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Search Results: 1 - 10 of 119948 matches for " Chiou-Miin Wang "
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A new member of the GM130 golgin subfamily is expressed in the optic lobe anlagen of the metamorphosing brain of Manduca sexta
Chiou-Miin Wang,Chun-Liang Chen,Hugh M. Robertson,Susan E. Fahrbach
Journal of Insect Science , 2003,
Abstract: During metamorphosis of the insect brain, the optic lobe anlagen generate the proliferation centers for the visual cortices. We show here that, in the moth Manduca sexta, an 80 kDa Golgi complex protein (Ms-golgin80) is abundantly expressed in the cytoplasm of neuroblasts and ganglion mother cells in the optic lobe anlagen and proliferation centers. The predicted amino acid sequence for Ms-golgin80 is similar to that of several members of the GM130 subfamily of Golgi-associated proteins, including rat GM130 and human golgin-95. Homologs of Ms-golgin80 from Drosophila melanogaster, Caenorhabditis elegans, and Brugia malayi were identified through homology sequence search. Sequence similarities are present in three regions: the N-terminus, an internal domain of 89 amino acids, and another domain of 89 amino acids near the C-terminus. Structural similarities further suggest that these molecules play the same cellular role as GM130. GM130 is involved in the docking and fusion of coatomer (COP I) coated vesicles to the Golgi membranes; it also regulates the fragmentation and subsequent reassembly of the Golgi complex during mitosis. Abundant expression of Ms-golgin80 in neuroblasts and ganglion mother cells and its reduced expression in the neuronal progeny of these cells suggest that this protein may be involved in the maintenance of the proliferative state.
Avatar-Based Commerce: The Business World of the Future?
Chiou-Pirng Wang
Communications of the IBIMA , 2008,
Abstract: In order to keep up with fierce competition in the forever distributed, global and virtual business world, big name companies like IBM, Toyota, etc. have ventured into exploiting the potential of Massively Multiplayer Online Role-playing Games (MMORPG) technology, via Second Life, to reinvent themselves. Investigating existing business models in Second Life, a virtual world, to see whether the avatar-based commerce is a hype or a real potential. In this preliminary study, based on the tool, Internet Business Graph Analysis Models (IBGAM) developed by the author in 2003, the analysis of the business models of 14 avatar-based business unveiled that the avatar-based commerce, though growing rapidly, it may not be roaring like the Internet businesses in the 1990’s due to a fundamental structural constraint in running avatar-based business, as they have to run with the restricted tools, services, and rules provided by the owners of virtual worlds. These restrictions are a major deviation from the Internet, which has no owner. The author also found that indirect business models such as brokerage, e-auction, etc. are hard to be found in the virtual worlds. Consequently, direct exchange business models will most likely flourish in virtual worlds and avatar-based business may face some constraints.
MicroRNA-22E Inhibits HER-3 Protein Expression to Facilitate Metastasis of Lung Adenocarcinomas  [PDF]
Hsin-Yuan Fang, Tze-Yi Lin, Shiow-Her Chiou, Liang-Shun Wang, Kuan-Chih Chow
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64039

MicroRNA-22 (miR-22), a short non-coding RNA that post-transcriptionally regulates mRNA stability and protein synthesis, has been shown to enhance metastatic potential and to suppress HER-3, an important mRNA marker for non-small cell lung cancer (NSCLC). However, the effect of miR-22 has not been investigated in lung adenocarcinoma (LADC), the most common type of NSCLC in the Far East. In this study, we analyzed the role of miR-22 expression in LADC patients. Expression of miR-22 was detected by reverse-transcription polymerase chain reaction (RT-PCR), and confirmed by cDNA sequencing. Signals of miR-22 in LADC sections were identified using in situ hybridization (ISH). The association between miR-22 expression and survival was evaluated by the log-rank test. Induction of miR-22 expression and the effect on HER-3 levels, as well as the subsequent cell behavior were also investigated In vitro. Two types of miR-22: miR-22 and miR-22H, were detected by RT-PCR. The miR-22H had extra 13 bases, 5’-TGTGTTCAGTGGT-3’, at the 3’-end, and this segment was named miR-22E. Using ISH, miR-22E overexpression was detected in 225 (83.0%) of 271 LADC patients. A significant difference was found in cumulative survival between patients with high miR-22E levels and those with low miR-22E levels (p < 0.0001). In vitro, epidermal growth factor induced miR-22, but reduced HER-3 expression. Expression of miR-22 increased cell movement ability. In conclusion, expression of miR-22 is closely associated with tumor recurrence, metastasis and overall survival in LADC patients by suppressing HER-3 protein expression to enhance epithelial-mesenchymal transition and metastasis.

Polynomial Method for PLL Controller Optimization
Ta-Chung Wang,Sanjay Lall,Tsung-Yu Chiou
Sensors , 2011, DOI: 10.3390/s110706575
Abstract: The Phase-Locked Loop (PLL) is a key component of modern electronic communication and control systems. PLL is designed to extract signals from transmission channels. It plays an important role in systems where it is required to estimate the phase of a received signal, such as carrier tracking from global positioning system satellites. In order to robustly provide centimeter-level accuracy, it is crucial for the PLL to estimate the instantaneous phase of an incoming signal which is usually buried in random noise or some type of interference. This paper presents an approach that utilizes the recent development in the semi-definite programming and sum-of-squares field. A Lyapunov function will be searched as the certificate of the pull-in range of the PLL system. Moreover, a polynomial design procedure is proposed to further refine the controller parameters for system response away from the equilibrium point. Several simulation results as well as an experiment result are provided to show the effectiveness of this approach.
On Delay Independent Stabilization Analysis for a Class of Switched Large-Scale Time-Delay Systems
Chi-Jo Wang,Juing-Shian Chiou
Abstract and Applied Analysis , 2013, DOI: 10.1155/2013/849578
Abstract: In view of the state-driven switching method, the sufficient stability conditions with delay independence will be derived for the switched large-scale time-delay systems. A new stability criterion of switched large-scale time-delay systems is deduced by Lyapunov stability theorem. The method can be applied to cases when all individual switched systems are unstable. Finally, one example is exploited to illustrate the proposed schemes. 1. Introduction Switched systems form an important class of hybrid systems. Such systems can be described by a family of continuous-time subsystems (or discrete-time subsystems) and a rule that orchestrates the switching among them. It is well known that a wide class of physical systems in power systems, chemical procedure control systems, navigation systems, automobile speed change systems, and so forth may be appropriately described by the switched model [1–10]. In the study of switched systems, most works have been centered on the problem of stability. In the last two decades, there have been increasing interests in the stability analysis for such switched systems; see, for example, [11] and the references cited therein. Two important methods are used to construct the switching law for the stability analysis of the switched systems. One is the state-driven switching strategy; the other is the time-driven switching strategy. The time-driven switching method is formed based on the main concept of a dwell time. If at least one stable subsystem exits, then the switched system is stable with a proper dwell time switching law. However, in reality, it is not unusual to encounter cases in which all subsystems are unstable. Therefore, [6] proposed that all subsystem can be unstable for time-driven switching method. We would have to turn to the state-driven switching strategy, from which many choices of switching laws ensuring stability exist, even if all the subsystems are unstable. Reference [5] proposed quadratic stabilizability via state feedback for both continuous-time and discrete-time switched linear systems that are composed of polytopic uncertain subsystems. For continuous-time switched linear systems, if there exists a common positive definite matrix for stability of all convex combinations of the extreme points which belong to different subsystem matrices, then the switched system is quadratically stabilizable via state feedback. The switching rules can be obtained by using the obtained common positive definite matrix. Furthermore, the time-delay phenomenon is also unavoidable in practical systems, for instance,
Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
Chi-Yun Wang,Chiou-Feng Lin
Disease Markers , 2014, DOI: 10.1155/2014/308976
Abstract: Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management. 1. Introduction Annexin A2 (also called p36, annexin II, ANXA2, calpactin I, lipocortin II, chromobindin VIII, or placental anticoagulant protein IV), a 36?kDa protein [1], is located on chromosome 15q22.2 [2]. ANXA2 is expressed in some tumor cells, endothelial cells, macrophages, and mononuclear cells. ANXA2 contains three distinct functional regions: the N-terminal region, the C-terminal region, and the core region. The N-terminal region contains the tissue plasminogen activator (tPA)- [3] and S100/A10 (also called p11)-binding site [4]. The core region of ANXA2 contains the calcium and phospholipid-binding site [1, 5]. The C-terminal region contains the F-actin- [6], heparin- [7] and plasminogen-binding sites [8]. The core domain contains four repeats, and each repeat features five alpha-helices. In ANXA2, the core domain possesses two annexin-type calcium-binding sites with the sequence GxGT-[38 residues]-D/E [1, 5]. ANXA2 is activated in a calcium-dependent manner and undergoes a conformational change that exposes a hydrophobic amino acid to form a heterotetramer with p11. This complex shows a high affinity for phospholipids [9]. ANXA2 exists as a monomer or heterotetramer composed of two ANXA2 molecules and two p11 molecules and has four forms, including secrete, membrane-bound, cytoplasmic, and nuclear form. ANXA2 heterotetramer would translocate from the cytoplasm to the extracellular plasma membrane [10]. In general, ANXA2 expressed in the nucleus is cell-cycle-dependent. 2. Physiological Function of ANXA2 Intracellular ANXA2 has been reported to play roles in exocytosis [11], endocytosis [12, 13], and membrane trafficking [14]. Knockdown of ANXA2 inhibits cell division and proliferation [15]. Protein kinase C-dependent phosphorylation of ANXA2 blocks the ability of the protein to aggregate phospholipid vesicles but does not affect its lipid vesicle binding properties
Localization of the VP2 Protein of Canine Parvovirus Type 2 on the Baculovirus Envelop and Its Immunogenicity in a Mouse Model  [PDF]
Chih H. Tsai, Jing Y. Wang, Xin G. Xu, De W. Tong, Hsin Y. Lu, Yi H. Chen, Ming T. Chiou, Ching D. Chang, Hung J. Liu
Open Journal of Veterinary Medicine (OJVM) , 2012, DOI: 10.4236/ojvm.2012.24028
Abstract: In this study, the full-length VP2 gene of canine parvovirus type 2 (CPV-2) was cloned into the pBacSC vector which possesses baculovirus transmembrane domain (gp64 TM) gene, baculovirus cytoplasmic domain (gp64 CTD) gene, and green florescence protein (GFP) gene. Baculovirus gp64 TM and gp64 CTD in the pBacSC vector were designed to display heterologous proteins on the baculovirus envelope. After cloning the VP2 gene of CPV-2 into pBacSC vector, the recombinant plasmid pBacSC-VP2 was transformed into E. coli DH10Bac competent cells to form recombinant bacmid DNA. One recombinant baculovirus BacSC-VP2 that expresses the VP2 protein of CPV-2 was obtained. Confocal microscopy and immunogold electron microscopy were used to verify whether VP2 expressing on baculovirus envelope or cell membrane. Immunization of BALB/c mice with recombinant baculovirus BacSC-VP2, demonstrated that serum from the BacSC-VP2 treated models had higher levels of virus neutralization titers than the control groups. The results show that the recombinant baculovirus BacSC-VP2 can induce a strong immune response in a mouse model, suggesting that the pseudotyped baculovirus BacSC-VP2 can serve as a potential vaccine against CPV infections.
Steam Reforming of Ethanol over CoMg/SBA-15 Catalysts  [PDF]
Josh Y. Z. Chiou, Shih-Yi Yang, Chin-Liang Lai, Hsuan-Ying Kung, Chih-Wei Tang, Chen-Bin Wang
Modern Research in Catalysis (MRC) , 2013, DOI: 10.4236/mrc.2013.22A003

Hydrogen production through steam reforming of ethanol (SRE) over Mg modified Co-based catalysts supported on mesoporous SBA-15 was studied herein to evaluate the catalytic activity and the behavior of coke deposition. The CoyMgx/SBA-15 catalysts are obtained according to the steps of consecutive impregnation of Mg (x = 5 and 10 wt%) to be incorporated on SBA-15 and then follow the loading of Co (y = 10 and 20 wt%) using the incipient wetness impregnation method. The catalysts are characterized by using X-ray diffraction (XRD), temperature programmed reduction (TPR), transmission electron microscopy (TEM) and BET techniques. Also, the spent catalysts are further characterized by using XRD and TEM. The catalytic activity of the SRE is evaluated in a fixed-bed reactor under 22,000 h-1 GHSV and with an H2O/EtOH molar ratio of 13. All the CoyMgx/SBA-15 catalysts present a mesoporous structure, even after the SRE reaction. The optimum catalyst of Co20Mg5/SBA-15-H650 comes from the high loading of Co and high reduction temperature pretreatment, which show a high catalytic activity and stability at 550°C with a hydrogen yield (YH2) up to 5.78 and CO selectivity around 3.10%.

Side-scan sonar techniques for the characterization of physical properties of artificial benthic habitats
Tian, Wen-Miin;
Brazilian Journal of Oceanography , 2011, DOI: 10.1590/S1679-87592011000500010
Abstract: side-scan sonar observations conducted at mito artificial habitat site in the southwest coast off taiwan, documented the locations of both concrete cubic blocks (more than 10,000 units) and scrapped steel boats (39 units) deployed previously. based on their geographic locations, the concrete cubic artificial reefs could be grouped into 14 reef sets. about 30% of the reefs were deployed out of the promulgated site area. for the purpose of artificial habitat site identification and fishery resources management, a database structure was designed to accommodate types and positions of reefs, information of reef sets, bathymetric contours, textures of bottom sediments and geomorphological characteristics. the effectiveness of mito artificial habitat site was evaluated to be positive after the deployment of both concrete block reefs and steel boat reefs.
Side-scan sonar techniques for the characterization of physical properties of artificial benthic habitats
Wen-Miin Tian
Brazilian Journal of Oceanography , 2011,
Abstract: Side-scan sonar observations conducted at Mito artificial habitat site in the southwest coast off Taiwan, documented the locations of both concrete cubic blocks (more than 10,000 units) and scrapped steel boats (39 units) deployed previously. Based on their geographic locations, the concrete cubic artificial reefs could be grouped into 14 reef sets. About 30% of the reefs were deployed out of the promulgated site area. For the purpose of artificial habitat site identification and fishery resources management, a database structure was designed to accommodate types and positions of reefs, information of reef sets, bathymetric contours, textures of bottom sediments and geomorphological characteristics. The effectiveness of Mito artificial habitat site was evaluated to be positive after the deployment of both concrete block reefs and steel boat reefs. Observa es com sonar de varredura lateral ao largo de Mito na costa sudoeste de Taiwan, revelou a localiza o de mais de 10.000 blocos de concreto e 39 embarca es de ferro assentados previamente como recifes artificiais. Com base nas imagens obtidas, os cubos de concreto formam 14 grupos separados. Cerca de 30% das unidades de concreto foram assentadas fora das áreas previstas. Para a identificac o correta dos recifes artificiais e manejo adequado dos recursos pesqueiros, foi organizada uma base de dados com informa es sobre forma, materiais e posi o, e arranjo espacial das unidades recifais, bem como dados de batimetria, natureza do sedimento do fundo e geomorfologia. A eficiência dos recifes artificiais de Mito foi avaliada positivamente após o assentamento tanto das unidades de concreto quanto das embarca es de ferro.
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