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Evaluations of antidepressant activity of Anacyclus pyrethrum root extract
Badhe S,Badhe R,Ghaisas M,Chopade V
International Journal of Green Pharmacy , 2010,
Abstract: The present study was designed to screen antidepressant activity of Anacyclus pyrethrum (AP) root extract. An experiment was designed by different method such as Locomotor activity, Haloperidol-induced catalepsy, Forced swim test (FST), Tail suspension test (TST), Clonidine-induced hypothermia and Reserpine-induced hypothermia on Swiss male albino mice. Standard root extract of Anacyclus pyrethrum (AP root extract) showed an increase in ambulatory behaviour indicating a stimulant effect of the photoactometer. AP root extract produces a significant antidepressant effect in both FST and TST as they reduced the immobility. AP root extract was found to be effective in reversing hypothermia produced by clonidine and reserpine. In our study, we found that AP root extract inhibited haloperidol-induced catalepsy. These study suggest that AP root extract might produce antidepressant effect by interaction with adrenergic and dopamine receptor thereby increasing the level of noradrenaline and dopamine in brains of mice.
Simultaneous Estimation of Metformin HCl and Gliclazide by Q- Analysis Method
Jyotsna R. Chopade,Sanjeev V. Deshpande,Sandesh Shah
International Journal For Pharmaceutical Research Scholars , 2013,
Abstract: Q- Analysis method for simultaneous estimation of Metformin HCl and Gliclazide in tablet dosage form have been developed. The method was simple, precise, accurate, reproducible and economical. Linearity was observed in the concentration range of 2-12 μg/ml for GLZ and 2-12 μg/ml for MET. The result of analysis have been validated as per ICH Guidelines.
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF PHENOBARBITONE AS BULK DRUG AND IN PHARMACEUTICAL FORMULATION
P.R. Mhatre*, S.H. Gatkal, V.V. Chopade and P.D. Chaudhari
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: A sensitive, selective, precise and stability indicating high performance thin layer chromatographic method of analysis of Phenobarbitone both as a bulk drug and in formulations was developed and validated in pharmaceutical dosage form. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of dichloromethane: ethyl acetate: glacial acetic acid (9.5:0.5:0.1 v/v/v/v). This system was found to give compact spots for Phenobarbitone (Rf value of 0.70). Phenobarbitone was subjected to acid and alkali hydrolysis, oxidation, photodegradation and dry heat treatment also the degraded products were well separated from the pure drug. Densitometric analysis of Phenobarbitone was carried out in the absorbance mode at 244 nm. The linear regression data for the calibration plots showed good linear relationship with r2=/0.998/ in the concentration range of 200-/600 ng/band. The method was validated for precision, accuracy, ruggedness and recovery. The limits of detection and quantitation were 5.82 and 14.60 ng per spot, respectively. The drug undergoes degradation under acidic, alkaline conditions, oxidation and dry heat treatment. Peaks of degraded product were resolved from the standard drug with significantly different Rf values. This indicates that the drug is susceptible to acid hydrolysis/alkaline hydrolysis, oxidation, dry heat degradation. Statistical analysis proves that the method is reproducible and selective for the estimation of the said drug. As the method could effectively separate the drug from its degradation products, it can be employed as a stability indicating one.
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING ASSAY METHOD OF MESALAMINE BY USING DIFFERENT STRESS DEGRADATION CONDITIONS
S. H. Gatkal*, P. R. Mhatre, V. V. Chopade and P. D. Chaudhari
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of mesalamine in bulk and tablet dosage form. Solution of mesalamine in distilled water shows maximum absorbance at 330 nm. Beer’s law was obeyed in the concentration range of 2-16 μg/ml with the slope, intercept, correlation coefficient, detection and quantitation limits were also calculated. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablets dosage forms. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of mesalamine in bulk and solid dosage form. The method was then validated for different parameters as per the ICH (International Conference for Harmonization) guidelines. Mesalamine was subjected to stress degradation under different conditions recommended by ICH. The samples generated were used for degradation studies using the developed method.
Validated Analytical Methods For Determination Of Active Ingredients From Bulk Drugs And Pharmaceutical Dosage Forms
Mr. Vitthal V. Chopade,Mr. Sameer Lakade,Miss. Suvarna J. Kshirsagar,Prof.Satish A. Polshettiwar
Pharmaceutical Reviews , 2008,
Abstract: Method validation has received considerable attention in literature and from industrial committees and regulatory agencies.The International Conference on Harmonization (ICH) of technical requirements for the registration of pharmaceuticals for human use has developed a consensus text on the validation of analytical procedures. The document includes definition of different validation parameters. The United States Environmental Protection agency (US EPA), Resource Conservation and Recovery Act (RCRA). The American Association of Official Analytical Chemist (AOAC), United States Environmental Protection Agency (USP) and other scientific organizations provide methods that are validated through multi-laboratory studies1. The United States Food and Drug Administration (US FDA) has proposed guidelines on submitting sample and analytical data for methods validation. The United States Pharmacopoeia (USP) has published specific guidelines for method validation and compound evaluation2. The objective of validation of analytical procedures is to demonstrate that it is suitable for its intended purpose. The discussion of the validation of analytical procedures is directed to the four most common types3
Hepato-Protective activity of the aqueous extract of launaea intybacea (Jacq) Beauv against carbon tetrachloride-induced hepatic injury in Albino Rats
Takate.S.B,Pokharkar.R.D,Chopade.V.V,Gite.V.N
Journal of Pharmaceutical Science and Technology , 2010,
Abstract: The present study was conducted to evaluate the hepato-protective activity of aqueous extract of aerial parts of launaea intybacea are evaluated in carbon tetrachloride -induced hepatic injury in albino rats. Silymarin (200mg/kg) was given as reference standard. The hepatic injury of CCl 4 and the hepatoprotective effect of aqueous extract of launaea intybacea were estimated their liver function tests. The aqueous extract of aerial parts of launaea intybacea have shown very significant hepatoprotection against carbon tetrachloride -induced hepatic injury in albino rats in reducing serum total bilirubin, SALP, SGPT , SGOT levels and liver homogenates LPO, SOD,CAT, GPX, GST and GSH levels.
Antibiotic Activity of Herbal Plants
M. S. Wani,Prof. (Dr). S. R. Parakh,Prof.Satish A. Polshettiwar,V.V.Chopade
Pharmaceutical Reviews , 2007,
Abstract: Long before mankind discovered the existence of microbes, the idea that certain plants had healing potential, indeed, that they contained what we would currently characterize as antimicrobial principles, was well accepted. Since antiquity, man has used plants to treat common infectious diseases and some of these traditional medicines are still included as part of the habitual treatment of various maladies. For example, the use of cranberry juice (Vaccinium macrocarpon) to treat urinary tract infections is reported in different manuals of phytotherapy, while species such as lemon balm (Melissa of cinalis), garlic (Allium sativum) and tea tree (Melaleuca alternifolia) are described as broad-spectrum antimicrobial agents. That being said, it has generally been the essential oils of these plants rather than their extracts that has been the greatest use in the treatment of infectious pathologies in the respiratory system, urinary tract, gastrointestinal and biliary systems, as well as on the skin. For example, the use of the essential oil (tea tree oil) is a common therapeutic tool to treat acne and other infectious troubles of the skin rather than their extracts.1 In the present work, we analyze the past, present and future of medicinal plants, both as potential antimicrobial crude drugs as well as a source for natural compounds that act as new anti-infection agents.
SPIHT: Highly Efficient Technique for Image Transmission and Coding
Chopade Nilkanth,Ghatol A
IETE Technical Review , 2008,
Abstract: Uncompressed multimedia data (graphics, audio and video) requires considerable storage and transmission bandwidth. A fundamental goal of data compression is to reduce the bit rate for transmission or storage while maintaining acceptable quality. Image coding and compression technique, converts an image that requires low memory storages space, smaller bandwidth for transmission, high PSNR with acceptable image quality. This paper presents wavelet based coding algorithm SPIHT to encode and compress an image data. The coding and decoding process is comparatively fast. The numerical results obtained using MATLAB shows that the output image has high value of PSNR with good compression ratio for low bit rate.
Review On Medication Errors
Mr.Vitthal V.Chopade,Miss. Suvarna J. Kshirsagar,Prof.A.N.Tankar
Pharmaceutical Reviews , 2008,
Abstract: The stability indicating method can be defined as Validated Quantitative analytical method that can detect the change with time in the chemical, physical or microbiological properties of the drug substance and drug product, and that are specific so that the content of active ingredient, degradation can be accurately measured without interference. The ICH guideline indicates that stress testing is designed to determine the intrinsic stability of the molecule by establishing degradation pathway in order to identify the likely degradation products and to validate the stability indicating power of the analytical procedure used1. The International Conference on Harmonization (ICH) guidelines ‘stability testing of new drug substances and products’ Q1A requires that stress testing should be carried out to elucidate the substance. It suggests that the degradation product that are formed under the variety of condition should include the effect of temperature, humidity where appropriate oxidation, photolysis and susceptibility to hydrolysis across a wide range of pH value2-6.
Effect Of Voltage Variation On MRR For Stainless Steel EN Series 58A (AISI 302B) In Electrochemical Machining: A Practical Approach
S. S. Uttarwar,I. K. Chopade
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
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