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Search Results: 1 - 10 of 338533 matches for " Clarissa S. Lima "
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Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
Marcella L Porto, Leandro CF Lima, Thiago MC Pereira, Breno V Nogueira, Clarissa L Tonini, Bianca P Campagnaro, Silvana S Meyrelles, Elisardo C Vasquez
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-155
Abstract: We investigated vascular lipid deposition, vascular remodeling, oxidative stress, and endothelial nitric oxide synthase (eNOS) expression in apoE KO mice treated with spleen MNCs isolated from lacZ transgenic mice (apoE KO-MNC) for 8 weeks compared to untreated control mice (apoE KO).Histological analysis of aortas showed a significant reduction in the lipid deposition area in apoE KO-MNC mice compared to apoE KO mice (0.051 ± 0.004 vs 0.117 ± 0.016 mm2, respectively, p < 0.01). In addition, vessel morphometry revealed that MNC therapy prevented the outward (positive) remodeling in apoE KO mice that is normally observed (apoE KO-MNC: 0.98 ± 0.07 vs apoE KO: 1.37 ± 0.09), using wild-type mice (C57BL/6J) as a reference. ApoE KO-MNC mice also have reduced production of superoxide anions and increased eNOS expression compared to apoE KO mice. Finally, immunohistochemistry analysis revealed a homing of endothelial progenitor cells (EPCs) in the aortas of apoE KO-MNC mice.MNC therapy attenuates the progression of atherosclerosis in the aortas of apoE KO mice. Our data provide evidence that the mechanism by which this attenuation occurs includes the homing of EPCs, a decrease in oxidative stress and an upregulation of eNOS expression.Atherosclerosis is a chronic and degenerative disease of the wall of the large arteries and is a leading cause of mortality and morbidity [1,2]. Despite progress in the treatment and repair of this disease, researchers are continually challenged to develop new successful approaches. Therapy using stem/progenitor cells has emerged as an alternative to conventional treatments for atherosclerosis, as demonstrated by some positive results in experimental and clinical studies [3,4].The apolipoprotein E knockout (apoE KO) mouse, developed two decades ago [5,6], has been used as an experimental model of atherosclerosis because it spontaneously develops hypercholesterolemia and atherosclerosis in a reproducible manner, similar to what is observed in h
Rela??o entre os índices de matura??o das vértebras cervicais e os estágios de calcifica??o dentária
Vieira, Clarissa Lopes;Oliveira, Ana Emília Figueiredo de;Ribeiro, Cecília Cláudia Costa;Jacintho Lima, Andréa Arraes dos S.;
Revista Dental Press de Ortodontia e Ortopedia Facial , 2009, DOI: 10.1590/S1415-54192009000200006
Abstract: aim: to evaluate the relationship between the different cervical vertebrae maturation indicators and the dental calcification stages, as well as to verify the existent differences among gender, in a sample of subjects with 10 to 14 years-old. methods: the sample consisted of lateral cephalometric and panoramic radiographs of 464 subjects of both gender, classified in agreement with the cervical vertebrae maturation indicators described by hassel and farman (1995) and the calcification stages described by nolla (1960). results: the obtained results showed correlation among the studied variables (p < 0,05). conclusions: confirming data from the literature, a precocity was observed as much in the cervical vertebrae maturation indicators, as in the dental calcification stages for the females in relation to the males.
Family agriculture public policies in Brazil Políticas públicas para a agricultura familiar no Brasil
Clarissa Pereira Junqueira,Jandir Ferrera de Lima
Semina : Ciências Sociais e Humanas , 2008, DOI: 10.5433/
Abstract: This article analyzes the relationship between some family agriculture public policies and their effects on the development of this type of agriculture in Brazil. It analyzes the National Program for Strengthening Family Agriculture – Pronaf, which has contributed strongly for the development of the sector , mainly in the Southern region of the country; the implementation of the Rural Social Welfare Program as a palliative to social exclusion; and the Food Acquisition Program –PAA which guarantees the purchasing of great part of family agriculture and cattle raising production. O presente artigo faz uma análise da rela o entre algumas políticas públicas aplicadas ao setor agropecuário familiar, e seus efeitos para o desenvolvimento da agricultura familiar no Brasil. S o analisados: o Programa Nacional de Fortalecimento da Agricultura Familiar – Pronaf, que vem contribuindo fortemente para o desenvolvimento do setor, principalmente na regi o Sul do país; a implementa o da Previdência Social Rural como paliativo à exclus o social; e o Programa de Aquisi o de Alimentos – PAA, que dá garantia de compra a parte da produ o agropecuária familiar.
A SAR and QSAR Study of New Artemisinin Compounds with Antimalarial Activity
Cleydson Breno R. Santos,Josinete B. Vieira,Cleison C. Lobato,Lorane I. S. Hage-Melim,Raimundo N. P. Souto,Clarissa S. Lima,Elizabeth V. M. Costa,Davi S. B. Brasil,Williams Jorge C. Macêdo,José Carlos T. Carvalho
Molecules , 2014, DOI: 10.3390/molecules19010367
Abstract: The Hartree-Fock method and the 6-31G** basis set were employed to calculate the molecular properties of artemisinin and 20 derivatives with antimalarial activity. Maps of molecular electrostatic potential (MEPs) and molecular docking were used to investigate the interaction between ligands and the receptor (heme). Principal component analysis and hierarchical cluster analysis were employed to select the most important descriptors related to activity. The correlation between biological activity and molecular properties was obtained using the partial least squares and principal component regression methods. The regression PLS and PCR models built in this study were also used to predict the antimalarial activity of 30 new artemisinin compounds with unknown activity. The models obtained showed not only statistical significance but also predictive ability. The significant molecular descriptors related to the compounds with antimalarial activity were the hydration energy (HE), the charge on the O11 oxygen atom (QO11), the torsion angle O1-O2-Fe-N2 (D2) and the maximum rate of R/Sanderson Electronegativity (RTe +). These variables led to a physical and structural explanation of the molecular properties that should be selected for when designing new ligands to be used as antimalarial agents.
A presen a da doen a de Alzheimer e suas repercuss es na dinamica familiar
Irani I. de Lima Argimon,Clarissa Marceli Trentini
Revista Brasileira de Ciências do Envelhecimento Humano , 2006,
Abstract: O presente trabalho aborda a doen a de Alzheimer (DA) e o seu impacto na família. Por meio de uma breve revis o teórica discute-se a dinamica familiar a partir da presen a de um diagnóstico de DA num de seus elementos. Explanam-se dados históricos e estatísticos, bem como cren as, valores de autonomia, auto-estima e modifica o de papéis. Por fim, é apresentada uma proposta de interven o para situa es de exaust o na família.
Controlling the Tax Evasion Dynamics via Majority-Vote Model on Various Topologies  [PDF]
Francisco W. S. Lima
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.21017
Abstract: Within the context of agent-based Monte-Carlo simulations, we study the well-known majority-vote model (MVM) with noise applied to tax evasion on simple square lattices (LS), Honisch-Stauffer (SH), directed and undirected Bara-basi-Albert (BAD, BAU) networks. In to control the fluctuations for tax evasion in the economics model proposed by Zaklan, MVM is applied in the neighborhod of the noise critical qc to evolve the Zaklan model. The Zaklan model had been studied recently using the equilibrium Ising model. Here we show that the Zaklan model is robust because this can be studied using equilibrium dynamics of Ising model also through the nonequilibrium MVM and on various topologies cited above giving the same behavior regardless of dynamic or topology used here.
Tax Evasion Dynamics via Non-Equilibrium Model on Complex Networks  [PDF]
Francisco W. S. Lima
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.56089
Abstract: The Zaklan model has become an excellent mechanism to control the tax evasion fluctuations (TEF) in a people- or agent-based community. Initially, the equilibrium Ising model (IM) had been used as a dynamic of temporal evolution of the Zaklan model near the critical point of the IM. On some complex network the IM presents no critical points or well-defined phase transitions. Then, through Monte Carlo simulations we study the recurring problem of the TEF control using the version of non-equilibrium Zaklan model as a control mechanism for TEF via agent-based non-equilibrium majority-vote model (MVM). Here we study the TEF on directed Barabási-Albert (BAD) and Apollonian (ANs) networks where the IM is not applied. We show that the Zaklan model can be also studied using non-equilibrium dynamics through of the non-equilibrium MVM on complex topologies cited above, giving the behavior of the TEF regardless of dynamic or topology used here.
Entanglement in the Quantum Phase Transition of the Half-Integer Spin One-Dimensional Heisenberg Model  [PDF]
Leonardo S. Lima
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.615228
Abstract: We use the Bethe’s ansatz method to study the entanglement of spinons in the quantum phase transition of half integer spin one-dimensional magnetic chains known as quantum wires. We calculate the entanglement in the limit of the number of particles \"\". We obtain an abrupt change in the entanglement next the quantum phase transition point of the anisotropy parameter \"\"?from the gapped phase \"\"?to gapless phase \"\".
Tax Evasion Dynamics via Non-Equilibrium Model on Directed Small-World Networks  [PDF]
Francisco W. S. Lima
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.64086
Abstract: Based on people or agent community, we use the Zaklan model as a mechanism to control the tax evasion fluctuations. Here, we use the non-equilibrium Sánchez-López-Rodríguez model (SLR), i.e. directed Watts-Strogatz networks, as a dynamics of the temporal evolution of the Zaklan model. We simulate the response of tax cheaters to punishment by an auditing authority as well as to the behavior of their neighbors. The higher the punishment is, the smaller is the simulated probability to cheat. This reasonable result shows that our model is qualitatively good.
The Concurrence of Hypercholesterolemia and Aging Promotes DNA Damage in Apolipoprotein E-Deficient Mice  [PDF]
Sara P Dalboni, Silvana S Meyrelles, Bianca P Campagnaro, Clarissa L Tonini, Elisardo C Vasquez
Open Journal of Blood Diseases (OJBD) , 2012, DOI: 10.4236/ojbd.2012.23010
Abstract: Recent evidence shows that increased oxidative stress and aging contribute to DNA damage in various cardiovascular diseases such as lipid disorders and atherosclerosis. In the present study, we used the comet assay to evaluate the influ- ence of aging on DNA damage in whole blood cells from apolipoprotein E-deficient (apoE?/?) mice and compared the results to those found in cells from wild-type C57BL/6 (C57) mice. Using the alkaline comet assay and fluorescent ethidium bromide staining, DNA damage was analyzed in the peripheral whole blood (5 μL) cells that were isolated from either young (8-week-old) and elderly (72-week-old) apoE?/? mice or from age-matched C57 mice. The levels of total plasma cholesterol were approximately 6-fold higher in apoE?/? mice of both ages compared to C57 mice. Elderly apoE?/? mice showed significantly higher levels of DNA damage (19%) compared to elderly C57 mice (8%, p < 0.01) and young apoE?/? mice (10%, p < 0.01). The comet assay in whole blood cells is a suitable technique for the detection of DNA damage in the apoE?/? mouse; it is an easy, rapid, inexpensive and sensitive method. The novelty of this study is that DNA damage occurring in whole blood cells of this murine model requires the concurrence of aging and oxida- tive stress-related hypercholesterolemia.
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