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CASE STUDY ON THE IMPLEMENTATION OF A VIDEO STORY-BASED INTERVENTI-ON WITH SELF-MODELING TREATMENT PACKAGE TO REDUCE STEREOTYPICAL SPITTING BEHAVIOR IN A YOUNG GIRL WITH AUTISM
Cindy NELSON-HEAD,Doris ADAMS HILL,Margaret FLORES
Journal of Special Education and Rehabilitation , 2012,
Abstract: The purpose of this study was to investigate the use of a video story-based intervention with self-modeling to decrease spitting behavior in a female pre-school student with autism during an extended school year ser-vices program. An A-B-A-B design was used to demonstrate a functional relation between a video story-based intervention with self-modeling and decreased spitting be-havior. The results showed that spitting behavior de-crea-sed as a result of the video-based in-ter-vention package. The implications of these re-sults will be explored.
Top Quark Spin Correlations at the Tevatron
Tim Head
Physics , 2010,
Abstract: Recent measurements of the correlation between the spin of the top and the spin of the anti-top quark produced in proton anti-proton scattering at a centre of mass energy of 1.96 TeV by the CDF and D0 collaborations are discussed. Using up to 4.3 fb^-1 of data taken with the CDF and D0 detectors the spin correlation parameter C, the degree to which the spins are correlated, is measured in dileptonic and semileptonic final states. The measurements are found to be in agreement with Standard Model predictions.
Zero-temperature criticality in a simple glass model
David Head
Physics , 1999, DOI: 10.1088/0305-4470/33/3/303
Abstract: We introduce the strongly-interacting trap model, a version of Bouchaud's trap model for glasses [Bouchaud J-P 1992 {\em J. Phys. I France {\bf 2}} 1705]. At finite temperatures the model exhibits glassy relaxation over intermediate timeframes but reaches a steady state at finite times. In limit of zero temperature and with a suitably renormalised timescale the model maps onto the Bak-Sneppen model, widely studied in the context of self-organised criticality [Bak P and Sneppen K 1993 {\em Phys. Rev. Lett. {\bf 71}} 4083]. Hence zero temperature is a critical point in all dimensions. These claims are supported by mean field analysis of the stationary solution and numerical simulations of a finite-dimensional lattice model.
Cancer: Tumor Iron Metabolism, Mitochondrial Dysfunction and Tumor Immunosuppression; “A Tight Partnership—Was Warburg Correct?”  [PDF]
Robert L. Elliott, Jonathan F. Head
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.34039
Abstract: Over the last 30 years there have been numerous worldwide investigators involved in cancer research. Billions of dollars have been spent on drug development and cancer research; however, with all of the new agents and modalities of treatment, we have honestly not significantly improved the overall survival of the Stage IV cancer patient. There is and will not be a magic bullet treatment, thus the extensive title of this paper. We are convinced that unless we use multiple innovative therapies in combination with conventional treatment, we will never truly defeat this disease. We have attempted to address this problem by presenting in detail some of these complex mechanisms involved in tumorigenesis, progression, escape, and metastasis. Most investigators have their own special area of interest, but if we are to conquer this scourge, we must develop an extensive, multifaceted, comprehensive approach. Hopefully this article will contribute to awareness and further insight into this very serious and complicated problem, so we can improve quality of life and improve the survival of the Stage IV cancer patient.
25th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 10–14 December 2002 Update on clinical research
Alistair Ring, Julia Head
Breast Cancer Research , 2002, DOI: 10.1186/bcr576
Abstract: The 25th Annual San Antonio Breast Cancer Symposium attracted nearly 5000 physicians and researchers in breast oncology, as well as other health care professionals and patient advocates with an interest in breast cancer. This meeting has become a key forum for the presentation and discussion of both translational scientific aspects as well as clinical aspects of breast cancer care. The present report will focus on the clinical highlights of the meeting. The preclinical and translational research presented at the meeting is discussed in another report, also published in the present issue of Breast Cancer Research [1].This year, the traditional WL McGuire memorial lecture was given by Michael Baum (University College London, UK). Baum described his 30 years' experience in breast cancer research in an entertaining and wide-ranging talk. In particular, he outlined what he sees as a paradigm shift in the design of clinical trials from an empirical approach to a hypothesis-driven approach. There were two further clinical plenary lectures, given by Stephen Feig (Mount Sinai School of Medicine, New York, USA) and Craig Jordan (University of California, San Francisco, CA, USA). These critical, informative reviews concerned the validity and interpretation of existing mammography trials. There were also minisymposia addressing the changing face of adjuvant therapy and the use of aromatase inhibitors. General sessions comprised short communications of original research, panel discussions of clinical scenarios and more than 500 poster presentations.The current status of adjuvant chemotherapy was summarised in a minisymposium by Hyman Muss (University of Vermont, Burlington, VT, USA) and Charles Vogel (University of Miami, FL, USA). On the basis of data from the Oxford Overviews, chemotherapy regimes that incorporate anthracyclines are still preferred to those that do not. This was reinforced by an update of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG)
The quality of material care provided by grandparents for their orphaned grandchildren in the context of HIV/AIDS and poverty: a study of Kopanong municipality, Free State
T Tamasane, J Head
SAHARA J (Journal of Social Aspects of HIV/AIDS Research Alliance) , 2010,
Abstract: A pervasive argument in the literature on AIDS orphans in South Africa is that grandparents, who often care for their orphaned grandchildren, lack the material means to provide adequate care. This study investigated that claim in an area of ubiquitous poverty and very high unemployment. It is based on the analysis of data obtained from two surveys carried out by the HSRC in the semi-rural municipality of Kopanong in the Free State. The first study was a census which targeted the whole population. The second, smaller survey sampled households which accommodated orphaned and vulnerable children. Based on four proxy indicators for material care: possession of birth certificates, uptake of welfare grants, levels of school attendance, and the number of meals consumed daily, the study revealed that there was very little difference in the quality of care provided by grandparents and other carers, including biological parents. Indeed, since the old age pension is much higher than the child support grant and the foster care grant it may be that grandparents who are pensioners generally have higher incomes than most other adults. In line with the findings of other research, the study found that poverty is a major problem confronting all carers in the area. It concludes that interventions that primarily target orphans overlook the material needs of all poor children. It therefore joins the calls of other researchers for greater state support for all poor children, irrespective of whether they are orphans and who their carers are.
Critical Role of Gap Junction Coupled K(ATP)Channel Activity for Regulated Insulin Secretion.
Rocheleau,Remedi,Granada,Head
PLOS Biology , 2006,
Abstract: Pancreatic beta-cells secrete insulin in response to closure of ATP-sensitive K(+) (K(ATP)) channels, which causes membrane depolarization and a concomitant rise in intracellular Ca(2+) (Ca(i)). In intact islets, beta-cells are coupled by gap junctions, which are proposed to synchronize electrical activity and Ca(i) oscillations after exposure to stimulatory glucose (>7 mM). To determine the significance of this coupling in regulating insulin secretion, we examined islets and beta-cells from transgenic mice that express zero functional K(ATP) channels in approximately 70% of their beta-cells, but normal K(ATP) channel density in the remainder. We found that K(ATP) channel activity from approximately 30% of the beta-cells is sufficient to maintain strong glucose dependence of metabolism, Ca(i), membrane potential, and insulin secretion from intact islets, but that glucose dependence is lost in isolated transgenic cells. Further, inhibition of gap junctions caused loss of glucose sensitivity specifically in transgenic islets. These data demonstrate a critical role of gap junctional coupling of K(ATP) channel activity in control of membrane potential across the islet. Control via coupling lessens the effects of cell-cell variation and provides resistance to defects in excitability that would otherwise lead to a profound diabetic state, such as occurs in persistent neonatal diabetes mellitus.
Exciting Challenges Ahead For Integrative And Regulatory Physiology
Geoffrey A Head
Frontiers in Physiology , 2010, DOI: 10.3389/fphys.2010.00127
Abstract:
Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2
Brian Head,Alejandro Aballay
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004609
Abstract: The mechanisms involved in the recognition of microbial pathogens and activation of the immune system have been extensively studied. However, the mechanisms involved in the recovery phase of an infection are incompletely characterized at both the cellular and physiological levels. Here, we establish a Caenorhabditis elegans-Salmonella enterica model of acute infection and antibiotic treatment for studying biological changes during the resolution phase of an infection. Using whole genome expression profiles of acutely infected animals, we found that genes that are markers of innate immunity are down-regulated upon recovery, while genes involved in xenobiotic detoxification, redox regulation, and cellular homeostasis are up-regulated. In silico analyses demonstrated that genes altered during recovery from infection were transcriptionally regulated by conserved transcription factors, including GATA/ELT-2, FOXO/DAF-16, and Nrf/SKN-1. Finally, we found that recovery from an acute bacterial infection is dependent on ELT-2 activity.
Well defined transition to gel-like aggregates of attractive athermal particles
D. A. Head
Physics , 2007,
Abstract: In an attempt to extend the range of model jamming transitions, we simulate systems of athermal particles which attract when slightly overlapping. Following from recent work on purely repulsive systems, dynamics are neglected and relaxation performed via a potential energy minimisation algorithm. Our central finding is of a transition to a low-density tensile solid which is sharp in the limit of infinite system size. The critical density depends on the range of the attractive regime in the pair-potential. Furthermore, solidity is shown to be related to the coordination number of the packing according to the approximate constraint-counting scheme known as Maxwell counting, although more corrections need to be considered than with the repulsive-only case, as explained. We finish by discussing how the numerical difficulties encountered in this work could be overcome in future studies.
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