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Search Results: 1 - 10 of 16936 matches for " Chow Yin Wong "
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Proteome-Wide Profiling of the MCF10AT Breast Cancer Progression Model
Lee Yee Choong,Simin Lim,Poh Kuan Chong,Chow Yin Wong,Nilesh Shah,Yoon Pin Lim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011030
Abstract: Mapping the expression changes during breast cancer development should facilitate basic and translational research that will eventually improve our understanding and clinical management of cancer. However, most studies in this area are challenged by genetic and environmental heterogeneities associated with cancer.
Activation of Eosinophils Interacting with Dermal Fibroblasts by Pruritogenic Cytokine IL-31 and Alarmin IL-33: Implications in Atopic Dermatitis
Chun-Kwok Wong, Karen Ming-Lam Leung, Huai-Na Qiu, Joyce Yin-Sau Chow, Angela On Kei Choi, Christopher Wai-Kei Lam
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029815
Abstract: Background IL-31 is a pruritogenic cytokine, and IL-33 is an alarmin for damaging inflammation. They together relate to the pathogenesis of atopic dermatitis (AD). Eosinophil infiltration into the inner dermal compartment is a predominant pathological feature of AD. We herein investigated the in vitro inflammatory effects of IL-31 and IL-33 on the activation of human eosinophils and dermal fibroblasts. Methodology/Principal Findings Receptors, adhesion molecules and signaling molecules were assessed by Western blot or flow cytometry. Chemokines and cytokine were quantitated by multiplex assay. Functional IL-31 receptor component IL-31RA, OSMR-β and IL-33 receptor component ST2 were constitutively expressed on the surface of eosinophils. Co-culture of eosinophils and fibroblasts significantly induced pro-inflammatory cytokine IL-6 and AD-related chemokines CXCL1, CXCL10, CCL2 and CCL5. Such inductions were further enhanced with IL-31 and IL-33 stimulation. IL-31 and IL-33 could significantly provoke the release of CXCL8 from eosinophils and fibroblasts, respectively, which was further enhanced upon co-culture. In co-culture, eosinophils and fibroblasts were the main source for the release of CCL5, and IL-6, CXCL1, CXCL8, CXCL10 and CCL2, respectively. Direct interaction between eosinophils and fibroblasts was required for CXCL1, CXCL10, CXCL8 and CCL5 release. Cell surface expression of intercellular adhesion molecule-1 on eosinophils and fibroblasts was up-regulated in co-culture upon IL-31 and IL-33 stimulation. The interaction between eosinophils and fibroblasts under IL-31 and IL-33 stimulation differentially activated extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, nuclear factor-κB and phosphatidylinositol 3-kinase–Akt pathways. Using specific signaling molecule inhibitors, the differential induction of IL-31 and IL-33-mediated release of cytokines and chemokines such as IL-6 and CXCL8 from co-culture should be related to their distinct activation profile of intracellular signaling pathways. Conclusions/Significance The above findings suggest a crucial immunopathological role of IL-31 and IL-33 in AD through the activation of eosinophils-fibroblasts interaction via differential intracellular signaling mechanisms.
The Genetic and Environmental Foundation of the Simple View of Reading in Chinese
Connie Suk-Han Ho, Bonnie Wing-Yin Chow, Simpson Wai-Lap Wong, Mary M. Y. Waye, Dorothy V. M. Bishop
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047872
Abstract: The Simple View of Reading (SVR) in Chinese was examined in a genetically sensitive design. A total of 270 pairs of Chinese twins (190 pairs of monozygotic twins and 80 pairs of same-sex dizygotic twins) were tested on Chinese vocabulary and word reading at the mean age 7.8 years and reading comprehension of sentences and passages one year later. Results of behavior-genetic analyses showed that both vocabulary and word reading had significant independent genetic influences on reading comprehension, and the two factors together accounted for most but not all of the genetic influences on reading comprehension. In addition, sentence comprehension had a stronger genetic correlation with word reading while passage comprehension showed a trend of stronger genetic overlap with vocabulary. These findings suggest that the genetic foundation of the SVR in Chinese is largely supported in that language comprehension and decoding are two core skills for reading comprehension in nonalphabetic as well as alphabetic written languages.
Genetic and Environmental Influences on Chinese Language and Reading Abilities
Bonnie Wing-Yin Chow,Connie Suk-Han Ho,Simpson Wai-Lap Wong,Mary M. Y. Waye,Dorothy V. M. Bishop
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016640
Abstract: This study investigated the etiology of individual differences in Chinese language and reading skills in 312 typically developing Chinese twin pairs aged from 3 to 11 years (228 pairs of monozygotic twins and 84 pairs of dizygotic twins; 166 male pairs and 146 female pairs). Children were individually given tasks of Chinese word reading, receptive vocabulary, phonological memory, tone awareness, syllable and rhyme awareness, rapid automatized naming, morphological awareness and orthographic skills, and Raven's Coloured Progressive Matrices. All analyses controlled for the effects of age. There were moderate to substantial genetic influences on word reading, tone awareness, phonological memory, morphological awareness and rapid automatized naming (estimates ranged from .42 to .73), while shared environment exerted moderate to strong effects on receptive vocabulary, syllable and rhyme awareness and orthographic skills (estimates ranged from .35 to .63). Results were largely unchanged when scores were adjusted for nonverbal reasoning as well as age. Findings of this study are mostly similar to those found for English, a language with very different characteristics, and suggest the universality of genetic and environmental influences across languages.
A Quantum Representation of the Homogeneous 5D Manifold and the Perelman Mappings of 5D onto Non-Homogeneous Lorentz 4D Manifolds  [PDF]
Kai Wai Wong, Peter Chin Wan Fung, Wan Ki Chow
Journal of Modern Physics (JMP) , 2019, DOI: 10.4236/jmp.2019.105039
Abstract: The expression of the Maxwell magnetic monopole was employed to correlate the space to space projection that gives rise to the Gell-Mann standard model, and space to time projection which gives the leptons; and how does it correlate to the Perelman mappings from the homogeneous 5D manifold to the Lorentz 4D manifold, together with correlating the physical consequences caused by the breaking of the Diagonal Long Range Order [DLRO] of the monopoles quantum states affected by the motion of massive particles in the Lorentz 4D boundary of the 5D manifold, which leads to gravitons and the gravity field via the General Relativity covariant Riemannian 4D curvatures metric equation.
Comparison of Legal System of Occupational Safety and Health between Hong Kong and Mainland China  [PDF]
Qiang Chen, Yin-Ge Cao, Wan-Ki Chow
Open Journal of Safety Science and Technology (OJSST) , 2012, DOI: 10.4236/ojsst.2012.23016
Abstract: The legal system of occupational safety and health (OSH) and the supervisory organization in Mainland China and Hong Kong are briefly reviewed in this article. It appears that there are several similar areas of OSH between Hong Kong and Mainland China, such as on the management of occupational health, safety production, fire safety, dangerous goods, the boilers and pressure vessels, etc. Characteristics of the legal system both in Hong Kong and Mainland China are summarized, and areas which are used for reference reciprocally to improve OSH are proposed. Finally, the challenges of OSH legal system facing jointly are identified.
The periodicity of sleep duration – an infradian rhythm in spontaneous living
Wong SN, Halaki M, Chow CM
Nature and Science of Sleep , 2013, DOI: http://dx.doi.org/10.2147/NSS.S38116
Abstract: iodicity of sleep duration – an infradian rhythm in spontaneous living Original Research (1245) Total Article Views Authors: Wong SN, Halaki M, Chow CM Published Date January 2013 Volume 2013:5 Pages 1 - 6 DOI: http://dx.doi.org/10.2147/NSS.S38116 Received: 14 September 2012 Accepted: 01 November 2012 Published: 18 January 2013 Shi Ngar Wong, Mark Halaki, Chin Moi Chow Discipline of Exercise and Sport Science, University of Sydney, Sydney, NSW, Australia Abstract: The sleep–wake cycle is a process not only dictated by homeostatic and circadian factors but also by social and environmental influences. Thus, the total sleep time partly reflects sleep need, which is integral to the dynamics of sleep loss recovery. This study explored the nature of the observed oscillations in total sleep time in healthy adults under spontaneous living conditions. Actigraph-measured sleep data for 13 healthy young male adults were collected over 14 consecutive days and analyzed for habitual sleep duration. The total sleep time periodicity was modeled using the cosinor method for each individual across the 14 days. The findings confirm the existence of periodicity in habitual sleep duration as there were clear periodic patterns in the majority of the participants. Although exclusive to each individual, the observed oscillations may be a resultant response of homeostatic sleep need, circadian timing, and/or social and environmental influences. These findings instigate further indepth studies into the periodicity of sleep duration in healthy individuals to provide a better understanding of sleep need in short versus long sleepers, in predicting work performance, and reducing sleepiness-related accidents following shift work, and how this periodicity may impact sleep treatment outcome in clinical populations.
The periodicity of sleep duration – an infradian rhythm in spontaneous living
Wong SN,Halaki M,Chow CM
Nature and Science of Sleep , 2013,
Abstract: Shi Ngar Wong, Mark Halaki, Chin Moi ChowDiscipline of Exercise and Sport Science, University of Sydney, Sydney, NSW, AustraliaAbstract: The sleep–wake cycle is a process not only dictated by homeostatic and circadian factors but also by social and environmental influences. Thus, the total sleep time partly reflects sleep need, which is integral to the dynamics of sleep loss recovery. This study explored the nature of the observed oscillations in total sleep time in healthy adults under spontaneous living conditions. Actigraph-measured sleep data for 13 healthy young male adults were collected over 14 consecutive days and analyzed for habitual sleep duration. The total sleep time periodicity was modeled using the cosinor method for each individual across the 14 days. The findings confirm the existence of periodicity in habitual sleep duration as there were clear periodic patterns in the majority of the participants. Although exclusive to each individual, the observed oscillations may be a resultant response of homeostatic sleep need, circadian timing, and/or social and environmental influences. These findings instigate further indepth studies into the periodicity of sleep duration in healthy individuals to provide a better understanding of sleep need in short versus long sleepers, in predicting work performance, and reducing sleepiness-related accidents following shift work, and how this periodicity may impact sleep treatment outcome in clinical populations.Keywords: sleep regulation, homeostasis, habitual sleep, spontaneous living, healthy males
Ridge Structure associated with the Near-Side Jet in the (Delta phi)-(Delta eta) Correlation
Wong, Cheuk-Yin
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevC.76.054908
Abstract: In the (Delta phi)-(Delta eta) correlation associated with a near-side jet observed by the STAR Collaboration in heavy-ion collisions at RHIC [Ref. 1-6], the ridge structure can be explained by the momentum kick model in which the ridge particles are identified as medium partons which suffer a collision with the jet and acquire a momentum kick along the jet direction. If this is indeed the correct mechanism, the ridge structure associated with the near-side jet may be used to probe the parton momentum distribution at the moment of the jet-parton collision, leading to the result that at that instant the parton temperature is slightly higher and the rapidity width substantially greater than corresponding quantities of their evolution product inclusive particles at the end point of the nucleus-nucleus collision.
Lectures on Landau Hydrodynamics
Wong, Cheuk-Yin
High Energy Physics - Phenomenology , 2008,
Abstract: Landau hydrodynamics is a plausible description for the evolution of the dense hot matter produced in high-energy heavy-ion collisions. We review the formulation of Landau hydrodynamics to pave the way for its application in high-energy heavy-ion collisions. It is found that Landau's rapidity distribution needs to be modified to provide a better quantitative description. In particular, the rapidity distribution in the center-of-mass system should be more appropriately given as dN/dy \exp{\sqrt{y_b^2-y^2}}, where y_b=\ln{\sqrt{s_NN}/m_p} is the beam nucleon rapidity, instead of Landau's original result of dN/dy({Landau}) \exp{\sqrt{L^2-y^2}} where L=\ln{\sqrt{s_NN}/2m_p}. The modified distribution is compared with the Landau distribution and experimental data. It is found that the modified distribution agrees better with experimental $dN/dy$ data than the Landau distribution and it differs only slightly from the Landau Gaussian distribution dN/dy(Landau-Gaussian) \exp{-y^2/2L}. Past successes of the Gaussian distribution in explaining experimental rapidity data arises, not because it is an approximation of the original Landau distribution, but because it is in fact a close representation of the modified distribution.
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