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Search Results: 1 - 10 of 468770 matches for " Claudio A.; Carrillo "
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Trypanosoma cruzi: Transporte de metabolitos esenciales obtenidos del hospedador
Pereira,Claudio A.; Carrillo,Carolina; Miranda,Mariana R.; Bouvier,León A.; Cánepa,Gaspar E.;
Medicina (Buenos Aires) , 2008,
Abstract: trypanosoma cruzi is the etiological agent of chagas disease, a disease endemic not only in argentina but also in all of latinamerica. t. cruzi presents several metabolic characteristics which are completely absent in its insect vectors and in mammalian hosts. some of these differences were acquired after millions of years of adaptation to parasitism, during which this protozoan replaced many biosynthetic routes for transport systems. in the present review, we describe the advances in the knowledge of t. cruzi transport processes and the molecules involved. in particular, we focus on aminoacid and polyamine transporters from the aaap family (amino acid/auxin permeases), because they seem to be exclusive transporters from trypanosomatids. taking into account that these permeases are completely absent in mammals, they could be considered as a potential target against trypanosoma cruzi.
Trypanosoma cruzi: Transporte de metabolitos esenciales obtenidos del hospedador Trypanosoma cruzi: Transport of essential metabolites acquired from the host
Claudio A. Pereira,Carolina Carrillo,Mariana R. Miranda,León A. Bouvier
Medicina (Buenos Aires) , 2008,
Abstract: El Trypanosoma cruzi es el agente causal de la enfermedad de Chagas, endémica en Argentina y en toda América Latina. Presenta numerosas características metabólicas diferenciales respecto a sus hospedadores insectos y mamíferos. Algunas de estas diferencias fueron consecuencia de millones de a os de adaptación al parasitismo en los cuales estos organismos protozoarios reemplazaron, a lo largo de su evolución, muchas rutas metabólicas de biosíntesis por sistemas de transporte de metabolitos desde el hospedador. En esta revisión se describen los avances en el conocimiento de los sistemas de transporte tanto bioquímicos como también de las moléculas involucradas en dichos procesos. Se aborda con especial énfasis los transportadores de aminoácidos y poliaminas de T. cruzi de la familia AAAP (Amino Acid/Auxin Permeases) ya que parece ser exclusiva de los tripanosomátidos. Teniendo en cuenta que estas moléculas se encuentran completamente ausentes en mamíferos podrían ser consideradas como potenciales blancos contra el Trypanosoma cruzi. Trypanosoma cruzi is the etiological agent of Chagas disease, a disease endemic not only in Argentina but also in all of Latinamerica. T. cruzi presents several metabolic characteristics which are completely absent in its insect vectors and in mammalian hosts. Some of these differences were acquired after millions of years of adaptation to parasitism, during which this protozoan replaced many biosynthetic routes for transport systems. In the present review, we describe the advances in the knowledge of T. cruzi transport processes and the molecules involved. In particular, we focus on aminoacid and polyamine transporters from the AAAP family (Amino Acid/Auxin Permeases), because they seem to be exclusive transporters from trypanosomatids. Taking into account that these permeases are completely absent in mammals, they could be considered as a potential target against Trypanosoma cruzi.
A gripe de longe e de perto: compara??es entre as pandemias de 1918 e 2009
Alvarez, Adriana;Carbonetti, Adrián;Carrillo, Ana María;Bertolli Filho, Claudio;Souza, Christiane Maria Cruz de;Bertucci, Liane Maria;Azevedo, Nara;
História, Ciências, Saúde-Manguinhos , 2009, DOI: 10.1590/S0104-59702009005000001
Abstract: in this debate, latin american historians compare the 1918-1919 flu pandemic with the one sweeping the continent in 2009, focusing especially on the experiences in mexico, argentina, and brazil. they analyze the strategies adopted on both occasions, above all isolation measures, port and airport surveillance, and urban interventions. comparisons are drawn between the actions of federal and local governments, positions taken by doctors and the media, and people's behavior, particularly regarding fear and death. the debaters also analyze the performance of assistance structures, the treatment and prevention measures recommended by public health agencies and private groups with a vested interest in drug sales, and popular and home remedies. the debate extends to how the 1918 experience has influenced the evaluation of today's crisis and what legacy it may leave behind.
Economía, política y salud pública en el México porfiriano (1876-1910)
Carrillo, Ana María;
História, Ciências, Saúde-Manguinhos , 2002, DOI: 10.1590/S0104-59702002000400004
Abstract: the article examines the scientific, political, and economic elements that permitted the birth of modern public health in mexico under the porfirio díaz administration (1876-1910). firstly, a portion of mexican physicians were open to the discoveries of microbiology, immunology, and epidemiology. secondly, the state's growing concentration of power in public health matters ran parallel to its concentration of disciplinary political power and enabled this new knowledge to be placed at the service of collective health problem prevention. lastly, both imperialism and the porfirian elite needed to protect their business interests. the article evaluates public health achievements and limitations during the porfirian period, abruptly interrupted by the revolution begun in 1910.
Entre el 'sano temor' y el 'miedo irrazonable': la Campa?a Nacional Contra el Cáncer en México
Carrillo, Ana María;
História, Ciências, Saúde-Manguinhos , 2010, DOI: 10.1590/S0104-59702010000500006
Abstract: the article examines the first socially organized efforts to fight cancer in mexico. it analyzes how the national campaign against cancer (campa?a nacional contra el cáncer), which ran from 1941 to the early 1990s, played a role in the use of cancer treatment and detection services. it also explores the irrational fear of cancer that some healthy people developed and, at the other extreme, the false hopes the sanitary campaign raised among many of the ill, while looking as well at discrimination of these ill and the popular belief that cancer was contagious. another focus is on efforts by sanitary authorities to collect epidemiological information and the challenges they ran into. lastly, it analyzes the scope and limitations of the fight against this disease.
Análisis comparativo del gen P de Rinderpest Virus (RPV)
Vagnozzi,A; Carrillo,C;
InVet , 2006,
Abstract: rinderpest virus (rpv) is the causative agent of a serious disease of domestic cattle. rpv is an enveloped virus with a single stranded, non-segmented, negative rna genome (-ssrna), that is organized in six non-overlapping genes. p gene is the most complex of such genes. its sequence codifies for a structural (p) and two non-structural proteins (c and v). the p protein is essential for viral replication and is involved in every aspect of the viral cycle, whereas, c and v proteins are non essential for viral replication, at least in vitro. here we have made a comparative analysis of sequences of the p gene and its codified proteins from 16 different isolations of rpv, focusing in conserved regions and its functional role. rinderpest has been one of the most important threats to the cattle health. actually, the disease is present just in some regions of asia. the present comparative genomic analysis will be useful as epidemiological work and an important contribution to the current knowledge of rpv biology.
Profesiones sanitarias y lucha de poderes en el México del siglo XIX
Carrillo, Ana María
Asclepio : Revista de Historia de la Medicina y de la Ciencia , 1998,
Abstract: To establish their knowledge as a power base was one of the 19th century Mexican doctors' objectives. In order to achieve that, they tried to convince the State and the population of the superiority of 'scientific medicine', as they refered to it, by means of their professional associations and periodicals. In addition to this, they intended to control the disciplines that had started developing within medicine, and openly fought against medical practices which invaded what they thought was their exclusive domain. In general, they sought to organize medical knowledge, rank it, make it a concern of State and of socio-economic status. Other health professions reacted collectivelly against these attemps at control and exclusion, struggling for their autonomy. In that century there was an accelerated growth in the field of medicine and medical procedures. For instance, in the case of epidemics, the State forced the population to receive medical attention. One of the keys to understand the professionalisation of 19th century Mexican medicine is the relationship between medical knowledges and its procedures, on the one hand, and on the other, the medical profession's own organizations, other medical knowledges, the State and the uninitiated world. Establecer su saber como poder, fue uno de los objetivos de los médicos mexicanos del siglo XIX. Para lograrlo, intentaron convencer al Estado y a la población de la superioridad de la medicina autodenominada científica, y lo hicieron por medio de sus asociaciones gremiales y publicaciones periódicas. Pretendieron, asimismo, controlar a aquellas disciplinas que habían comenzado a desarrollarse dentro de la medicina, y combatieron abiertamente las prácticas médicas que invadían el área que ellos consideraban de su competencia exclusiva. En general, buscaron organizar el saber médico, jerarquizarlo, hacerlo asunto de Estado y de estatus económico y social. Las otras profesiones sanitarias reaccionaron colectivamente contra esos intentos de control y exclusión, luchando por su autonomía. En esa centuria, hubo una extensión creciente del campo y de los poderes médicos; en caso de epidemias, por ejemplo, el Estado obligó a la población a recibir atención médica. La relación que en el XIX mexicano hubo entre el conocimiento y procedimientos médicos, por un lado, y la propia organización profesional, otros saberes médicos, el Estado y el mundo profano, por el otro, es una de las claves de la profesionalización de la medicina en México.
A genetic model for the Los Uvares gold deposit, Baja California Sur, Mexico
A. Carrillo,H. Huyck
Geofísica internacional , 1997,
Abstract: Los Uvares gold deposit is a relatively small ore deposit (~500,000 tons of ore averaging 3 grams of gold per ton), lo cated in the crystalline complex of the Cabo San Lucas block in southern Baja California peninsula. Previous proposed ge netic models for Los Uvares gold deposit are: porphyry gold, and tonalite dike-fault (Escandón, 1983, Romero, 1986). However, the petrographic evidence suggests that Los Uvares is a fault-related disseminated gold deposit (Carrillo, 1990; Carrillo and Huyck, 1990). A comparison between the Los Uvares deposit with porphyry gold-copper, detachment-fault, Carlin type and epithermal deposits suggests that the Uvares is most similar to epithermal gold deposits. The model presented here could be applied as an exploration tool for other deposits in the Baja California peninsula.
Análisis comparativo del gen P de Rinderpest Virus (RPV) Comparative analysis of Rinderpest Virus (RPV) P gene
A Vagnozzi,C Carrillo
InVet , 2006,
Abstract: Rinderpest Virus (RPV) es el agente causal de una severa enfermedad del ganado doméstico. Es un virus envuelto, cuyo genoma RNA no segmentado, de cadena simple y negativa (-ssRNA), está organizado en seis genes no superpuestos. El gen P es el más complejo de dichos genes, codificando una proteína estructural (P) y dos no estructurales (C y V). La proteína P es esencial para la replicación viral y está involucrada en todos los aspectos del ciclo viral. En cambio, las proteínas C y V son consideradas no esenciales para la replicación, al menos in vitro. En este trabajo hemos secuenciado el gen P de 16 aislamientos diferentes de RPV, y realizado el análisis comparativo de las secuencias obtenidas, poniendo el énfasis en las regiones conservadas en relación a su importancia funcional. Rinderpest ha sido una de las amenazas mas importantes para la salud del ganado domestico. En la actualidad la enfermedad se presenta en ciertas regiones de Asia y está en vías de ser erradicada del planeta. La secuenciación y el análisis comparativo realizado en este trabajo es una herramienta sumamente útil y eficiente tanto para seguimiento epidemiológico del virus como para la evaluación de su biología. Rinderpest Virus (RPV) is the causative agent of a serious disease of domestic cattle. RPV is an enveloped virus with a single stranded, non-segmented, negative RNA genome (-ssRNA), that is organized in six non-overlapping genes. P gene is the most complex of such genes. Its sequence codifies for a structural (P) and two non-structural proteins (C and V). The P protein is essential for viral replication and is involved in every aspect of the viral cycle, whereas, C and V proteins are non essential for viral replication, at least in vitro. Here we have made a comparative analysis of sequences of the P gene and its codified proteins from 16 different isolations of RPV, focusing in conserved regions and its functional role. Rinderpest has been one of the most important threats to the cattle health. Actually, the disease is present just in some regions of Asia. The present comparative genomic analysis will be useful as epidemiological work and an important contribution to the current knowledge of RPV biology.
CALIDAD DE LAS LEYES: ALGUNOS PUNTOS CRíTICOS
Yoel Carrillo García
Ratio Juris , 2012,
Abstract: El autor se pregunta sobre las posibilidades y límites de mejorar la calidad de las leyes y el significado de las expresiones “calidad de la legislación” y “calidad de las leyes”. Seguidamente, a partir de una muestra de estudios sobre el tema, identifica el método de diagnóstico utilizado en ellos, hace un compendio de los principales problemas que afectan la calidad de las leyes y las soluciones propuestas para superarlos, y las pone en relación conlas áreas de estudios que integran la Teoría de la Legislación. La principal conclusión es que la “calidad de las leyes” está asociada a factores consustanciales al Derecho moderno como su vinculación a las fuerzas políticas actuantes en la sociedad, su carácter formal-racional, su producción centralizada y burocrática y el lenguaje técnico-especializado y cuasi-formalizado en que se expresan.
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