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Search Results: 1 - 10 of 161902 matches for " Christopher H. Bailey "
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Peripheral Nerve Blockade in a Patient with Mastocytosis  [PDF]
Christopher H. Bailey, Kent P. Weinmeister
Open Journal of Anesthesiology (OJAnes) , 2015, DOI: 10.4236/ojanes.2015.53010
Abstract: Mastocytosis is a rare group of disorders with chronic and episodic mast cell release of mediators which can have systemic and cutaneous manifestations. Triggers of anaphylaxis include commonly used medications for anesthesia, analgesia, and muscle relaxation. There is little in the literature regarding local anesthesia in emergent surgery for patients with mastocytosis. This case details the use of a peripheral nerve blockade for multiple surgeries and pain control in a patient with biopsy-proven mastocytosis.
Basal cell adenocarcinoma of the supraglottic larynx: treatment of recurrent disease with tamoxifen
Christopher H. Bailey,Patrick J. Donovan,Glen J. Weiss
Rare Tumors , 2011, DOI: 10.4081/rt.2011.e55
Abstract: At the age of 83, a woman presented with an extremely rare cancer, basal cell adenocarcinoma (BCAC) of the supraglottic larynx. Pathology revealed a stage IVA tumor, pathological stage T4N0M0. She was treated with surgery and did not receive any adjuvant chemotherapy or radiation therapy. At the age of 93, during a routine examination, the patient was found to have palpable adenopathy and underwent a fine needle aspiration in June 2010. Pathology revealed similar histologic characteristics of her 2001 BCAC diagnosis, and further IHC stains revealed positive estrogen receptor staining.
Using knowledge management to make health systems work
Bailey Christopher
Bulletin of the World Health Organization , 2003,
Abstract:
Progression-free Survival Decreases with Each Subsequent Therapy in Patients Presenting for Phase I Clinical Trials
Christopher H. Bailey, Gayle Jameson, Chao Sima, Sharon Fleck, Erica White, Daniel D. Von Hoff, Glen J. Weiss
Journal of Cancer , 2012,
Abstract: Background: There is often a finite progression-free interval of time between one systemic therapy and the next when treating patients with advanced cancer. While it appears that progression-free survival (PFS) between systemic therapies tends to get shorter for a number of factors, there has not been a formal evaluation of diverse tumor types in an advanced cancer population treated with commercially-available systemic therapies. Methods: In an attempt to clarify the relationship between PFS between subsequent systemic therapies, we analyzed the records of 165 advanced cancer patients coming to our clinic for consideration for participation in six different phase I clinical trials requiring detailed and extensive past medical treatment history documentation. Results: There were 77 men and 65 women meeting inclusion criteria with a median age at diagnosis of 55.3 years (range 9.4-81.6). The most common cancer types were colorectal (13.9%), other gastrointestinal (11.8%), prostate (11.8%). A median of 3 (range 1-11) systemic therapies were received prior to phase I evaluation. There was a significant decrease in PFS in systemic therapy for advanced disease from treatment 1 to treatment 2 to treatment 3 (p = 0.002), as well as, from treatment 1 through treatment 5 (p < 0.001). Conclusions: In an advanced cancer population of diverse tumor types, we observe a statistically significant decrease in PFS with each successive standard therapy. Identification of new therapies that reverse this trend of decreasing PFS may lead to improved clinical outcomes.
Investigation of a Superscalar Operand Stack Using FO4 and ASIC Wire-Delay Metrics
Christopher Bailey,Brendan Mullane
VLSI Design , 2014, DOI: 10.1155/2014/493189
Abstract: Complexity in processor microarchitecture and the related issues of power density, hot spots and wire delay, are seen to be a major concern for design migration into low nanometer technologies of the future. This paper evaluates the hardware cost of an alternative to register-file organization, the superscalar stack issue array (SSIA). We believe this is the first such reported study using discrete stack elements. Several possible implementations are evaluated, using a 90?nm standard cell library as a reference model, yielding delay data and FO4 metrics. The evaluation, including reference to ASIC layout, RC extraction, and timing simulation, suggests a 4-wide issue rate of at least four Giga-ops/sec at 90?nm and opportunities for twofold future improvement by using more advanced design approaches. 1. Introduction Current trends in semiconductor technology, and in particular the International Technology Roadmap for Semiconductors [1], suggest that future concerns in microarchitecture at the VLSI level will pose significant challenges. These include increasing power density [2], progressively severe thermal hot spots in increasingly complex designs [3], the impact of growing static power [4], and the problem of wire versus gate-delay and power scaling [5, 6]. Such problems are often most acutely exposed in key mainstream processor components such as cache, register related logic such as reorder buffers, rename logic, and the register file itself. Any alternative scheme to the traditional register-based computing paradigm can therefore open up the possibility of new approaches to these problems. However, register files are so highly optimized that measuring alternatives now requires complete layout of an optimal design for comparison, followed by timing and power analysis and nothing as simple as functional comparison of abstract logic. This paper focuses upon one possible unexplored option for operand storage which is alternative in its structure to that of a register file. The questions we examine are (a) can a LIFO (last-in-first-out) stack support superscalar operand access and (b) what is its performance relative to established mainstream approaches. This work is undertaken with a 90?nm UMC CMOS process library; however, we ultimately utilize FO4 as a delay metric [7] in order to provide a general measure of performance that can be scaled to other process nodes. The work is undertaken using standard cell digital libraries and not at the transistor level. Although this is not therefore an optimal solution, it permits rapid assessment of multiple
A comparison of pulmonary artery occlusion pressure (PaOP) measurements using pressure controlled ventilation (PCV) versus airway pressure release ventilation (APRV)
LJ Kaplan, H Bailey
Critical Care , 2000, DOI: 10.1186/cc727
Abstract: Ten consecutive patients with acute lung injury (ALI) managed with PCV and a pulmonary artery catheter (PAC) were studied. Demographic data was recorded. Patients served as their own controls and were ventilated by a Drager Evita 4 Pulmonary Workstation. No patients received paralytics. PCV settings (AC mode) achieved a pCO2 of 35–45 (torr) and a pO2 > 60 (torr) on 60% O2; PEEP was not controlled. Hemodynamic profiles were recorded 30 min after achieving the above pCO2 and pO2values. Patients were then changed to APRV to achieve the same pCO2 and pO2 values and hemodynamic measurements were repeated at 30 min. All medications were held constant. PaOP tracings (mmHg) were recorded and compared to the downloaded flow-time trace from the ventilator (Evitaview software). The PCV PaOP was recorded at the end of exhalation and served as the standard for comparisons. PaOP was recorded during the APRV phase cycle (positive pressure and release) and compared to the PCV value. Data are shown as means ± standard deviation and were compared using a two-tailed paired t-test; significance assumed for P < 0.05.Principal diagnoses were trauma (66%), abdominal sepsis (32%), and other (2%). Mean age was 54 ± 6.2years. PCV blood gas values were pH 7.34 ± 0.04, pCO239.3 ± 3.8, pO2 77.4 ± 9.5. APRV blood gas values were pH 7.37 ± 0.03, pCO2 35.5 ± 2.8, pO2 98 ± 11, (P< 0.05 vs PCV). The PCV PaOP was 16.3 ± 3 on a PEEP of 13.6 ± 2.2 cmH2O with a CI of 3.2 ± 0.5 L/min/m2 and an SvO2 of 76.8 ± 4.5% at a hemoglobin of 9.6 ± 1.04 gm%.The APRV PaOP during the positive pressure phase was 21.2 ± 3.3 (initial), 19 ± 2.5 (mid), and 20.5 ± 2.8 (end); P<0.01 for all versus PCV. The APRV PaOP during the release phase was 19 ± 2.7 (initial, P < 0.05), 17.7 ± 2.3 (mid, P = 0.09), and 16.4 ± 2.6 (end, P = 0.9). CI was significantly increased at 3.6 ± 0.4 (P<0.01 vs PCV) while SvO2 was unchanged at 79.1 ± 4.1 (P> 0.05 vs PCV).APRV increases the measured PaOP during the positive pressure phase. PaOP may
Lessons learned from airway pressure release ventilation
LJ Kaplan, H Bailey
Critical Care , 2001, DOI: 10.1186/cc1089
Abstract: Consecutive patients transitioned from either volume or pressure targeted ventilation to APRV in a University hospital ICU were retrospectively reviewed. Patients initially ventilated with APRV were excluded. Initial APRV settings for correction of hypoxemia (pO2 ≤ 60 on FIO2 ≥ 0.9) were a Phigh at the prior plateau pressure, a Thigh of 6.0 s and a Tlow of 0.8 s. Hypercarbic (pCO2 ≥ 55 and pH ≤ 7.3) patients were set at a Thigh of 5.0 s with a Tlow of 1.0 s. IRB approved data included principal diagnoses, ventilation parameters, laboratory values, and ventilator associated complications. Data before and after APRV were compared using an unpaired two-tailed t-test; significance at P < 0.05 (*).Patient mix was 43% trauma, 32% sepsis, 8% cardiac surgery, 12% vascular surgery and 5% other. Transitioning to APRV was most frequent for hypoxemia (88%) and hypercarbia less often (12%). The mean time to correct hypoxemia (SaO2 ≥ 92%) was 7 ± 4 min while the mean time to correct pCO2 (pCO2 ≤ 40 Torr) was 42 ± 7 min. Maximal CO2 clearance was achieved by 76 ± 12 min. The mean minute ventilation on APRV decreased by 3.3 ± 0.9 l/min (*) but achieved superior CO2 clearance and oxygenation. The mean time to achieve FIO2 ≤ 0.6 was 5.2 ± 0.9 hours. Four of 38 patients developed a pneumothorax although none developed hypotension; one had bilateral pneumothoraces. All four patients evidenced decreased CO2 clearance and decreased release phase volumes as their only manifestation of a pneumothorax. 97% of patients on APRV with a Phigh ≥ 20 cmH2O pressure who were transported out of the ICU using bag-valve ventilation developed hypoxemia within 5 min. 100% of patients with a Phigh ≤ 20 cmH2O pressure were safely hand ventilated during transport without developing hypoxemia.APRV is a safe rescue mode of ventilation for hypoxemic or hypercarbic respiratory failure and requires a lower minute ventilation than does conventional modes. Decreasing release phase volumes and a rising pCO2 are ex
Holiness Sex: Conservative Christian Sex Practices as Acts of Sanctification
Ludger H. Viefhues-Bailey
Journal of Men, Masculinities and Spirituality , 2012,
Abstract: In this article about conservative Christian heterosex advice manuals I will pursue two lines of inquiry: First, I will argue exegetically that these texts represent a particular modern intertwining of sexual and religious discourses. Here, the bodies of the Christian heterosexual couple are shaped as tension-filled sites: In their sexual bodies the Evangelical men and women, who consume and contribute to these texts, are tasked to negotiate and endure the antinomies of sexual discourses in high modernity in addition to those of Christian theologies of grace. While these manuals combine a discourse that highlights the importance of freely enjoying sexual pleasures, they also echo a wider cultural sense that sexuality is a dangerous power in need of constant disciplining. In terms of theology, this complicated shaping of heterosex enables a body theology of grace, in which it remains constantly unclear how much agency and submission the Christian man or Christian wife have to perform in the drama of salvation. As my second and theoretical line of inquiry, I will demonstrate how the proliferation of Christian advice products is part of the modernization of Evangelical heterosex discourse by creating a specific marketable and consumable identity of Christian sexuality.
Identification and Characterisation of an Iron-Responsive Candidate Probiotic
Jennifer R. Bailey, Christopher S. J. Probert, Tristan A. Cogan
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026507
Abstract: Background Iron is an essential cofactor in almost all biological systems. The lactic acid bacteria (LAB), frequently employed as probiotics, are unusual in having little or no requirement for iron. Iron in the human body is sequestered by transferrins and lactoferrin, limiting bacterial growth. An increase in the availability of iron in the intestine by bleeding, surgery, or under stress leads to an increase in the growth and virulence of many pathogens. Under these high iron conditions, LAB are rapidly out-competed; for the levels of probiotic bacteria to be maintained under high iron conditions they must be able to respond by increasing growth rate to compete with the normal flora. Despite this, iron-responsive genera are poorly characterised as probiotics. Methodology/Principal Findings Here, we show that a panel of probiotics are not able to respond to increased iron availability, and identify an isolate of Streptococcus thermophilus that can increase growth rate in response to increased iron availability. The isolate of S. thermophilus selected was able to reduce epithelial cell death as well as NF-κB signalling and IL-8 production triggered by pathogens. It was capable of crossing an epithelial cell barrier in conjunction with E. coli and downregulating Th1 and Th17 responses in primary human intestinal leukocytes. Conclusions/Significance We propose that an inability to compete with potential pathogens under conditions of high iron availability such as stress and trauma may contribute to the lack of efficacy of many LAB-based probiotics in treating disease. Therefore, we offer an alternative paradigm which considers that probiotics should be able to be competitive during periods of intestinal bleeding, trauma or stress.
Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion
Mark J Pallen, Scott A Beatson, Christopher M Bailey
BMC Microbiology , 2005, DOI: 10.1186/1471-2180-5-9
Abstract: We have performed a fresh bioinformatics analysis of the LEE. Using PSI-BLAST we have been able to identify several novel homologies between LEE-encoded and Ysc-Yop-associated proteins: Orf2/YscE, Orf5/YscL, rORF8/EscI, SepQ/YscQ, SepL/YopN-TyeA, CesD2/LcrR. In addition, we highlight homology between EspA and flagellin, and report many new homologues of the chaperone CesT.We conclude that the vast majority of LEE-encoded proteins do indeed possess homologues and that homology data can be used in combination with experimental data to make fresh functional predictions.Type-III secretion is one of five different types of protein secretion employed by Gram-negative bacteria to move proteins from the cytoplasm across two membranes to the external milieu [1-5]. Any given type-III secretion system (T3SS) consists of a multi-protein complex that spans both the inner and outer membranes and the periplasm so that proteins are delivered to the exterior in an ATPase-dependent fashion without a periplasmic intermediate. Type-III secretion systems can be classified into two major groups: those associated with flagellar biosynthesis and those associated with interactions between bacteria and eukaryotic cells [5]. Type-III secretion is thus central to our understanding of bacterial motility, virulence, symbiosis, and ecology. Type-III secretion also provides an attractive drug and vaccine target [6] and has been exploited in the biotechnology arena as a antigen delivery system [7,8]The important human pathogens, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) utilise type-III secretion to subvert eukaryotic signalling pathways by injecting bacterial effector proteins into the host cell cytoplasm [1,9-12]. Within these pathovars, a well-characterised T3SS is responsible for the development of a characteristic attaching-effacing (AE) lesion and for other effects on enterocyte function [9,11-13] (Figure 1). In common with most other T3SSs, this sy
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