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Search Results: 1 - 10 of 230690 matches for " Claudio Rómulo Galmarini "
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Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats
Marcela Alejandra Vazquez-Prieto,Cecilia Rodriguez Lanzi,Carina Lembo,Claudio Rómulo Galmarini,Roberto Miguel Miatello
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/475216
Abstract: This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F
Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats
Marcela Alejandra Vazquez-Prieto,Cecilia Rodriguez Lanzi,Carina Lembo,Claudio Rómulo Galmarini,Roberto Miguel Miatello
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/475216
Abstract: This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1?mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400?mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables. 1. Introduction Metabolic syndrome (METS), characterized by hypertension, hyperlipidemia, diabetes mellitus, and obesity is an important risk factor for cardiovascular disease [1]. One of the most important causes that contribute to the growing worldwide prevalence of METS, obesity, and type 2 diabetes is the change of dietary habits principally due to the increased intake of simple sugars, mainly fructose, commonly used in the food industry and sugar-sweetened drinks [2]. Feeding carbohydrate-enriched diets to normal rats has been shown to induce insulin resistance and hyperinsulinemia associated with an elevation of systolic blood pressure (SBP) [3]. Fructose-fed rats (FFRs) provide a model of dietary-induced insulin resistance, which has been used to assess the pathophysiological mechanisms of the metabolic and cardiovascular changes associated with METS [4, 5]. Endothelial dysfunction is also associated with this experimental model [6]. Our group previously reported a decrease of the endothelial nitric oxide synthase activity (eNOS) at cardiovascular level, and an increase in oxidative stress and vascular alterations [5, 7]. The major sources of reactive oxygen species (ROS) in vascular tissue are membrane-associated NAD(P)H oxidases [8]. An increase in ROS has been implicated as an important mechanism contributing to endothelial dysfunction and to the pathogenesis of many cardiovascular diseases and their risk factors like METS [9]. ROS induce the expression of different molecules in the endothelial cell surface such as vascular cell adhesion molecule-1 (VCAM-1), which stimulates monocyte binding
Variation for Health-Enhancing Compounds and Traits in Onion (Allium cepa L.) Germplasm  [PDF]
E. Marina Insani, Pablo F. Cavagnaro, Virginia M. Salomón, Leandro Langman, María Sance, Adriana A. Pazos, Fernando O. Carrari, Olga Filippini, Laura Vignera, Claudio R. Galmarini
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.77059
Abstract: Consumption of onion has been associated with reduced incidence of chronic diseases. Phenolic, organosulfur and carbohydrate compounds present are largely responsible for these effects. This study examined compositional variation for health-enhancing compounds in a genetically diverse collection of onion cultivars. Total antioxidant activity and aroma profiles were characterized. Significant variation in bulb concentration for total and individual phenolic compounds, thiosulfinates, carbohydrates, and total and soluble solids was found. The range of variation was particularly large (>50-fold difference between the cultivars with the highest and lowest content) for fructo-oligosaccharides (FOS) and the polyphenols quercetin, epigallocatechin gallate and epicatechin gallate. Amino acid profiles varied significantly as well with substantial variation (~10 fold) observed in both total and essential amino acids. Total antioxidant activity was positively correlated with polyphenols content, and quercetin in particular (r = 0.83), suggesting a major contribution from phenolic compounds to onion antioxidant properties. Significant positive correlation was also found between solids and thiosulfinates content (r = 0.74) and between solids and FOS (r = 0.81), suggesting a dilution/concentration effect for organosulfur compounds and FOS in onion bulbs. The present study revealed broad variation for health-enhancing compounds content in onion germplasm, which can be exploited in breeding programs aiming at increasing onion nutraceutical value.
Towards genetic transformation of local onion varieties
Marinangeli,Pablo; Deluchi,Bernardo; Ríos,Raúl; Franzone,Pascual; Galmarini,Claudio; Rosselló,Fernando; Curvetto,Néstor;
Electronic Journal of Biotechnology , 2006,
Abstract: the aim of this work was to explore the possibility of obtaining transgenic plants of onion varieties cultivated in argentina, starting from calli induced from mature zygotic embryos, using two strains of agrobacterium tumefaciens as transfection vectors. mature embryos from three varieties of 'valenciana' onion, torrentina, cobriza inta and grano de oro were in vitro cultivated for callus induction. after three to four months an average of 57.4% success for the three varieties was reached. transformation was carried out with agl1 or lba 4404 a. tumefaciens strains, both carrying a binary vector containing the marker gene gus a and the selection gene nptii. selection was done in callus induction medium containing 10 mgl-1 geneticin during three subcultures. at the end of the selection period, 342 portions of calli were recovered and transferred to regeneration medium. of the selected calli evaluated by the expresión of the β-glucuronidase enzyme, 42% presented extensive blue areas or were completely blue. at the end of the first subculture in the regeneration medium, 54 calli were considered potentially organogenic because of the green areas observed. at the end of the wole regeneration period, just one normal plant was obtained, that was negative to pcr analysis using specific primers for gus a and nptii. all selected calli came from the torrentina variety and the highest quantity of them were transformed with the strain lba 4404.
Aplica??o de Zr/Ti-PILC no processo de adsor??o de Cu(II), Co(II) e Ni(II) utilizando modelos físico-químicos de adsor??o e termodinamica do processo
Guerra, Denis Lima;Airoldi, Claudio;Lemos, Vanda Porpino;Angélica, Rmulo Sim?es;Viana, Rúbia Ribeiro;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000200031
Abstract: the aim of this investigation is to study how zr/ti-pilc adsorbs metals. the physico-chemical proprieties of zr/ti-pilc have been optimized with pillarization processes and cu(ii), ni(ii) and co(ii) adsorption from aqueous solution has been carried out, with maximum adsorption values of 8.85, 8.30 and 7.78 x10-1 mmol g-1, respectively. the langmuir, freundlich and temkin adsorption isotherm models have been applied to fit the experimental data with a linear regression process. the energetic effect caused by metal interaction was determined through calorimetric titration at the solid-liquid interface and gave a net thermal effect that enabled the calculation of the exothermic values and the equilibrium constant.
Síndrome do impacto do tornozelo na ressonancia magnética: ensaio iconográfico
Lima, Claudio Marcio Amaral de Oliveira;Ribeiro, Erica Barreiros;Coutinho, Elisa Pompeu Dias;Vianna, Evandro Miguelote;Domingues, Rmulo C?rtes;Coutinho Júnior, Antonio Carlos;
Radiologia Brasileira , 2010, DOI: 10.1590/S0100-39842010000100013
Abstract: ankle impingement syndrome is a painful condition resulting from friction of joint tissues that is both cause and effect of an altered joint biomechanics. the leading causes of such condition are post-traumatic lesions, particularly the ligamentous ones, resulting in chronic ankle pain. from an anatomic and clinical point of view, these syndromes may be classified as anterolateral, anterior, anteromedial, posteromedial, and posterior. magnetic resonance imaging is an excellent diagnostic method for demonstrating bone and soft tissue abnormalities resulting from different types of ankle impingement, providing useful data to confirm the diagnosis as well as to rule out other possible causes of joint pain. the present essay is aimed at illustrating the main magnetic resonance imaging findings in ankle impingement syndrome.
Independência temporal das respostas do esfor?o percebido e da freqüência cardíaca em rela??o à velocidade de corrida na simula??o de uma prova de 10km
Bertuzzi, Rmulo Cássio de Moraes;Nakamura, Fábio Yuzo;Rossi, Luiz Claudio;Kiss, Maria Augusta Peduti Dal'Molin;Franchini, Emerson;
Revista Brasileira de Medicina do Esporte , 2006, DOI: 10.1590/S1517-86922006000400003
Abstract: the objective of this study was to investigate pacing strategy, perceived exertion and heart rate during a competitive run simulation. eight recreational runners ran a 10 km distance in an outdoor 400 m track with 28-30oc temperature. before the run they were asked to run the 10 km as faster as possible. the run velocity, the perceived exertion and the heart rate were measured each 400 m. the speed of run decreased on 19th and 20th laps (p < 0.05). the heart rate increased significantly on 7th and 10th laps (p < 0.05) and achieved steady state afterwards, while the perceived exertion increased statistically until the 13th lap (p < 0.05). these data suggest that pacing strategy, perceived exertion and heart rate have different temporal adjustments during a competitive run. possibly the run strategy is established before the competition simulation and has an economic aspect to the last lap. this economic effect of run strategy is determined until the half of the distance is completed by rate of perceived exertion modulation, which is a result of metabolic, context and cognitive feedbacks.
Fauna used in popular medicine in Northeast Brazil
Rmulo RN Alves
Journal of Ethnobiology and Ethnomedicine , 2009, DOI: 10.1186/1746-4269-5-1
Abstract: In order to examine the diversity of animals used in traditional medicine in Northeast of Brazil, all available references or reports of folk remedies based on animals sources were examined. 34 sources were analyzed. Only taxa that could be identified to species level were included in assessment of medicinal animal species. Scientific names provided in publications were updated.The review revealed that at least 250 animal species (178 vertebrates and 72 invertebrates) are used for medicinal purposes in Northeast of Brazil. The inventoried species comprise 10 taxonomic categories and belong to 141 Families. The groups with the greatest number of species were fishes (n = 58), mammals (n = 47) and reptiles (n = 37). The zootherapeutical products are used for the treatment of different illnesses. The most widely treated condition were asthma, rheumatism and sore throat, conditions, which had a wide variety of animals to treat them with. Many animals were used for the treatment of multiple ailments. Beyond the use for treating human diseases, zootherapeutical resources are also used in ethnoveterinary medicineThe number of medicinal species catalogued was quite expressive and demonstrate the importance of zootherapy as alternative therapeutic in Northeast of Brazil. Although widely diffused throughout Brazil, zootherapeutic practices remain virtually unstudied. There is an urgent need to examine the ecological, cultural, social, and public health implications associated with fauna usage, including a full inventory of the animal species used for medicinal purposes and the socio-cultural context associated with their consumption.Humans depend on biodiversity and the capacity of ecosystems to provide a multitude of goods and services that underpin a healthy human and natural environment. Biodiversity is essential for human health, for example, in the provision of the raw materials for medicines. Indeed, some 20,000 species are used in traditional medicine, which forms the b
Efecto del ácido indolbutírico (AIB) y de la presencia de hojas en el arraigamiento de estacas de Nothofagus glauca (Phil.) Krasser cosechadas en dos épocas diferentes
Ecolog?-a austral , 2007,
Abstract: nothofagus glauca (phil.) krasser is a endemic tree of the mesomorphic zone of chile. because of anthropogenic action, currently this species has a delicate conservation status and yet the factors that affect vegetative propagation are not well known. in this study, the rooting capacity of stem cuttings was analyzed. vegetative material was collected from stump sprouts of adult trees (20 years or older) in the andean foothills of the talca province. the effect of indolebutyric acid (iba = 0, 0.5, and 1.5%), and leaf presence (with and without leaves) on rhizogenesis was analyzed using cuttings collected in january of 1996 and november 1997. the trials were carried out in a plastic covered greenhouse located in the forest nursery of the universidad católica del maule in talca-chile. the greenhouse was equipped with a mist system and bottom heating that maintained a constant temperature of 21-25°c at the base of the stem cuttings. each trial was kept under observation for between 2.5 and 4 months, depending on the response of the cuttings to the different treatments. results indicate that maximal rooting (66.7%) was obtained with stem cuttings from root sprouts collected in november and treated with iba 1.5%. the mortality of vegetative material collected in january was complete. the presence of leaves was fundamental for the survival and rhizogenesis process in stem cuttings. the presence of leaves during the vegetative period of maximum growth may be an important factor in obtaining adequate rooting.
La mortalidad prematura en Venezuela: 1970-1995
Orta Cabrera,Rómulo;
Gaceta Médica de Caracas , 2002,
Abstract: the statistics of lost potential years of life speak of a serious problem of public health that, however, it doesn't constitute a priority for the international organisms that design the fundamental orientations of population's politics and development; the priorities of attention concentrate on the maternal and infantile population and in the programs related with the reproductive health, without assigning a lot of interest to the fact that it is among the population with ages between 15 and 64 years in the one that this loss acquires impressive dimensions. in venezuela, the population that died at ages inside that interval added in 1970 a 474 819 of lost potential years of life; in 1995 that figure reached the 928 568 years, and however, for the year 2000, the programs of the ministry of health and social development privileged the infantile and maternal attention and the distribution of contraceptives.
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