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Search Results: 1 - 10 of 7816 matches for " Claudio; Arranz Calzado "
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Diabetes autoinmune del adulto en diabéticos tipo 2: frecuencia y características
Cabrera-Rode,Eduardo; Perich Amador,Pedro; Díaz Horta,Oscar; Molina Matos,Gisela; Suárez Fonseca,Leonel; Tiberti,Claudio; Arranz Calzado,Celeste; Licea Puig,Manuel; Puig Domingo,Manuel; de Leiva,Alberto; Di Mario,Umberto;
Revista Cubana de Endocrinolog?-a , 2001,
Abstract: this paper was aimed at knowing the frequency, clinico-biochemical, immunologic and genetic characteristics of autoimmune diabetes in adults (lada) in 1 000 type 2 diabetic patients aged 35 or over with different times of duration of diabetes. glycemia, anti-pancreatic islet cell antibodies (ica), anti-gad65 antibodies, anti-ica512bdc/ia2 antibodies, anti-microsomal thyroid antibodies (amt), anti-gastric parietal antibodies (agp), antinuclear antibodies (an), microalbuminuria and peptide c during fasting were determined. these patients were surveyed and some clinical characteristics were registered. they were divided into 2 groups according to the presence of ica. all the type 2 + diabetics for anti-islet cell autoantibodies (ica and/or antigad65) were identified as lada. 3.4 % of type 2 ica + were detected. 22.0 % of type 2 ica - diabetics had anti-gad65 antibodies. it was found that type 2 ica + diabetics were younger, that their diabetes was shorter, that they had lower bmi, reduced levels of fasting peptide c, less dm2 history family (parents), lower values of diastolic and systolic arterial pressure, higher presence of anti-gad65 antibodies, amt and agp in comparison with type 2 ica - diabetics. it was observed that type 2 ica+ diabetics (lada) have specific characteristics that make them similar to type 1 diabetics, which would lead to important variations in their treatment and evolution as regards type 2 ica - diabetics. among the cuban type 2 diabetics it was detected a low frequency of ica and a high frequency of gad, which were different to those found in the caucasian populations. the anti-gad65 antibodies were higher than ica to detect lada. the clinical and immunological characteristics of these patients show the slow progression of the autoimmune destruction of b-cells with therapeutic implications.
Heterogeneidad de los trastornos metabólicos de las etapas iniciales de la diabetes mellitus 2
González Suárez,Roberto M.; Perich Amador,Pedro; Arranz Calzado,Celeste;
Revista Cubana de Endocrinolog?-a , 2009,
Abstract: backgrounds: the prediabetes has been defined as a risk situation related with the presence of future diabetes, preceding appearance of clinical ways of the disease, and it is provoked by disorders from insulin secretion and the sensitivity to insulin. objective: to establish a metabolic disorders profile from a group of subjects in the diabetes mellitus subclinical stage to identify subpopulations sensitive to specific interventions. methods: we used the information gathered on glucose tolerance stage, on insulin-sensitivity, and on insulin secretion in an initial study of 40 patients participating in a prospective research, which two years later were diagnosed with manifest diabetes. results: subjects with initial diabetes mellitus had a wide range of disorders related to a glucose tolerance (tolerance to normal glucose (22 %), tolerance to altered glucose (35 %), and tolerance to altered glucose + altered fast glycemia (43 %). the 95 % of the obese subjects and the 50% of the non-obese ones had a insulin resistance, whereas there was a decrease of insulin secretion in 50 % of subjects of both groups. there as not a association between deterioration level of tolerance to glucose and study metabolic disorders. conclusions: subjects in early stages of diabetes are a heterogeneous population with different levels of energy metabolism deterioration, where interventions to prevent diabetes in these persons need a diagnosis and personalized treatment.
Trastornos metabólicos asociados con la evolución hacia la diabetes mellitus tipo 2 en una población en riesgo
González Suárez,Roberto M.; Perich Amador,Pedro; Arranz Calzado,Celeste;
Revista Cubana de Endocrinolog?-a , 2010,
Abstract: abstract introduction: the clinical and metabolic state of persons in risk of suffer type 2 diabetes mellitus (dm2) is very heterogeneous. objective: to identify the factors influencing in progression to diabetes in subgroups of patients with different types and the severity of metabolic disorders. methods: a prospective study was conducted in 209 subjects in high risk of progression to type 2 diabetes mellitus (backgrounds of disorders related to glucose tolerance without fasting hyperglycemia) to examine the metabolic disorders associating with progression to diabetes. glucose tolerance, insulin secretion and insulin sensitivity were studied at onset and two years later. results: we found that the risk to develop diabetes mellitus was in a significant dependence of the deterioration degree of glucose tolerance present in the initial study (normal glucose tolerance, 10 %; altered glucose tolerance, 14,6 %; altered glucose tolerance + altered fasting glycemia, 56,7 %). in the group with a normal glucose tolerance the fundamental predictive factor of evolution to diabetes mellitus was the failure of initial insulin secretory response (or: 8,13; 95 % ci; 1,83 to 36,0). in the subjects with altered glucose tolerance with fasting altered glycemia and without it, determinant factor was the fasting glycemia (or: 5,41; 95 % ci; 2,15 to 13,6). the insulin resistance was not a significant predictive factor in any study subgroups. conclusions: postprandial glycemia disorders in early stages of evolution to type 2 diabetes mellitus are changeable or reversible and insufficient to base its early diagnosis and the preventive or therapeutical activities. appearance of an altered fasting glycemia is the onset of an accelerated progression stage to type 2 diabetes mellitus, thus, in this group it is necessary to intensify the measures to revert or slow the metabolic deterioration. in group with a high risk of diabetes and a normal glucose tolerance the only metabolic factor identif
Factores metabólicos asociados con la progresión hacia la diabetes mellitus en sujetos con tolerancia a la glucosa alterada
González Suárez,Roberto M.; Perich Amador,Pedro; Valdés Ramos,Eduardo; Arranz Calzado,Celeste;
Revista Cubana de Endocrinolog?-a , 2007,
Abstract: a prospective study was conducted in 84 patients with impaired glucose tolerance (igt) diagnosed 18 years before to identify metabolic factors found in the initial study that could be associated with the progression to diabetes mellitus (dm) detected in the evolutive study. the severity of the glucose tolerance disorder, the reduction or increase of insulin secretion on fasting or during an oral glucose tolerance test (ogtt), as well as the resistance to insulin detected on fasting or during the ogtt, were considered as risk factors. all of them were determined by methods and criteria of interpretation that were previously established and validated. it was observed that a low initial insulin response (reduced ii0-30) was significantly associated with the progression to diabetes in the group of studied individuals with igt. this finding was consistent with all the aspects of the evaluated phenomenon (absolute values of the variables in the group of subjects classified according to their evolution, risk of evolution toward diabetes mellitus and time elapsed until the diagnosis of dm) and agreed with the criteria that the genetically determined factor that conditions the development of dm is a defect of the initial capacity of the insulin secretory response to glycaemia changes.
Desarrollo de un método inmunoenzimático para determinar progesterona
González Suárez,Roberto M.; Arranz Calzado,María Celeste; García Dafonte,Gema;
Revista Cubana de Endocrinolog?-a , 2002,
Abstract: an immunoenzimatic, competitive liquid stage method , with separation by antibodies coupled to magnetizable particles was developed to determine progesterone in plasma, it is based on the competence for the binding sites of a monoclonal antibody between the hormone present in the sample and a hormone-enzime conjugate in the presence of blocking agents of the proteins transporting steroids from plasma. the antigen-antibody complex is trapped by a second mouse antiglobulin antibody coupled to magnetizable particles that allow to separate it from the non reacting components of the system and to develop in its surface the color reaction with which the analyte is quantified. this system does not require either extraction of the steroids from plasma with organic solvents or centrifugation and the final product of the reaction may be read in a conventional colorimeter. all this make it accessible to the equipment of a laboratory of conventional clinical biochemistry. the parameters of calibration and quality of both methods were studied and compared with 2 similar commercial analytic systems and with the results of progesterone determination in 200 samples. it was proved that there were no statistical differences between them. it was concluded that this system has all the necessary requirements to be incorporated as a routine method in the laboratories of the national health system.
Evaluación crítica del sistema de diagnóstico de la diabetes mellitus, propuesto por la Asociación Americana de Diabetes
González Suárez,Roberto M.; Arranz Calzado,María Celeste; Perich Amador,Pedro;
Revista Cubana de Endocrinolog?-a , 2002,
Abstract: a retrospective study was carried out in 370 subjects with glucose tolerance disorders aimed at evaluating the methodology for diagnosing type 2 diabetes mellitus that leaves out the oral glucose tolerance test (gtt) proposed by the ada, it was found that fasting glycaemia allowed to diagnose 27 % of the diabetics and 56 % of the individuals with glycaemia regulation disorders that would have been diagnosed according to the who criteria that include the gtt. the third part of those cases classified as normal based only in glycaemia during fasting presented some type of glucose tolerance disorder. it was proved that the diabetics detected by hyperglycemia at the second hour had higher levels of circulating glucose during the test evaluated by the total area under the glucose curve. the pattern of insulinic response of these cases was characterized by a diminished initial response that increased up to reaching maximum values at the second hour. the frequency of cases with low insulinic response and/or insulin resistance was high. it was concluded that the fasting glycaemia test by itself was not sensitive enough to detect glucose tolerance disorders, diabetes mellitus and those cases with postprandial hyperglycaemia, and that’s why they can only be detected by gtt. as these patients present important metabolic disorders that require an early detection and treatment, it is recommended the systematic use of gtt in the diagnosis of diabetes mellitus.
Desarrollo de un método inmunoenzimático para determinar progesterona Development of an immunoenzimatic method to determine progesterone
Roberto M. González Suárez,María Celeste Arranz Calzado,Gema García Dafonte
Revista Cubana de Endocrinología , 2002,
Abstract: Se desarrolló un método inmunoenzimático, competitivo, en fase líquida, con separación por anticuerpos acoplados a partículas magnetizables, para determinar progesterona en plasma; se basa en la competencia por los sitios de unión de un anticuerpo monoclonal, entre la hormona presente en la muestra y un conjugado hormona-enzima, en presencia de agentes bloqueadores de las proteínas de transporte de esteroides del plasma. El complejo antígeno-anticuerpo es atrapado por un segundo anticuerpo antiglobulina de ratón acoplado a partículas magnetizables que permite separarlo de los componentes no reaccionantes del sistema y desarrollar en su superficie la reacción de color con la que se cuantifica el analito. Este sistema no requiere extracción de los esteroides del plasma con solventes orgánicos, ni centrifugación y el producto final de la reacción puede ser leído en un colorímetro convencional. Todo lo anterior lo hace accesible al equipamiento de un laboratorio de bioquímica clínica convencional. Se estudiaron los parámetros de calibración y de calidad de ambos métodos, se compararon con 2 sistemas analíticos comerciales similares y con los resultados de la determinación de progesterona en 200 muestras y se comprobó que no existían diferencias estadísticas entre ellos. Se concluyó que este sistema cuenta con los requisitos necesarios para ser incorporado como método de rutina en los laboratorios del Sistema Nacional de Salud. An immunoenzimatic, competitive liquid stage method , with separation by antibodies coupled to magnetizable particles was developed to determine progesterone in plasma, It is based on the competence for the binding sites of a monoclonal antibody between the hormone present in the sample and a hormone-enzime conjugate in the presence of blocking agents of the proteins transporting steroids from plasma. The antigen-antibody complex is trapped by a second mouse antiglobulin antibody coupled to magnetizable particles that allow to separate it from the non reacting components of the system and to develop in its surface the color reaction with which the analyte is quantified. This system does not require either extraction of the steroids from plasma with organic solvents or centrifugation and the final product of the reaction may be read in a conventional colorimeter. All this make it accessible to the equipment of a laboratory of conventional clinical biochemistry. The parameters of calibration and quality of both methods were studied and compared with 2 similar commercial analytic systems and with the results of progesterone determination
Evaluación crítica del sistema de diagnóstico de la diabetes mellitus, propuesto por la Asociación Americana de Diabetes Critical evaluation of the diagnostic system of diabetes mellitus proposed by the American Diabetes Association
Roberto M. González Suárez,María Celeste Arranz Calzado,Pedro Perich Amador
Revista Cubana de Endocrinología , 2002,
Abstract: Se realizó un estudio retrospectivo en 370 sujetos con trastornos de tolerancia a la glucosa, para evaluar la metodología de diagnóstico de la diabetes mellitus tipo 2, que prescinde de la prueba de tolerancia a la glucosa oral (PTG), propuesto por la ADA. Se encontró que la glucemia en ayunas permitió diagnosticar el 27 % de los diabéticos y el 56 % de los sujetos con trastornos de la regulación de la glucemia, que se hubieran diagnosticado siguiendo los criterios de la OMS que incluyen la PTG; la tercera parte de los casos clasificados como normales según la glucemia en ayunas solamente, presentó algún tipo de trastorno de la tolerancia a la glucosa. Se comprobó que los diabéticos detectados mediante la hiperglucemia a la segunda hora de la PTG, presentan niveles superiores de glucosa circulante durante la prueba, evaluados por el área total bajo la curva de glucosa. El patrón de respuesta insulínica de estos casos se caracterizó por una respuesta inicial disminuida que se incrementó hasta alcanzar valores máximos a la segunda hora; la frecuencia de casos con baja respuesta insulínica y/o resistencia a la insulina fue alta. Se concluyó que la glucemia en ayunas, como única prueba, no tiene sensibilidad suficiente para detectar trastornos de la tolerancia a la glucosa y diabetes mellitus y los casos con hiperglucemia posprandial únicamente, y que por ello solo pueden ser detectados por la PTG, presentan trastornos metabólicos importantes que requieren su detección y tratamiento precoz por lo cual es recomendable el uso sistemático de la PTG en el diagnóstico de la diabetes mellitus. A retrospective study was carried out in 370 subjects with glucose tolerance disorders aimed at evaluating the methodology for diagnosing type 2 diabetes mellitus that leaves out the oral glucose tolerance test (GTT) proposed by the ADA, It was found that fasting glycaemia allowed to diagnose 27 % of the diabetics and 56 % of the individuals with glycaemia regulation disorders that would have been diagnosed according to the WHO criteria that include the GTT. The third part of those cases classified as normal based only in glycaemia during fasting presented some type of glucose tolerance disorder. It was proved that the diabetics detected by hyperglycemia at the second hour had higher levels of circulating glucose during the test evaluated by the total area under the glucose curve. The pattern of insulinic response of these cases was characterized by a diminished initial response that increased up to reaching maximum values at the second hour. The frequency of cases with low
Deficiencia androgénica en hombres de 60 a os y más del área de salud Vedado Androgen deficiency in men aged 60 or more from Vedado health area
Eduardo álvarez Seijas,Gilda Monteagudo Pe?a,Manuel Gómez Alzugaray,Celeste Arranz Calzado
Revista Cubana de Endocrinología , 2009,
Abstract: El declinar de la función testicular propia del envejecimiento ha adquirido relevancia en los últimos a os, sin embargo aún no se conoce su prevalencia, ni existe uniformidad para el diagnóstico. Se realizó un estudio descriptivo transversal con el objetivo de determinar la prevalencia y características clínico-hormonales del déficit androgénico en varones de 60 a os y más. Se incluyeron 70 sujetos de un área de salud, seleccionados mediante muestreo aleatorio estratificado polietápico, a los cuales se interrogó sobre la presencia de síntomas de deficiencia androgénica, se les realizó examen físico general y genital y determinaciones de testosterona total, hormona luteinizante y hormona folículo estimulante en sangre periférica. De acuerdo con las concentraciones de la testosterona se dividieron en 2 grupos: a) sujetos con deficiencia androgénica y b) sujetos sin deficiencia androgénica. Los que presentaron déficit androgénico tenían un peso significativamente superior, una proporción mayor de obesidad y una talla significativamente inferior. Los síntomas de déficit androgénico fueron frecuentes, los refirieron indistintamente los integrantes de ambos grupos y se presentaron independientemente de las concentraciones de las hormonas sexuales. En general, las gonadotropinas estaban aumentadas fundamentalmente a expensas de hormona folículo estimulante y su comportamiento fue independiente de las concentraciones de testosterona. Decline of testicular function typical of aging has acquired relevance in past years, however yet it is unknown its prevalence and there is not evenness for its diagnosis. A cross-sectional and descriptive study was made to determine the prevalence and clinical-hormonal features of androgen deficit in males aged 60 or more. Included are 70 subjects from a health area selected by multistage stratified randomized sampling that were interrogated about presence of androgen deficiency syndrome and underwent a physical and genital examination and total testosterone determinations, luteinizing hormone and follicle-stimulating hormone in peripheral blood. According the testosterone concentrations they were divided into two groups: a) subjects presenting with androgen deficiency and b) subjects without this type of deficiency. Those with androgen deficit had a higher weight, a higher obesity ratio, and a significantly lower height. The symptoms of androgen deficit were frequent, recounted indiscriminately by both groups and independently of sexual hormone concentrations. Generally, gonadotropins were increased mainly at the expense of folli
Frecuencia y caracterización del síndrome metabólico según criterios de la Federación Internacional de Diabetes en familiares de primer grado de personas con diabetes tipo 1 Frequency and characterization of metabolic syndrome according to the criteria of the International Federation of Diabetes in first degree relatives of persons with type 1 diabetes
Judith Parlá Sardi?as,Eduardo Cabrera Rode,Sigrid Marichal Madrazo,Celeste Arranz Calzado
Revista Cubana de Endocrinología , 2011,
Abstract: Introducción: el síndrome metabólico se ha definido como la asociación de varios factores precursores de enfermedad cardiovascular y de diabetes mellitus tipo 2. Objetivo: determinar la frecuencia de síndrome metabólico, según los criterios de la Federación Internacional de Diabetes en familiares de primer grado de diabéticos tipo 1. Métodos: se seleccionaron 96 adultos y 97 adolescentes, se les aplicó un cuestionario, y se les realizó un examen físico general. Además, se les realizaron determinaciones en ayunas de glucosa, insulina, colesterol, triglicéridos y HDL colesterol, y se calculó el índice de resistencia a la insulina. Resultados: la frecuencia del síndrome metabólico fue mayor en los adultos 17,7 % (17/96) que en los adolescentes 3,09 % (3/97), y la resistencia a la insulina en los adultos fue similar en los sujetos con y sin síndrome metabólico. La historia familiar de enfermedad cardiovascular, diabetes mellitus tipo 2, obesidad, dislipidemia e hipertensión arterial no está asociada con la presencia del síndrome metabólico en los familiares de primer grado de diabéticos tipo 1. Conclusiones: el síndrome metabólico, según los criterios de la Federación Internacional de Diabetes, es más frecuente en los adultos que en los adolescentes familiares de primer grado de diabéticos tipo 1, y la resistencia a la insulina en estos sujetos no está exclusivamente asociada al síndrome metabólico. Introduction: the metabolic syndrome is defined as the association of some factors causing cardiovascular disease and of type 2 diabetes mellitus. Objective: to determine the frequency of the metabolic syndrome according to the criteria of the International Federation of Diabetes in first degree relatives of persons with type 1diabetes. Methods: ninety six adults and 97 adolescents were selected to apply a questionnaire and a general physical examination. Also, assessment of fast glucose, insulin, cholesterol, triglycerides and HDL-cholesterol were carried out, estimating the rate of insulin-resistance. Results: the frequency of metabolic syndrome was higher in adults for a 17,7 % (17/96) than in adolescents for a 3,09 % (3/97) and the insulin resistance in adults was similar in those subjects with and without metabolic syndrome. The family history of cardiovascular disease, type 2 diabetes mellitus, obesity, dyslipemia and high blood pressure is not associated with the presence of metabolic syndrome in first degree relative of persons with type 1 diabetes. Conclusions: the metabolic syndrome, according the criteria of the International Federation of Diabetes, i
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