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Search Results: 1 - 10 of 483540 matches for " Claudio Alberto; Atehortúa-Becerra "
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Diferencias socioeconómicas en los a?os de vida perdidos por cáncer de mama y cáncer cérvico-uterino en Colombia, 1997 y 2007
Agudelo-Botero,Marcela; Dávila-Cervantes,Claudio Alberto; Atehortúa-Becerra,Sara Catalina;
Revista Gerencia y Políticas de Salud , 2011,
Abstract: the years of life lost (yll) due to breast cancer (bc) and cervical cancer (cc) for colombia were calculated for the years 1997 and 2007, according to the socioecononuc strata. female deaths were included for bc and cc. the unsatisfied basic needs index was employed at departmental level and mortality tables from departamento administrativo nacional de estadística (dane). in 2007, there were 48.098 years of life lost (yll) due to bc and cc, 56,6% due to the first cause. a slight decrease was observed in the yll due to cc (0,9%) and an increase due to bc (49,8%). women from the middle and upper strata had the biggest increase of yll due to bc, while those from the poorest strata did due to cc. it's necessary to reinforce the current measures aimed at decreasing and easing the gaps in mortality due to both cancers, as it's also important to consider socioeconomic differences in the formulation of public policies around the subject.
Reconfiguraciones de género y vulnerabilidad al VIH/Sida en mujeres transgénero en Colombia
Estrada-Montoya,John Harold; García-Becerra,Andrea;
Revista Gerencia y Políticas de Salud , 2010,
Abstract: this investigation sought to identify the most significant ways in which sexuality is represented and imagined within the culture of transgender women in colombia. we performed an exploratory descriptive study using surveys, in-depth interviews, focus groups and ethnographic strategies with 18 transgender women. the collected information was analyzed, taking into account the following dimensions of interpretation: 1. love, erotic, and sexual relations. 2. gender and sexual identities. 3. sexual behavior and practices. 4. self-care, human inmunodeficiency virus (hiv) risk perception and life goals. the transgender women reached in this investigation expressed the belief that adopting a feminine identity involved taking sexual risks because the space socially assigned for them is that of street prostitution in conditions of vulnerability. we propose interventions with transgender women that favor autonomy, joy, and self-care as the central elements of a quality life and equal citizenship focused on reducing stigma.
Mechanisms of Resistance to Endocrine Therapy in Breast Cancer: Focus on Signaling Pathways, miRNAs and Genetically Based Resistance
Rocío García-Becerra,Nancy Santos,Lorenza Díaz,Javier Camacho
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14010108
Abstract: Breast cancer is the most frequent malignancy diagnosed in women. Approximately 70% of breast tumors express the estrogen receptor (ER). Tamoxifen and aromatase inhibitors (AIs) are the most common and effective therapies for patients with ERα-positive breast cancer. Alone or combined with chemotherapy, tamoxifen significantly reduces disease progression and is associated with more favorable impact on survival in patients. Unfortunately, endocrine resistance occurs, either de novo or acquired during the course of the treatment. The mechanisms that contribute to hormonal resistance include loss or modification in the ERα expression, regulation of signal transduction pathways, altered expression of specific microRNAs, balance of co-regulatory proteins, and genetic polymorphisms involved in tamoxifen metabolic activity. Because of the clinical consequences of endocrine resistance, new treatment strategies are arising to make the cells sensitive to tamoxifen. Here, we will review the current knowledge on mechanisms of endocrine resistance in breast cancer cells. In addition, we will discuss novel therapeutic strategies to overcome such resistance. Undoubtedly, circumventing endocrine resistance should help to improve therapy for the benefit of breast cancer patients.
Sitios de acción inhibitoria de la prolactina sobre la síntesis de estradiol inducida por la hormona folículo estimulante en las células de la granulosa
Larrea, Fernando;Sánchez-González, Sergio;García-Becerra, Rocío;Méndez, Isabel;
Gaceta médica de México , 2005,
Abstract: we studied the sites of prolactin inhibition upon fsh induced ovarian steroidogenesis and the ability of prolactin (prl) to inhibit the synthesis of estradiol and camp accumulation under the stimulation of fsh or camp dependent activators. the participation of other signal pathways such as pkc and gi proteins on the inhibitory actions of prl was also investigated using calfostine c andpertusis toxin as inhibitors. results showed a dose dependent prolactin decrease in fsh-induced estradiol and camp production prior and after the generation of the cyclic nucleotide by a mechanism involving the catalytic subunit of adenyl cyclase and/or through activation of pkc or by the interaction with pertusin toxin sensitive g proteins. our results suggest a mechanism by which g protein coupled receptors are linked with those coupled with tyrosine kinase through the involvement of a gi protein mediated mechanism.
Primer registro del ratón de los volcanes (Neotomodon alstoni) para el estado de Hidalgo, México First record of the volcano mouse (Neotomodon alstoni) from the State of Hidalgo, Mexico
Alejandro García-Becerra,Sergio Daniel Hernández-Flores,Gonzalo Herrera-Mu?oz,Cristian Aguilar-Miguel
Revista mexicana de biodiversidad , 2012,
Abstract: El ratón de los volcanes (Neotomodon alstoni) se registra por primera vez en el estado de Hidalgo, México. Los ejemplares se recolectaron en diciembre de 2010, en el municipio de Almoloya, aproximadamente a 32.8 km al norte de la localidad documentada más cercana al estado de Tlaxcala, por lo que este nuevo registro se convierte en el más norte o para la distribución conocida del ratón de los volcanes. The volcano mouse (Neotomodon alstoni) is firstly recorded in the State of Hidalgo. Specimens were collected in December 2010, at the municipality of Almoloya, approximately 32.8 km to the north from the nearest locality in the state of Tlaxcala. Therefore, this is the northernmost record for the range of the Mexican volcano mouse.
Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy
Janice García-Quiroz, Rocío García-Becerra, David Barrera, Nancy Santos, Euclides Avila, David Ordaz-Rosado, Mariana Rivas-Suárez, Ali Halhali, Pamela Rodríguez, Armando Gamboa-Domínguez, Heriberto Medina-Franco, Javier Camacho, Fernando Larrea, Lorenza Díaz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045063
Abstract: Background Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis. Astemizole, a new promising antineoplastic drug, targets Eag1 by blocking ion currents. Herein, we characterized the interaction between calcitriol and astemizole as well as their conjoint antiproliferative action in SUM-229PE, T-47D and primary tumor-derived breast cancer cells. Methodology/Principal Findings Molecular markers were studied by immunocytochemistry, Western blot and real time PCR. Inhibitory concentrations were determined by dose-response curves and metabolic activity assays. At clinically achievable drug concentrations, synergistic antiproliferative interaction was observed between calcitriol and astemizole, as calculated by combination index analysis (CI <1). Astemizole significantly enhanced calcitriol’s growth-inhibitory effects (3–11 folds, P<0.01). Mean IC20 values were 1.82±2.41 nM and 1.62±0.75 μM; for calcitriol (in estrogen receptor negative cells) and astemizole, respectively. Real time PCR showed that both drugs alone downregulated, while simultaneous treatment further reduced Ki-67 and Eag1 gene expression (P<0.05). Astemizole inhibited basal and calcitriol-induced CYP24A1 and CYP3A4 mRNA expression (cytochromes involved in calcitriol and astemizole degradation) in breast and hepatoma cancer cells, respectively, while upregulated vitamin D receptor (VDR) expression. Conclusions/Significance Astemizole synergized calcitriol antiproliferative effects by downregulating CYP24A1, upregulating VDR and targeting Eag1. This study provides insight into the molecular mechanisms involved in astemizole-calcitriol combined antineoplastic effect, offering scientific support to test both compounds in combination in further preclinical and clinical studies of neoplasms expressing VDR and Eag1. VDR-negative tumors might also be sensitized to calcitriol antineoplastic effects by the use of astemizole. Herein we suggest a novel combined adjuvant therapy for the management of VDR/Eag1-expressing breast cancer tumors. Since astemizole improves calcitriol bioavailability and activity, decreased calcitriol dosing is advised for conjoint administration.
El control en las empresas de servicios públicos domiciliarios
Carlos Alberto Atehortúa Ríos
Contexto , 2004,
La transformación del sector de las telecomunicaciones y sus efectos en los usuarios
Carlos Alberto Atehortúa Ríos
Contexto , 2004,
Factores de riesgo para la infección por Clostridium difficile
Becerra,María Gabriela; Ospina,Sigifredo; León Atehortúa,Santiago; Berbes,Dedsy Yajaira;
Infectio , 2011,
Abstract: introduction: clostridium difficile is a gram positive strict anaerobic spore-forming bacillus, so it is able to persist under adverse conditions for long time. this microorganism is a the most common cause of health care associated infection, with clinical manifestations ranging from uncomplicated diarrhea to sepsis and even death. the purpose of this study was to determine the risk factors for c. difficile infection in a teaching hospital. materials and methods: we conducted a case control study in patients over 18 years, of both gender, who had developed diarrhea during their hospitalization in teaching hospital of san vicente fundación and who underwent the toxin test for c. difficile, between september 2009 and december 2010. from this population we selected 22 cases and 44 controls. results: the risk factors that were found associated were: age over 65 years (or = 3.4 95% ci 1.1 to 10.1, p = 0.05), stay in icu (or = 4.0, 95% ci 1.3 to 12.2, p = 0.02) and the use of the proton pump inhibitors (or = 5.15, 95% ci 1.6 to 15.9, p <0.05). conclusions: this study identified factors associated with infection by c. difficile, according with those most frequently described in literature. although no association was found with prior use of antibiotics in multivariate analysis, there was an association with previous use of third-generation cephalosporins in the bivariate analysis.
Las condiciones laborales de los profesionales de la salud a partir de la Ley 100 de 1993: evolución y un estudio de caso para Medellín
Florez Acosta,Jorge Hernán; Atehortúa Becerra,Sara Catalina; Arenas Mejía,Alba Cristina;
Revista Gerencia y Políticas de Salud , 2009,
Abstract: the purpose of this article is to analyze the major changes in working conditions of human resources in health since act 100 of 1993. this paper is divided in two parts: the first one refers to the working conditions of health professionals in colombia based on secondary sources and the second shows the results of a survey of a sample of medellin professionals. we found that after the implementation of the act, working conditions have been deteriorated, especially for those professionals who do not have a direct engagement with health agencies, it also has generated wage gaps between professionals from different fields and even within the same; and has increased the working-day hours and underemployment found it in the area.
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