what means snoaring disease. data on the disease were obtained through informations, own observations, clinical and postmortem examinations of 12 affected bovines, completed by histopathological examinations and chemical analyses of liver samples for microelements. the main symptoms are the snoaring sound during inspiration, which arises or is intensified the more one leades with the animal, irritability, continuous worsening of the nutritional state and death after a few months up to 2 years. blood examinations, performed during the studies in piauí, showed a normocytic and hypocromic condition; blood smears did not reveal any abnormality. at postmortem examination sometimes an orange discolouration of the liver and an orange-brown colour of the lymphnodes of the liver hilus was observed. careful examinations of the nasal cavity, especially of the turbinates, and of the larynx did not disclose any lesions. histopathological examinations revealed, as the main lesion, severe hemosiderosis of the liver, always seen, as well as of the spleen and lymphnodes. chemical analyses of liver samples revealed in all by "ronca" affected animals of the three regions very low copper and very high iron values. two bovines affected by "ronca" and transferred to a region where the disease does not occur, continued with the snoaring respiration during more than a year. at postmortem examination no lesions besides a few not related to the disease were found. histopathological examinations revealed hemosiderosis in liver, spleen and lymphnodes, but less pronounced than in the animals affected by "ronca" which stayed at the original farm. chemical anlyses of the liver samples of the two transferred animals revealed normal values for copper and high levels of iron, but these were lower than those found in the animals affected
IMUNIDADE CRUZADA PELAS SEMENTES DE Abrus precatorius E Ricinus communis EM BOVINOS
Tokarnia, Carlos Hubinger;Dbereiner, Jürgen;
Pesquisa Veterinária Brasileira , 1997, DOI: 10.1590/S0100-736X1997000100005
Abstract: five bovines immunized against the toxicity of the seeds of abrus precatorius l. (jequiriti bean) did not get poisoned or only slightly so when the seeds of ricinus communis l. (castor bean) were given in amounts that in bovines, which never before ingested the seeds of a. precatorius or r. communis, caused moderate to severe poisoning or even death. a sixth bovine, which was not well immunized against the toxic action of the seeds of a. precatorius, was severely poisoned when given a high dose of the seeds of r. communis. on the other side, from five bovines immunized against the toxic action of the seeds of r. communis four were severely poisoned and the fifth one moderately when the seeds of a. precatorius were given in doses that in bovines, which never before ingested seeds of r. communis or a. precatorius, caused slight to severe poisoning. it is concluded that bovines immunized against the toxic action of the seeds of a. precatorius are resistant to the toxic action of the seeds of r. communis, but that the contrary is not the case; this is, bovines immunized against the toxic action of the seeds of r. communis were not protected against the poisoning by a. precatorius. earlier studies by other authors had shown that the toxalbumins of the seeds of a. precatorius and r. communis, respectively abrin and ricin, are different as to their antigenic properties. a possible explanation for the difference in results can be.that in the present study polygastric animals were used which received the seeds orally, but in the earlier studies monogastric animals received the seeds or toxins by parenteral route. the administration of the fresh leaves or the pericarp of the fruits r. communis to bovines, which had been immunized against the action of the seeds of the plant, had the same toxic effect as to not immunized animals, showing that the immunity due to ricin does not give protection against the action of ricinin, the toxic principle of the leaves and the pericarp.
IMUNIDADE CRUZADA PELAS SEMENTES DE Abrus precatorius E Ricinus communis EM BOVINOS
Tokarnia Carlos Hubinger,Dbereiner Jürgen
Pesquisa Veterinária Brasileira , 1997,
Abstract: Cinco bovinos imunizados contra a a o tóxica das sementes de Abrus precatorius L. ("tento", "jiquiriti") n o adoeceram ou somente levemente pela administra o das sementes de Ricinus communis L. ("mamona"), em doses que em bovinos que antes nunca ingeriram sementes de A. precatorius ou R. communis, causaram intoxica o de intensidade de grau moderado a acentuado ou até a morte. Um sexto bovino, que n o ficou bem imunizado contra a a o tóxica das sementes de A. precatorius, adoeceu em grau acentuado pela administra o de dose elevada das sementes de R. communis. Já dos cinco bovinos imunizados contra a a o tóxica das sementes de R. communis quatro adoeceram em grau acentuado, oquinto em grau moderado, pela administra o das sementes de A. precatorias em doses que em bovinos que antes nunca ingeriram sementes de R. communis ou A. precatorius causaram intoxica o de intensidade leve a acentuada. Estes resultados permitem concluir que bovinos imunizados contra a a o tóxica das sementes de A. precatorius s o resistentes à a o tóxica das sementes de R. communis, mas que o contrário n o ocorre, isto é, bovinos imunizados contra a a o tóxica das sementes de R. communis, n o se mostraram protegidos contra a intoxica o por A. precatorius. Estudos anteriores por outros autores mostraram que as toxalbuminas de A. precatorius e R. communis, respectivamente abrina e ricina, s o diferentes do ponto de vista antigênico. Uma explica o para a divergência desses resultados com os nossos poderia estar no fato de que no presente estudo foram usados poligástricos que receberam as sementes por via oral, enquanto que nos estudos anteriores foram usados monogástricos em que as sementes ou as toxinas foram aplicadas por via parenteral. A administra o de folhas frescas ou do pericarpo do fruto de R. communis a bovinos imunizados contra a a o das sementes desta planta tiveram o mesmo efeito tóxico que em animais n o imunizados, demonstrando que a imunidade conferida pela ricina n o inibe a a o da ricinina, o principio tóxico das folhas e do pericarpo.
Sobre o "ronca", doen a de etiologia obscura em bovinos, caracterizada por respira o ruidosa
Tokarnia Carlos Hubinger,Dbereiner Jürgen
Pesquisa Veterinária Brasileira , 1998,
Abstract: S o apresentados os resultados de estudos realizados sobre uma doen a de evolu o cr nica em bovinos, de etiologia obscura, cuja caraterística principal é uma respira o ruidosa. Esta doen a é conhecida nos Estados do Piauí, Rio de Janeiro e Mato Grosso do Sul, onde a sua ocorrência foi verificada, pelos nomes populares de "ronca", "roncadeira" ou "ronqueira". Os dados mais importantes da doen a, baseados nos históricos, em observa es próprias, exames clínicos, necropsias de 12 bovinos, complementadas por exames histopatológicos e analises químicas de amostras de fígado para microelementos, s o a respira o ruidosa na inspira o, que aparece ou se intensifica a medida que se lida com os animais, irritabilidade, emagrecimento progressivo e morte após alguns meses até dois anos. Exames de sangue, realizados nos estudos no Piauí, revelaram uma condi o normo-cítica hipocr mica; esfrega os de sangue n o revelaram nada digno de nota. à necropsia se constatou às vezes colora o alaranjada do fígado e colora o alaranjada/marrom dos linfonodos do hilo do fígado. Exames da cavidade nasal, especialmente dos cornetos, e da laringe, n o revelaram nenhuma altera o. Os exames histopatológicos evidenciaram como les o principal hemossiderose acentuada do fígado, sempre presente, bem como do ba o e de linfonodos. Análises de amostras de fígado revelaram em todos os animais afetados pela doen a, nas três regi es, valores muito baixos de cobre e muito elevados de ferro. Dois bovinos afetados pela doen a, transferidos para regi o indene, continuaram com a respira o ruidosa durante mais de um ano. à necropsia destes animais n o foram encontradas les es, além de alguns achados n o relacionáveis com a doen a. Nos exames histopatológicos foi constatada hemosside-rose no fígado, ba o e em linfonodos, porém menos acentuada que nos casos de "ronca" examinados no local de sua procedência. As análises de amostras de fígado revelaram valores normais para cobre e de ferro ainda altos, mas menos acentuados que nos bovinos com "ronca" no local de sua procedência. Os estudos realizados n o permitiram desvendar a raz o da respira o ruidosa. é levantada a suspeita, que a deficiência de cobre tenha influência na patogênese do "ronca", em que, porém, devem estar envolvidos ainda outros fatores para a forma o do quadro.
Sensibilidade toxicológica e especificidade do teste de microfixa??o de complemento na detec??o de toxinas botulínicas C e D em meio de cultura e fígado de camundongos
Menegucci, Edna A.;Dutra, Iveraldo S.;Dbereiner, Jürgen;
Pesquisa Veterinária Brasileira , 1998, DOI: 10.1590/S0100-736X1998000200001
Abstract: the toxicological sensitivity and specificity of the micro-complement fixation test (mcf) for the detection of botulinum toxins c and d were studied in supernatants of the bacterial cultures and in livers of mice inoculated with lethal and sublethal doses. botulinum toxins c and d were produced in hemoline culture medium, titered through the determination of ld50 by the mouse test and adjusted to dilutions of 10, 1, 0.1, 0.01 and 0.001 ld50. two experimental models were used to determine the toxicological sensitivity of mcf in the supernatant of the culture medium with the dilutions described, and also in liver extracts of mice weighing 20 g and inoculated with the same dilutions. detection of the botulinum toxins was attempted in liver extracts of mice which had received lethal doses of the respective toxins, and in others which had been inoculated with sublethal doses and were sacrificed in intervals of 5 days. the results show that the toxicological sensitivity of mcf, regarding the two types of toxins at the level of 0.001 ld50, was 100% when the supernatants of the culture medium were tested; this means that the sensitivity was 100 times higher than with the mouse test. the toxicological sensitivity of mcf in the liver extracts of mice inoculated with 1 and 10 ld50 of botulinum toxins c and d was inferior, giving values of 100, 80, 89 and 72% respectively. by this test it was also possible to detect botulinum toxins type c and d in liver extracts of mice inoculated with sublethal doses, up to 15 days after the injection. the specificity of mcf was 88% and 92%, when liver extracts of healthy control mice were tested and when challenged with antitoxins c and d; and 100% when challenged with the supernatant of the culture medium. these results indicate that mcf could be of importance for research and could substitute in vivo tests.
Botulismo em bovinos de corte e leite alimentados com cama de frango
Dutra, Iveraldo S.;Dbereiner, Jürgen;Souza, Aires M.;
Pesquisa Veterinária Brasileira , 2005, DOI: 10.1590/S0100-736X2005000200009
Abstract: outbreaks of botulism caused by type c and d of the botulinum toxin are frequent in brazil, and are associated with bone chewing and ingestion of contaminated food and water. this paper reports the epidemiological, clinical, pathological and laboratorial aspects of 7 outbreaks of botulism in beef and dairy cattle fed with poultry litter, which occurred in the states of s?o paulo and minas gerais, 1989-2000. five outbreaks occurred in beef cattle herds, raised in confinement or under pasture conditions and supplemented with poultry litter, and 2 outbreaks occurred in dairy farms. from o total of 1,535 cattle supplemented regularily with poultry litter 455 animals (29.64%) died within 2 to 4 weeks. morbidity and mortality varied from 3.47 to 100% in the 7 outbreaks. in one of the farms the lethality was 60.52%, and in others more than 88.43%, reaching 100% in three farms. clinical signs were progressive paralysis, difficulties in moving, decubitus, normal alertness, decreased muscular tonus of tongue and tail, sialorrhoe and dyspnoe. at post-mortem examination of 30 cattle no noteable changes were observed. spores of clostridium botulinum were found in poultry litter samples collected on 7 farms. in liver, ruminal and intestinal fluid samples from 30 necropsied cattle botulinum toxin of type c (5) and d (9) or of the cd complex (1) were found in at least one of the samples collected from 15 animals, which confirms the clincial, pathological and epidemiological diagnosis of botulism.
Deficiências minerais em animais de fazenda, principalmente bovinos em regime de campo
Tokarnia Carlos H.,Dbereiner Jürgen,Peixoto Paulo V.
Pesquisa Veterinária Brasileira , 2000,
Abstract:
Sensibilidade toxicológica e especificidade do teste de microfixa o de complemento na detec o de toxinas botulínicas C e D em meio de cultura e fígado de camundongos
Menegucci Edna A.,Dutra Iveraldo S.,Dbereiner Jürgen
Pesquisa Veterinária Brasileira , 1998,
Abstract: No presente estudo pretendeu-se verificar a sensibilidade toxicológica e especificidade do Teste de Microfixa o de Complemento (MCF) na detec o de toxinas botulínicas C e D no sobrenadante de cultivos bacterianos e em fígados de camundongos inoculados com doses letais e subletais. As toxinas foram produzidas em meio de cultura Hemoline, tituladas através da determina o da DL50 pelo Bioensaio em Camundongo e diluídas nas concentra es de 10, 1, 0,1, 0,01 e 0,001 DL50. Desta forma, foram utilizadas em dois modelos experimentais, onde foi determinada a sensibilidade toxicológica do MCF no sobrenadante do meio de cultura com as dilui es descritas acima e ainda em extratos hepáticos de camundongos com peso corporal de 20g, inoculados com as mesmas dilui es. A tentativa de evidencia o das toxinas botulínicas nos extratos hepáticos de camundongos foi realizada através da sua extra o após a morte pela administra o das doses letais e ainda pelo sacrifício dos animais inoculados com doses subletais, em intervalos de 5 dias. Os resultados evidenciaram uma sensibilidade toxicológica para o MCF de 100% para os dois tipos de toxinas ao nível de 0,01 DL50, quando testados os sobrenadantes de meio de cultura, portanto 100 vezes superior ao Bioensaio em Camundongo. A sensibilidade toxicológica do MCF, quando examinados extratos hepáticos de camundongos inoculados com 1 e 10 DL50 de toxinas botulínicas C e D, foi inferior, com valores de 100, 80, 89 e 72%, respectivamente. Pelo teste foi possível detectar toxinas botulínicas tipos C e D nos extratos hepáticos de camundongos inoculados com doses subletais até 15 dias após a sua inocula o. A especificidade do MCF foi de 88 e 92%, quando testados extratos hepáticos de camundongos sadios, e confrontados com as antitoxinas C e D; e 100% no sobrenadante do meio de cultura. Os resultados apontam para uma possível utiliza o do teste como importante instrumento de pesquisa e ainda na eventual substitui o dos testes in vivo pelas suas implica es éticas e limita es práticas.
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