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Search Results: 1 - 10 of 360235 matches for " Dênis Pires de Lima "
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Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class of antihypertensive drugs
Lima, Dênis Pires de;
Química Nova , 1999, DOI: 10.1590/S0100-40421999000300016
Abstract: this report outlines the discovery, the design and development of new compounds, and, structure-activity relationships for this drug category. updated approaches to planned syntheses of new worthy ace-inhibitors are also exploited.
Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class of antihypertensive drugs
Lima Dênis Pires de
Química Nova , 1999,
Abstract: This report outlines the discovery, the design and development of new compounds, and, structure-activity relationships for this drug category. Updated approaches to planned syntheses of new worthy ACE-inhibitors are also exploited.
Editorial: Chemistry: A key science to fight neglected diseases/Química: Ciência central para combater doen as negligenciadas
Adilson Beatriz,Dênis Pires de Lima
Orbital : the Electronic Journal of Chemistry , 2009,
Abstract: Over the past century, chemical and pharmaceutical industries have made substantial strides in the development of new pharmaceuticals for a range of human diseases. Discovering and developing new drugs are part of a costly process that involves not only the search for new drug candidates, but also the performance of clinical trials. It is not uncommon to find reports of costs reaching US$ 500 million—and even US$ 1 billion—engaging multidisciplinary teams for periods of 10 or 15 years. To a large extent, these costs are borne by consumers in richer countries. In contrast, diseases that predominantly affect residents of poorer nations tend to be left out of the modern process of drug discovery. Moreover, most of the world population stricken by these illnesses is incapable of supporting the costs involved in developing the drugs they need. Because these infirmities, with few exceptions, have been ignored by those in charge of research programs, both in the public and private sectors, they have been referred to as neglected diseases. On its website, the World Health Organization categorizes 14 health conditions as “tropical diseases,”.......................
Chemistry: A key science to fight neglected diseases Química: Ciência central para combater doen as negligenciadas
Adilson Beatriz,Dênis Pires de Lima
Orbital : the Electronic Journal of Chemistry , 2010,
Four years of crusade! Quatro anos de luta!
Adilson Beatriz,Dênis Pires de Lima
Orbital : the Electronic Journal of Chemistry , 2012,
Abstract: Orbital - The Electronic Journal of Chemistry is entering its 4th year of existence which is a reason to celebrate. A great work has been devoted to preserve a scientific journal of international reputation. This work was not always without mistakes or any trouble. However, these very adversities stimulate additional efforts in order to overcome our errors and, continuing with our serious proposal of editing a journal which scientists from all over the world can submit online their original works manuscripts to be published in peer review and open-access style. Beginning this year, Orbital was classified by the Chemistry Coordination Area on the B5 rank of CAPES Qualis (Brazil) and, leveled as B4 by Coordination Areas of Materials and Engineering II. These important details demonstrate that Orbital is progressively attaining the acknowledgment of the Brazilian scientific community. The recognition by CAPES Qualis is crucial as the system evaluates the generation of knowledge in the Brazilian universities and the method by which this same knowledge disseminated to society. Not all these were possible without endeavoring of editors and volunteer assistance of advisors from several national and international institutions. Recently, the young Professors Kleber Thiago de Oliveira (UFSCAR), Grégoire Demetz (USP-RP) and Amilcar Machulek Júnior (UFMS) have joined us to share the idea and philosophy of Orbital by accepting our invitation to be associated editors. The tasks and challenges are enormous and, we are sure that new participants will support us on the way to achieve indexation in new Databases systems as SCOPUS, ISI and Scielo. Consequently, the international success of this electronic journal will be assured. We sincerely hope that in the academic Brazilian scenario, Orbital can figure as a solid bridge to interchange real creative science that is happening in various locations around the world. A revista Orbital está comemorando seu quarto ano de existência. Um grande esfor o tem sido dedicado para cumprir nosso objetivo de torná-la uma revista científica de reputa o internacional. Todo o trabalho devotado n o foi sempre sem erros nem problemas. No entanto, as próprias adversidades serviram de estímulos adicionais para superarmos nossas falhas e continuarmos nossa proposta séria de editar um jornal onde cientistas de todo o mundo possam submeter seus trabalhos originais para serem publicados em um processo de revis o por pares e de acesso livre. No início deste ano, a revista Orbital foi classificada com QUALIS B5 pela Coordena o da área de Química
Symmetrical molecules from reaction of beta-cyclohexanediones with acetylenedicarboxylic acid in aqueous medium
Leonardo Ribeiro Martins,Adilson Beatriz,Dênis Pires de Lima
Orbital : the Electronic Journal of Chemistry , 2012,
Abstract: In an attempt to obtain Michael adducts in aqueous medium, 1,3-cyclohexanedione (1) or dimedone (2) and acetylenedicarboxylic acid monopotassium (3) were dissolved in water and heated to reflux. Under these conditions, two products were isolated from the reaction mixture between 1 and 3: 2-[1-(2,6-dioxocyclohexyl)ethyl]-1,3-cyclohexanedione (6) and a xanthenedione (7), which corresponds to the cyclization of 6. The reaction between 2 and 3 gave only the 2-[1-(4,4-dimethyl-2,6-dioxocyclohexyl)ethyl]-5,5-dimethyl-1,3-cyclohexanedione (8).
Glicerol: um breve histórico e aplica??o em sínteses estereosseletivas
Beatriz, Adilson;Araújo, Yara J. K.;Lima, Dênis Pires de;
Química Nova , 2011, DOI: 10.1590/S0100-40422011000200025
Abstract: presently glycerol is considered a co-product of biodiesel industry. as the biodiesel production is exponentially increasing, glycerol generated from the transesterification of vegetable oils and fats is also being produced on a large scale, and turned out to be essential seeking for novel alternatives to the consumption of the extra volume, in crude and/or as derivatives high added value. this review mainly deals with chemical and enzymatic transformations of glycerol to obtain chiral building blocks for synthesis of pharmaceuticals and natural products.
Chemical identification of Tagetes minuta Linnaeus (Asteraceae) essential oil and its acaricidal effect on ticks Caracteriza o química e efeito acaricida do óleo essencial de Tagetes minuta Linnaeus (Asteraceae) em carrapatos
Marcos Valério Garcia,Jaqueline Matias,Jacqueline Cavalcante Barros,Dênis Pires de Lima
Revista Brasileira de Parasitologia Veterinária , 2012, DOI: 10.1590/s1984-29612012000400011
Abstract: The control of tick species that affect animal production is vital for the economic welfare of the cattle industry. This study focused on testing the acaricidal activity of the essential oil from the leaves and stems of Tagetes minuta against several Brazilian tick species, including Rhipicephalus (Boophilus) microplus, Rhipicephalus sanguineus, Amblyomma cajennense and Argas miniatus. The chemical composition of the essential oil was determined by chromatography and spectroscopy analyses, which revealed the presence of monoterpenes. The adult immersion test (AIT) and the larval packet test (LPT) were used to evaluate the efficacy of T. minuta essential oil in tick management at concentrations of 2.5, 5, 10, 20 and 40%. The results demonstrated that the T. minuta essential oil had over 95% efficacy against four species of ticks at a concentration of 20%. These results suggest that the essential oil of T. minuta could be used as an environmentally friendly acaricide. O controle de carrapatos que causa impacto na produ o de bovinos possui importancia econ mica para a cadeia produtiva. Neste trabalho objetivou-se testar a atividade acaricida do óleo essencial das folhas e caules de Tagetes minuta contra várias espécies de carrapatos brasileiros, incluindo Rhipicephalus (Boophilus) microplus, Rhipicephalus sanguineus, Amblyomma cajennense e Argas miniatus. A composi o química do óleo foi determinada por GC-MS e análises de espectroscopia de RMN, que revelaram a presen a de monoterpenos. Na avalia o destas substancias no controle do carrapato foram empregados os testes de imers o de adulto (TIA) e o de pacote de larvas (TPL) para o extrato de óleo de T. minuta nas concentra es de 2,5%; 5%; 10%; 20% e 40%. Os resultados do TPL e TIA demonstraram que o óleo essencial na concentra o de 20% de T. minuta apresenta eficácia superior a 95% nas quatro espécies de carrapato. Estes resultados sugerem que o óleo essencial de T. minuta pode ser usado como um acaricida eficaz e com baixo impacto ambiental.
Preliminary study on enzymatic kinetic resolution of isopropylidene glycerol
Yara Jaqueline Kerber Araujo,Dênis Pires de Lima,Adilson Beatriz
Orbital : the Electronic Journal of Chemistry , 2009,
Abstract: This work presents a preliminary screening directed to obtaining optically active glycerol derivatives. It was tested six lipases from different sources as a means for kinetic resolution.
Biotransformation of a cage-like diels-alder adduct and derivatives by Mucor ramosissimus samutsevitsch
Ito, Felicia Megumi;Mena, Ana Elisa Maciel;Marques, Maria Rita;Lima, Dênis Pires de;Beatriz, Adilson;
Brazilian Journal of Microbiology , 2009, DOI: 10.1590/S1517-83822009000300019
Abstract: the present study aimed to evaluate the ability for biotransformation of the diels-alder adduct tricyclo[,7]undeca-4,9-dien-3,6-dione (1) and two synthetic derivatives by the saprobe fungus mucor ramosissimus samutsevitsch. products from oxidation, isomerization and, regioselective and enantioselective reduction were achieved.
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