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OALib Journal期刊

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Design of Library Management System  [PDF]
Chunchao Liu, Sheng Ma
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104974
Abstract:
The library management system runs on the DOS system, based on the C lan-guage as the main programming language and Visual C as the development environment. According to the characteristics of the system, we construct the development model and then build structural analysis, system function modules and system flow chart through the demand analysis of the system. Through the analysis of each function module, the definition and attributes of the data and the realization of each function are determined. In the paper, the design of the library management system includes the user module, the administrator module and the module of tourists and also achieves the usual function including borrowing books, returning books and books management.
Using Integrating Method to Teach Biochemical Pharmacy Technology  [PDF]
Chunchao Han
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.13021
Abstract: An integrating method to teach Biochemical Pharmacy Technology was developed to help students understand the technology to produce biochemical pharmacy well in this paper. By the integrating method, students can compare the main content of the biochemical pharmacy and the technology to produce them. Students were encouraged to demonstrate the connection and difference of the various biochemical pharmacies. The results showed that the performance of students with integrating method is significantly better than that of students without integrating method (p < 0.05). In conclusion, integrating method can enhance students’ performance on Biochemical Pharmacy Technology.
Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus
Jun Ren, Jin-Li Shi, chunchao han, Zhen-Quan Liu, jianyou guo
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-52
Abstract: The effects of TFC on cytokines levels, total antioxidant activity, antinociceptive effects in vivo, LD50 and tactile hyperalgesia were analyzed respectively.TFC treatment decreased the levels of cytokines and total antioxidant status (TAOS) and inhibited the acetic acid-induced abdominal constrictions in mice. In addition, TFC reduced CFA-induced tactile hyperalgesia in a dose-dependent manner and the LD50 of TFC was determined to be 400?mg/kg. However, TFC did not significantly inhibit the reaction time to thermal stimuli in the hot-plate test.TFC showed anti-inflammatory, antioxidant, peripheral antinociceptive and antihyperalgesic activity in various models of inflammatory pain. The data suggest that TFC may be a viable treatment option for inflammatory pain.
Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes
Dan Wang,HongYing Su,YanHong Liu,ChangQiang Wu,ChunChao Xia,JiaYu Sun,FaBao Gao,QiYong Gong,Bin Song,Hua Ai
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-5073-7
Abstract: Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T 2 relaxation rate of the labeled cells is 98.2 s 1, significantly higher than that of the control ones of 2.3 s 1. This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo.
Histomorphological and Ultrastructural Changes of Retinopathy in Diabetic Rabbit Model
Wentao Sun,ChunLing Lei,Sihai Zhao,LiLun Wang,ChunChao Bi,Rui Wang,XiaoLiang Zhou,Enqi Liu,MingXia Chen
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.133.137
Abstract: Observation on morphological and ultrastructural changes of retinopathy in diabetic rabbit long been fed with high sucrose and fat fodders. Use alloxan to establish diabetic rabbit model. Feed the rabbits with high sucrose and fat fodders conduct a Fluorescein Fundus Angiography test (FFA) every 3~4 months to observe morphological changes in retina. Conduct Transmission Electron Microscopy (TEM) examination on eyeball of the model 10~12 months later so as to get wise to the ultrastructural changes in the rabbit retina. The FFA indicated that with the protraction of the disease, Fluorescein Isothiocyanate (FITC) leakage and neo-vasulariztion shadows similar to that of human were seen in the diabetic rabbit model. TEM examination showed that no abnormality was seen in the ultrastructure of the rabbit retina of normal group. The retina of the diabetic rabbit exhibited microfilament and focal dissolving, myelin sheath structure loosening and partial demyelination changes, pericyte mitochondrion tumefaction, endothelial cell layering, space increasing, mitochondrion tumefaction on the nerve fiber layer. Glycogenosome accumulation was seen in the outer nuclear layer retina cells.
Modeling of IEEE1588 on OPNET and Analysis of Asymmetric Synchronizing Error in Smart Substation  [PDF]
Jiongcong Chen, Haizhu Wang, Chunchao Hu, Kai Ma, Zexiang Cai
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B103
Abstract:

The IEEE1588 network time synchronization, matched with smart substation information network transmission, is becoming the next generation advanced data synchronization of the smart substation. It is known that the inherent asymmetry error of the network synchronization approach in the smart substation is highlighted, which is concerned particularly. This paper models the synchronization process of the IEEE1588 based on the communication simulation software of OPNET Modeler. Firstly, it builds the models of master-slave clock, IEEE1588 protocol and network synchroniza- tion model, and analyzes the composition and influencing factors of the asymmetry error. Secondly, it quantitatively analyzes the influence of the synchronous asymmetric error of the IEEE1588 affected by the network status differences and the clock synchronization signal transmission path differences. Then its correction method is analyzed, in order to improve the IEEE1588 synchronization reliability and gives the solutions to its application in smart substation.

Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes
QiaoYing Wang,HongYing Su,ChunChao Xia,JiaYu Sun,Chen Liu,ZhiYong Wang,QiYong Gong,Bin Song,FaBao Gao,Hua Ai,ZhongWei Gu
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0255-7
Abstract: Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol 1·s 1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of 60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (〈4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were 44% and 31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis.
mRNA-seq Analysis of the Gossypium arboreum transcriptome Reveals Tissue Selective Signaling in Response to Water Stress during Seedling Stage
Xueyan Zhang, Dongxia Yao, Qianhua Wang, Wenying Xu, Qiang Wei, Chunchao Wang, Chuanliang Liu, Chaojun Zhang, Hong Yan, Yi Ling, Zhen Su, Fuguang Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054762
Abstract: The cotton diploid species, Gossypium arboreum, shows important properties of stress tolerance and good genetic stability. In this study, through mRNA-seq, we de novo assembled the unigenes of multiple samples with 3h H2O, NaCl, or PEG treatments in leaf, stem and root tissues and successfully obtained 123,579 transcripts of G. arboreum, 89,128 of which were with hits through BLAST against known cotton ESTs and draft genome of G. raimondii. About 36,961 transcripts (including 1,958 possible transcription factor members) were identified with differential expression under water stresses. Principal component analysis of differential expression levels in multiple samples suggested tissue selective signalling responding to water stresses. Venn diagram analysis showed the specificity and intersection of transcripts’ response to NaCl and PEG treatments in different tissues. Self-organized mapping and hierarchical cluster analysis of the data also revealed strong tissue selectivity of transcripts under salt and osmotic stresses. In addition, the enriched gene ontology (GO) terms for the selected tissue groups were differed, including some unique enriched GO terms such as photosynthesis and tetrapyrrole binding only in leaf tissues, while the stem-specific genes showed unique GO terms related to plant-type cell wall biogenesis, and root-specific genes showed unique GO terms such as monooxygenase activity. Furthermore, there were multiple hormone cross-talks in response to osmotic and salt stress. In summary, our multidimensional mRNA sequencing revealed tissue selective signalling and hormone crosstalk in response to salt and osmotic stresses in G. arboreum. To our knowledge, this is the first such report of spatial resolution of transcriptome analysis in G. arboreum. Our study will potentially advance understanding of possible transcriptional networks associated with water stress in cotton and other crop species.
A Hypothesis: Supplementation with Mushroom-Derived Active Compound Modulates Immunity and Increases Survival in Response to Influenza Virus (H1N1) Infection
Han Chunchao,Jian-you Guo
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/neq037
Abstract: We hypothesize that the mushroom-derived active compound may be a potential strategy for increasing survival in response to influenza virus (H1N1) infection through the stimulation of host innate immune response. The validity of the hypothesis can be tested by immune response to influenza infection as seen through survival percentage, virus clearance, weight loss, natural killer cell cytotoxicity, Tumor Necrosis Factor-α (TNF-α) and Interferon-gamma (IFN-γ) levels, lytic efficiency in the spleens of mice and inducible nitric oxide synthase mRNA expressions in RAW 264.7 murine macrophage cells. The hypothesis may improve people's quality of life, reduce the medical cost of our healthcare system and eliminate people's fears of influenza outbreak.
Optimization of Conditions for Charantin Extraction in PEG/Salt Aqueous Two-Phase Systems Using Response Surface Methodology
Chunchao HanJihui WangMomordica charantiaMomordica charantia withp
The Open Complementary Medicine Journal , 2009, DOI: 10.2174/1876391X00901010046]
Abstract: Momordica charantia, commonly known as karela or bitter melon, is used as a vegetable in Chinese, Indian subcontinent. However, in Chinese traditional medicine, the plant is usually used as an antidiabetic agent. One of the active components is charantin. Aqueous two-phase systems (ATPS) were used for the purifying saponin because of their low cost. ATPS can reduce amount of organic solvent and the danger of explosion necessitates special equipment leading to increased costs. The levels of blood glucose decreased after administration of charantin purified from Momordica charantia with (ATPS (p<0.05).
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