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Search Results: 1 - 10 of 191460 matches for " D Padula "
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Establishment of immortalized periodontal ligament progenitor cell line and its behavioural analysis on smooth and rough titanium surface
D Docheva,D Padula,C Popov,P Weishaupt
European Cells and Materials (ECM) , 2010,
Abstract: Periodontal ligament (PDL) can be obtained from patients undergoing orthodontic treatment. PDL contains progenitor cells that can be expanded and differentiated towards several mesenchymal lineages in vitro. Furthermore, PDL-derived cells have been shown to generate bone- and PDL-like structures in vivo. Thus, PDL cells, combined with suitable biomaterials, represent a promising tool for periodontitis-related research and PDL engineering.Here, a new PDL cell line using lentiviral gene transfer of human telomerase reverse transcriptase (hTERT) was created. HTERT-expressing PDL cells showed similar morphology and population doubling time but an extended lifespan compared to the primary cells. In addition, PDL-hTERT cells expressed several characteristic genes and upon osteogenic stimulation produced a calcified matrix in vitro. When cultivated on two topographically different titanium scaffolds (MA and SLA), PDL-hTERT cells exhibited augmented spreading, survival and differentiation on smooth (MA) compared to rough (SLA) surfaces. These findings differ from previously reported osteoblast behaviour, but they are in agreement with the behaviour of chondrocytes and gingival fibroblasts, suggesting a very cell type-specific response to different surface textures.In summary, we report the testing of titanium biomaterials using a new PDL-hTERT cell line and propose this cell line as a useful model system for periodontitis research and development of novel strategies for PDL engineering.
IMAGING OF PSORIATIC ARTHRITIS
I. Olivieri,E. Scarano,A. Padula,S. D'Angelo
Reumatismo , 2011, DOI: 10.4081/reumatismo.2007.1s.73
Abstract: Imaging of psoriatic arthritis (PsA) is important for two reasons: the differential diagnosis from other arthritides and the assessment of structural damage that can be inhibited by the new drugs such as the anti-TNFα agents. Plain film radiographic findings of peripheral arthritis have been important in elaborating the concept of PsA as a separate disease entity. Characteristic aspects of psoriatic peripheral arthritis help the differentiation from rheumatoid arthritis. High-resolution ultrasonography (US), US combined with power Doppler (PDUS) and magnetic resonance imaging (MRI) can be used to image joint synovitis of PsA. Radiologic features of spondylitis associated with psoriasis are similar to spondylitis associated with reactive arthritis and differ from those of primary ankylosing spondylitis (AS) and the spondylitis associated with inflammatory bowel disease. MRI is very sensitive for the early diagnosis of sacroiliitis. There have been no MRI studies on the spine of patients with PsA. In primary AS bone oedema in the vertebral bodies is an indicator of active disease and can ameliorate during anti-TNFα therapy. Historically, plain film radiography have played a pivotal role in defining enthesitis lesions of SpA. However, entheseal bone changes appear late. US and MRI have proved to be a highly sensitive and non invasive tools. Recent US and MRI studies on both finger and toe dactylitis have established that dactylitis is due to flexor tenosynovitis and marked adjacent soft tissue swelling with a variable degree of small joint synovitis. There is no evidence of enthesitis of the insertion of the flexor digitorum tendons and of the attachment of the caspsule of the digit joints. Key words: Enthesitis, dactylitis, spondyloarthritis, ultrasound, magnetic resonance, imaging
Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer
Matthew D Schmitz, Gilbert DA Padula, Patrick Y Chun, Alan T Davis
Radiation Oncology , 2010, DOI: 10.1186/1748-717x-5-80
Abstract: A retrospective cohort research design was used. A total of 133 patients with clinical stage T1c to T3b prostate cancer (2002 AJCC staging) treated in a community setting between January 2002 and July 2005 were reviewed for time to PSA normalization using 1 ng/mL and 2 ng/mL as criteria. All patients received IMRT as part of their management. Times to PSA normalization were calculated using the Kaplan-Meier method. Significance was assessed at p < 0.05.Fifty-six of the 133 patients received NAAD (42.1%). Thirty-one patients (23.8%) received radiation to a limited pelvic field followed by an IMRT boost, while 99 patients received IMRT alone (76.2%). The times to serum PSA normalization < 2 ng/mL when treated with or without NAAD were 298 ± 24 and 302 ± 33 days (mean ± SEM), respectively (p > 0.05), and 303 ± 24 and 405 ± 46 days, respectively, for PSA < 1 ng/mL (p < 0.05). Stage T1 and T2 tumors had significantly increased time to PSA normalization < 1 ng/mL in comparison to Stage T3 tumors. Also, higher Gleason scores were significantly correlated with a faster time to PSA normalization < 1 ng/mL.Use of NAAD in conjunction with IMRT leads to a significantly shortened time to normalization of serum PSA < 1 ng/mL in patients with clinically localized prostate cancer.Prostate cancer is a prominent cause of morbidity and mortality among men. In 2009, over 190,000 men were diagnosed and over 25,000 died of this disease in the United States alone [1]. The utilization of prostate specific antigen (PSA) screening has resulted in improved detection of this malignancy in its early stages. Current management options for localized prostate cancer include radical prostatectomy, external beam radiation therapy, brachytherapy, and active surveillance. Both external beam radiation therapy (EBRT) and brachytherapy may be combined with neoadjuvant androgen deprivation therapy (NAAD). While there is much debate about which modality provides the optimal treatment for localized disease,
Analysis of reporting of systematic reviews in physical therapy published in Portuguese Análise da apresenta o textual de revis es sistemáticas em fisioterapia publicadas no idioma português
Rosimeire S. Padula,Raquel S. Pires,Sandra R. Alouche,Luciana D. Chiavegato
Brazilian Journal of Physical Therapy , 2012,
Abstract: BACKGROUND: Systematic reviews are considered the best design to synthesize all existing information of a given research topic. To date, there is no study that investigated the quality of reporting of systematic reviews relevant to physical therapy published in Portuguese. Objective: To analyse the quality of reporting of systematic reviews in the field of physical therapy published in Portuguese by using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) checklist. METHOD: All systematic reviews published in Portuguese that were indexed on PEDro database up to August 2011 were included. The quality of reporting of the eligible papers was analysed by using the PRISMA checklist. Each quality assessment was performed by two independent reviewers with arbitration of a third reviewer if necessary. RESULTS: A total of 37 systematic reviews were identified. These studies were published between 2003 and 2010. Less than 30% of the PRISMA checklist items were satisfied, being most of the items related to the introduction and discussion sections. No improvements over time were observed. CONCLUSIONS: Most of the studies did not satisfy the items from the PRISMA Checklist. It seems that most of authors did not know the existence of this checklist. The implementation of reporting statements such as the PRISMA statement by Portuguese-written journals is likely to help authors to write their systematic reviews in a more transparent and clear way. CONTEXTUALIZA O: As revis es sistemáticas s o consideradas a melhor forma de sintetizar toda a informa o existente sobre um determinado tópico, porém n o se conhece, até o momento, a qualidade da apresenta o textual das revis es sistemáticas em fisioterapia publicadas no idioma português. Objetivo: Analisar a apresenta o textual de revis es sistemáticas em fisioterapia publicadas no idioma português utilizando as recomenda es PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). MéTODO: Foram analisadas todas as revis es sistemáticas apresentadas na base de dados PEDro até o mês de agosto de 2011. Para a análise da descri o textual foi utilizada a lista de verifica o PRISMA. Cada revis o foi avaliada por pares de revisores independentes e, em caso de discordancia entre os pares, um terceiro avaliador fez a arbitragem final. RESULTADOS: Foram identificadas 37 revis es sistemáticas que foram publicadas entre os anos de 2003 e 2010. Menos de 30% dos itens da lista de verifica o PRISMA foram descritos pelos autores, sendo que a maioria dos itens satisfeitos se refere às
Ecología y evolución de hantavirus en el Cono Sur de América
Murua,R; Padula,P;
Archivos de medicina veterinaria , 2004, DOI: 10.4067/S0301-732X2004000100001
Abstract: hantavirus are associated with a single primary rodent host of the familiy muridae in three sub families, two of them murinae and arvicolinae distributed in the paleartic region (europa, asia, china) and the sub family sigmodontinae in north, central and south america besides an arvicolinae genus (microtus) in north america. studies on the host and virus phylogeny show close similarities when are compared which implies that hantavirus are very ancient infectious agents which have coevolved with the rodent host. the history of earth, tectonic movements and climatic changes which affected the continents in the past are relevant to understand the host reservoir and its micro parasites current geographic distribution. this review provides historical biogeography of the sigmodontine rodents, phylogentic analyses of hantavirus, its molecular epidemiology and its geographical distribution in south america in order to sustain the proposal that the virus- rodent interaction has coevolved in the neartic before the family muridae was detached in subfamilies and before the sigmodontines rodents spread into the south american continent. it is described the existence of a large number of hantavirus lineages with small differences which make difficult to establish so far, well define species of hantavirus. an analisis between similarities and differences in the ecology and pathogenesis of two virus which have produced an important number of human cases in north america (sin nombre) and in the southern cone of america (virus andes) is discussed.
Chromosomal effects of infections in malnourished and eutrophic children of Gran La Plata
Padula,G; Seoane,A;
BAG. Journal of basic and applied genetics , 2008,
Abstract: the aim of this study was to assess the induction of structural chromosomal aberrations in peripheral blood lymphocytes of malnourished and eutrophic children with bacterial infections. thirty-six infants concurrent to the hospital interzonal de agudos y crónicos dr. alejandro korn, la plata, argentina were included in this analysis; 11 infected and malnourished (im), 7 infected and eutrophic (ie) and 18 non-infected and eutrophic (ne). children aged 1-60 months. anthropometric and clinic evaluation were performed to assess nutritional condition. we scored structural chromosome aberrations (sca) in 100 metaphases per individual. statistical analysis was performed by the epi dat 3.0 (ops-oms, 2003), through ?test de diferencias entre dos proporciones muestrales? (p<0.05). total sce frequency was five times higher in im children than that of ie ones (15,1% vs. 3,33% p<0,001) and two times greater in ie than in ne children (3,33% vs. 1,88% p<0.05). results presented here showed an increase frequency of sca not only in relation with malnutrition but also with the presence of bacterial infections. it is difficult to discern whether structural chromosome aberrations are due to malnutrition per se, bacterial or viral infections, antibiotics or all of these factors acting on malnourished tissues. in conclusion, mutagenic factors cause chromosomal changes more easily in an altered environment.
HBT interferometry: historical perspective
Padula, Sandra S.;
Brazilian Journal of Physics , 2005, DOI: 10.1590/S0103-97332005000100005
Abstract: i review the history of hbt interferometry, since its discovery in the mid 1950's, up to the recent developments and results from bnl/rhic experiments. i focus the discussion on the contributions to the subject given by members of our brazilian group.
Editorial
Maria Inez Padula Anderson
Revista Brasileira de Medicina de Família e Comunidade , 2010, DOI: 10.5712/rbmfc1(2)141
Abstract: Mudar, no ambito individual, comportamentos e atitudes constitui um processo complexo. Envolve disponibilidade interior, reflex o, motiva o genuína e clareza de propósitos. Todos essas condi es, em conjunto, poder o formar um ambiente facilitador para iniciar o caminho da transforma o. Colocado no ambito de uma na o, o processo de mudan a é ainda mais complexo. N o envolve apenas um, mas milh es de atores, cada um com sua cren a, seu olhar, com sua possibilidade de compreens o e capacidade de interven o. No campo das mudan as sociais, adiciona-se a essa equa o, a diversidade de interesses e de necessidades e, ainda (num país capitalista como o nosso), o poder dos grandes capitais. Papel insubstituível do governo nesse jogo de for as, é representar a popula o e fazer valer seus interesses. Passados 16 anos da implanta o do Sistema único de Saúde e 10 anos da Estratégia da Saúde da Família, o povo brasileiro ainda n o consegue ver atendidas - com qualidade, eficácia, eficiência e efetividade suas necessidades de saúde, seja no nível primário, no secundário ou terciário. As iniciativas muitas - parecem n o ser suficientes para tornar o sistema mais justo e equanime. A saúde enquanto direito do cidad o e dever do estado, bem como o sonho de um SUS para todos os brasileiros, parecem cada vez mais distantes, à medida que aumenta, progressivamente. O percentual da popula o (hoje, cerca de 30%) que se vê obrigada a pagar um plano de saúde para ter assegurada sua assistência. Os 70% restantes, parcela que permanece exclusivamente no SUS, o faz pela impossibilidade de arcar com os custos (extraordinários) das mensalidades dos planos de saúde. Insatisfa o tem sido a t nica, seja no nível público ou privado. O que fazer? Onde está o caminho que nos levará, mais uma vez, a acalentar esperan a? Há mais de 30 anos, sabemos que o ponto estratégico está na Aten o Primária à Saúde -APS. Nível do sistema com maior poder para cuidar da saúde, com qualidade e resolutividade, do maior número de pessoas, e com a melhor raz o custo-benefício. Obviamente, nenhum sistema de saúde pode prescindir dos outros níveis de aten o. Mas, repousa na APS, desde que bem feita, bem planejada e implementada com toda a infraestrutura necessária, a maior possibilidade de retorno dos investimentos. Mas, o que afinal entendemos por APS? Qual a compreens o dos governos, da popula o, dos médicos e suas sociedades; das institui es de saúde, das universidades; das organiza es sociais? Quando nos referimos a APS, focamos o mesmo objeto'? Falamos de uma aten o básica, de uma aten o simp
A Sociedade Brasileira de Medicina de Família e Comunidade de agosto de 2004 a julho de 2008: um olhar sobre a sua história.
Maria Inez Padula Anderson
Revista Brasileira de Medicina de Família e Comunidade , 2010, DOI: 10.5712/rbmfc4(13)209
Abstract:
Editorial
Maria Inez Padula Anderson
Revista Brasileira de Medicina de Família e Comunidade , 2010, DOI: 10.5712/rbmfc3(11)332
Abstract: Provocar e promover mudan as de rumo na forma o, nas práticas e na organiza o dos servi os de saúde num país que, de forma hegem nica, privilegiou, e ainda privilegia, o paradigma anátomo-clínico e, com ele, a medicina da doen a, a super-especializa o e a tecnologia industrial como sin nimos de boa prática médica e status profissional, n o s o tarefas corriqueiras. Esta edi o da RBMFC é constituída por artigos que pretendem deixar uma contribui o ao processo de mudan a vivenciado hoje no Brasil em prol da Aten o Primária à Saúde (APS). Refere-se, especificamente, à forma o e capacita o médica no nível da gradua o e pós-gradua o no campo da Medicina de Família e Comunidade e da Estratégia de Saúde da Família. Neste cenário, os desafios s o muitos: Como instituir as mudan as estruturais e conjunturais fundamentais para que ocorra este processo de mudan a? Quais as modifica es que se fazem necessárias no seio da escola médica? Como lidar com o aumento da demanda por especialistas em Medicina de Família e Comunidade, sem um número suficiente de programas de pós-gradua o? Como capacitar em servi o? Como formar e aumentar o quantitativo de educadores que possam, a um só tempo, atender a estas diferentes necessidades? Como sociedade científica, a SBMFC, deve ser e estar genuinamente comprometida em colaborar no enfrentamento destes desafios. Para além das atividades de cunho cientifico que promove, através dos congressos e eventos afins, ela deve deixar registradas as iniciativas que desenvolve no ambito técnico e político que, em última análise, possam servir de base para orientar este processo de transforma o. Sem a pretens o de esgotar a temática, esta edi o especial da RBMFC traz o registro de algumas destas iniciativas, promovidas no decorrer da gest o da Diretoria da SBMFC dos últimos quatro anos. Contribuíram para sua elabora o, profissionais com diferentes tipos e tempos de inser o nesta caminhada, todos comprometidos e experientes no ensino e na prática da Medicina de Família e Comunidade e da Estratégia de Saúde da Família. Os textos que constituem esta revista vêm se somar a outros já escritos e divulgados pela própria RBMFC, por outras publica es da área e também pelo Ministério da Saúde nos últimos períodos. Conformam, assim, um conjunto de reflex es e, também, de estratégias de a o acessíveis a todos que, de algum modo, atuam e colaboram na consolida o qualificada do ensino e da forma o em Aten o Primária à Saúde em nosso país. Comp em esta edi o, seis artigos, a saber: 1. Programa de Residência em Medicina de Família e Comun
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