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Search Results: 1 - 10 of 84575 matches for " Clyde W. Yancy "
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Left Atrial Appendage Exclusion for Stroke Prevention in Atrial Fibrillation
Taral K. Patel,Clyde W. Yancy,Bradley P. Knight
Cardiology Research and Practice , 2012, DOI: 10.1155/2012/610827
Abstract: The public health burden of atrial fibrillation (AF) and associated thromboembolic stroke continues to grow at alarming rates. AF leads to a fivefold increase in the risk of stroke. Therefore, stroke prevention remains the most critical aspect of AF management. Current standard of care focuses on oral systemic anticoagulation, most commonly with warfarin and now with newer agents such as dabigatran, rivaroxaban, and apixaban. However, the challenges and limitations of oral anticoagulation have been well documented. Given the critical role of the left atrial appendage (LAA) in the genesis of AF-related thromboembolism, recent efforts have targeted removal or occlusion of the LAA as an alternative strategy for stroke prevention, particularly in patients deemed unsuitable for oral anticoagulation. This paper highlights recent advances in mechanical exclusion of the LAA. The problem of AF and stroke is briefly summarized, followed by an explanation for the rationale behind LAA exclusion for stroke prevention. After briefly reviewing the history of LAA exclusion, we highlight the most promising LAA exclusion devices currently available. Finally, we discuss future challenges and opportunities in this growing field. 1. Introduction: Atrial Fibrillation and Stroke Atrial fibrillation (AF) is the most common arrhythmia in modern clinical practice, currently affecting up to 5 million people in the United States [1, 2]. The prevalence rises sharply with age, from approximately 1% among people aged 55–59 years to over 10% among those aged greater than 80 years [3]. Importantly, the burden of AF is expected to rise threefold by 2050 to an estimated 12–16 million Americans [4]. The most feared clinical consequence of AF is stroke due to thromboembolism. Stroke is the third leading cause of death and the number one cause of major disability in the United States [5]. AF is a powerful risk factor for stroke; a diagnosis of AF increases stroke risk fivefold and conveys an overall stroke rate of 5% per year [5]. Of the estimated 800,000 annual strokes in the USA, the percentage attributable to AF ranges from 1.5% (50–59 years old) to 23.5% (80–89 years old) [5]. As AF is commonly silent and undiagnosed, the influence of AF on stroke is almost certainly underestimated. 2. The Role of the Left Atrial Appendage AF promotes thromboembolism through a variety of mechanisms, most significantly mechanical dysfunction in the atria leading to impaired blood flow and stasis. Additional factors including endothelial dysfunction, inflammation, platelet activation, and a
La estrategia de la excelencia selectiva
Clyde W. Barrow
Perfiles educativos , 1997,
Abstract: Las asignaciones de recursos en la educación superior estadounidense están bajo el control, por un lado, de las restricciones que impone una crisis fiscal estructural y, por el otro, de las presiones que ejercen los líderes empresariales y políticos para que las universidades coadyuven en la superación de los retos que presenta el nuevo orden económico. El resultado es una exigencia contradictoria de que la educación superior haga más con menos. Mientras el logro de este objetivo podría parecer imposible para cada institución o docente, el dilema está resolviéndose a un nivel sistémico, por medio de una combinación de respuestas institucionales ante las fuerzas del mercado y de una planificación estratégica a nivel estatal, regional y federal.
Were the First Europeans Pale or Dark Skinned?  [PDF]
Clyde Winters
Advances in Anthropology (AA) , 2014, DOI: 10.4236/aa.2014.43016

This is an overview of the Out of Africa (OoA) settlement of Europe during the Aurignacian period. Klyosov claims that the first Europeans were fair (pale) skin, and Neanderthal who never lived in Africa. Archaeological evidence indicated that Neanderthals originated in Africa and between 139 kya and 125 kya the Neanderthals migrated back into Africa and spread from Morocco to East Africa. The archaeological, anthropological and genetic evidence indicated that the first Europeans were dark skin Sub-Saharan Africans who carried mtDNA haplogroup N and Y-chromosome C6 into Europe.

Knowledge Shared is Power: Utilizing Knowledge Management Activities to Replicate Lean Sigma Best Practices
Dennis C. Chen,Clyde W. Holsapple
Knowledge Management & E-Learning : an International Journal , 2009,
Abstract: Lean Sigma programs produce localized gains within corporations. The knowledge generated by these local successes should be manipulated by the organization, so that the gains can be replicated, and savings multiplied across the organization. However, why does knowledge often fail to be successfully manipulated within an organization? This paper discusses a case study analysis in knowledge manipulation activities of a multi- national consumer products company through the lens of the Knowledge Management (KM) Ontology. We then identify and document common obstacles, and offer potential solutions.
Project EX: Four trials so far
Sussman Steve,Dent Clyde W,Lichtman Kara,Johnson C Anderson
Tobacco Induced Diseases , 2005, DOI: 10.1186/1617-9625-3-22
Peer group self-identification among alternative high school youth: A predictor of their psychosocial functioning five years later
Steve Sussman,Jennifer B. Unger,Clyde W. Dent
International Journal of Clinical and Health Psychology , 2004,
Abstract: La afiliación autoidentificada de grupos paritarios en adolescentes ha sido asociada a conductas de riesgo de salud, tal como el abuso de sustancias y la violencia. Sin embargo, no existen estudios prospectivos que hayan investigado las relaciones de la autoidentificación de grupos paritarios en la adolescencia con las conductas problema en los primeros a os de la edad adulta entre jóvenes de alto riesgo. Este estudio ex post facto investigó en 532 estudiantes de instituto la asociación entre la afiliación auto-informada de grupos paritarios durante la ense anza secundaria y el funcionamiento psicosocial a los cinco a os. Entre los estudiantes que se habían auto-identificado con grupos paritarios de alto riesgo durante la edad escolar era más probable que se informara sobre su participación en el uso de drogas y violencia durante la edad adulta y era significativamente menos probable el haberse graduado o encontrado un empleo fijo. Sin embargo, muchos jóvenes con un alto riesgo en uso de drogas y violencia al principio de la edad adulta no se identificaron con un grupo específico y distinto. Estos resultados sugieren que la influencia percibida de los grupos paritarios durante la adolescencia puede continuar en los primeros a os de la edad adulta y quizás a lo largo del curso de la vida. Hacen falta investigaciones adicionales sobre la clasificación de grupos paritarios autoidentificados.
Gatifloxacin Ophthalmic Solution for Treatment of Bacterial Conjunctivitis: Safety, Efficacy and Patient Perspective
Clyde Schultz
Ophthalmology and Eye Diseases , 2012, DOI: 10.4137/OED.S7383
Abstract: Gatifloxacin is a fourth generation fluroquinolone antibiotic that has been prescribed for systemic use. However, the drug which was developed by Kyorin (Japan) was linked to toxic reactions and death and was banned in the United States and Canada for use as an oral dosage form. It continues to be used as a topical application for ophthalmic conditions as the systemic toxicity seen when taking the drug orally has not been observed with ophthalmic use. The available data indicate that ocular use of gatifloxacin is safe, and effective against a broad spectrum of bacteria, including intracellular bacteria and anaerobes.
Tafluprost for the Reduction of Interocular Pressure in Open Angle Glaucoma and Ocular Hypertension
Clyde Schultz
Ophthalmology and Eye Diseases , 2012, DOI: 10.4137/OED.S4253
Abstract: Tafluprost is an FP receptor antagonist that has been shown in clinical studies in Europe and Japan to be extremely useful in treating elevated intraocular pressure and glaucoma. The drug is well tolerated and appears to be at least equal in effectiveness and perhaps superior to other protanoids for routine use comparison to be superior to other treatments for the elevated IOP as the side effects and other related symptomology appear to be less, while maintaining a level of pressure control for prolonged periods.
Book Review: Newspeak in the 21st Century
Clyde Sanger
Global Media Journal : Canadian Edition , 2010,
Voclosporin as a Treatment for Noninfectious Uveitis
Clyde Schultz
Ophthalmology and Eye Diseases , 2013,
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