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Search Results: 1 - 10 of 57066 matches for " Chun-Yao Huang "
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Fabrication of a Cu(InGa)Se2 Thin Film Photovoltaic Absorber by Rapid Thermal Annealing of CuGa/In Precursors Coated with a Se Layer
Chun-Yao Hsu,Peng-Cheng Huang,Yu-Yao Chen,Dong-Cherng Wen
International Journal of Photoenergy , 2013, DOI: 10.1155/2013/132105
Good Response to Gefitinib for Lung Adenocarcinoma with Hyperamylasemia: A Case Report
How-Wen Ko,Ying-Huang Tsai,Chih-Teng Yu,Chun-Yao Huang
Chang Gung Medical Journal , 2008,
Abstract: Hyperamylasemia in patients with bronchogenic carcinoma has been reported rarely.Gefitinib, an oral tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) signaling,has shown activity for treating patients with refractory advanced non-small cell lungcancer (NSCLC). This report describes a case of lung adenocarcinoma coexisting withhyperamylasemia in a 67-year-old man. Abdominal computed tomograhy and ultrasonographydemonstrated a normal pancreas. A mutational analysis of the EGFR gene indicated anin-frame deletion at exon 19. He underwent treatment with gefitinib. Chest radiography follow-up showed a partial response and the amylase level also decreased to normal. We suggestthat treatment with gefitinib is an effective therapeutic option for this rare patient subset.
Managing Technology Transfer in Open Innovation: The case study in Taiwan
Tao Huang,Wen Cheng Wang,Yun Ken,Chun-Yao Tseng
Modern Applied Science , 2010, DOI: 10.5539/mas.v4n10p2
Abstract: Universities, especially for technology transfer activities, always play the role of intermediaries in the innovation process. This study investigates three main issues related to open innovation based on bureaucratic perspective and scientific perspective. First, the protection power of technology is evaluated. Secondly, this study demonstrates determinants of successful technology transfer. Finally, this study examines the efficacy of technology transfer office in open innovation. Basing on literature reviews, we take the case study in Taiwan and try to make further insights for managing technology transfer in open innovation.
Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors
Huang-Pin Wu, Chi-Chung Shih, Chun-Yao Lin, Chung-Ching Hua, Duen-Yau Chuang
Critical Care , 2011, DOI: 10.1186/cc10464
Abstract: We designed this prospective observational study to measure monocyte human leukocyte antigen (HLA)-DR expression, plasma cytokine levels and cytokine responses on days 1 and 7 in stimulated peripheral blood mononuclear cells (PBMCs) of healthy controls and patients with severe sepsis.Of the 35 enrolled patients, 23 survived for 28 days and 12 died, 6 of whom died within 7 days. Plasma levels of IL-1β, IL-6, IL-10, IL-17, transforming growth factor (TGF)-β1 and TNF-α were higher, but plasma IL-12 level was lower in septic patients than those in controls. Day 1 plasma levels of IL-1β, IL-6, IL-10 and TGF-β1 in nonsurvivors were higher than those in survivors. Day 7 plasma IL-10 levels in nonsurvivors were higher than in survivors. IL-1β response was higher, but IL-12 and TNF-α responses were lower in septic patients than in controls. Day 1 IL-6 response was lower, but day 1 TGF-β1 response was higher in nonsurvivors than in survivors. Plasma IL-6 and IL-10 levels were decreased in survivors after 6 days. IL-6 response was decreased in survivors after 6 days, but IL-12 response was increased. Monocyte percentage was higher, but positive HLA-DR percentage in monocytes and mean fluorescence intensity (MFI) of HLA-DR were lower in septic patients than in controls. MFI of HLA-DR was increased in survivors after 6 days.Monocyte HLA-DR expression and IL-12 response from PBMCs are restored in patients who survive severe sepsis.Sepsis is characterized by an acute release of many inflammatory mediators. The balance between pro- and anti-inflammatory mediators influences the survival rate of septic patients. In severe sepsis, immune system failure and sepsis-induced immunosuppression may result in death [1,2]. Loss of macrophage and monocyte expression of the major histocompatibility complex is one of the mechanisms involved, as is diminished surface expression of human leukocyte antigen-DR (HLA-DR) on monocytes [3]. However, not all studies have shown such results [4,5].A shift
Prolonged mechanical ventilation in a respiratory-care setting: a comparison of outcome between tracheostomized and translaryngeal intubated patients
Yao-Kuang Wu, Ying-Huang Tsai, Chou-Chin Lan, Chun-Yao Huang, Chih-Hsin Lee, Kuo-Chin Kao, Jui-Ying Fu
Critical Care , 2010, DOI: 10.1186/cc8890
Abstract: This was a retrospective observational study of 985 tracheostomy and 227 translaryngeal intubated patients who received treatment in a 24-bed RCC between November 1999 and December 2005. Treatment and mortality outcomes were compared between tracheostomized and translaryngeal intubated patients, and the factors associated with positive outcomes in all patients were determined.Duration of RCC (22 vs. 14 days) and total hospital stay (82 vs. 64 days) and total mechanical ventilation days (53 vs. 41 days) were significantly longer in tracheostomized patients (all P < 0.05). The rate of in-hospital mortality was significantly higher in the translaryngeal group (45% vs. 31%;P < 0.05). No significant differences were found in weaning success between the groups (both were >55%) or in RCC mortality. Because of significant baseline between-group heterogeneity, case-match analysis was performed. This analysis confirmed the whole cohort findings, except for the fact that a trend for in-hospital mortality was noted to be higher in the translaryngeal group (P = 0.08). Stepwise logistic regression revealed that patients with a lower median severity of disease (APACHE II score <18) who were properly nourished (albumin >2.5 g/dl) or had normal metabolism (BUN <40 mg/dl) were more likely to be successfully weaned and survive (all P < 0.05). Patients who were tracheostomized were also significantly more likely to survive (P < 0.05)These findings suggest that the type of mechanical ventilation does not appear to be an important determinant of weaning success in an RCC setting. Focused care administered by experienced providers may be more important for facilitating weaning success than the ventilation method used. However, our findings do suggest that tracheostomy may increase the likelihood of patient survival.Increasingly frequently, patients maintained on prolonged mechanical ventilation (PMV) are given a tracheostomy [1]. Tracheostomy is thought to offer several advantages over tr
Gender-Specific Prognosis and Risk Impact of C-Reactive Protein, Hemoglobin and Platelet in the Development of Coronary Spasm
Ming-Yow Hung, Kuang-Hung Hsu, Wei-Syun Hu, Nen-Chung Chang, Chun-Yao Huang, Ming-Jui Hung
International Journal of Medical Sciences , 2013,
Abstract: Background: Scarce data are available on hemoglobin and platelet in relation to coronary artery spasm (CAS) development. We sought to determine the roles that high-sensitivity C-reactive protein (hs-CRP), hemoglobin and platelet play in CAS patients. Methods: Patients (337 women and 532 men) undergoing coronary angiography with or without CAS but without obstructive coronary artery disease were evaluated during a 12-year period. Results: Among women with high hemoglobin levels, the odds ratios (OR) from the lowest (<1 mg/l) to the highest tertiles (>3 mg/l) of hs-CRP were 1.21, 2.15, and 5.93 (p=0.009). In women with low hemoglobin levels, an elevated risk was found from the middle to the highest tertiles of hs-CRP (OR 0.59 to 3.85) (p=0.004). This relationship was not observed in men. In men, platelet count was the most significant risk factor for CAS (p=0.004). The highest likelihood of developing CAS was found among women with the highest hs-CRP tertile and low platelet counts (OR 8.77; 95% confidence interval [CI] 2.20-35.01) and among men with the highest hs-CRP tertile and high platelet counts (OR 4.58; 95% CI 0.48-43.97). Neither hemoglobin level nor platelet count was associated with frequent recurrent angina in both genders with CAS whereas death and myocardial infarction were rare. Conclusions: There are positive interactions among hs-CRP, hemoglobin and platelet in women with this disease, but not in men. While hemoglobin is a modifier in CAS development in women, platelet count is an independent risk factor for men. Both women and men have good prognosis of CAS.
Deco: A Decentralized, Cooperative Atomic Commit Protocol
Daniel J. Buehrer,Chun-Yao Wang
Journal of Computer Networks and Communications , 2012, DOI: 10.1155/2012/782517
Abstract: An atomic commit protocol can cause long-term locking of databases if the coordinator crashes or becomes disconnected from the network. In this paper we describe how to eliminate the coordinator. This decentralized, cooperative atomic commit protocol piggybacks transaction statuses of all transaction participants onto tokens which are passed among the participants. Each participant uses the information in the tokens to make a decision of when to go to the next state of a three-phase commit protocol. Transactions can progress to ensure a uniform agreement on success or failure, even if the network is partitioned or nodes temporarily crash. 1. Introduction 1.1. Network Computing Network-based computing has several programming frameworks, such as peer-to-peer (P2P), grid, and web service computing [1]. For applications which involve many companies or individual users with their own databases (e.g., network supply chain or distributed health-care monitoring), the P2P approach seems to be a natural infrastructure. Each company or user can set the security on their local databases and decide which data to share with other members of the distributed application, based on an authenticated query sender (i.e., application executor). Some network applications will require the ability to execute actions involving several databases, such as deciding which products to purchase in a supply chain or a battlefield command/control decision on whether or not there are sufficient resources for an attack to succeed. It has been proven [2] that such network-wide decisions can be delayed (i.e., blocked) for an indefinitely long time as the members of a transaction alternately fail and recover, or as the network communications suffer temporary disconnections. It is necessary to make the assumption that eventually all computers and network connections will be working long enough for a decision to be made, even though this assumption may not be true in the real world. In the case of long-term failures, our protocol will usually time out and abort. However, as we see below, there is a small possibility of blocking when the clocks are disabled during the final commit decision. In the P2P environment, it has long been recognized that providing a persistent, consistent distributed commit protocol is a very important and difficult issue [3]. Many e-business systems, such as electronic reservations, funds transfer, and inventory control, have benefited from distributed atomic commit protocol (ACP) technology. These ACP protocols typically work on a multitier architecture on a WAN,
Starvation Induces Phenotypic Diversification and Convergent Evolution in Vibrio vulnificus
Hwajiun Chen, Chun-Yao Chen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088658
Abstract: Starvation is a common stress experienced by bacteria living in natural environments and the ability to adapt to and survive intense stress is of paramount importance for any bacterial population. A series of starvation experiments were conducted using V. vulnificus 93U204 in phosphate-buffered saline and seawater. The starved population entered the death phase during the first week and approximately 1% of cells survived. After that the population entered a long-term stationary phase, and could survive for years. Starvation-induced diversification (SID) of phenotypes was observed in starved populations and phenotypic variants (PVs) appeared in less than 8 days. The cell density, rather than the population size, had a major effect on the extent of SID. SID was also observed in strain YJ016, where it evolved at a faster pace. PVs appeared to emerge in a fixed order: PV with reduced motility, PV with reduced proteolytic activity, and PV with reduced hemolytic activity. All of the tested PVs had growth advantages in the stationary phase phenotypes and increased fitness compared with 93U204 cells in co-culture competition experiments, which indicates that they had adapted to starvation. We also found that SID occurred in natural seawater with a salinity of 1%–3%, so this mechanism may facilitate bacterial adaptation in natural environments.
Porphyromonas gingivalis GroEL Induces Osteoclastogenesis of Periodontal Ligament Cells and Enhances Alveolar Bone Resorption in Rats
Feng-Yen Lin, Fung-Ping Hsiao, Chun-Yao Huang, Chun-Ming Shih, Nai-Wen Tsao, Chien-Sung Tsai, Shue-Fen Yang, Nen-Chung Chang, Shan-Ling Hung, Yi-Wen Lin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102450
Abstract: Porphyromonas gingivalis is a major periodontal pathogen that contains a variety of virulence factors. The antibody titer to P. gingivalis GroEL, a homologue of HSP60, is significantly higher in periodontitis patients than in healthy control subjects, suggesting that P. gingivalis GroEL is a potential stimulator of periodontal disease. However, the specific role of GroEL in periodontal disease remains unclear. Here, we investigated the effect of P. gingivalis GroEL on human periodontal ligament (PDL) cells in vitro, as well as its effect on alveolar bone resorption in rats in vivo. First, we found that stimulation of PDL cells with recombinant GroEL increased the secretion of the bone resorption-associated cytokines interleukin (IL)-6 and IL-8, potentially via NF-κB activation. Furthermore, GroEL could effectively stimulate PDL cell migration, possibly through activation of integrin α1 and α2 mRNA expression as well as cytoskeletal reorganization. Additionally, GroEL may be involved in osteoclastogenesis via receptor activator of nuclear factor κ-B ligand (RANKL) activation and alkaline phosphatase (ALP) mRNA inhibition in PDL cells. Finally, we inoculated GroEL into rat gingiva, and the results of microcomputed tomography (micro-CT) and histomorphometric assays indicated that the administration of GroEL significantly increased inflammation and bone loss. In conclusion, P. gingivalis GroEL may act as a potent virulence factor, contributing to osteoclastogenesis of PDL cells and resulting in periodontal disease with alveolar bone resorption.
Advances on the Study of Protoplast Culture of Gramineae

Li Chun-yao,

植物学报 , 1993,
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