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Search Results: 1 - 10 of 78296 matches for " Chunxia Chen "
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Ubiquitin-conjugating enzyme involved in the immune response caused by pathogens invasion  [PDF]
Liang Chen, Chen Cheng, Chunxia Zhang, Qin Yao, Ermi Zhao
Open Journal of Immunology (OJI) , 2013, DOI: 10.4236/oji.2013.33013

Ubiquitin-proteasome pathway (UPP) is a significant way of protein degradation and modification in eukaryotic cell and involved in a complex series of intracellular processes. As a key component in UPP, ubiquitin-conjugating enzyme (E2) plays an extremely important role in ubiquitin (Ub) transferring and substrate specific recognition. Abundant evidences have proved that UPP is involved in cells immune reaction caused by pathogens and the attendance of E2 has a significant effect on host cells and pathogen. This article presents an overview of the current research on E2s that is involved in immune response caused by viruses and bacteria.

Comparative Analysis of E2F Family Member Oncogenic Activity
Chunxia Chen, Andrew D. Wells
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000912
Abstract: The E2F family of transcription factors consists of nine members with both distinct and overlapping functions. These factors are situated downstream of growth factor signaling cascades, where they play a central role in cell growth and proliferation through their ability to regulate genes involved in cell cycle progression. For this reason, it is likely that the members of the E2F family play a critical role during oncogenesis. Consistent with this idea is the observation that some tumors exhibit deregulated expression of E2F proteins. In order to systematically compare the oncogenic capacity of these family members, we stably over-expressed E2F1 through 6 in non-transformed 3T3 fibroblasts and assessed the ability of these transgenic cell lines to grow under conditions of low serum, as well as to form colonies in soft agar. Our results show that these six E2F family members can be divided into three groups that exhibit differential oncogenic capacity. The first group consists of E2F2 and E2F3a, both of which have strong oncogenic capacity. The second group consists of E2F1 and E2F6, which were neutral in our assays when compared to control cells transduced with vector alone. The third group consists of E2F4 and E2F5, which generally act to repress E2F-responsive genes, and in our assays demonstrated a strong capacity to inhibit transformation. Our results imply that the pattern of expression of these six E2F family members in a cell could exert a strong influence over its susceptibility to oncogenic transformation.
Comparative Analysis of Eight Undergraduate Universities Based on InCites Database  [PDF]
Chunxia Guo
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.74022
Abstract: This paper selects the papers collected by Web of Science from 8 local universities in Shandong Province from 2008 to 2018 in the InCites database as a research sample for chemistry, mathematics, engineering, biology and biochemistry, environment and ecology, physics, computer science, and analyzes the amount of documents and the frequency of citations. At the same time, the secondary disciplines with more than 15 papers published in 7 university departments also carried out statistical analysis on the number of publications, citation frequency, and frequency. Using these 7 disciplines, the eight universities will be compared horizontally, and the scientific research gaps between different universities will be located to reveal the research status of the undergraduate universities in Shandong Province of China.
Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents  [PDF]
Chunxia Chen, Minghui Lu, Zhihui Liu, Junting Wan, Zhengchao Tu, Tianyu Zhang, Ming Yan
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.34015
Abstract: A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities
were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious
antitubercular activities could be observed (MIC > 10 ug/mL). The results are in sharp contrast with the previously reported
Identifying codes and locating-dominating sets on paths and cycles
Chunxia Chen,Changhong Lu,Zhengke Miao
Mathematics , 2009,
Abstract: Let $G=(V,E)$ be a graph and let $r\ge 1$ be an integer. For a set $D \subseteq V$, define $N_r[x] = \{y \in V: d(x, y) \leq r\}$ and $D_r(x) = N_r[x] \cap D$, where $d(x,y)$ denotes the number of edges in any shortest path between $x$ and $y$. $D$ is known as an $r$-identifying code ($r$-locating-dominating set, respectively), if for all vertices $x\in V$ ($x \in V\backslash D$, respectively), $D_r(x)$ are all nonempty and different. In this paper, we provide complete results for $r$-identifying codes in paths and odd cycles; we also give complete results for 2-locating-dominating sets in cycles.
Aqueous Synthesis of 1-H-2-Substituted Benzimidazoles via Transition-Metal-Free Intramolecular Amination of Aryl Iodides
Chunxia Chen,Chen Chen,Bin Li,Jingwei Tao,Jinsong Peng
Molecules , 2012, DOI: 10.3390/molecules171112506
Abstract: A straightforward method has been developed for the synthesis of the benzimidazole ring system through a carbon-nitrogen cross-coupling reaction. In the presence of 2.0 equiv. of K2CO3 in water at 100 °C for 30 h, the intramolecular cyclization of N-(2-iodoaryl)benzamidine provides benzimidazole derivatives in moderate to high yields. Remarkably, the procedure occurs exclusively in water and doesn’t require the use of any additional reagent/catalyst, rendering the methodology highly valuable from both environmental and economical points of view.
State Reconstruction for Complex Dynamical Networks with Noises  [PDF]
Chunxia Fan, Guoping Jiang
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2012, DOI: 10.4236/ijmnta.2012.11001
Abstract: The state reconstruction problem is addressed for complex dynamical networks coupled with states and outputs respectively, in a noisy transmission channel. By using Lyapunov stability theory and H performance, two schemes of state reconstruction are proposed for the complex dynamical networks with the nodes coupled by states and outputs respectively, and the estimation errors are convergent to zeros with H performance index. A numerical simulation demonstrates the effectiveness of the proposed observers.
Improving Personal Product Recommendation via Friendships’ Expansion  [PDF]
Chunxia Yin, Tao Chu
Journal of Computer and Communications (JCC) , 2013, DOI: 10.4236/jcc.2013.15001

The trust as a social relationship captures similarity of tastes or interests in perspective. However, the existent trust information is usually very sparse, which may suppress the accuracy of our personal product recommendation algorithm via a listening and trust preference network. Based on this thinking, we experiment the typical trust inference methods to find out the most excellent friend-recommending index which is used to expand the current trust network. Experimental results demonstrate the expanded friendships via superposed random walk can indeed improve the accuracy of our personal product recommendation.

Effect of Rare Earth Ions on the Properties of Composites Composed of Ethylene Vinyl Acetate Copolymer and Layered Double Hydroxides
Lili Wang, Bin Li, Xiaohong Zhao, Chunxia Chen, Jingjing Cao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037781
Abstract: Background The study on the rare earth (RE)-doped layered double hydroxides (LDHs) has received considerable attention due to their potential applications in catalysts. However, the use of RE-doped LDHs as polymer halogen-free flame retardants was seldom investigated. Furthermore, the effect of rare earth elements on the hydrophobicity of LDHs materials and the compatibility of LDHs/polymer composite has seldom been reported. Methodology/Principal Findings The stearate sodium surface modified Ni-containing LDHs and RE-doped Ni-containing LDHs were rapidly synthesized by a coprecipitation method coupled with the microwave hydrothermal treatment. The influences of trace amounts of rare earth ions La, Ce and Nd on the amount of water molecules, the crystallinity, the morphology, the hydrophobicity of modified Ni-containing LDHs and the adsorption of modifier in the surface of LDHs were investigated by TGA, XRD, TEM, contact angle and IR, respectively. Moreover, the effects of the rare earth ions on the interfacial compatibility, the flame retardancy and the mechanical properties of ethylene vinyl acetate copolymer (EVA)/LDHs composites were also explored in detail. Conclusions/Significance S-Ni0.1MgAl-La displayed more uniform dispersion and better interfacial compatibility in EVA matrix compared with other LDHs. Furthermore, the S-Ni0.1MgAl-La/EVA composite showed the best fire retardancy and mechanical properties in all composites.
Function modification of SR-PSOX by point mutations of basic amino acids
Weiwei Liu, Lan Yin, Chunxia Chen, Yalei Dai
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-59
Abstract: A cell model to study the functions of SR-PSOX was successfully established. Based on the cell model, a series of mutants of human SR-PSOX were constructed by replacing the single basic amino acid residue in the non-conservative region of the chemokine domain (arginine 62, arginine 78, histidine 80, arginine 82, histidine 85, lysine 105, lysine 119, histidine 123) with alanine (designated as R62A, R78A, H80A, R82A, H85A, K105A, K119A and H123A, respectively). Functional studies showed that the mutants with H80A, H85A, and K105A significantly increased the activities of oxLDL uptake and bacterial phagocytosis compared with the wild-type SR-PSOX. In addition, we have also found that mutagenesis of either of those amino acids strongly reduced the adhesive activity of SR-PSOX by using a highly non-overlapping set of basic amino acid residues.Our study demonstrates that basic amino acid residues in the non-conservative region of the chemokine domain of SR-PSOX are critical for its functions. Mutation of H80, H85, and K105 is responsible for increasing SR-PSOX binding with oxLDL and bacteria. All the basic amino acids in this region are important in the cells adhesion via SR-PSOX. These findings suggest that mutagenesis of the basic amino acids in the chemokine domain of SR-PSOX may contribute to atherogenesis.Atherosclerosis (AS) is a common cardiovascular disease that threatens human health. The pathological features of AS include infiltration of monocytes, formation of foam cells and proliferation of smooth muscle cells [1-4]. The first macroscopically recognizable lesion of atherosclerosis arises from the accumulation of macrophage-derived foam cells with cholesterylester-rich lipid droplets [5]. A high level of plasma concentration of low-density lipoprotein (LDL) is an important risk factor for atherosclerosis. When LDL molecules are trapped in an arterial wall, they are modified or oxidized and internalized by macrophage via a relatively large family of scavenger r
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