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Search Results: 1 - 10 of 208403 matches for " Cinda L. Cupido "
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Impaired Perinatal Growth and Longevity: A Life History Perspective
Deborah M. Sloboda,Alan S. Beedle,Cinda L. Cupido,Peter D. Gluckman,Mark H. Vickers
Current Gerontology and Geriatrics Research , 2009, DOI: 10.1155/2009/608740
Abstract: Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype is adaptively more appropriate to the anticipated environment. Thus, maternal and/or neonatally derived nutritional or endocrine cues suggesting a threatening environment may favour early growth and reproduction over investment in tissue reserve and repair capacity. These may directly affect longevity, as well as prioritise insulin resistance and capacity for fat storage, thereby increasing susceptibility to metabolic dysfunction and obesity. These shifts in developmental trajectory are associated with long-term expression changes in specific genes, some of which may be underpinned by epigenetic processes. This normative process of developmental plasticity may prove to be maladaptive in human environments in transition towards low extrinsic mortality and energy-dense nutrition, leading to the development of an inappropriate phenotype with decreased potential for longevity and/or increased susceptibility to metabolic disease.
Trends in Suicidology: Personality as an Endophenotype for Molecular Genetic Investigations
Jonathan B Savitz ,Cinda-Lee Cupido,Rajkumar S Ramesar
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030107
Technical Analysis of cDNA Microarrays
Cinda P. Scott, Jeff VanWye, M. Danielle McDonald, Douglas L. Crawford
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004486
Abstract: Background There is extensive variation in gene expression among individuals within and between populations. Accurate measures of the variation in mRNA expression using microarrays can be confounded by technical variation, which includes variation in RNA isolation procedures, day of hybridization and methods used to amplify and dye label RNA for hybridization. Methodology/Principal Findings In this manuscript we analyze the relationship between the amount of mRNA and the fluorescent signal from the microarray hybridizations demonstrating that for a wide-range of mRNA concentrations the fluorescent signal is a linear function of the amount of mRNA. Additionally, the separate isolation, labeling or hybridization of RNA does not add significant amounts of variation in microarray measures of gene expression. However, single or double rounds of amplification for labeling do have small but significant affects on 10% of genes, but this source of technical variation is easy to avoid. To examine both technical and stochastic biological variation, mRNA expression was measured from the same five individuals over a six-week time course. Conclusion There were few, if any, meaningful differences in gene expression among time points. Thus, microarray measures using standard laboratory procedures can be precise and quantitative and are not subject to significant random biological noise.
Manifestaciones oculares como presentación de un síndrome de vena cava superior
Barquero-Romero,J.; López Cupido,V.; Torrado Sierra,O.; Valencia Terrón,M.;
Anales de Medicina Interna , 2008, DOI: 10.4321/S0212-71992008000700009
Abstract: superior vena cava syndrome is obstruction of blood flow through the superior vena cava (svc). it is most commonly caused by neoplasm, especially lung cancer. an obstructed svc initiates collateral venous return to the heart from the upper half of the body and the classic symptoms and signs become obvious. superior vena cava síndrome is a rare cause of ocular manifestations. we report a case of periorbital swelling, conjunctival edema an orbital proptosis in a male patient presenting malignant superior vena cava obstruction.
A rare phenomenon of atypical Lipodystrophy in a patient on HAART in the absence of a protease inhibitor regimen
M Mitha, G Cupido, J Taljaard
Southern African Journal of HIV Medicine , 2010,
Abstract: Lipodystrophy is a complication of patients on antiretroviral (ARV) medication; however, it is commonest in patients on long-term treatment and those on protease inhibitor (PI) regimens.1,2 We present a rare case of atypical lipodystrophy, presenting as multiple subcutaneous lipomas, in a patient who had been on a non-PI ARV regimen for 6 weeks.
Caracterización cariotípica en mitosis y meiosis del robalo blanco Centropomus undecimalis (Pisces: Centropomidae)
Arias-Rodriguez,Lenin; Indy,Jeane R.; Ahumada-Hernández,Rosa I.; Barragán-Cupido,Helen; ávalos-Lázaro,Antonieta A.; Páramo-Delgadillo,Salomón;
Revista de Biología Tropical , 2011,
Abstract: karyotypic characterization in mitosis and meiosis of the common snook centropomus undecimalis (pisces: centropomidae). the common snook centropomus undecimalis inhabits marine, brackish and freshwater habitats in the western central atlantic ocean, including the gulf of mexico. common snook is an economically important fish in many localities, nevertheless the number of studies on its biology and genetics are still few. the present study attempts to establish the cytogenetic profiles of the specimens collected in paraiso municipality tabasco, mexico. tissue of five females and eight male organisms were processed by conventional cytological techniques to obtain chromosome slides of high quality in order to assemble the karyotype. the results from the kidney tissue analysis showed that 85.1% of 288 mitosis had a 2n=48 chromosomes, and 52.8% of 104 meiosis exhibited the haploid number 1n=24. the diploid karyotype showed 48 monoarmed chromosomes of the telocentric (t) type. there was no chromosome heteromorphism between females and males. the diploid karyotype was very similar to that observed in the majority of marine fishes. rev. biol. trop. 59 (2): 683-692. epub 2011 june 01.
A 5 GHz LNA for a Radio-Astronomy Experiment
Miguel Bergano,Luis Cupido,Armando Rocha,Domingos Barbosa
Physics , 2011,
Abstract: The paper describes the project, implementation and test of a C-band (5GHz) Low Noise Amplifier (LNA) using new low noise Pseudomorphic High Electron Mobility Transistors (pHEMTS) from Avago. The amplifier was developed to be used as a cost effective solution in a receiver chain for Galactic Emission Mapping (GEM-P) project in Portugal with the objective of finding affordable solutions not requiring strong cryogenic operation, as is the case of massive projects like the Square Kilometer Array (SKA), in Earth Sensing projects and other niches like microwave reflectometry. The particular application and amplifier requirements are first introduced. Several commercially available low noise devices were selected and the noise performance simulated. An ultra-low noise pHEMT was used for an implementation that achieved a Noise Figure of 0.6 dB with 13 dB gain at 5 GHz. The design, simulation and measured results of the prototype are presented and discussed.
Rosetta and Mars Express observations of the influence of high solar wind pressure on the Martian plasma environment
N. J. T. Edberg, U. Auster, S. Barabash, A. B wetter, D. A. Brain, J. L. Burch, C. M. Carr, S. W. H. Cowley, E. Cupido, F. Duru, A. I. Eriksson, M. Fr nz, K.-H. Glassmeier, R. Goldstein, M. Lester, R. Lundin, R. Modolo, H. Nilsson, I. Richter, M. Samara,J. G. Trotignon
Annales Geophysicae (ANGEO) , 2009,
Abstract: We report on new simultaneous in-situ observations at Mars from Rosetta and Mars Express (MEX) on how the Martian plasma environment is affected by high pressure solar wind. A significant sharp increase in solar wind density, magnetic field strength and turbulence followed by a gradual increase in solar wind velocity is observed during ~24 h in the combined data set from both spacecraft after Rosetta's closest approach to Mars on 25 February 2007. The bow shock and magnetic pileup boundary are coincidently observed by MEX to become asymmetric in their shapes. The fortunate orbit of MEX at this time allows a study of the inbound boundary crossings on one side of the planet and the outbound crossings on almost the opposite side, both very close to the terminator plane. The solar wind and interplanetary magnetic field (IMF) downstream of Mars are monitored through simultaneous measurements provided by Rosetta. Possible explanations for the asymmetries are discussed, such as crustal magnetic fields and IMF direction. In the same interval, during the high solar wind pressure pulse, MEX observations show an increased amount of escaping planetary ions from the polar region of Mars. We link the high pressure solar wind with the observed simultaneous ion outflow and discuss how the pressure pulse could also be associated with the observed boundary shape asymmetry.
Case report Malaria: A cerebral approach
R Court, D Stead, K Barnes, C Cupido, I Joubert, M Mendelson
Continuing Medical Education , 2012,
Abstract: An increasing number of patients with severe complicated Plasmodium falciparum malaria are presenting to South African hospitals, having travelled through malariaendemic countries from Central and East Africa. This report concerns an immigrant from Pakistan who developed severe cerebral malaria.
Design of an IF section for a Galactic Emission Mapping experiment
Miguel Bergano,Luis Cupido,Domingos Barbosa,Rui Fonseca,Dinis M. Santos,George Smoot
Physics , 2007,
Abstract: In the context of the Galactic Emission Mapping collaboration, a galactic survey at 5GHz is in preparation to properly characterize the galactic foreground to the Cosmic Microwave Background Radiation (CMBR). For the North sky survey, a new receiver is being developed. This 5GHz heterodyne polarimeter has a high gain IF (intermediate frequency) chain using the latest RF technology and microstrip design that we describe in the present article. Working at 600MHz central frequency, it consists of a pre-amplifier with an integral band-pass filter followed by an amplifier with digitally controlled gain and a frequency converter to zero-IF that feeds the ADC of a four channel digital correlator (outside the scope of the present article). This paper focuses the design options and constraints and presents the simulations and experimental results of a circuit prototype.
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