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Search Results: 1 - 10 of 12586 matches for " Clara Azalea; Alfonso Castillo "
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Toxicidad a dosis repetidas de Azadirachta indica A. Juss. (árbol del Nim) Repeated dose toxicity in Azadichfa indica A. Juss (Neem tree)
Clara Azalea Berenguer Rivas,Alfredo Alfonso Castillo,Onel Fong Lores,Aníbal Domínguez Odio
Revista Cubana de Plantas Medicinales , 2010,
Abstract: INTRODUCCIóN: Azadirachta indica A. Juss., conocida como árbol del Nim, tiene múltiples aplicaciones para la agricultura, la medicina veterinaria y la salud, es una especie vegetal de importancia relevante por su uso como antimicrobiano, antiparasitario e inmunoestimulante. OBJETIVO: detectar signos de toxicidad tras la administración diaria durante 28 d de la decocción de A. indica. MéTODOS: se realizó un ensayo de toxicidad a dosis repetidas a una decocción de esta planta administrando una dosis de 1 000 mg/kg por vía oral a ratas Sprague Dawley durante 28 d. Se evaluaron los signos clínicos y el peso corporal de los animales en estudio y se realizaron exámenes de hematología, bioquímica sanguínea, análisis anatomopatológico e histopatológico. RESULTADOS: la decocción de la planta no produjo alteraciones significativas en el peso corporal, ni hubo signos clínicos indicadores de toxicidad. No se observaron alteraciones en los indicadores hematológicos y bioquímicos atribuibles a la sustancia de ensayo. Los resultados anatomopatológicos no mostraron alteraciones sobre sistemas, órganos y tejidos. CONCLUSIONES: el estudio no demostró efectos tóxicos en el modelo animal utilizado, que pudieran estar asociados a la administración repetida de la decocción de la planta A. indica en las condiciones empleadas. INTRODUCTION: Azadirachta indica A. Juss, known as Neem tree, has various applications in agriculture, veterinary medicine and health care, thus it is a relevant vegetable species due to its antimicrobial, antiparasitic and immunostimulating properties. OBJECTIVE: to detect any signal of toxicity after daily oral administration of decoction for 28 days. METHODS: a repeated dose toxicity assay using a A. indica decoction at a dose of 1000 mg/kg, orally administered to Sprague Dawley rats for 28 days. Clinical signs and body weight of the study animals were evaluated together with hamatological, blood chemistry, anatomopathological and histopathological analyses. RESULTS: this decoction brought about neither significant change in the body weight nor clinical signs indicating toxicity. There were not altered hematological and biochemical indicators that may be attributed to the substance under testing. The anatomopathological results did not show any alteration upon systems, organs and tissues. CONCLUSIONS: the study did not reveal toxic effects in the animal model that might be connected with the repeated oral administration of A. indica decoction under the study conditions.
Toxicidad a dosis repetidas de Azadirachta indica A. Juss. (árbol del Nim)
Berenguer Rivas,Clara Azalea; Alfonso Castillo,Alfredo; Fong Lores,Onel; Domínguez Odio,Aníbal; Betancourt Hernandez,Juan E.; Laramendi Gri?an,Dani; Salas Martínez,Hilario; Puentes Zapata,Edgar; Wawoe Díaz,Nioslaymy;
Revista Cubana de Plantas Medicinales , 2010,
Abstract: introduction: azadirachta indica a. juss, known as neem tree, has various applications in agriculture, veterinary medicine and health care, thus it is a relevant vegetable species due to its antimicrobial, antiparasitic and immunostimulating properties. objective: to detect any signal of toxicity after daily oral administration of decoction for 28 days. methods: a repeated dose toxicity assay using a a. indica decoction at a dose of 1000 mg/kg, orally administered to sprague dawley rats for 28 days. clinical signs and body weight of the study animals were evaluated together with hamatological, blood chemistry, anatomopathological and histopathological analyses. results: this decoction brought about neither significant change in the body weight nor clinical signs indicating toxicity. there were not altered hematological and biochemical indicators that may be attributed to the substance under testing. the anatomopathological results did not show any alteration upon systems, organs and tissues. conclusions: the study did not reveal toxic effects in the animal model that might be connected with the repeated oral administration of a. indica decoction under the study conditions.
Evaluación de la toxicidad aguda oral e irritación sobre mucosa bucal de la solución CM-95 tratada magnéticamente Oral acute toxicity and irritation on buccal mucosa evaluation of the CM-95 solution magnetically treated
Jorge Díaz Bestard,Clara Esther Martínez Manrique,Alfredo Alfonso Castillo,Ana Maria Pardo Terga
Acta Toxicológica Argentina , 2008,
Abstract: La Solución CM-95 tratada magnéticamente es un producto en desarrollo que mostró propiedades inmunoestimulantes en ensayos preclínicos, característica que la hacen adecuada como candidata a inmunopotenciador. En este trabajo se evaluaron los posibles efectos tóxicos preclínicos de la Solución CM-95 tratada magnéticamente, por el método de las Clases de Toxicidad Aguda y el de irritación de la mucosa oral, adaptando las normas OECD 423 y la ISO 10993-10, respectivamente. En el método de las Clases de Toxicidad Aguda se utilizó el ensayo límite, en ratas Sprague Dawley hembras, en el cual la dosis estuvo relacionada con el nivel de inducción magnética, en este caso 0,16 T, aplicado a la Solución CM-95; y el volumen a administrar de la misma, calculado sobre la base de 2 ml de la solución por 100 g de peso corporal. La determinación de la irritación de la mucosa oral se llevó a cabo en hámster Sirios Dorados hembras mediante un ensayo a dosis repetidas durante 7 días de tratamiento en la bolsa gular derecha, con pellet de algodón impregnado con 0,5 ml de la solución tratada magnéticamente con la misma inducción. No se encontró mortalidad ni evidencias de signos tóxicos para el ensayo de toxicidad aguda, y se obtuvo un índice de irritación sobre mucosa oral de 0, por lo que la sustancia estudiada se enmarcó como "No clasificada" y "No irritante" según la metodología empleada. Estos resultados complementarán otros estudios toxicológicos para avalar la seguridad de esta Solución para su uso futuro como fármaco por vía oral. CM-95 solution magnetically treated is a product which showed immunologic properties in preliminary tests, characteristic that makes it adequate as inmunopotentiator candidate. In this study the possible preclinical toxic effects of CM-95 Solution magnetically treated were evaluated, by the Acute Toxicity Class method and oral mucosa irritation test, adapting guideline OECD 423 and ISO 10993-10. In Acute Toxicity Class method was used the Limit Test, in Sprague Dawley females rats, where the dose was related to the magnetic induction level, in this case 0.16 T, applied to CM-95 Solution; and the administration volume of aqueous solution was calculated on base 2 ml per 100 g body weight. Determination of oral mucosa irritation was carried out in female golden Syrian hamsters by means of a repeated doses test during 7 days of treatment in right gular bag, with a cotton pellet impregnated with 0.5 ml of CM-95 Solution magnetically treated with the same induction. Neither mortality nor evidences of toxic signs were observed for the test of acu
Intoxicaciones por plantas tóxicas atendidas desde un servicio de información toxicológica
Macías Peacok,Beatriz; Suárez Crespo,Maykel Fernando; Berenguer Rivas,Clara Azalea; Pérez Jackson,Liliana;
Revista Cubana de Plantas Medicinales , 2009,
Abstract: introduction: in many countries, the accidental or intentional exposure to toxic substances is the frequent cause of acute and chronic pathological processes that represent the second cause of death after the infectious illnesses. in statistical reports, poisoning from pscyho drugs and herbicides prevail, but there are others as those caused by vegetable substances that are also commonly treated in the emergency services. objectives: to ascertain the incidence and mortality of poisoning from plants reported in the pharmacological and toxicological consultancy service of toximed. methods: the record of poisoned patients seen at this service from 1998 to december 2007 was used; the universe of patients was 290. each register provided data like sex, clinical manifestations, circumstances around the poisoning, name of the toxic plant, place of origin of the poisoned person and the patient's final evolution. results: twenty four consultation services for poisoned patients caused by toxic plants were recorded. (8,3 %). male patients (75 %) and intentional poisoning for toxic mania (54 %) prevailed; being (datura stramonium l.) the most used plant. the highest percent of poisoned persons was found in santiago de cuba province (75 %) where the patients from santiago de cuba municipality (38,9 %) predominated. there were 4 deaths (16,7 %). conclusions: the population of the eastern region of the country traditionally uses some plants that have been barely studied or not studied at all from the toxicological viewpoint, so it is necessary to continue studying these plants, and to disseminate information in order to reduce morbidity and mortality from toxic vegetables.
Intoxicaciones por plantas tóxicas atendidas desde un servicio de información toxicológica Cases of poisoning caused by toxic plants seen at a toxicological information service
Beatriz Macías Peacok,Maykel Fernando Suárez Crespo,Clara Azalea Berenguer Rivas,Liliana Pérez Jackson
Revista Cubana de Plantas Medicinales , 2009,
Abstract: INTRODUCCIóN: en muchos países la exposición accidental o voluntaria a sustancias tóxicas es causa frecuente de procesos patológicos agudos y crónicos, que constituyen la segunda causa de muerte, después de las enfermedades infecciosas. En reportes estadísticos predominan las intoxicaciones por psicofármacos y plaguicidas, pero existen otras como las provocadas por sustancias vegetales que también son consultas frecuentes en los servicios de urgencias. OBJETIVO: determinar la incidencia y mortalidad de intoxicaciones por plantas reportadas en el servicio de Consultoría Fármaco-Toxicológica de TOXIMED. MéTODOS: se empleó el registro de pacientes intoxicados atendidos en este servicio, desde 1998 hasta diciembre de 2007, para un universo de 290 pacientes. De cada registro se obtuvieron datos como sexo, manifestaciones clínicas, circunstancias de la intoxicación, nombre de la planta tóxica, lugar de procedencia del intoxicado, evolución final del paciente. RESULTADOS: se atendieron 24 consultas de pacientes intoxicados por plantas tóxicas (8,3 %). Predominaron los pacientes del sexo masculino (75 %) y las intoxicaciones voluntarias por toxicomanía (54 %) en las cuales el clarín (Datura stramonium L.) fue la planta más utilizada. El mayor porcentaje de intoxicados fue de la provincia Santiago de Cuba (75 %) y predominaron los pacientes del municipio Santiago de Cuba (38,9 %). Hubo 4 fallecidos (16,7 %). CONCLUSIONES: la población de la región oriental del país emplea de manera tradicional plantas poco o nada estudiadas toxicológicamente, por lo que se hace necesario continuar con su estudio, y realizar labores de divulgación para disminuir la morbilidad y mortalidad por vegetales tóxicos. INTRODUCTION: in many countries, the accidental or intentional exposure to toxic substances is the frequent cause of acute and chronic pathological processes that represent the second cause of death after the infectious illnesses. In statistical reports, poisoning from pscyho drugs and herbicides prevail, but there are others as those caused by vegetable substances that are also commonly treated in the emergency services. OBJECTIVES: to ascertain the incidence and mortality of poisoning from plants reported in the Pharmacological and Toxicological Consultancy Service of TOXIMED. METHODS: The record of poisoned patients seen at this service from 1998 to December 2007 was used; the universe of patients was 290. Each register provided data like sex, clinical manifestations, circumstances around the poisoning, name of the toxic plant, place of origin of the poisoned person and
Evaluación de la toxicidad aguda oral e irritación sobre mucosa bucal de la solución CM-95 tratada magnéticamente
Díaz Bestard,Jorge; Martínez Manrique,Clara Esther; Alfonso Castillo,Alfredo; Pardo Terga,Ana Maria; Esmérido Betancourt,Juan; Salas Martínez,Hilario; Puente Zapata,Edgar; Sede?o Soularit,Narvis;
Acta toxicol?3gica argentina , 2008,
Abstract: cm-95 solution magnetically treated is a product which showed immunologic properties in preliminary tests, characteristic that makes it adequate as inmunopotentiator candidate. in this study the possible preclinical toxic effects of cm-95 solution magnetically treated were evaluated, by the acute toxicity class method and oral mucosa irritation test, adapting guideline oecd 423 and iso 10993-10. in acute toxicity class method was used the limit test, in sprague dawley females rats, where the dose was related to the magnetic induction level, in this case 0.16 t, applied to cm-95 solution; and the administration volume of aqueous solution was calculated on base 2 ml per 100 g body weight. determination of oral mucosa irritation was carried out in female golden syrian hamsters by means of a repeated doses test during 7 days of treatment in right gular bag, with a cotton pellet impregnated with 0.5 ml of cm-95 solution magnetically treated with the same induction. neither mortality nor evidences of toxic signs were observed for the test of acute toxicity, and an irritation index of 0 was obtained on oral mucosa irritation test, reason why the studied substance was framed as "not classified" and "non irritating" according to the applied methodology. these results will complement other toxicological studies to guarantee the safety of this solution for its future use as a drug by oral route.
Determinación de la necesidad de tratamiento periodontal en jóvenes de una escuela militar
Doncel Pérez,Clara; Castillo Castillo,Arturo;
Revista Cubana de Medicina Militar , 2008,
Abstract: a descriptive cross-sectional study of 250 students of both sexes aged 19-23 from "josé martí" military technical institute, in havana city, was conducted in order to identify their needs of periodontal treatment. a simple randomized sample was taken, and the index of necessity of periodontal treatment in the community was used. the results showed that 67.6 % of those who were examined were periodontally affected. the average of healthy sextans was 4.54, whereas 47.2 % needed basic periodontal treatment. statistical graphics were made. it was concluded that the condition of periodontally sound decreased with age and that the oral hygiene instruction was the most frequent need of treatment, followed by the need of basic periodontal treatment.
Papel de los herpes virus en la enfermedad periodontal. Revisión de literatura
Doncel Pérez,Clara; Castillo Castillo,Arturo;
Revista Habanera de Ciencias M??dicas , 2011,
Abstract: introduction: periodontitis is a multifactor disease where bacteria do not play a unique role in its origin and development. the progress of microbiological studies have proved the presence of herpes virus in the different clinical manifestations of this disease. objective:the aim of this research is to show different elements that place the infection by herpes virus and the beginning and development of periodontitis very close related one to another. material and methods: reference systems such as medline, pubmed, and scielo were consulted. it was also made a revision of descriptions like herpes virus, cytomegalovirus, epstein-barr virus and periodontal disease. conclusion: it was concluded that the inflammatory cells infected by herpetic virus promote the production of cytokines that destroyed the periodontal tissues decreasing the capacity of defence against bacteria presence.
Determinación de la necesidad de tratamiento periodontal en jóvenes de una escuela militar Determination of the need of periodontal treatment in the young from a military school
Clara Doncel Pérez,Arturo Castillo Castillo
Revista Cubana de Medicina Militar , 2008,
Abstract: Se realizó un estudio descriptivo de corte transversal en 250 alumnos de uno y otro sexos, comprendidos entre 19 y 23 a os de edad, pertenecientes al Instituto Técnico Militar "José Martí", en Ciudad de La Habana, con el objetivo de identificar sus necesidades de tratamiento periodontal. Se tomó una muestra simple aleatoria, se utilizó el índice de necesidad de tratamiento periodontal en la comunidad. Los resultados expresaron que el 67,6 % de los examinados estaban afectados periodontalmente, el promedio de sextantes sanos fue de 4,54 y necesitó tratamiento periodontal básico el 47,2 %. Se confeccionaron gráficos estadísticos. Se llegó a la conclusión que la condición de sano periodontal disminuyó con la edad y que la instrucción de higiene bucal constituyó la necesidad de tratamiento más frecuente, seguido de la necesidad de tratamiento periodontal básico. A descriptive cross-sectional study of 250 students of both sexes aged 19-23 from "José Martí" Military Technical Institute, in Havana city, was conducted in order to identify their needs of periodontal treatment. A simple randomized sample was taken, and the index of necessity of periodontal treatment in the community was used. The results showed that 67.6 % of those who were examined were periodontally affected. The average of healthy sextans was 4.54, whereas 47.2 % needed basic periodontal treatment. Statistical graphics were made. It was concluded that the condition of periodontally sound decreased with age and that the oral hygiene instruction was the most frequent need of treatment, followed by the need of basic periodontal treatment.
Papel de los herpes virus en la enfermedad periodontal. Revisión de literatura Role of herpes virus in the periodontal disease. Consultation of literature
Clara Doncel Pérez,Arturo Castillo Castillo
Revista Habanera de Ciencias M??dicas , 2011,
Abstract: Introducción: La periodontitis es una enfermedad multifactorial, donde las bacterias no tienen un papel único en su origen y desarrollo. Con el avance de los estudios microbiológicos se ha demostrado la presencia de los herpes virus en las diferentes manifestaciones clínicas de la misma. Objetivo: mostrar diferentes elementos en los cuales se relaciona la infección por herpes virus con el inicio y desarrollo de las periodontopatías. Material y Métodos: Se realizó una revisión bibliográfica mediante la consulta de bases de datos de los sistemas referativos, como MEDLINE, PubMed y Scielo, con la utilización de descriptores como herpes virus, citomegalovirus, Epstein-Barr virus, periodontal disease, pathogenesis. Conclusiones: Se llegó a la conclusión que las células inflamatorias infectadas con virus herpéticos provocan la producción de citocinas que destruyen los tejidos periodontales y pueden disminuir la capacidad de defensa frente a la exposición bacteriana. Introduction: Periodontitis is a multifactor disease where bacteria do not play a unique role in its origin and development. The progress of microbiological studies have proved the presence of Herpes virus in the different clinical manifestations of this disease. Objective:The aim of this research is to show different elements that place the infection by Herpes virus and the beginning and development of periodontitis very close related one to another. Material and Methods: Reference systems such as MEDLINE, PUBMED, and SCIELO were consulted. It was also made a revision of descriptions like herpes virus, Cytomegalovirus, Epstein-Barr virus and periodontal disease. Conclusion: It was concluded that the inflammatory cells infected by herpetic virus promote the production of Cytokines that destroyed the periodontal tissues decreasing the capacity of defence against bacteria presence.
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