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Search Results: 1 - 10 of 11985 matches for " Choi Seung-Ho "
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Outcome after gastrectomy in gastric cancer patients with type 2 diabetes
Jong Won Kim,Jae-Ho Cheong,Woo Jin Hyung,Seung-Ho Choi
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i1.49
Abstract: AIM: To evaluate the prognosis of type II diabetes mellitus (T2DM) after gastrectomy and related factors in gastric cancer patients. METHODS: 403 gastric cancer patients with T2DM were studied, who underwent gastrectomy between May 2003 and September 2009. A review of medical records and telephone interviews was performed in this cross-sectional study. The factors included in the statistical analysis were as follows: gender, age, type of surgery, preoperative body mass index (BMI), current BMI, BMI reduction ratio, preoperative insulin or oral diabetic medicine requirement, follow-up duration, and current state of diabetes. Assessment of diabetes status after surgery was classified into four categories according to the change in hypoglycemic agents after surgery and present status of T2DM: resolution, improvement, same, and worse. RESULTS: The mean follow-up duration was 33.7 mo (± 20.6 mo), preoperative BMI was 24.7 kg/m2 (± 3.0 kg/m2), and BMI reduction ratio was 9.8% (± 8.6%). After surgery, T2DM was cured in 58 patients (15.1%) and was improved in 117 patients (30.4%). According to the type of surgery, the BMI reduction ratio was significantly higher in the total gastrectomy and Roux-en-Y reconstruction group [14.2% ± 9.2% vs 9.2% ± 7.7% (Billroth II group), P < 0.001] and significantly lower in the subtotal gastrectomy and Billroth I reconstruction group [7.6% ± 8.0%, 9.2% ± 7.7% (Billroth II group), P < 0.001]. The BMI reduction ratio, follow-up duration after surgery, type of surgery, extent of gastrectomy, and performance of duodenal bypass were significantly correlated to the course of T2DM (P < 0.05). The BMI reduction ratio was the most influential factor on T2DM status. In a subgroup analysis of patients with a BMI reduction ratio of 10% or less (n = 206), T2DM was cured in 15 (7.6%) patients and was improved in 57 (28.8%) patients after surgery, and only the duration of surgery was significantly correlated to T2DM status (P = 0.022). CONCLUSION: The course of T2DM was significantly correlated to the BMI reduction ratio but not to the type of surgery without a significant change in BMI.
Exploring the Utility of Partial Cytochrome c Oxidase Subunit 1 for DNA Barcoding of Gobies
Hyung-Bae Jeon,Seung-Ho Choi,Ho Young Suk
Animal Systematics, Evolution and Diversity , 2012, DOI: http://dx.doi.org/10.5635/ased.2012.28.4.269
Abstract: Gobiids are hyperdiverse compared with other teleost groups, with about 2,000 species occurring in marine, freshwater, and blackish habitats, and they show a remarkable variety of morphologies and ecology. Testing the effectiveness of DNA barcodes on species that have emerged as a result of radiation remains a major challenge in evolutionary biology. Here, we used the cytochrome c oxidase subunit 1 (COI) sequences from 144 species of gobies and related species to evaluate the performance of distance-based DNA barcoding and to conduct a phylogenetic analysis. The average intra-genus genetic distance was considerably higher than that obtained in previous studies. Additionally, the interspecific divergence at higher taxonomic levels was not significantly different from that at the intragenus level, suggesting that congeneric gobies possess substantial interspecific sequence divergence in their COI gene. However, levels of intragenus divergence varied greatly among genera, and we do not provide sufficient evidence for using COI for cryptic species delimitation. Significantly more nucleotide changes were observed at the third codon position than that at the first and the second codons, revealing that extensive variation in COI reflects synonymous changes and little protein level variation. Despite clear signatures in several genera, the COI sequences did resolve genealogical relationships in the phylogenetic analysis well. Our results support the validity of COI barcoding for gobiid species identification, but the utilization of more gene regions will assist to offer a more robust gobiid species phylogeny.
Prognostic value of expression of molecular markers in adenoid cystic cancer of the salivary glands compared with lymph node metastasis: a retrospective study
Lee Seok Ki,Kwon Min Su,Lee Yoon Se,Choi Seung-Ho
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-266
Abstract: Background Adenoid cystic cancer arising in the salivary glands has distinctive features such as perineural invasion, distant metastasis, and a variable prognosis. In salivary gland cancer, c-kit, EGFR, and VEGF are representative molecular markers that may predict remnant and recurrent tumors. In this study, the expression of c-kit, EGFR, and VEGF in adenoid cystic cancer was evaluated, and the relationships between the expression of these markers and the clinical findings were investigated. Methods The medical records of 48 patients who were treated for parotid adenoid cystic cancer from January 1990 to January 2006 were reviewed. The tumor location, size, histological subtypes, perineural invasion, the resected margin status, and lymph node metastasis were assessed. Immunohistochemical staining and semiquantitative analysis of c-kit, EGFR and VEGF were performed. The relationship between the expression of each marker and the clinicopathological factors were analyzed. Results Positive c-kit immunostaining was present in 45 patients (94%), with weak positivity (+1) in 23, moderate positivity (+2) in 19 and strong positivity (+3) in three. Positive EGFR immunostaining was observed in 27 (56%), with weak positivity (+1) in 19 and moderate positivity (+2) in eight with no strong positive staining. Positive VEGF immunostaining was present in 42 patients (88%) with weak positivity (+1) in 12, moderate positivity (+2) in 17, and strong positivity (+3) in 13. Only the expression of VEGF was significantly higher in parotid gland tumors than in any other gland (P = 0.032). Marginal involvement was associated with strong VEGF expression (P = 0.02). No marker was significantly correlated with recurrence or the survival rate. Lymph node status was related to the survival rate. Conclusions The expression of c-kit, EGRF, and VEGF had no predictive value for recurrence or the prognosis of adenoid cystic cancer. Only the lymph node status was related to the prognosis.
Multidirectional instability of the shoulder – current concept
Seung-Ho Kim
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology , 2009, DOI: 10.1186/1758-2555-1-12
Abstract: The multidirectional instability of the shoulder is a complex problem in terms of diagnosis and treatment. Distinct from multidirectional hyperlaxity, multidirectional instability has symptoms related with increased translations in more than one direction. Increased translation by the increased capsular ligamentous laxity is underlying pathology of the posterior and multidirectional instability. This increased capsular laxity can be in-borne or developmental and asymptomatic or minimally symptomatic initially. In this stage, attempted translation does not produce symptoms. Jerk and Kim tests reveal posterior clunk without shoulder pain [1,2].However, repetitive subluxation overloads the posteroinferior glenoid labrum by the excessive rim-loading of the humeral head. This excessive rim-loading eventually develops posteroinferior labral lesion varying from simple retroversion to incomplete detachment (Figure 1). In this stage, patient's symptom which is shoulder pain, originates from the labral lesion when the humeral head glides over the pathologic labrum. The compressive force on the torn labrum in the jerk and Kim tests generates shoulder pain. Therefore, intact labrum does not produce shoulder pain no matter how lax the glenohumeral joint is. Increased translation alone produces asymptomatic posterior clunk until the repetitive rim-loading eventually develops posteroinferior labral lesion [3].Four type of the labral lesion have been reported. The Kim lesion is a concealed and incomplete tear of the posteroinferior labrum which is characterized by loss of labral height and retroversion, marginal crack, and loose inside. The lesion is similar to the intratendinous tear of the rotator cuff in that it is not evident in the initial observation. The surgeon should be aware of the lesion and palpate with probe (Figure 2).The retroversion of the glenoid labrum decrease the containment function of the glenohumeral joint which further decrease the shoulder's stability (Figu
Development of an Electrogenerated Chemiluminescence Biosensor using Carboxylic acid-functionalized MWCNT and Au Nanoparticles
Ming-Hua Piao,Dae-Soo Yang,Kuk-Ro Yoon,Seung-Ho Lee,Seong-Ho Choi
Sensors , 2009, DOI: 10.3390/s90301662
Abstract: A COOH-F-MWCNT-Nafion-Ru(bpy)32+-Au-ADH electrogenerated chemi-luminescence (ECL)electrode using COOH-functionalized MWCNT (COOH-F-MWCNT) and Au nanoparticles synthesized by the radiation method was fabricated for ethanol sensing. A higher sensing efficiency for ethanol for the ECL biosensor prepared by PAAc-g-MWCNT was measured compared to that of the ECL biosensor prepared by PMAc-g-MWCNT, and purified MWCNT. Experimental parameters affecting ethanol detection were also examined in terms of pH and the content of PAAc-g-MWCNT in Nafion. Little interference of other compounds was observed for the assay of ethanol. Results suggest this ECL biosensor could be applied for ethanol detection in real samples.
The Biological Safety of Stainless Steel Needles Used in Warm-Needling
Sabina Lim,Seunghun Lee,Seung-Ho Yi,Yang-Sun Son,Sung-min Choi,Young-Kon Kim
Evidence-Based Complementary and Alternative Medicine , 2010, DOI: 10.1093/ecam/nen066
Abstract: Warm-needling (also called thermo-acupuncture) is a combination of acupuncture and moxibustion. Due to the intense heat involved, there have been concerns over the biological safety of the acuneedles used in the treatment. This paper reports two phases of a safety test. For a preliminary test, we compared the temperature change patterns of stainless steel (SS304) needles and traditional gold alloy needles, which have been increasingly replaced by the former. To verify the effects of the presence of coating materials, the main test involved three different kinds of SS304: silicone-coated, salicylic acid-coated and non-coated needles. Each group of needles was tested for pH level, heavy metals and UV absorbance spectrum along with biological tests on the cytotoxicity and hemolysis of the needle. All the tests on the extractants from the needles were negative. In the biological tests, each test result showed a significant difference from the positive control samples, while no significant difference was observed compared with the negative control samples. In the hemolysis tests, all samples satisfied the Korean Government Standards. All the results suggest that SS304 needles are biologically safe to be used in warm-needling, though they can be improved to perform as well as the gold alloy needles in terms of temperature fluctuations.
Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers
You-Kyung Jeon, Sung-Hee Kim, Seung-Ho Choi, Kyung-Hee Kim, Byong-Chul Yoo, Ja-Lok Ku, Jae-Gahb Park
World Journal of Gastroenterology , 2010,
Abstract: AIM: To understand CD133 promoter hypermethylation and expression in 32 colorectal cancer cell lines.METHODS: Nucleic acid was isolated from 32 colorectal cancer cell lines and CD133 expression levels were measured by reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR. Promoter methylation status of the CD133 gene was analyzed with a methylation-specific PCR after sodium-bisulfite modification and by clonal sequencing analysis. The correlation between expression and promoter methylation of CD133 gene was confirmed with treatment of 5-aza-2’-deoxycytidine.RESULTS: We measured CD133 expression levels in 32 colorectal cancer cell lines. RT-PCR analysis showed undetectable or low levels of CD133 expression in 34.4% of cell lines. To verify the relation between CD133 expression and methylation status of the CD133 gene promoter in colorectal carcinogenesis, CD133 gene promoter hypermethylation was analyzed in 32 cancer cell lines. Promoter hypermethylation was detected in 13 (40.6%) of the cell lines using methylation specific-PCR and confirmed by bisulfite sequencing analysis. Treatment of 11 of the cell lines with the demethylation agent 5-aza-2’-deoxycytidine recovered CD133 expression in most of them.CONCLUSION: Transcriptional repression of CD133 is caused by promoter hypermethylation of the CD133 CpG islands in some of colorectal cancer cell lines. The study may contribute to the understanding of the role of CD133 inactivation in the progression of colorectal cancers.
Geodesic Motions in 2+1 Dimensional Charged Black Holes
Dong Hyun Park,Seung-ho Yang
Physics , 1999, DOI: 10.1023/A:1026733026282
Abstract: We study the geodesic motions of a test particle around 2+1 dimensional charged black holes. We obtain a class of exact geodesic motions for the massless test particle when the ratio of its energy and angular momentum is given by square root of cosmological constant. The other geodesic motions for both massless and massive test particles are analyzed by use of numerical method.
Turning refuse plastic into multi-walled carbon nanotube forest
Eugene Oh, Jaegeun Lee, Seung-Ho Jung, Seungho Cho, Hye-Jin Kim, Sung-Hyun Lee, Kun-Hong Lee, Kyong-Hwa Song, Chi-Hoon Choi and Do Suck Han
Science and Technology of Advanced Materials , 2012,
Abstract: A novel and effective method was devised for synthesizing a vertically aligned carbon nanotube (CNT) forest on a substrate using waste plastic obtained from commercially available water bottles. The advantages of the proposed method are the speed of processing and the use of waste as a raw material. A mechanism for the CNT growth was also proposed. The growth rate of the CNT forest was ~2.5 μm min 1. Transmission electron microscopy images indicated that the outer diameters of the CNTs were 20–30 nm on average. The intensity ratio of the G and D Raman bands was 1.27 for the vertically aligned CNT forest. The Raman spectrum showed that the wall graphitization of the CNTs, synthesized via the proposed method was slightly higher than that of commercially available multi-walled carbon nanotubes (MWCNTs). We expect that the proposed method can be easily adapted to the disposal of other refuse materials and applied to MWCNT production industries.
Comparative Study of Various Preparation Methods of Colloidal Silica  [PDF]
Hyung Mi Lim, Jinho Lee, Jeong-Hwan Jeong, Seong-Geun Oh, Seung-Ho Lee
Engineering (ENG) , 2010, DOI: 10.4236/eng.2010.212126
Abstract: Colloidal silica can be prepared by various methods and starting materials including ion exchange of aqueous silicates, hydrolysis and condensation of silicon compounds, direct oxidation of silicon, and milling and peptization of silica powder. Various silica sols having particle sizes of 10-60 nm prepared by these methods and the preparation methods have been compared on the basis of their shape, size uniformity, sphericity, stability against pH variation, cation concentration, and price, etc. Silica sol prepared from tetraethoxysilane affords uniform size control and growth, and high purity, despite the relatively high costs. Silica sol prepared from liquid silicates affords relatively easy size and shape control; however, it is difficult to lower the alkali content to a level that is appropriate for carrying out semiconductor chemical mechanical polishing processes; in addition, the waste water treatment carried out for recovering the ion exchange resin gives rise environmental consideration. The properties of colloidal silica prepared from fumed silica powder by milling and dispersion depend on the starting silica source and it is relatively difficult to obtain monodispersed particles using this method. Colloidal silica prepared from silicon by direct oxidation has a monodispersed spherical shape and purity control with reasonable prices. It generates less waste water because it can be directly produced in relatively high concentrations. The cation fraction located in the particle relative to the free cation in the fluid is relatively lower in the silica sol prepared by the direct oxidation than others. A careful comparison of colloidal silica and the preparation methods may help in choosing the proper colloidal silica that is the most appropriate for the application being considered.
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