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Search Results: 1 - 10 of 14777 matches for " Christian Anglade "
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La autonomía del Estado y el imperio de la ley. Notas para una teoría del Estado desarrollista
Christian Anglade
Revista mexicana de ciencias políticas y sociales , 2000,
Abstract: El papel del Estado en el proceso de desarrollo es función de su capacidad de cumplir con sus responsabilidades constitucionales y en particular de aplicar la ley. El poder limitado que tiene para hacer cumplir el imperio de la ley limita a su vez el papel desamllista del Estado en América Latina, y esa limitación es el resultado de la fragmentación del control social que prevalece en el area.
L’Ancien Cimetière israélite de Casablanca, Maroc.
Marie-Pierre Anglade
EspacesTemps.net , 2005,
Abstract: L’Ancien Cimetière israélite de Casablanca jouxte l’Ancienne Médina, dans le centre-ville. Plus aucun enterrement n’y a lieu depuis 1947, date à laquelle des concessions aux religions juives et catholiques ont été accordées au cimetière de Ben M’Sik, un quartier situé en périphérie. Des gardiens sont supposés assurer les fonctions élémentaires d’entretien des lieux : nettoyage, filtrage d’individus indésirables tels que voleurs ou tout habitant du quartier à la ...
Sensory Analyses and Nutritional Qualities of Hand-Made Breads with Organic Grown Wheat Bread Populations  [PDF]
Camille Vindras-Fouillet, Olivier Ranke, Jean-Pierre Anglade, Bruno Taupier-Letage, Chable Véronique, Isabelle Goldringer
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.519199
Abstract: Population varieties can meet the needs of organic farming as they are composed of diverse genotypes and have nutritional and sensory characteristics of interest. Their intra-specific genetic variability helps to adapt to the diversity of soil and climate conditions, management practices and needs. Moreover, an integrated organic bread sector has emerged willing to use more wheat populations. To explore sensory and nutritional potential of bread wheat populations, hedonic tests, sensory profile and nutritional analyses were implemented on eight wheat population varieties and one modern variety. Hedonic tests revealed consensus among consumer when ranking according to specific sensory characteristics and showed preferences for red wheat breads. Descriptive sensory test showed significant differences between genotypes on 6 out of 11 descriptors and confirmed the sensory specificity of red wheat accessions. Nutritional analyses showed differences especially on minerals content. Sensory differences between breads from different genotypes can be perceived both by trained and untrained panels as suggested by results. Moreover, red accessions showed specific sensory characteristics which are well-perceived by the two panels. Breeding effort should be maintained for high diverse genotypes with improved sensory and nutritional qualities adapted to organic farming conditions. Indicators like kernel colour should be sought to help integrate such criteria.
A new agent for the treatment of noninfectious uveitis: rationale and design of three LUMINATE (Lux Uveitis Multicenter Investigation of a New Approach to Treatment) trials of steroid-sparing voclosporin
Eddy Anglade,Launa J Aspeslet,Sidney L Weiss
Clinical Ophthalmology , 2008,
Abstract: Eddy Anglade1, Launa J Aspeslet2, Sidney L Weiss11Lux Biosciences Inc., Jersey City, NJ, USA; 2Isotechnika Inc., Edmonton, AB, CanadaAbstract: Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Currently available therapies are burdened with toxicities and/or lack definitive evidence of efficacy. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a favorable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. The LUMINATE (Lux Uveitis Multicenter Investigation of a New Approach to TrEatment) clinical development program was initiated in 2007 to assess the safety and efficacy of voclosporin for the treatment, maintenance, and control of all forms of noninfectious uveitis. If LUMINATE is successful, voclosporin will become the first Food and Drug Administration-approved corticosteroid-sparing agent for this condition.Keywords: voclosporin, calcineurin inhibitors, LX211, LUMINATE trials, ophthalmic diseases, uveitis, ISA247
Increased cardiac index due to terbutaline treatment aggravates capillary-alveolar macromolecular leakage in oleic acid lung injury in dogs
Raphael Briot, Sam Bayat, Daniel Anglade, Jean-Louis Martiel, Francis Grimbert
Critical Care , 2009, DOI: 10.1186/cc8137
Abstract: We used a recently developed broncho-alveolar lavage (BAL) technique to repeatedly measure (every 15 min. for 4 hours) the time-course of capillary-alveolar leakage of a macromolecule (fluorescein-labeled dextran) in 19 oleic acid (OA) lung injured dogs. BAL was performed in a closed lung sampling site, using a bronchoscope fitted with an inflatable cuff. Fluorescein-labeled Dextran (FITC-D70) was continuously infused and its concentration measured in plasma and BAL fluid. A two-compartment model (blood and alveoli) was used to calculate KAB, the transport rate coefficient of FITC-D70 from blood to alveoli. KAB was estimated every 15 minutes over 4 hours. Terbutaline intra-venous perfusion was started 90 min. after the onset of the injury and then continuously infused until the end of the experiment.In the non-treated injured group, the capillary-alveolar leakage of FITC-D70 reached a peak within 30 minutes after the OA injury. Thereafter the FITC-D70 leakage decreased gradually until the end of the experiment. Terbutaline infusion, started 90 min after injury, interrupted the recovery with an aggravation in FITC-D70 leakage.As cardiac index increased with terbutaline infusion, we speculate that terbutaline recruits leaky capillaries and increases FITC-D70 leakage after OA injury. These findings suggest that therapies inducing an increase in cardiac output and a decrease in pulmonary vascular resistances have the potential to heighten the early increase in protein transport from plasma to alveoli within the acutely injured lung.Acute lung injury (ALI) is a major syndrome in patients in the intensive care unit, and it has a high mortality rate. An increased capillary-alveolar permeability to plasma proteins is an early marker of the acute phase of lung injury andcontributes to the development of fibroproliferation [1]and lung fibrosis, which both contribute to a negative outcome [2]. Plasma proteins that flood the alveoli include pro-coagulant factors and initiate a
Aproximación facial y paleodieta en un esqueleto de la necrópolis de El Vergel (ávila-Espa a).
Serrulla Rech, Fernando,Grandal D'ANGLADE, Aurora,Vilar Labarta, Santiago,Gómez, María
Munibe Antropologia-Arkeologia , 2011,
Abstract: OBJETIVOS: El objetivo principal de este trabajo es profundizar en el conocimiento de nuestra historia mediante la aplicación tanto de métodos convencionales como novedosos. MATERIAL y METODOS: Presentamos una síntesis de las investigaciones realizadas en la necrópolis romana de "El Vergel" (San Pedro del Arroyo, ávila-Espa a). Para el estudio antropológico hemos empleado además de métodos convencionales, técnicas de aproximación facial para 2D. Para el estudio de paleodieta, obtenemos colágeno purificado de una muestra ósea que se introduce en un analizador elemental unido a un espectrómetro de masas de relaciones isotópicas. RESULTADOS: Hemos obtenido un rostro basado en las proporciones craneo-faciales así como en los datos que ha suministrado el estudio antropológico. Las se ales isotópicas del colágeno para el esqueleto estudiado indican el consumo de "garum". CONCLUSIONES: El rostro obtenido es una aproximación a la realidad, pero de tratarse de un caso forense pensamos podría contribuir a la identificación.
Nuclear Progesterone Receptors Are Up-Regulated by Estrogens in Neurons and Radial Glial Progenitors in the Brain of Zebrafish
Nicolas Diotel, Arianna Servili, Marie-Madeleine Gueguen, Svetlana Mironov, Elisabeth Pellegrini, Colette Vaillant, Yong Zhu, Olivier Kah, Isabelle Anglade
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028375
Abstract: In rodents, there is increasing evidence that nuclear progesterone receptors are transiently expressed in many regions of the developing brain, notably outside the hypothalamus. This suggests that progesterone and/or its metabolites could be involved in functions not related to reproduction, particularly in neurodevelopment. In this context, the adult fish brain is of particular interest, as it exhibits constant growth and high neurogenic activity that is supported by radial glia progenitors. However, although synthesis of neuroprogestagens has been documented recently in the brain of zebrafish, information on the presence of progesterone receptors is very limited. In zebrafish, a single nuclear progesterone receptor (pgr) has been cloned and characterized. Here, we demonstrate that this pgr is widely distributed in all regions of the zebrafish brain. Interestingly, we show that Pgr is strongly expressed in radial glial cells and more weakly in neurons. Finally, we present evidence, based on quantitative PCR and immunohistochemistry, that nuclear progesterone receptor mRNA and proteins are upregulated by estrogens in the brain of adult zebrafish. These data document for the first time the finding that radial glial cells are preferential targets for peripheral progestagens and/or neuroprogestagens. Given the crucial roles of radial glial cells in adult neurogenesis, the potential effects of progestagens on their activity and the fate of daughter cells require thorough investigation.
Proteomic comparison of the cytosolic proteins of three Bifidobacterium longum human isolates and B. longum NCC2705
Julio Aires, Patricia Anglade, Fabienne Baraige, Monique Zagorec, Marie-Christine Champomier-Vergès, Marie-José Butel
BMC Microbiology , 2010, DOI: 10.1186/1471-2180-10-29
Abstract: Pulsed field electrophoresis genotyping revealed genetic heterogeneity with low intraspecies strain relatedness among the four strains tested. Using two-dimensional gel electrophoresis, we analyzed qualitative differences in the cytosolic protein patterns. There were 45 spots that were present in some strains and absent in others. Spots were excised from the gels and subjected to peptide mass fingerprint analysis for identification. The 45 spots represented 37 proteins, most of which were involved in carbohydrate metabolism and cell wall or cell membrane synthesis. Notably, the protein patterns were correlated with differences in cell membrane properties like surface hydrophobicity and cell agglutination.These results showed that proteomic analysis can be valuable for investigating differences in bifidobacterial species and may provide a better understanding of the diversity of bifidobacteria and their potential use as probiotics.Bifidobacteria are anaerobic high G + C Gram-positive bacteria that belong to the Bifidobacterium genus, which contains more than 30 species. Bifidobacterium is a prevalent bacterial genus in the human colon that represents up to 90% of all bacteria in fecal samples of breast-fed infants and 3 to 5% of adult fecal microbiota [1,2]. In full-term breast-fed infants, the intestinal microbiota is rapidly dominated by bifidobacteria that are acquired from mothers' microbiota during birth. These bacteria contribute to the establishment of healthy intestinal ecology and can confer health benefits to their host. Indeed, impairment of bifidobacterial colonization is a risk factor for allergic diseases [3] and for necrotizing enterocolitis in preterm infants [4]. Consequently, bifidobacteria are the subject of growing interest due to their assumed contribution to the maintenance of gastrointestinal health [5-12]. For these reasons, some bifidobacterial strains are used as health-promoting or probiotic components in functional food products [13].Altho
Role of Estradiol, Progestins, Insulines and Adipocytokines in Breast Cancer Promotion in Post-Menopausal Women  [PDF]
Christian Jamin
Journal of Cancer Therapy (JCT) , 2010, DOI: 10.4236/jct.2010.11007
Abstract: Estrogens and artificial progestins used in hormone replacement therapy increase breast cancer risk. This seems to bedue to a promoting and not initiating effect. A synergic effect of estradiol and hyperinsulinism has been shown. Insulinplays a role in the increase of breast cancer risk when associated with android obesity, sedentariness, type II diabetes,and high glycemic index food, alcohol and trans fatty acids intake. Natural menopause induces insulin resistance anddoes not induce a risk decrease. The role of insulin gives a new outlook on the influence of HRT in breast cancer promotion:estradiol alone, which improves insulin-sensitivity, does not increase breast cancer risk. Artificial progestinsassociated with estrogens increase the risk, whereas estrogens associated with progesterone do not. This could be dueto the fact that artificial progestins increase insulin resistance, whereas natural progesterone does not. Adipose tissue,which is an endocrine gland, is insulin dependant. Breast cancer and its seriousness are correlated to adipocytokincirculating levels such as resistin, leptin, interleukin 1, adipocyte fatty acid-binding protein, and are inversely correlatedto the level of adiponectin. Insulin could play a synergic role with sexual steroids by a direct effect and by increasingadipose tissue secretions.
The Timeliness of Direct Democracy in the EU—The Example of Nuclear Energy in the EU and the Institutionalisation of the European Citizens’ Initiative in the Lisbon Treaty  [PDF]
Christian Joerges
Beijing Law Review (BLR) , 2012, DOI: 10.4236/blr.2012.31001
Abstract: The catastrophic nuclear incident in Fukushima in March 2011 has shocked Europe. Its impact was particularly strong in Germany with its decade-old anti-nuclear movements. Political and technological re-orientations were initiated in that country without considering at any depth the potential of European law and politics to control or obstruct such moves. Somewhat paradoxically, the Euratom Treaty of 1957 and also the new Treaty of Lisbon confirm the right of each Member State to decide upon the use of nuclear energy autonomously. This means that European citizens remain exposed to the risks of that technology until the highly unlikely consent of all Member States to abstain from its further use. That constellation poses a dilemma for democracy because it implies that each political decision taken within parts of the Union exerts external pan-European effects. The article considers the chances for an inclusive democratic process which would lead to a legitimated European decision. It examines the possibilities offered by the new European Citizens Initiative which the Lisbon Treaty has institutionalized in its Article 12 and concludes that this instrument could indeed be used to instigate a European-wide debate which may eventually lead to pertinent changes in the Treaties.
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