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Search Results: 1 - 10 of 6920 matches for " Chris Lane "
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The University of Toronto as a World Leader in Medical Genetics: Past, Present and Future
Charis Kepron,Chris Lane,David Maslove,Vladislav Miropolsky
University of Toronto Medical Journal , 2000, DOI: 10.5015/utmj.v78i1.969
Rigidin E, a New Pyrrolopyrimidine Alkaloid from a Papua New Guinea Tunicate Eudistoma Species
Rohan A. Davis,Lane V. Christensen,Adam D. Richardson,Rosana Moreira Da Rocha,Chris M. Ireland
Marine Drugs , 2003, DOI: 10.3390/md101027
Abstract: A new pyrrolopyrimidine alkaloid, rigidin E (1) and the known metabolites rigidin (2) and 1-methylherbipoline (3) have been isolated from a Papua New Guinea tunicate Eudistoma sp. A combination of spectroscopic data were used to determine the structures of these metabolites.
A Lack of Parasitic Reduction in the Obligate Parasitic Green Alga Helicosporidium
Jean-Fran?ois Pombert,Nicolas Achille Blouin,Chris Lane,Drion Boucias,Patrick J. Keeling
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004355
Abstract: The evolution of an obligate parasitic lifestyle is often associated with genomic reduction, in particular with the loss of functions associated with increasing host-dependence. This is evident in many parasites, but perhaps the most extreme transitions are from free-living autotrophic algae to obligate parasites. The best-known examples of this are the apicomplexans such as Plasmodium, which evolved from algae with red secondary plastids. However, an analogous transition also took place independently in the Helicosporidia, where an obligate parasite of animals with an intracellular infection mechanism evolved from algae with green primary plastids. We characterised the nuclear genome of Helicosporidium to compare its transition to parasitism with that of apicomplexans. The Helicosporidium genome is small and compact, even by comparison with the relatively small genomes of the closely related green algae Chlorella and Coccomyxa, but at the functional level we find almost no evidence for reduction. Nearly all ancestral metabolic functions are retained, with the single major exception of photosynthesis, and even here reduction is not complete. The great majority of genes for light-harvesting complexes, photosystems, and pigment biosynthesis have been lost, but those for other photosynthesis-related functions, such as Calvin cycle, are retained. Rather than loss of whole function categories, the predominant reductive force in the Helicosporidium genome is a contraction of gene family complexity, but even here most losses affect families associated with genome maintenance and expression, not functions associated with host-dependence. Other gene families appear to have expanded in response to parasitism, in particular chitinases, including those predicted to digest the chitinous barriers of the insect host or remodel the cell wall of Helicosporidium. Overall, the Helicosporidium genome presents a fascinating picture of the early stages of a transition from free-living autotroph to parasitic heterotroph where host-independence has been unexpectedly preserved.
Helping Oncology Nurses Advise Younger Patients about Self Care: Feasibility of Using Animated and DVD Formats for Nurse Instruction  [PDF]
Ivan Beale, Vivien Lane
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.11008
Abstract: This study explored the perceptions of oncology nurses about the usefulness of a video-game or an animated DVD intervention designed to teach young patients about self care. The study also measured the effects of these interventions on nurses’ cancer knowledge and perceived self-efficacy to communicate with patients about self-care. Twenty-two oncology nurses were randomly assigned either to use a video game “Re-Mission” or to view instructional animations from the game on DVD. They completed tests and rating scales before and after, then rated the acceptability of the game or DVD. Only ten participants completed the study. For these ten, ratings of the acceptability and credibility of the game or DVD were moderately positive, regardless of age or nursing experience. Self-efficacy for communicating to patients about self-care increased following use of the game or DVD. Cancer knowledge was not affected. It was concluded that oncology nurses in Australia are not generally enthusiastic about the concept of instruction via video game and animated DVD formats, although those who participated rated the experience positively.
Global Environmental Coordination: How to Overcome the Double Collective Action Problematic?  [PDF]
Jan-Erik Lane
Sociology Mind (SM) , 2013, DOI: 10.4236/sm.2013.31013

The need for stronger global coordination of environmental policies has become ever more obvious, but there are no formal arrangements in sight. The UN framework of UNEP is not delivering effective policies. Only global environmental coordination on the successful model of the World Band and the IMF can stem the rising emissions numbers and projections—quantitative voting reflecting the differences in size between the states of the world. However, the system of weighted voting typical of the WB and the IMF must be reformed in an egalitarian manner, when a global ecology organisation is set up, reducing their excessive voting power disparities. This paper suggests a simple but effective mechanism for reducing these voting power disparities, decreasing all member country votes by either the square root or the cube root expression.

The Principal-Agent Approach to Politics: Policy Implementation and Public Policy-Making  [PDF]
Jan-Erik Lane
Open Journal of Political Science (OJPS) , 2013, DOI: 10.4236/ojps.2013.32012

The principal-agent models may be employed to elucidate central problems in interaction between principals and agents in both policy implementation and public policy-making concerning performance and remuneration. One then hits upon the double principal-agent relationships that are typical of the policy cycle, from policy-making to policy implementation and back: 1) government as principal for agents in public service delivery; 2) the population as principal for political agents under various forms of rulership.

Civilisations and Capitalism: On Economic Growth and Institutions  [PDF]
Jan-Erik Lane
Sociology Mind (SM) , 2014, DOI: 10.4236/sm.2014.41003

Theories of political culture have typically refrained from a reinterpretation of the idea of civilisations, as a few well-known traditional approaches to this concept have been severely criticized. Yet, one may probe into the relevance of the concept of a set of civilisations for mankind in the period of globalisation. However, it is not the Weber thesis linking religion with modern capitalism or economic growth that appears most promising today when enquiring into cultural effects. Instead, it is the spread of respect for the rule of law regime, which has a much longer history than the democratic polity.

Institutionality: “Institution” and “Institutions Matter”  [PDF]
Jan-Erik Lane
Open Journal of Political Science (OJPS) , 2014, DOI: 10.4236/ojps.2014.41004

Theories of institutions have become very popular in the social sciences. Thus, we often encounter the claim “Institutions Matter” in the new literature, which is called “institutionalism”. It is time to make a critique of this theme, asking what an institution is and what it “matters” for. “Institution” stands for two very different sorts of entities in social reality—rules and organisations—and the new institutionalism comes in two corresponding versions, economic or atomistic neo-institutionalism against sociological or holistic neoinstitutionalism. The notion of new logic of individual behaviour—a logic of appropriateness—is flawed, as it is not in agreement with basic notions in the philosophy of action.

Political Modernisation: The Rule of Law Perspective on Good Governance  [PDF]
Jan-Erik Lane
Open Journal of Political Science (OJPS) , 2015, DOI: 10.4236/ojps.2015.51002
Abstract: The United Nations, the WB as well as the IMF speak much of “good governance”, but what is the meaning and reference of this elusive expression? In this paper, I will link it with the concept(s) of rule of law. Rule of law notions are spreading around the globe, being relevant for the transformation of monarchies and one-party states. Thus, world media are now reporting that for instance China’s leadership is seriously debating making state reforms that would be conducive to more of the rule of law in the country. This is not be interpreted as a push towards western democracy. To clarify the relation between rule of law and competitive party democracy, this paper presents an enquiry into rule of law I and rule of law II. This distinction has a long history in political thought and constitutional developments. Data from the encompassing World Bank Governance project is used to validate these concepts referentially.
Greenhouse Gas Emissions: “Potemkin Villages” and Global Resilience  [PDF]
Jan-Erik Lane
Sociology Mind (SM) , 2015, DOI: 10.4236/sm.2015.54026
Abstract: The climate change problematic, becoming more relevant every day, is almost exclusively approached as a natural sciences concern. Thus, scholars debate what drives global warming physically as well as whether a fundamental turn to renewable energy would mean much difference. The point in this paper is that what the social sciences have to say about the possibility and desirability of a global policy must NOT be pushed aside. Of course, the chemical and biological processes inherent in global warming should be identified and measured in an ever more detailed manner, but policy-making is conducted by human beings in social, economic and political settings. Only the governments of the world can engage in global coordination to halt global warming, but the lessons from political theory underlining opportunism as well as self-seeking with guile and moreover game theory with asymmetric information teach humbleness and scepticism about these prospects. The states coordination coin has two sides: talk, meetings, declarations, promises on the one side, and reneging, cheating and opportunism with guile on the other less shining side.
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