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Search Results: 1 - 10 of 224210 matches for " Curi R. "
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Meal-feeding scheme: twenty years of research in Brazil
Bazotte, R.B.;Batista, M.R.;Curi, R.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000000900001
Abstract: naomi shinomiya hell was the first researcher to investigate the physiological adaptations to a meal-feeding scheme (mfs) in brazil. over a period of 20 years, from 1979 to 1999, naomi's group determined the physiological and metabolic adaptations induced by this feeding scheme in rats. the group showed the persistence of such adaptations even when mfs is associated with moderate exercise training and the performance to a session of intense physical effort. the metabolic changes induced by the feeding training were discriminated from those caused by the effective fasting period. naomi made an important contribution to the understanding of the mfs but a lot still has to be done. one crucial question still remains to be satisfactorily answered: what is the ideal control for the mfs?
Meal-feeding scheme: twenty years of research in Brazil
Bazotte R.B.,Batista M.R.,Curi R.
Brazilian Journal of Medical and Biological Research , 2000,
Abstract: Naomi Shinomiya Hell was the first researcher to investigate the physiological adaptations to a meal-feeding scheme (MFS) in Brazil. Over a period of 20 years, from 1979 to 1999, Naomi's group determined the physiological and metabolic adaptations induced by this feeding scheme in rats. The group showed the persistence of such adaptations even when MFS is associated with moderate exercise training and the performance to a session of intense physical effort. The metabolic changes induced by the feeding training were discriminated from those caused by the effective fasting period. Naomi made an important contribution to the understanding of the MFS but a lot still has to be done. One crucial question still remains to be satisfactorily answered: what is the ideal control for the MFS?
Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils
Curi R.,Newsholme P.,Pithon-Curi T.C.,Pires-de-Melo M.
Brazilian Journal of Medical and Biological Research , 1999,
Abstract: Eric Newsholme's laboratory was the first to show glutamine utilization by lymphocytes and macrophages. Recently, we have found that neutrophils also utilize glutamine. This amino acid has been shown to play a role in lymphocyte proliferation, cytokine production by lymphocytes and macrophages and phagocytosis and superoxide production by macrophages and neutrophils. Knowledge of the metabolic fate of glutamine in these cells is important for the understanding of the role and function of this amino acid in the maintenance of the proliferative, phagocytic and secretory capacities of these cells. Glutamine and glucose are poorly oxidized by these cells and might produce important precursors for DNA, RNA, protein and lipid synthesis. The high rate of glutamine utilization and its importance in such cells have raised the question as to the source of this glutamine, which, according to current evidence, appears to be muscle.
Arachidonic acid triggers an oxidative burst in leukocytes
Pompeia, C.;Cury-Boaventura, M.F.;Curi, R.;
Brazilian Journal of Medical and Biological Research , 2003, DOI: 10.1590/S0100-879X2003001100013
Abstract: the change in cellular reducing potential, most likely reflecting an oxidative burst, was investigated in arachidonic acid- (aa) stimulated leukocytes. the cells studied included the human leukemia cell lines hl-60 (undifferentiated and differentiated into macrophage-like and polymorphonuclear-like cells), jurkat and raji, and thymocytes and macrophages from rat primary cultures. the oxidative burst was assessed by nitroblue tetrazolium reduction. aa increased the oxidative burst until an optimum aa concentration was reached and the burst decreased thereafter. in the leukemia cell lines, optimum concentration ranged from 200 to 400 μm (up to 16-fold), whereas in rat cells it varied from 10 to 20 μm. initial rates of superoxide generation were high, decreasing steadily and ceasing about 2 h post-treatment. the continuous presence of aa was not needed to stimulate superoxide generation. it seems that the nadph oxidase system participates in aa-stimulated superoxide production in these cells since the oxidative burst was stimulated by nadph and inhibited by n-ethylmaleimide, diphenyleneiodonium and superoxide dismutase. some of the effects of aa on the oxidative burst may be due to its detergent action. there apparently was no contribution of other superoxide-generating systems such as xanthine-xanthine oxidase, cytochromes p-450 and mitochondrial electron transport chain, as assessed by the use of inhibitors. eicosanoids and nitric oxide also do not seem to interfere with the aa-stimulated oxidative burst since there was no systematic effect of cyclooxygenase, lipoxygenase or nitric oxide synthase inhibitors, but lipid peroxides may play a role, as indicated by the inhibition of nitroblue tetrazolium reduction promoted by tocopherol.
Arachidonic acid triggers an oxidative burst in leukocytes
Pompeia C.,Cury-Boaventura M.F.,Curi R.
Brazilian Journal of Medical and Biological Research , 2003,
Abstract: The change in cellular reducing potential, most likely reflecting an oxidative burst, was investigated in arachidonic acid- (AA) stimulated leukocytes. The cells studied included the human leukemia cell lines HL-60 (undifferentiated and differentiated into macrophage-like and polymorphonuclear-like cells), Jurkat and Raji, and thymocytes and macrophages from rat primary cultures. The oxidative burst was assessed by nitroblue tetrazolium reduction. AA increased the oxidative burst until an optimum AA concentration was reached and the burst decreased thereafter. In the leukemia cell lines, optimum concentration ranged from 200 to 400 μM (up to 16-fold), whereas in rat cells it varied from 10 to 20 μM. Initial rates of superoxide generation were high, decreasing steadily and ceasing about 2 h post-treatment. The continuous presence of AA was not needed to stimulate superoxide generation. It seems that the NADPH oxidase system participates in AA-stimulated superoxide production in these cells since the oxidative burst was stimulated by NADPH and inhibited by N-ethylmaleimide, diphenyleneiodonium and superoxide dismutase. Some of the effects of AA on the oxidative burst may be due to its detergent action. There apparently was no contribution of other superoxide-generating systems such as xanthine-xanthine oxidase, cytochromes P-450 and mitochondrial electron transport chain, as assessed by the use of inhibitors. Eicosanoids and nitric oxide also do not seem to interfere with the AA-stimulated oxidative burst since there was no systematic effect of cyclooxygenase, lipoxygenase or nitric oxide synthase inhibitors, but lipid peroxides may play a role, as indicated by the inhibition of nitroblue tetrazolium reduction promoted by tocopherol.
Glutamine and glutamate as vital metabolites
Newsholme, P.;Lima, M.M.R.;Procopio, J.;Pithon-Curi, T.C.;Doi, S.Q.;Bazotte, R.B.;Curi, R.;
Brazilian Journal of Medical and Biological Research , 2003, DOI: 10.1590/S0100-879X2003000200002
Abstract: glucose is widely accepted as the primary nutrient for the maintenance and promotion of cell function. this metabolite leads to production of atp, nadph and precursors for the synthesis of macromolecules such as nucleic acids and phospholipids. we propose that, in addition to glucose, the 5-carbon amino acids glutamine and glutamate should be considered to be equally important for maintenance and promotion of cell function. the functions of glutamine/glutamate are many, i.e., they are substrates for protein synthesis, anabolic precursors for muscle growth, they regulate acid-base balance in the kidney, they are substrates for ureagenesis in the liver and for hepatic and renal gluconeogenesis, they act as an oxidative fuel for the intestine and cells of the immune system, provide inter-organ nitrogen transport, and act as precursors of neurotransmitter synthesis, of nucleotide and nucleic acid synthesis and of glutathione production. many of these functions are interrelated with glucose metabolism. the specialized aspects of glutamine/glutamate metabolism of different glutamine-utilizing cells are discussed in the context of glucose requirements and cell function.
Fisiologia da nutri o humana: aspectos básicos, aplicados e funcionais
Rui Curi
Revista Brasileira de Ciências Farmacêuticas , 2007, DOI: 10.1590/s1516-93322007000300019
Abstract:
Histology
Rui Curi
Brazilian Journal of Pharmaceutical Sciences , 2011, DOI: 10.1590/s1984-82502011000100031
Abstract:
On the existence of Stone-Cech compactification
Giovanni Curi
Mathematics , 2009,
Abstract: In [G. Curi, "Exact approximations to Stone-Cech compactification'', Ann. Pure Appl. Logic, 146, 2-3, 2007, pp. 103-123] a characterization is obtained of the locales of which the Stone-Cech compactification can be defined in constructive type theory CTT, and in the formal system CZF+uREA+DC, a natural extension of Aczel's system for constructive set theory CZF by a strengthening of the Regular Extension Axiom REA and the principle of dependent choice. In this paper I show that this characterization continues to hold over the standard system CZF plus REA, thus removing in particular any dependency from a choice principle. This will follow by a result of independent interest, namely the proof that the class of continuous mappings from a compact regular locale X to a regular a set-presented locale Y is a set in CZF, even without REA. It is then shown that the existence of Stone-Cech compactification of a non-degenerate Boolean locale is independent of the axioms of CZF (+REA), so that the obtained characterization characterizes a proper subcollection of the collection of all locales. The same also holds for several, even impredicative, extensions of CZF+REA, as well as for CTT. This is in contrast with what happens in the context of Higher-order Heyting arithmetic HHA - and thus in any topos-theoretic universe: by constructions of Johnstone, Banaschewski and Mulvey, within HHA Stone-Cech compactification can be defined for every locale.
On some peculiar aspects of the constructive theory of point-free spaces
Giovanni Curi
Mathematics , 2009, DOI: 10.1002/malq.200910014
Abstract: This paper presents several independence results concerning the topos-valid and the intuitionistic (generalized) predicative theories of locales. In particular, certain consequences of the consistency of a general form of Troelstra's uniformity principle with constructive set theory and type theory are examined.
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