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Search Results: 1 - 10 of 118030 matches for " Claudiu T. Supuran "
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Complexes With Biologically Active Ligands. Part 2. Preparation ofCopper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide
Claudiu T. Supuran
Metal-Based Drugs , 1996, DOI: 10.1155/mbd.1996.57
Abstract:
Complexes With Biologically Active Ligands. Part 4. CoordinationCompounds of Chlorothiazide With Transition Metal Ions Behave asStrong Carbonic Anhydrase Inhibitors
Claudiu T. Supuran
Metal-Based Drugs , 1996, DOI: 10.1155/mbd.1996.79
Abstract:
Thienothiopyransulfonamides as Complexing Agents for thePreparation of Dual Carbonic Anhydrase Inhibitors
Claudiu T. Supuran
Metal-Based Drugs , 1995, DOI: 10.1155/mbd.1995.327
Abstract:
Complexes With Biologically Active Ligands. Part 1. Synthesis ofCoordination Compounds of Diazoxide With Transition- andMain-Group Cations
Claudiu T. Supuran
Metal-Based Drugs , 1996, DOI: 10.1155/mbd.1996.25
Abstract:
Metal Complexes of 1,3,4-Thiadiazole-2,5-Disulfonamide are StrongDual Carbonic Anhydrase Inhibitors, although the Ligand Possessesvery Weak such Properties
Claudiu T. Supuran
Metal-Based Drugs , 1995, DOI: 10.1155/mbd.1995.331
Abstract:
Inhibition of carbonic anhydrase IX as a novel anticancer mechanism
Claudiu T Supuran
World Journal of Clinical Oncology , 2012, DOI: 10.5306/wjco.v3.i7.98
Abstract: Carbonic anhydrases (CA, EC 4.2.1.1) catalyze the interconversion bewteen carbon dioxide and bicarbonate with generation of protons. The carbonic anhydrase isozyme IX (CA IX) is highly overexpresed in hypoxic tumors and shows very restricted expression in normal tissues. CA IX is a dimeric protein possessing very high catalytic activity for the hydration of carbon dioxide to protons and bicarbonate. Its quaternary structure is unique among members of this family of enzymes, allowing for structure-based drug design campaigns of selective inhibitors. Inhibition of CA IX with sulfonamide and/or coumarin inhibitors was recently shown to lead to a potent retardation for the growth of both primary tumors and metastases. Some fluorescent sulfonamides were shown to accumulate only in hypoxic tumor cells overexpressing CA IX, and might be used as diagnostic tools for imaging of hypoxic cancers. Sulfonamide inhibitors were also more effective in inhibiting the growth of the primary tumors when associated with irrdiation. CA IX is thus both a diagnostic and therapeutic validated target for the management of hypoxic tumors normally non-responsive to classical chemio- and radiotherapy.
Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives
Antonio Mastrolorenzo,Claudiu T. Supuran
Metal-Based Drugs , 2000, DOI: 10.1155/mbd.2000.49
Abstract:
Complexes With Biologically Active Ligands. Part 101 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1 b]-1,3,4-Thiadiazole-2-Sulfonamide
Andrea Scozzafava,Claudiu T. Supuran
Metal-Based Drugs , 1997, DOI: 10.1155/mbd.1997.19
Abstract:
Carbonic Anhydrase Inhibitors. Part 461 Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
Giovanna Mincione,Andrea Scozzafava,Claudiu T. Supuran
Metal-Based Drugs , 1997, DOI: 10.1155/mbd.1997.27
Abstract:
Carbonic Anhydrase Activators. Part 191 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines
Fabrizio Briganti,Andrea Scozzafava,Claudiu T. Supuran
Metal-Based Drugs , 1997, DOI: 10.1155/mbd.1997.221
Abstract:
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