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Search Results: 1 - 10 of 313 matches for " Corn PG "
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The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development
Corn PG
Cancer Management and Research , 2012, DOI: http://dx.doi.org/10.2147/CMAR.S32839
Abstract: umor microenvironment in prostate cancer: elucidating molecular pathways for therapy development Review (2185) Total Article Views Authors: Corn PG Published Date July 2012 Volume 2012:4 Pages 183 - 193 DOI: http://dx.doi.org/10.2147/CMAR.S32839 Received: 11 April 2012 Accepted: 02 May 2012 Published: 25 July 2012 Paul G Corn Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA Abstract: Mechanisms leading to the development of virulent prostate cancer are not confined to the cancer epithelial cell, but also involve the tumor microenvironment. Multiple signaling pathways exist between epithelial cells, stromal cells, and the extracellular matrix to support tumor progression from the primary site to regional lymph nodes and distant metastases. Prostate cancers preferentially metastasize to the skeleton, prompting considerable research effort into understanding the unique interaction between prostate cancer epithelial cells and the bone microenvironment. This effort has led to the discovery that signaling pathways involved in normal prostate and bone development become dysregulated in cancer. These pathways stimulate excessive cell growth and neovascularization, impart more invasive properties to epithelial cells, weaken antitumor immune surveillance, and promote the emergence of castrate-resistant disease. An improved understanding of the complex relationship between cancer epithelial cells and the organ-specific microenvironments with which they interact has created a powerful opportunity to develop novel therapies.
The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development
Corn PG
Cancer Management and Research , 2012,
Abstract: Paul G CornDepartment of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX, USAAbstract: Mechanisms leading to the development of virulent prostate cancer are not confined to the cancer epithelial cell, but also involve the tumor microenvironment. Multiple signaling pathways exist between epithelial cells, stromal cells, and the extracellular matrix to support tumor progression from the primary site to regional lymph nodes and distant metastases. Prostate cancers preferentially metastasize to the skeleton, prompting considerable research effort into understanding the unique interaction between prostate cancer epithelial cells and the bone microenvironment. This effort has led to the discovery that signaling pathways involved in normal prostate and bone development become dysregulated in cancer. These pathways stimulate excessive cell growth and neovascularization, impart more invasive properties to epithelial cells, weaken antitumor immune surveillance, and promote the emergence of castrate-resistant disease. An improved understanding of the complex relationship between cancer epithelial cells and the organ-specific microenvironments with which they interact has created a powerful opportunity to develop novel therapies.Keywords: prostate cancer, molecular signaling, prostate cancer therapy, tumor microenvironment, castrate-resistant prostate cancer
Simultaneous reconstructive surgery for radical mastectomy
PG Robb
Breast Cancer Research , 2005, DOI: 10.1186/bcr1214
Abstract: The increased use of postmastectomy radiation therapy in patients with early-stage breast cancer has increased the complexity of planning for immediate breast reconstruction. Studies have evaluated the outcomes of breast reconstruction performed before radiation therapy, revealing a high incidence of complications and poor aesthetic outcomes [3]. Moreover, immediate breast reconstruction can interfere with the delivery of postmastectomy radiation therapy. Multidisciplinary breast conference identification of early breast cancer patients at high risk for radiation therapy has evolved a unique and highly successful 'delayed immediate' reconstruction [4] approach that preserves the aesthetic outcomes of immediate reconstruction and avoids radiation injury to the reconstructive tissues. This is accomplished by utilizing a filled subpectoral tissue expander to temporarily preserve the breast skin envelope until the final tissue pathology is confirmed and the patient either goes on to definitive reconstruction or to radiation therapy with the expander deflated. A total of 28 high-risk early breast cancer patients have undergone the delayed immediate approach with 20 patients (71%) not ultimately requiring radiation therapy. Nineteen patients in the non-radiated group (95%) have now completed definitive reconstruction, primarily with the use of autologous tissues. The eight patients who required radiation have completed the radiation therapy and six (75%) have undergone tissue re-expansion and skin-preserving delayed reconstruction designed to be as similar in outcome to immediate reconstruction as possible. The complication rate for the initial expander placement at the time of mastectomy was 18% for all patients. Five nonradiated patients (25%) had complications in the second stage of definitive reconstruction and one patient (17%) following radiation therapy had complications in the skin-preserving delayed reconstruction.Finally, following the successful experience of t
The Nile river question and the Riparian States: Contextualising Uganda's Foreign Policy Interests
PG Okoth
African Sociological Review / Revue Africaine de Sociologie , 2007,
Abstract:
Out-of-pocket payment for health services: constraints and implications for government employees in Abakaliki, Ebonyi state, South east Nigeria
PG Oyibo
African Health Sciences , 2011,
Abstract: Background: Each year, 100 million people are impoverished globally as a result of expenditure on health. Objective: To assess the constraints and implications of out-of-pocket payment for health services among government employees in Abakaliki, Ebonyi State, south east Nigeria. Method: This was a cross-sectional descriptive study. The study instrument was a pre-tested, semi-structured self administered questionnaire. Results: Over half of the respondents (62.8 %) reported a history of illness in their household in the preceding four weeks before the study. Sixty-nine percent of these respondents relied on out-of-pocket payment in order to pay for health services at the moment of seeking medical treatment for themselves or their dependants; while 28.4 % and 2.6 % relied on a prepayment package (National Health Insurance Scheme) and borrowed money respectively to pay for health services at the moment of seeking medical treatment for themselves or their dependants. The vast majority of respondents (63.6 %) who relied on out-of-pocket payment reported their difficulties in accessing quality health care services as a result of financial hardship at the moment of seeking medical treatment. Most of them (47.7 %) resolved to self medication, while 28.4 %, 17.1 % and 6.8 % of them delayed seeking health care, patronized herbalists and ignored their illness respectively. Conclusion: This study brings to the fore the fact that most government employees and their dependants in Abakaliki have difficulties in accessing quality health care services via paying for them out-of-pocket.
Endoscopic Ultrasonography: Impact in Diagnosis, Staging and Management of Pancreatic Tumors. An Overview
Arcidiacono PG
JOP Journal of the Pancreas , 2004,
Abstract:
Guest editorial:“Miraculous and Almost Godlike Tasks”?
Corné Schutte
South African Journal of Industrial Engineering , 2012,
Abstract: “Knowledge is power, and the right knowledge lets man perform miraculous, almost godlike tasks” - Prof Robert Langdon (The main character in Dan Brown’s novel “The Lost Symbol”) It is an honour to write the guest editorial for this special edition of our Journal. This edition commemorates 25 years of academic publishing. It contains articles that are an expansion of a selection from two conferences in 2011. And, our conferences have the same proud heritage. The first one took place in 1986 at the Burgerspark Hotel in Pretoria. As a post-graduate student at the University of Pretoria, I was there, and I participated, under the expert guidance of Proff Kris Adendorff and Paul Kruger, who both instilled the love for Industrial Engineering in me, and who made sure that I realise just how important activities such as the Journal and our annual conferences are for the continued growth of our discipline.
Tate-Shafarevich groups and K3 surfaces
Patrick Corn
Mathematics , 2007,
Abstract: Following (and elaborating on) a method of Logan and van Luijk, we exhibit explicit genus-2 curves whose Jacobians have nontrivial 2-torsion in their Tate-Shafarevich groups.
Del Pezzo surfaces of degree 6
Patrick Corn
Mathematics , 2004,
Abstract: We give a correspondence which associates, to any Del Pezzo surface X of degree 6 over a field k of characteristic 0, a collection of data consisting of a Severi-Brauer variety/k and a set of points defined over some extension of k.
Appendicitis as a cause of intestinal strangulation: a case report and review
Laxminarayan Bhandari, PG Mohandas
World Journal of Emergency Surgery , 2009, DOI: 10.1186/1749-7922-4-34
Abstract: We report a case of a 24 year old male presenting with classical features of intestinal obstruction. On laparotomy strangulated bowel was seen and appendix was found to be the cause. Although we obtained a history of appendicitis in this patient, it was not correlated to the present condition due to the rarity of such a scenario. We reviewed literature to find similar cases reported in the past.Intestinal obstruction is a common surgical emergency caused by varied conditions. Appendix as a cause of intestinal obstruction is uncommon and not usually suspected. Although it was described as early as 1901, very few reports are available which do a comprehensive review [1]. Intestinal strangulation caused by appendix is extremely rare with very few cases reported. Pre-operatively it is very difficult to diagnose this condition. The diagnosis is always made at the time of laparotomy. The treatment varies from appendicectomy to intestinal resection or even right hemicolectomy.We are reporting a case of intestinal strangulation caused by appendicitis, for which appendicectomy was done. This is a very rare complication of an extremely common disease. We reviewed the literature to find out about appendix producing intestinal obstruction in general and intestinal strangulation in particular.We have included a comprehensive discussion about appendicitis producing intestinal obstruction with regards to its various pathological types, different clinical presentations, diagnosis and management.A 24 year old man presented with on and off fever and diffuse abdominal pain since one week. He also had constipation, vomiting and abdominal distention since two days.He was apparently normal a week ago when he developed abdominal pain for which he visited a peripheral hospital. An Ultrasonography (USG) abdomen was done, which revealed the possibility of a mild appendicular inflammation. He was treated with oral antibiotics and analgesics following which his abdominal pain subsided. Few day
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