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Search Results: 1 - 10 of 2035 matches for " Cittelly; Bravo "
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Frecuencia de los genotipos babA2, oipA y cagE de Helicobacter pylori en pacientes colombianos con enfermedades gastroduodenales
Quiroga,Andrés Javier; Diana Marcela,Cittelly; Bravo,María Mercedes;
Biomédica , 2005,
Abstract: introduction. helicobacter pylori infection is associated with the development of several gastroduodenal diseases. bacterial virulence genes have been found associated with an increased risk for gastric disease. objectives. herein, associations were made between the presence of vaca, caga, cage, baba2 and oipa genes in h. pylori isolates and the range of clinical consequences of the infection. methods. pcr was used to amplify vaca, caga, cage, baba2 and oipa genes in 166 isolates- 50 patients with peptic ulcer, 39 with non-atrophic gastritis, 26 with atrophic gastritis, 26 with intestinal metaplasia and 25 with gastric adenocarcinoma. results. caga, cage, baba2 and oipa genes were found in 73%, 75%, 48% and 74% of isolates, respectively. the cytotoxic vaca s1m1/ caga positive/ cage positive genotype was present in 64% (100/157) of isolates. a higher frequency of cytotoxic strains was observed in cancer patients (84%), intestinal metaplasia (91%) and peptic ulcer (81%) in comparison with gastritis patients (50%) (p=0.002, 0.008, 0.007, respectively). the oipa and baba2 frequency was higher in cytotoxic isolates than in non-cytotoxic isolates ( oipa: 81% vs. 52%, p=0,003; baba2: 58% vs. 12% (p<0.001). no significant association was found among clinical outcomes and oipa or baba2 genotypes, analyzed alone or in combination with vaca and caga. conclusion. therefore, baba2 or oipa genes are not marker indicators of ulcer or cancer.
Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
Cittelly P,Diana M; Huertas,Mónica G; Martínez,Julián D; Oliveros,Ricardo; Posso,Héctor; Bravo,María Mercedes; Orozco D,Oscar;
Revista médica de Chile , 2002, DOI: 10.4067/S0034-98872002000200003
Abstract: background: helicobacter pylori is recognized as an etiologic agent of several gastric diseases. bacterial genotypes have been related to clinical outcome in several populations. aim: to compare caga, vaca and icea genotypes of colombian isolates from patients with several gastrointestinal diseases, including gastric cancer. material and methods: we used polymerase chain reactions to amplify vaca, caga and icea genes of 137 h pylori isolates coming from 26 patients with gastric cancer (gc), 34 with peptic ulcer (pu), 19 with intestinal metaplasia (im), 23 with atrophic gastritis (ag) and 35 with non atrophic gastritis (nag). results: vaca s1-m1, caga+, icea+ were the most frequently found genotypes. vaca s1 and m1 subtypes were found in 92 (67%) and 82 (60%) cases respectively. sixty three percent were caga+ and 85% were icea+. there was a lower prevalence of s1 allele in cases of nag (43%), compared with gc, pu and im (81%, 77% and 81% prevalence, respectively, p <0.01). isolates from nag also showed a low frequency of vaca m1 subtype (40%) compared with gc or im (81% and 84% respectively, p <0.01). the prevalence of caga+ strains was significantly higher in gc patients (80%) than in nag patients (51.4%, p <0.01). no differences in the frequency of vaca s1a, s1b and icea subtypes, were observed. conclusions: a lower frequency of cytotoxic h pylori genotypes such as caga and vaca s1m1 and a higher frequency of non cytotoxic genotypes, was observed in patients with nag, when compared to patients with gc or pu. these results suggest that even in colombia, vaca and caga could be used as markers of increased virulence (rev méd chile 2002; 130: 143-51)
Ovarian steroid hormones: what's hot in the stem cell pool?
Diana M Cittelly, Jennifer K Richer, Carol A Sartorius
Breast Cancer Research , 2010, DOI: 10.1186/bcr2627
Abstract: Lifetime exposure to circulating steroid hormones via the number of menstrual cycles, menopausal hormone therapy, and perhaps pregnancy all increase breast cancer risk [1]. The details underlying this increased risk, however, have long remained elusive. The re-emergence of the cancer stem cell (CSC) theory since its original inception over a century ago [2] has popularized mammary stem cells (MaSCs) as putative cells of origin for breast cancers. Since the MaSCs reside within the steroid receptor-negative basal epithelial compartment [3], it was presumed that steroid hormone signaling would have little impact on their regulation. This presumption was despite earlier work demonstrating that estrogen receptor (ER)-positive and progesterone receptor (PR)-positive luminal cells in the normal breast use a paracrine mechanism to instruct neighboring ER-negative/PR-negative cells to proliferate [4]. Two seminal papers now uncover a critical role for steroid hormones in controlling both the number and the regenerative function of MaSCs in the normal murine mammary gland. These exciting findings promise to revolutionize our perception of how the female sex steroid hormones regulate the differentiation state of the breast and influence the risk of breast disease [5,6].Asselin-Labat and colleagues establish that steroid hormone deprivation via ovariectomized or aromatasedeficient mice significantly reduces the ability of MaSCs (CD29hiCD24+) to repopulate a mammary gland in the cleared fat pad of syngeneic recipient mice [5]. A combination of 17β-estradiol plus progesterone, but not 17β-estradiol or progesterone alone, in ovariectomized mice restores the repopulating frequency of MaSCs. Blockade of either 17β-estradiol (letrozole) or progesterone (RU486) did not affect MaSC numbers, but did reduce their repopulating ability and ductal outgrowth formation, respectively - indicating that MaSCs rely on the luminal compartment for functional signals. Interestingly, the hormonal sta
Chilean University Students’ Call for Participation and Engagement in What Matters to Them: Is It Possible to Achieve a Shared Decision Making Process in Education Policy?  [PDF]
Paulina Bravo, Baltica Cabieses
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326155
Abstract: Chile is facing one of its major intellectual revolutions in the last century: organised high school, college and university students have led the most salient educational reform since the one that took place during the dictatorship period. This phenomenon is a pacific revolution based on the power of sound, evidence-based, clear and robust ideas. The purpose of this short essay is to reflect some ideas on the conceptualisation of a shared decision making (SDM) process and how they could be transferred to the current students’ educational revolution in Chile. It provides a reflection on how SDM might concretely contribute to this educational reform and on what future steps could be taken to truly achieves a “participatory” democracy in Chile. According to the authors, this debate illustrates the extent to which the level of participation must rely not on particular individuals but on the establishment of a partnership between parties.
CCS Membrane Development at CIUDEN’s Technology Development Centre for CO2 Capture  [PDF]
Jose A. Gutierrez Bravo
Journal of Power and Energy Engineering (JPEE) , 2018, DOI: 10.4236/jpee.2018.612001
Abstract: CO2 concentration to the atmosphere has risen faster than ever in the last century. This is highly due to fossil fuel combustion which is the major anthropogenic CO2 source. Membrane technology is an important alternative for reliability, flexibility and economically competitiveness for Carbon Capture and Storage (CCS) processes. The use of membranes has applicability to CCS technologies mainly for CO2, O2 or H2 separation, although most of the membrane studies for CO2/O2 production have been carried out at laboratory scale and will require a step further for commercial scale. This paper will present current membranes R & D needs when applied to CCS systems and CIUDEN capabilities for membrane technological development and testing under real conditions. It covers from O2 separation membrane integration in the process, and applied to the oxy-combustion CO2 capture, to post-combustion technologies for membrane CO2 separation, tested under real conditions or H2 production catalytic-membranes through gasification. At CIUDEN CCS facility important membrane evaluations can be carried out for the module integration, testing of materials performance and behavior under real conditions.
miR-200c Targets a NF-κB Up-Regulated TrkB/NTF3 Autocrine Signaling Loop to Enhance Anoikis Sensitivity in Triple Negative Breast Cancer
Erin N. Howe, Dawn R. Cochrane, Diana M. Cittelly, Jennifer K. Richer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049987
Abstract: Anoikis is apoptosis initiated upon cell detachment from the native extracellular matrix. Since survival upon detachment from basement membrane is required for metastasis, the ability to resist anoikis contributes to the metastatic potential of breast tumors. miR-200c, a potent repressor of epithelial to mesenchymal transition, is expressed in luminal breast cancers, but is lost in more aggressive basal-like, or triple negative breast cancers (TNBC). We previously demonstrated that miR-200c restores anoikis sensitivity to TNBC cells by directly targeting the neurotrophic receptor tyrosine kinase, TrkB. In this study, we identify a TrkB ligand, neurotrophin 3 (NTF3), as capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. We present the first evidence that anoikis resistant TNBC cells up-regulate both TrkB and NTF3 when suspended, and show that this up-regulation is necessary for survival in suspension. We further demonstrate that NF-κB activity increases 6 fold in suspended TNBC cells, and identify RelA and NF-κB1 as the transcription factors responsible for suspension-induced up-regulation of TrkB and NTF3. Consequently, inhibition of NF-κB activity represses anoikis resistance. Taken together, our findings define a critical mechanism for transcriptional and post-transcriptional control of suspension-induced up-regulation of TrkB and NTF3 in anoikis resistant breast cancer cells.
Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia Helicobacter pylori genotypes in non atrophic gastritis, peptic ulcer disease, premalignant lesions and gastric cancer in Colombia
Diana M Cittelly P,Mónica G Huertas,Julián D Martínez,Ricardo Oliveros
Revista médica de Chile , 2002,
Abstract: Background: Helicobacter pylori is recognized as an etiologic agent of several gastric diseases. Bacterial genotypes have been related to clinical outcome in several populations. Aim: To compare cagA, vacA and iceA genotypes of Colombian isolates from patients with several gastrointestinal diseases, including gastric cancer. Material and methods: We used polymerase chain reactions to amplify vacA, cagA and iceA genes of 137 H pylori isolates coming from 26 patients with gastric cancer (GC), 34 with peptic ulcer (PU), 19 with intestinal metaplasia (IM), 23 with atrophic gastritis (AG) and 35 with non atrophic gastritis (NAG). Results: vacA s1-m1, cagA+, iceA+ were the most frequently found genotypes. vacA s1 and m1 subtypes were found in 92 (67%) and 82 (60%) cases respectively. Sixty three percent were cagA+ and 85% were iceA+. There was a lower prevalence of s1 allele in cases of NAG (43%), compared with GC, PU and IM (81%, 77% and 81% prevalence, respectively, p <0.01). Isolates from NAG also showed a low frequency of vacA m1 subtype (40%) compared with GC or IM (81% and 84% respectively, p <0.01). The prevalence of cagA+ strains was significantly higher in GC patients (80%) than in NAG patients (51.4%, p <0.01). No differences in the frequency of vacA s1a, s1b and iceA subtypes, were observed. Conclusions: A lower frequency of cytotoxic H pylori genotypes such as cagA and vacA s1m1 and a higher frequency of non cytotoxic genotypes, was observed in patients with NAG, when compared to patients with GC or PU. These results suggest that even in Colombia, vacA and cagA could be used as markers of increased virulence (Rev Méd Chile 2002; 130: 143-51)
Ajab, el burlador burlado: Elementos comunicativos en 1Re 22,1-38
Bravo,Arturo;
Teología y vida , 2003, DOI: 10.4067/S0049-34492003000400001
Abstract: the objective of this article is to show the resources used in 1kings 22,1-38 to communicate its content. for it the problems and irregularities of the text are identified, the relations with their textual surroundings are settle down, their diverse layers and the sense of each one of them are presented to end up indicating the communicative elements or resources
First record and description of a new species of Sycorax Curtis (Diptera: Psychodidae, Sycoracinae) from the Brazilian Amazon
Bravo, Freddy;
Neotropical Entomology , 2007, DOI: 10.1590/S1519-566X2007000400007
Abstract: sycorax longispinosa sp. nov. is described from serra do cachorro, pará state, brazil. this new species is the first record of the genus from the brazilian amazon. an identification key for males of species of sycorax from the neotropical region is presented.
Cinco espécies novas de Caenobrunettia (Diptera: Psychodidae, Psychodinae) do Brasil
Bravo, Freddy;
Neotropical Entomology , 2003, DOI: 10.1590/S1519-566X2003000200013
Abstract: five new species of caenobrunettia wagner from brazil are described, caenobrunettia baiana sp. nov., caenobrunettia serrajiboiensis sp. nov., caenobrunettia serrulata sp. nov. and caenobrunettia variata sp. nov. from bahia state, and caenobrunettia carioca sp. nov. from rio de janeiro state. an identification key for males of species of caenobrunettia is presented.
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