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Search Results: 1 - 10 of 195161 matches for " Costa Terezinha de Jesus Thibes Bleyer Martins "
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Caminhos percorridos pelo dr. Jorge Clarke Bleyer nos campos da medicina tropical e da pré-história brasileira
Costa, Terezinha de Jesus Thibes Bleyer Martins;
História, Ciências, Saúde-Manguinhos , 2003, DOI: 10.1590/S0104-59702003000100010
Abstract: this research note presents a preliminary evaluation of the life history of georg carl adolf bleyer, physician, hygienist and naturalist who played a crucial role in the institution of public health in santa catarina and was a pioneer in tropical medicine, anthropology and archeology of brazil. adolpho lutz was one of the main partners in brazil of this equally multifaceted physician who published important articles in german journals. his most thorough study was important to the history of the disciplines with which he worked; it provides the basis for understanding the conditions of medical and scientific practice in places far from the urban centers of southeastern brazil that dominate the historiography of medicine and science.
Caminhos percorridos pelo dr. Jorge Clarke Bleyer nos campos da medicina tropical e da pré-história brasileira
Costa Terezinha de Jesus Thibes Bleyer Martins
História, Ciências, Saúde-Manguinhos , 2003,
Abstract: Esta nota de pesquisa apresenta uma avalia o preliminar da trajetória de Georg Carl Adolf Bleyer, médico, higienista e naturalista que desempenhou papel crucial na institui o da saúde pública em Santa Catarina, e que foi um dos pioneiros da medicina tropical, da antropologia e da arqueologia no Brasil. Adolpho Lutz foi um dos principais interlocutores, no Brasil, desse médico igualmente polivalente que publicou importantes trabalhos em periódicos alem es. O estudo mais aprofundado de sua trajetória, além de ser importante para a história das mencionadas disciplinas, permite conhecer as condi es em que eram exercidas as práticas médica e científica em cenários periféricos aos grandes centros urbanos do Sudeste do Brasil, que dominam a historiografia da medicina e das ciências.
Neuropathic pain characteristics in patients from Curitiba (Brazil) with spinal cord injury
Vall, Janaína;Costa, Carlos Mauricio de Castro;Santos, Terezinha de Jesus Teixeira;Costa, Samuel Bovy de Castro;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000100013
Abstract: this was a descriptive cross-sectional study on patients with spinal cord injuries living in curitiba, paraná, brazil. the aim was to evaluate the pain characteristics among such patients seen at referral care centers for spinal cord injury patients in curitiba. a total of 109 adults with spinal cord injury in this city were evaluated regarding the presence of pain, especially neuropathic pain. neuropathic pain was evaluated using the dn4 questionnaire, a universal instrument that has been translated and validated for portuguese. a visual analog scale (vas) was used to evaluate the intensity of pain. the prevalence of pain among these 109 patients was 31.2% (34 patients). the nociceptive pain presented was classified as musculoskeletal pain (nine patients), visceral pain (four patients) and mixed pain (one patient), thus totaling 14 patients (12.8%). another 20 patients (18.3%) showed symptoms of neuropathic pain and fulfilled the criteria for neuropathic pain with scores greater than 4 out 10 in the dn4 questionnaire. regarding the characteristics of the patients with neuropathic pain, most of them were male, younger than 40 years of age and paraplegic with incomplete lesions. they had become injured from 1 to more than 5 years earlier. the predominant etiology was gunshot wounds, and the intensity of their pain was high, with vas scores greater than 5. this study partially corroborates other studies conducted on this subject. studies of this type are important for understanding the profile of these patients, for the purpose of designing strategies for their rehabilitation, with a focus on the appropriate treatment and management of pain.
Compressive and diametral tensile strength of glass ionomer cements
Bresciani, Eduardo;Barata, Terezinha de Jesus Esteves;Fagundes, Ticiane Cestari;Adachi, Akimi;Terrin, Marina Martins;Navarro, Maria Fidela de Lima;
Journal of Applied Oral Science , 2004, DOI: 10.1590/S1678-77572004000400017
Abstract: the aim of this study was to compare, in different periods of time, the compressive and diametral tensile strength of a traditional high viscous glass ionomer cement: fuji ix (gc corporation), with two new brazilian gic's: vitro-molar (dfl) and bioglass r (biodinamica), all indicated for the atraumatic restorative treatment (art) technique. fifteen disk specimens (6.0mm diameter x 3.0mm height) for the diametral tensile strength (dts) test and fifteen cylindrical specimens (6.0mm diameter x 12.0mm height) for the compressive strength (cs) test were made of each gic. specimens were stored in deionized water at 37o c and 100% of humidity in a stove until testing. five specimens of each gic were submitted to cs and dts test in each period, namely 1 hour, 24 hours and 7 days. the specimens were tested in a testing machine (emic) at a crosshead speed of 1.0mm/min for cs and 0.5mm/min for the dts test until failure occurred. the data were submitted to two-way anova and tukey tests (a=0.05). the mean cs values ranged from 42.03 to 155.47mpa and means dts from 5.54 to 13.72 mpa, with test periods from 1h to 7 days. the cs and dts tests showed no statistically significant difference between fuji ix and vitro molar, except for cs test at 1-hour period. bioglass r had lowest mean value for cs of the cements tested. in dts test bioglass r presented no statistically significant differences when compared with all others tested gics at 1-hour period and bioglass r presented no difference at 24-hour and 7-day periods when compared to vitro-molar. further studies to investigate other physical properties such as fracture toughness and wear resistance, as well as chemical composition and biocompatibility, are now needed to better understand the properties of these new brazilian gic's.
Pharmacological, morphological and behavioral analysis of motor impairment in experimentally vitamin C deficient guinea pigs
Oriá, Reinaldo Barreto;Costa, Carlos Maurício de Castro;Santos, Terezinha de Jesus Teixeira;Vieira, Carlos Meton de Alencar G.;
Arquivos de Neuro-Psiquiatria , 2003, DOI: 10.1590/S0004-282X2003000100005
Abstract: the scurvy shows an inflammatory disease and gingival bleeding. nevertheless, in an animal model for guinea pigs, described by den hartog jager in 1985, scurvy was associated with a motor neuron disease with demyelinization of the pyramidal tract, provoking neurogenic atrophy of muscles. aiming at searching the protective role of vitamin c in nervous system, a pharmacological, morphological and behavioral study was conducted. three experimental groups were used: a100, animals receiving 100 mg/ vitamin c/ day; a5.0, animals receiving 5.0 mg/vitamin c/ day; and a0, animals without vitamin c. we analyzed the weight gain, muscular diameter and behavioral tests. in all tests examined, we found significant differences between the supplemented groups in comparison with scorbutic group (p<0.05). thereafter, the animals were killed for histopathology of gastrocnemius muscle, spinal cord and tooth tissues. in addition, a morphometric study of periodontal thickness and a-motor neuron cell body diameter were done. the vitamin c-diet free regimen seemed to induce a disruption in spinal cord morphology, involving the lower motor neuron, as confirmed by a significant reduction in neuron perycaria diameter and muscular atrophy, complicated by increased nutritional deficit.
Pharmacological, morphological and behavioral analysis of motor impairment in experimentally vitamin C deficient guinea pigs
Oriá Reinaldo Barreto,Costa Carlos Maurício de Castro,Santos Terezinha de Jesus Teixeira,Vieira Carlos Meton de Alencar G.
Arquivos de Neuro-Psiquiatria , 2003,
Abstract: The scurvy shows an inflammatory disease and gingival bleeding. Nevertheless, in an animal model for guinea pigs, described by Den Hartog Jager in 1985, scurvy was associated with a motor neuron disease with demyelinization of the pyramidal tract, provoking neurogenic atrophy of muscles. Aiming at searching the protective role of vitamin C in nervous system, a pharmacological, morphological and behavioral study was conducted. Three experimental groups were used: A100, animals receiving 100 mg/ vitamin C/ day; A5.0, animals receiving 5.0 mg/vitamin C/ day; and A0, animals without vitamin C. We analyzed the weight gain, muscular diameter and behavioral tests. In all tests examined, we found significant differences between the supplemented groups in comparison with scorbutic group (p<0.05). Thereafter, the animals were killed for histopathology of gastrocnemius muscle, spinal cord and tooth tissues. In addition, a morphometric study of periodontal thickness and alpha-motor neuron cell body diameter were done. The vitamin C-diet free regimen seemed to induce a disruption in spinal cord morphology, involving the lower motor neuron, as confirmed by a significant reduction in neuron perycaria diameter and muscular atrophy, complicated by increased nutritional deficit.
The effect of baclofen on spontaneous and evoked behavioural expression of experimental neuropathic chronic pain
SANTOS TEREZINHA DE JESUS T.,CASTRO-COSTA CARLOS M. DE,GIFFONI SíLVIO D. A.,SANTOS FRANKLIN J. C.
Arquivos de Neuro-Psiquiatria , 1999,
Abstract: Baclofen (beta-p-chlorophenyl-GABA) has been used in humans to treat spasticity, as well as trigeminal neuralgia. Since GABA (gamma-aminobutyric acid) has been implicated in inhibitory and analgesic effects in the nervous system, it was of interest to study the effect of baclofen in experimental neuropathic pain. With this purpose, experiments were carried out in 17 neuropathic rats with constrictive sciatic injury, as described by Bennet and Xie (1988), taking as pain parameters scratching behaviour and the latency to the thermal nociceptive stimulus. The results showed that baclofen induces, in a dose-dependent manner, significant decrease (p < 0.05) of scratching behaviour and significant increase (p < 0.05) of the latency to the nociceptive thermal stimulus. The absence of antagonism of naloxone suggested a non-participation of an opioid-mediated mechanism in this analgesic effect of baclofen on experimental neuropathic pain.
Western blot seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) in Fortaleza (Brazil): a serological and molecular diagnostic and epidemiological approach
Santos Terezinha de Jesus Teixeira,Costa Carlos Maurício de Castro,Goubau Patrick,Vandamme Anne-Mieke
Brazilian Journal of Infectious Diseases , 2003,
Abstract: How to handle Western blot (WB) seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) constitutes a challenge for blood banks and fam ilies. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA) reactive individuals from the hematological center (HEMOCE) of Fortaleza (Brazil), examining their serological (WB) and molecular (PCR) diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22%) were positive and 32 (78%) were negative for HTLV-1/2. The demographic analysis indicated a trend towards a predominance of males among the seroindeterminate individuals and females in the seropositive ones. The seroindeterminate individuals were younger than the seropositive ones. We did not find any association of these conditions with syphilis, Chagas disease or HIV or hepatitis, and with risk factors such as breast-feeding, blood transfusion, STD (syphilis) and IDU.
Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
Rocha Mendes,Eliane Terezinha; Sim?es,Manuel de Jesus; Alves Mora,Oswaldo; Martins Oliveira-Filho,Ricardo; Kulay Jr.,Luiz;
Revista chilena de anatomía , 2000, DOI: 10.4067/S0716-98682000000200007
Abstract: as a less potent opioid analgesic and cns depressant than morphine, propoxyphene abuse constitutes a potential risk among pregnant women. since literature data indicate the possibility of serious side effects on liver compartment, in this work we examined the effects the chronic administration of this drug on both pregnant rats and their concepts. female rats were treated during the entire pregnancy (from day 0 up to day 20) with 5, 15 or 45 mg/kg of propoxyphene napsylate once daily, by gavage. controls received the drug vehicle. at term, samples from both maternal and foetal kidneys and livers were taken and prepared for optical and electron microscopy examination. upon optical microscopy or electron microscopy examination, no morphological alterations were seen on either maternal or foetal livers of propoxyphene-treated pregnant rats. however, maternal and foetal kidneys showed signs of toxicity mainly in the group of rats treated with the highest dose of the drug, especially at the proximal convoluted tubules. our results suggest that, in the rat, the physiological modifications inherent to pregnancy shifted the main focus of toxicity of propoxyphene from the liver to the kidney. the mechanisms involved in such phenomenon are at present unresolved
Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats Efectos Hepáticos y Renales del Napsilato de Propoxifeno en Ratas Pre adas
Eliane Terezinha Rocha Mendes,Manuel de Jesus Sim?es,Oswaldo Alves Mora,Ricardo Martins Oliveira-Filho
Revista chilena de anatomía , 2000,
Abstract: As a less potent opioid analgesic and CNS depressant than morphine, propoxyphene abuse constitutes a potential risk among pregnant women. Since literature data indicate the possibility of serious side effects on liver compartment, in this work we examined the effects the chronic administration of this drug on both pregnant rats and their concepts. Female rats were treated during the entire pregnancy (from day 0 up to day 20) with 5, 15 or 45 mg/kg of propoxyphene napsylate once daily, by gavage. Controls received the drug vehicle. At term, samples from both maternal and foetal kidneys and livers were taken and prepared for optical and electron microscopy examination. Upon optical microscopy or electron microscopy examination, no morphological alterations were seen on either maternal or foetal livers of propoxyphene-treated pregnant rats. However, maternal and foetal kidneys showed signs of toxicity mainly in the group of rats treated with the highest dose of the drug, especially at the proximal convoluted tubules. Our results suggest that, in the rat, the physiological modifications inherent to pregnancy shifted the main focus of toxicity of propoxyphene from the liver to the kidney. The mechanisms involved in such phenomenon are at present unresolved El uso del napsilato de propoxifeno (NP), fármaco analgésico opioide y depresor del SNC, involucra riesgo potencial de abuso y sus consecuencias, particularmente durante el embarazo. Como en la literatura hay datos indicando la posibilidad de serios efectos colaterales del NP sobre el hígado, el objetivo de este trabajo fue examinar los efectos del NP en ratas pre adas y sus fetos. Ratas hembras fueron tratadas durante toda la pre ez (desde el día 0 hasta el día 20) con 5, 15 ó 45 mg/kg de NP, una vez al día, por gavage. Grupos controles recibieron el líquido usado como vehículo (aceite de acacia). Al término, muestras de hígado y ri ón de las ratas pre adas y sus fetos fueron extraídos. Las muestras fueron procesadas para microscopías óptica y electrónica. No se detectaron alteraciones morfológicas en hígados de ratas pre adas o fetos con ninguna dosis de NP empleada. Los rin nes de estos animales mostraron signos de toxicidad, particularmente, con la dosis más alta del fármaco y, especialmente, en las células de los túbulos contorneados proximales. Nuestros resultados sugieren que, en la rata, las alteraciones fisiológicas propias de la gravidez parecen cambiar el órgano-blanco de la toxicidad del NP, es decir, los efectos se manifiestan en el ri ón y no en el hígado. Los mecanismos involucrados en este
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