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Search Results: 1 - 10 of 42056 matches for " Chun-Chao Chang "
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Abnormal Gastroscopy Findings Were Related to Lower Meridian Energy
Sheng-Miauh Huang,Li-Yin Chien,Chun-Chao Chang,Ping-Ho Chen,Chen-Jei Tai
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/878391
Abstract: According to the theories of Traditional Chinese Medicine (TCM), energy runs through 12 meridians longitudinally up and down the body. The study objectives were to compare the meridian energy between subjects with and without abnormal gastroscopy findings. We applied a cross-sectional and correlational research design. The study included 1,223 participants who had their health examinations at a university hospital in Taipei from 1st August 2005 through 31st August 2007. Meridian energy was examined using a meridian energy analysis device. The gastroscopy was operated by certified gastroenterologists. Participants with abnormal stomach and esophageal findings using gastroscopy had significantly lower mean meridian energy. There were no significant differences in meridian energy between participants with and without abnormal duodenum findings. When all of the meridians were examined individually, participants with abnormal findings in esophagus and stomach had significantly lower meridian energy in each of the meridians. The results of this study demonstrated that structural abnormality in the gastric area was related to lower meridian energy. Whether enhancing meridian energy could improve gastric and esophageal health merits further studies.
Clinicopathological Correlation and Prognostic Significance of Protein Kinase Cα Overexpression in Human Gastric Carcinoma
Shee-Chan Lin, Wei-Yu Chen, Kai-Yuan Lin, Sheng-Hsuan Chen, Chun-Chao Chang, Sey-En Lin, Chia-Lang Fang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056675
Abstract: Objectives This study investigated the PKCα protein expression in gastric carcinoma, and correlated it with clinicopathological parameters. The prognostic significance of PKCα protein expression in gastric carcinoma was analyzed. Methods Quantitative real-time PCR test was applied to compare the PKCα mRNA expression in tumorous and nontumorous tissues of gastric carcinoma in ten randomly selected cases. Then PKCα protein expression was evaluated in 215 cases of gastric carcinoma using immunohistochemical method. The immunoreactivity was scored semiquantitatively as: 0 = absent; 1 = weak; 2 = moderate; and 3 = strong. All cases were further classified into two groups, namely PKCα overexpression group with score 2 or 3, and non-overexpression group with score 0 or 1. The PKCα protein expression was correlated with clinicopathological parameters. Survival analysis was performed to determine the prognostic significance of PKCα protein expression in patients with gastric carcinoma. Results PKCα mRNA expression was upregulated in all ten cases of gastric carcinoma via quantitative real-time PCR test. In immunohistochemical study, eighty-eight out of 215 cases (41%) of gastric carcinoma revealed PKCα protein overexpression, which was statistically correlated with age (P = 0.0073), histologic type (P<0.0001), tumor differentiation (P = 0.0110), depth of invasion (P = 0.0003), angiolymphatic invasion (P = 0.0373), pathologic stage (P = 0.0047), and distant metastasis (P = 0.0048). We found no significant difference in overall and disease free survival rates between PKCα overexpression and non-overexpression groups (P = 0.0680 and 0.0587). However, PKCα protein overexpression emerged as a significant independent prognostic factor in multivariate Cox regression analysis (hazard ratio 0.632, P = 0.0415). Conclusions PKCα protein is upregulated in gastric carcinoma. PKCα protein expression is statistically correlated with age, histologic type, tumor differentiation, depth of invasion, angiolymphatic invasion, pathologic stage, and distant metastasis. The PKCα protein overexpression in patients with gastric carcinoma is a significant independent prognostic factor in multivariate Cox regression analysis.

JIANG Chun-chao,

地球学报 , 1984,
Abstract: Since the Liaohe Group was named by Saido in 1938, the term has implied the stratigraphic unit between the Anshan Group and Sinian System. The present Liaohe Group is divided into five formations from bottom to top:Langzishan, Lieryu, Gaojiayu, Dashiqiao and Gaixian formations. Consequently come out two key questions: is the boron-bearing rock series in the eastern part of Liaoning over the Langxishan Formation or under it and is the Dashiqiao Formation under the Gaixian Formation or over it? As a result of our study,four groups are contained in the present Liaohe Group, i.e. Kuandian Group, Caohe Group, Dalizi Group and Liaoyang Group.The contact relations between them are unconformable.The two questions mentioned above are reviewed in this paper to explain why the Liaohe Group is improper. According to the demand of "Stratigraphical Guide of China", the term of Liaohe Group should be abandoned.
Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein
Shu-Lin Liu, Chun-Chia Cheng, Chun-Chao Chang, Fu-Der Mai, Chia-Chi Wang, Shui-Cheng Lee, Ai-Sheng Ho, Ling-Yun Chen, Jungshan Chang
Journal of Biomedical Science , 2011, DOI: 10.1186/1423-0127-18-52
Abstract: Serum samples derived from animals with AFL, NAFL, or liver fibrosis were characterized and compared using two-dimensional differential gel electrophoresis. A matrix-assisted laser desorption ionization-time of flight tandem mass spectrometer in conjunction with mascot software was used for protein identification. Subsequently, Western blotting and flexible multi-analyte profiling were used to measure the expressions of the putative biomarkers present in the serum of animals and clinical patients.Eight differential putative biomarkers were identified, and the two most differentiated proteins, including upregulated C-reactive protein (CRP) and downregulated haptoglobin (Hp), were further investigated. Western blotting validated that CRP was dramatically higher in the serum of AFL compared to healthy controls and other animals with liver disease of NAFL or liver fibrosis (p < 0.05). Moreover, we found that CRP and Hp were both lower in liver fibrosis of TAA-induced rats and clinical hepatitis C virus-infected patients.The results suggest that increased levels of CRP are an early sign of AFL in rats. The abnormally elevated CRP induced by ethanol can be used as a biomarker to distinguish AFL from normal or otherwise diseased livers.Excessive alcohol consumption affects lipid metabolism in the liver [1,2], contributing to the development of alcohol-related liver diseases. There are three main types of alcohol-related liver disease, these are: alcoholic fatty liver (AFL), alcoholic hepatitis, and alcoholic cirrhosis. AFL is the early stage of alcohol-related liver diseases. Therefore, identifying putative serum biomarkers of AFL for early and accurate diagnostic methods is vital.Histological assessment of liver biopsy specimens remains the gold standard for determining alcohol-related liver disease. However, the methodology of histological assessments needs to overcome several drawbacks such as its invasive character and sampling error [3]. Moreover, it has difficulty in
A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment
Chi-Jung Huang, Shung-Haur Yang, Shih-Ming Huang, Chih-Ming Lin, Chih-Cheng Chien, Yan-Chu Chen, Chia-Long Lee, Hao-Han Wu, Chun-Chao Chang
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-82
Abstract: Molecular analysis of feces was evaluated as a potential method for CRC detection. Expression of a predicted protein with unknown function, KIAA0247, was found in feces evaluated using specific quantitative real-time polymerase chain reaction. Its cellular function was then analyzed using immunofluorescent staining and the changes in the cell cycle in response to 5-fluorouracil (5-FU) were assessed.Gastrointestinal tissues and peripheral blood lymphocytes ubiquitously expressed KIAA0247. 56 CRC patients fell into two group categories according to fecal KIAA0247 mRNA expression levels. The group with higher fecal KIAA0247 (n = 22; ≥ 0.4897) had a significantly greater five-year overall survival rate than the group with lower fecal KIAA0247 (n = 30; < 0.4897) (66.0 ± 11.6%; p = 0.035, log-rank test). Fecal expression of KIAA0247 inversely related to CRC tumor size (Kendall's tau-b = -0.202; p = 0.047). Immunofluorescent staining revealed that the cytoplasm of CRC cells evenly expresses KIAA0247 without 5-FU treatment, and KIAA0247 accumulates in the nucleus after 40 μM 5-FU treatment. In HCT116 p53-/- cells, which lack p53 cell cycle control, the proportion of cells in the G2/M phase was larger (13%) in KIAA0247-silent cells than in the respective shLuc control (10%) and KIAA0247-overexpressing cells (7%) after the addition of low dose (40 μM) 5-FU. Expression of three cyclin genes (cyclin A2, cyclin B1, and cyclin B2) also downregulated in the cells overexpressing KIAA0247.This is the first description of a linkage between KIAA0247 and CRC. The study's data demonstrate overexpression of KIAA0247 associates with 5-FU therapeutic benefits, and also identify the clinical significance of fecal KIAA0247 in CRC.Colorectal cancer (CRC) is the predominant gastrointestinal malignancy and the leading cause of cancer death [1]. CRC usually arises as a consequence of the accumulation of genetic and epigenetic alterations in colonic epithelial cells during neoplastic transformati
The Frequencies of Gastroesophageal and Extragastroesophageal Symptoms in Patients with Mild Erosive Esophagitis, Severe Erosive Esophagitis, and Barrett’s Esophagus in Taiwan
Sung-Shuo Kao,Wen-Chih Chen,Ping-I Hsu,Seng-Kee Chuah,Ching-Liang Lu,Kwok-Hung Lai,Feng-Woei Tsai,Chun-Chao Chang,Wei-Chen Tai
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/480325
Abstract: Background. Gastroesophageal reflux disease (GERD) may present with gastroesophageal and extraesophageal symptoms. Currently, the frequencies of gastroesophageal and extragastroesophageal symptoms in Asian patients with different categories of GERD remain unclear. Aim. To investigate the frequencies of gastroesophageal and extragastroesophageal symptoms in patients with mild erosive esophagitis, severe erosive esophagitis, and Barrett’s esophagus of GERD. Methods. The symptoms of symptomatic subjects with (1) Los Angeles grade A/B erosive esophagitis, (2) Los Angeles grade C/D erosive esophagitis, and (3) Barrett’s esophagus proven by endoscopy were prospectively assessed by a standard questionnaire for gastroesophageal and extragastroesophageal symptoms. The frequencies of the symptoms were compared by Chi-square test. Result. Six hundred and twenty-five patients (LA grade A/B: 534 patients; LA grade C/D: 37 patients; Barrett’s esophagus: 54 patients) were assessed for gastroesophageal and extragastroesophageal symptoms. Patients with Los Angeles grade A/B erosive esophagitis had higher frequencies of symptoms including epigastric pain, epigastric fullness, dysphagia, and throat cleaning than patients with Los Angeles grade C/D erosive esophagitis. Patients with Los Angeles grade A/B erosive esophagitis also had higher frequencies of symptoms including acid regurgitation, epigastric acidity, regurgitation of food, nausea, vomiting, epigastric fullness, dysphagia, foreign body sensation of throat, throat cleaning, and cough than patients with Barrett’s esophagus. Conclusion. The frequencies of some esophageal and extraesophageal symptoms in patients with Los Angeles grade A/B erosive esophagitis were higher than those in patients with Los Angeles grade C/D erosive esophagitis and Barrett’s esophagus. The causes of different symptom profiles in different categories of GERD patients merit further investigations. 1. Introduction The Montreal Definition and Classification of Gastroesophageal Reflux Disease defines GERD as a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications [1]. Gastroesophageal reflux occurs when there is a transient decrease in tension in the lower esophageal sphincter, allowing gastric contents to leak into the esophagus [2]. In most people with GERD, gastric juice reflux causes heartburn, as a painful or burning sensation in the esophagus, but regurgitation of digestive juices is also common [3]. Other than two classic reflux symptoms above, dysphagia is reported by more than
Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study
Chun-chao Han, Hong Wei, Jianyou Guo
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-100
Abstract: EIU was induced in rats via a footpad injection of lipopolysaccharide (LPS). Immediately after the LPS inoculation, fermented and non-fermented extracts of S. flavescens (FSE and NFSE, respectively) were administered orally, and the aqueous humor was collected from both eyes 24 hours later. The anti-inflammatory effects of FSE and NFSE were examined in terms of regulation of nuclear factor kappa B (NF-κB) activation and the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), intercellular cell adhesion molecule (ICAM)-1, and cyclooxygenase-2 (COX-2). The regulation of maleic dialdehyde (MDA) levels and polymorphonuclear cell (PMN) infiltration by FSE and NFSE were also examined.Treatment with FSE significantly inhibited LPS-induced increases in IL-1β and TNF-α production and the expression of iNOS, ICAM-1 and COX-2. Moreover, FSE suppressed LPS-induced NF-κB activation, and reduced both MDA levels and infiltration by PMN.These results indicate that solid state fermentation may enhance the anti-inflammatory effects of S. flavescens.Inflammation plays an important role in a wide variety of chronic human diseases including cardiovascular diseases and cancer. Although various chemical regimens have been used to treat inflammation, efficacy can be unsatisfactory and may encounter the problem of drug resistance. To improve treatments based on anti-inflammatory chemicals, novel therapeutic strategies may be developed from medical plants used in Chinese Traditional Medicine. Of the huge array of candidates available, we chose to investigate Sophora flavescens (Leguminosae) because of its potential health promoting properties; it is anti-inflammatory, an anti-asthmatic, an anthelmintic, and a free radical scavenger, and it has antimicrobial activities and improves mental health [1-5].The roots of S. flavescens (Leguminosae) have been traditionally used in East Asian countries as an herbal medicine and food ingredient
Generation of Intense THz Pulsed Lasers Pumped Strongly by CO2 Pulsed Lasers

QI Chun-Chao,CHENG Zu-Hai,

中国物理快报 , 2009,
Abstract: A theoretical method dealing with two intense laser fields interacting with a three-level molecular system is proposed. A discussion is presented on the properties of the solutions for time-independent and time-dependent absorption coefficients and gain coefficient on resonance for strong laser fields, based on analytic evaluation of the rate equations for a homogeneously broadened, three-level molecular system. The pump intensity range can be estimated according to the analytic expression of pump saturation intensity. The effects of pulse width, gas pressure and path length on the energy absorbed from pump light are studied theoretically. The results can be applied to the analysis of pulsed, optically pumped terahertz lasers.
Clinical and radiological presentations of pelvic parachordoma: a case report
Chun-Chao Huang,She-Meng Cheng
Rare Tumors , 2012, DOI: 10.4081/rt.2012.e5
Abstract: Parachordoma is an extremely rare entity and there are only about 50 to 60 cases reported, in which there is only one definite pelvic parachordoma. We present a huge well-defined presacral tumor in a 48-year-old woman who has the symptoms of lower abdominal pain and difficulty in defecating. Radiological findings of the tumor on computed tomography and magnetic resonance imaging are described in detail. The reasons why we report the case are because the patient has rare clinical symptoms and because this is the second pelvic parachordoma. Then, we summarize the radiological features of parachordoma based on our study and the review of literature.
Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy
Chun-Chao Chang, Shung-Haur Yang, Chih-Cheng Chien, Shu-Hung Chen, Shiann Pan, Chia-Long Lee, Chih-Ming Lin, Hsiao-Lun Sun, Chi-Cheng Huang, Yih-Yiing Wu, Ruey-Neng Yang, Chi-Jung Huang
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-376
Abstract: The quantitation of fecal CK19 transcript was determined by a quantitative real-time reverse transcription polymerase chain in 129 CRC patients (45 younger than 60 years at diagnosis) and 85 healthy controls. The levels of CK19 protein were examined both in colonic cell lines and tissues.The analysis of 45 younger CRC patients (age ≤ 60 years) revealed that patients at the M1 stage had significantly higher expression levels of fecal CK19 mRNA when compared with healthy controls (p < 0.001) and patients at the M0 stage (p = 0.004). Additionally, the degree of consistency between the mean level of fecal CK19 mRNA and the distant metastatic rate in each age interval was up to 89% (p = 0.042).These results indicate that high levels of fecal CK19 mRNA represent a potential marker for colorectal malignancy and for aggressive treatment of younger CRC patients.Colorectal cancer (CRC), which is a predominant gastrointestinal malignancy, is one of the most commonly diagnosed tumors in both men and women, and is becoming one of the major medical causes of economic burden worldwide [1]. On average, the starting age of CRC incidence begins at 40 years of age and rises sharply at the age of 50-55 years [2]. Moreover, CRC is also the second most common cause of cancer-related deaths among men over 40 years of age [3].Several clinicopathological features of CRC have been studied to identify markers that could predict CRC outcomes [4]. Numerous studies have shown that metastasis through the blood or lymphatic vessels is a major complication of cancer, and affects the prognosis of patients with primary carcinomas [5], therefore, methods developed to detect disseminated tumor cells in the peripheral blood and lymph nodes of patients have been evaluated. Many genetic changes were found in metastatic tumors, and some of them could be molecular markers for disseminated tumor cells [6]. CRC development and progression were shown to be complex processes that are associated with multiple ge
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