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Search Results: 1 - 10 of 78256 matches for " Chinpan Chen "
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Effects of Single Nucleotide Polymorphisms on Human N-Acetyltransferase 2 Structure and Dynamics by Molecular Dynamics Simulation
M. Rajasekaran,Santhanam Abirami,Chinpan Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025801
Abstract: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations. Several polymorphisms of NAT2, including the single amino acid substitutions R64Q, I114T, D122N, L137F, Q145P, R197Q, and G286E, are classified as slow acetylators, whereas the wild-type NAT2 is classified as a fast acetylator. The slow acetylators are often associated with drug toxicity and efficacy as well as cancer susceptibility. The biological functions of these 7 mutations have previously been characterized, but the structural basis behind the reduced catalytic activity and reduced protein level is not clear.
An effective approach for generating a three-Cys2His2 zinc-finger-DNA complex model by docking
Chun-Chi Chou, M Rajasekaran, Chinpan Chen
BMC Bioinformatics , 2010, DOI: 10.1186/1471-2105-11-334
Abstract: The complex models we generated on the basis of two AIRs with a good geometric distribution in each domain are reasonable in terms of the number of models with wrap-around conformation, interface root mean square deviation, AIR energy and fraction native contacts. We derived the modeling approach for generating a three-Cys2His2 zinc-finger-DNA complex model according to the results of docking studies using the Zif268-DNA and other three crystal complex structures. Furthermore, the Sp1-DNA complex model was calculated with this approach, and the interactions between Sp1 and DNA are in good agreement with those previously reported.Our docking data demonstrate that two AIRs with a reasonable geometric distribution in each of the three-Cys2His2 zinc-finger domains are sufficient to generate an accurate complex model with protein wrapping around DNA. This approach is efficient for generating a zinc-finger protein-DNA complex model for unknown complex structures in which the protein wraps around DNA. We provide a flowchart showing the detailed procedures of this approach.Determining the structure of protein-DNA complexes and elucidating the details that govern their interaction is essential to better understand many biological processes. In many instances, limitations in crystallization and difficulties in obtaining the intermolecular nuclear Overhauser effects by NMR experiments are obstacles to determining the structure of protein-DNA complexes [1]. Homology modeling is an alternative approach to obtain a protein-DNA complex model. Programs such as TFmodeller can model the complex according to homologous complex structure [2]. The major limitation of this approach is that high conservation of interface residues between the target and template is required for generating a good homology complex model. The high conservation of interface residues may not be possible in many cases; for example, in the zinc finger protein family, the DNA recognition residues and the interacti
Research on the Incentive Mechanism of Hidilao Hotpot’s Employees Based on Grounded Theory  [PDF]
Chen Chen
Journal of Human Resource and Sustainability Studies (JHRSS) , 2018, DOI: 10.4236/jhrss.2018.61031
Abstract: The traditional classical incentive model only reveals the general rule of organizational incentive, and does not give specific operation rules. The matching between organizational incentives and employee needs is still black box, and it does not reveal its core operation mechanism from the perspective of mechanism. This paper took through the literature review, the Hidilao Hotpot company as a case study, through a variety of ways to collect data, the use of grounded theory to encode data analysis, and ultimately extracted 58 concepts, 26 sub-areas, 7 main areas, concluded that the Hidilao Hotpot Employee motivation formed the path, and ultimately extracted the micro-level employee motivation mechanism model. The research result of this article comes from the practice of the enterprise, which has enlightenment to the organizational incentive of the traditional catering industry and also provides a micro-research perspective and systematic mechanism research for the incentive field.
Digital Image Watermarking Based on Mixed Error Correcting Code  [PDF]
Yonghong Chen, Jiancong Chen
Journal of Information Security (JIS) , 2012, DOI: 10.4236/jis.2012.32018
Abstract: In this paper, we present a novel technique based on a mixed Error Correcting Code(ECC)-the convolutional code and the repetition code to enhance the robustness of the embedded watermark. Before embedding, the binary watermark is scanned to one-dimension sequence and later inputted into the (3, 1, 2) convolutional encoder and (3, 1) repetition encoder frame by frame, which will improve the error correcting capability of decoder. The output code sequence is scanned to some matrixes as the new watermark messages. The watermarking is selected in low frequency band of the Discrete Wavelet Transform (DWT) and therefore it can resist the destruction of image processing. Experimental results are presented to demonstrate that the robustness of a watermark with mixed ECC is much higher than the traditional one just with repetition coding while suffering JPEG lossy compression, salt and pepper noise and center cutting processing.
Operator Equation and Application of Variation Iterative Method  [PDF]
Ning Chen, Jiqian Chen
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.38127
Abstract: In this paper, we study some semi-closed 1-set-contractive operators A and investigate the boundary conditions under which the topological degrees of 1-set contractive fields, deg (I-A, Ω, p) are equal to 1. Correspondingly, we can obtain some new fixed point theorems for 1-set-contractive operators which extend and improve many famous theorems such as the Leray-Schauder theorem, and operator equation, etc. Lemma 2.1 generalizes the famous theorem. The calculation of topological degrees and index are important things, which combine the existence of solution of for integration and differential equation and or approximation by iteration technique. So, we apply the effective modification of He’s variation iteration method to solve some nonlinear and linear equations are proceed to examine some a class of integral-differential equations, to illustrate the effectiveness and convenience of this method.
Blow-Up and Attractor of Solution for Problems of Nonlinear Schrodinger Equations  [PDF]
Ning Chen, Jiqian Chen
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312263
Abstract: In this paper, the authors study the blow-up of solution for a class of nonlinear Schrodinger equation for some initial boundary problem. On the other hand, the authors give out some analyses and that new conclusion by Eigen-function method. In last section, the authors check the nonlinear parameter for light rule power by using of parameter method to get ground state and excite state correspond case, and discuss the global attractor of some fraction order case, and combine numerical test. To illustrate this physics meaning in dimension d = 1, 2 case. So, by numerable solution to give out these wave expression.
Some Approximation in Cone Metric Space and Variational Iterative Method  [PDF]
Ning Chen, Jiqian Chen
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312276
Abstract: In this paper, we give some new results of common fixed point theorems and coincidence point case for some iterative method. By using of variation iteration method and an effective modification of He’s variation iteration method discusses some integral and differential equations, we give out some new conclusion and more new examples.
Photoconductive Effect of Liquid and Utilization of Solar Energy  [PDF]
Ziwei Chen, Shihao Chen
Open Journal of Physical Chemistry (OJPC) , 2014, DOI: 10.4236/ojpc.2014.41003

Experiments described in this paper show that there is the photoconductive effect of liquid, i.e. when light shines into a sort of alkali, acid or salt solution, the conductivity of the solution will increase. The mechanism of the effect is explained as follows. When hydrated ions in the solution absorb photons with their high enough energies, they will decompose to naked ions and water-molecules. The naked ions can reach an anode or a cathode more easily and faster than the hydrated ions; It is possible that when a molecule in the solution absorbs a photon with its high enough energy, it will decompose to negative and positive ions. Based on the effect, a device producing hydrogen by the solar-energy had been devised.

The Shell Model of the Universe: A Universe Generated from Multiple Big Bangs  [PDF]
Tower Chen, Zeon Chen
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.77062
Abstract: The Current Standard Model of the Universe asserts that the universe is generated from a single Big Bang event followed by inflation. There is no center to this universe, hence, no preferential reference frame to describe the motions of celestial objects. We propose a new, Shell Model of the Universe, which contends that the universe is created from multiple, concentric big bangs. Accordingly, that origin presents itself as a unique, preferential reference frame, which furnishes the simplest description of the motions of galaxies in the cosmos. This is similar in manner to how planetary motion is more straightforwardly described via a sun-centered Solar System rather than an earth-centered one. The appeal of the Shell Model of the Universe lies in its simplistic ability to resolve the paradox of quasars, explain the variability in Hubble’s Constant, and solve the problematic accelerated expansion of the universe.
The Mode Research of China’s Urban Land Assets Securitization  [PDF]
Lulu Chen, Danyu Chen
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.45001

Urban land purchasing and reserving system is an innovation in urban land usage in china, despite several financial problems with it. Land securitization is the best choice for carrying out the urban land reserve system. In the framework of urban land purchasing and reserving system, the urban land securitization was divided into two subunits, land real assets securitization and land credit assets securitization, according to whether the assets are entity or not. According to the types of securities, the former includes land bonds, investment funds and land trust plan three modes, while the latter includes balance-in mode, balance-out mode, quasi-off-balance-sheet mode and off-shore four modes. Discussion the aforementioned operation modes lead to suggestions for improving urban land securitization.

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