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Search Results: 1 - 10 of 3716 matches for " Christina Schroeder "
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ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential
Christina I. Schroeder,Richard J. Lewis
Marine Drugs , 2006, DOI: 10.3390/md403193
Abstract: Highly selective N-type voltage-gated calcium (CaV) channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain. Earlier in 2005, Prialt (Elan) or synthetic ω-conotoxin MVIIA, was the first ω-conotoxin to be approved by Food and Drug Administration for human use. This review compares the action of three ω-conotoxins, GVIA, MVIIA and CVID, describing their structure-activity relationships and potential as leads for the design of improved N-type therapeutics that are more useful in the treatment of chronic pain.
The Survival of Head and Neck Carcinoma Patients Depends on Secondary Causes of Death  [PDF]
André Buchali, Winfried Huhnt, Ina Maekelburg, Sophia Rohrberg, Dietrich Sidow, Eyck Blank, Christina Schroeder, Achim Franzen
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.813102
Abstract: Purpose: The study aimed to analyse causes of death and differential survival after multimodal treatment of head and neck carcinoma patients. Methods and Materials: Between September 2000 and December 2015, 935 patients received a multimodal treatment of head and neck carcinoma. Of these, 562 patients (60.1%) underwent a resection of the primary tumour and a postoperative radio- or radiochemotherapy and 373 patients (39.9%) received definitive radio- or radiochemotherapy. The median follow-up was 21.0 months (0.5 - 175.4 months). Results: At the endpoint of the investigation, 465 patients (49.7%) were alive. The median survival of all patients was 44.8 months (0.5 - 164.3 months). A total of 470 patients (50.3%) died. The causes of death were divided into five groups: 22 patients (2.4%) died of therapy-associated complications with a median of 2.2 months (1.6 - 3.3 months). The 160 patients (17.1%) with intercurrent death, 117 patients (12.5%) with deaths from locoregional progression with or without metastasis, and 86 patients (9.2%) with deaths from metastasis without locoregional recurrence showed comparable survival curves with a median survival of 13.3 months, 13.6 months, and 14.4 months. Eighty-five patients (9.1%) died from second malignant diseases and controlled treated head and neck carcinomas with a median survival of 34.5 months (P < 0.001). Conclusion: Despite a locoregional control and metastasis-free survival of 78.3% patients, only 49.7% of the patients were alive, due to a high rate of intercurrent and second malignant diseases. The short median survival rate is mainly due to the tumours (locoregional and or distant progression) and intercurrent causes of death, with the second malignant diseases leading to death later on.
Correlation between the Changes in Lung Function and Lung Density Changes in Patients Following Radio- (Chemo-) Therapy for Thoracic Carcinomas  [PDF]
Christina Schroeder, Rita Engenhart-Cabillic, Sven Kirschner, Eyck Blank, André Buchali
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.103021
Abstract: Purpose: In this analysis we focused on the correlation of patients’ lung function (PFT) data and lung density changes (ΔHU) detected in follow-up CTs. Material and Methods: PFT and lung function data were available for 58 patients 12 weeks and 47 patients 6 months after radio- (chemo-) therapy for thoracic carcinomas (NSCLC, SCLC and esophageal carcinoma). The follow-up CT scans were matched with the planning CT scans of each patient and then subtracted to calculate ΔHU for each voxel using customized research software. PFT data regarding e.g. vital capacity (VC), total lung capacity (TLC) and diffusion capacity for carbon monoxide (DLCO) were collected before and at several follow-up appointments after treatment. Results: 12 weeks after therapy there was a statistically significant correlation between difference in DLCO and the maximum ΔHU as well as the difference in TLC and the minimum ΔHU. 6 months after treatment there was a significant correlation between the difference in VC and DLCO with numerous lung density parameters, e.g. the mean and median lung density changes and the 75th percentile of ΔHU. There was no significant correlation between the PFT parameters FEV1, pCO2 and pO2 and any lung density parameter at any follow-up appointment. Conclusion: There is a significant correlation between DLCO and ΔHU 6 months after treatment that most likely reflects the underlying pathological mechanisms in terms of the development of fibrotic lung tissue after RT. The relevance of the significant correlations 12 weeks after RT is questionable.
Central Body Rotation Drives Orbital Revolutions  [PDF]
Paul Schroeder
Journal of Geoscience and Environment Protection (GEP) , 2018, DOI: 10.4236/gep.2018.612005
Abstract: Prior to the development of physics as a science it was sufficient to have motion that offsets a perpendicular gravitational force and continues forever. The total absence of any friction could be assigned to the “void” of space. But perpetual motion and empty space are now seen as fallacies. Continuous motion needs a driving force for impetus.
Monitoring Genomic Sequences during SELEX Using High-Throughput Sequencing: Neutral SELEX
Bob Zimmermann,Tanja Gesell,Doris Chen,Christina Lorenz,Renée Schroeder
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009169
Abstract: SELEX is a well established in vitro selection tool to analyze the structure of ligand-binding nucleic acid sequences called aptamers. Genomic SELEX transforms SELEX into a tool to discover novel, genomically encoded RNA or DNA sequences binding a ligand of interest, called genomic aptamers. Concerns have been raised regarding requirements imposed on RNA sequences undergoing SELEX selection.
The Limits to Transforming the Environment and the Limits to Sociological Knowledge
Ralph Schroeder
Sustainability , 2010, DOI: 10.3390/su2082483
Abstract: This paper argues that the social sciences are fragmented in addressing the environmental challenge of increasing resource depletion. To address this problem, the paper puts forward a framework which encompasses several disciplinary approaches, and above all a long-term historical perspective and a realist sociology of science and technology which, in combination, provide a means of understanding the disruptive changes in the transformation of the environment. The paper then focuses on energy and gives an overview of the various social forces that can potentially counteract the future tensions arising from the foreseeable depletion of energy sources. It argues that only some of these countervailing forces—namely state intervention and technological innovation—provide viable potential solutions to these tensions. However, these solutions themselves face severe constraints. The paper concludes by arguing that a realistic assessment of constraints is the most useful, though limited, service that social science can contribute to our understanding of the relation between social and environmental transformation.
A importancia da física nas quatro primeiras séries do ensino fundamental
Schroeder, Carlos;
Revista Brasileira de Ensino de Física , 2007, DOI: 10.1590/S1806-11172007000100015
Abstract: this paper suggests that the importance of physics lessons during the first four years of elementary school lays on the possibility of fostering the development of the children's self-esteem and 'learning-to-learn' skills, rather than on utilitarian purposes, such as preparing students for secondary school studies. a sample of the activities proposed for children in the age bracket seven to ten years old is presented together with a discussion of the observed results. at this age the possibility of exploring physical phenomena may be useful for the development of 'learning-to-learn' skills.
South African Capital in the Land of Ujamaa: Contested Terrain in Tanzania
RA Schroeder
African Sociological Review / Revue Africaine de Sociologie , 2008,
Abstract: No
Incidence, prevalence, and hybrid approaches to calculating disability-adjusted life years
Schroeder S
Population Health Metrics , 2012, DOI: 10.1186/1478-7954-10-19
Abstract: When disability-adjusted life years are used to measure the burden of disease on a population in a time interval, they can be calculated in several different ways: from an incidence, pure prevalence, or hybrid perspective. I show that these calculation methods are not equivalent and discuss some of the formal difficulties each method faces. I show that if we don’t discount the value of future health, there is a sense in which the choice of calculation method is a mere question of accounting. Such questions can be important, but they don’t raise deep theoretical concerns. If we do discount, however, choice of calculation method can change the relative burden attributed to different conditions over time. I conclude by recommending that studies involving disability-adjusted life years be explicit in noting what calculation method is being employed and in explaining why that calculation method has been chosen.
Encyclopedia of Contemporary Christian Music: Pop, Rock, and Worship
Joy Schroeder
Theological Librarianship , 2010,
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