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Search Results: 1 - 10 of 1970 matches for " Chiara Salio "
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Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
Laura Lossi,Graziana Gambino,Chiara Salio,Adalberto Merighi
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.82
Linking Inflammation to Natural Killer T Cell Activation
Mariolina Salio,Vincenzo Cerundolo
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000226
Linking Inflammation to Natural Killer T Cell Activation
Mariolina Salio,Vincenzo Cerundolo
PLOS Biology , 2009, DOI: 10.1371/journal.pbio.1000226
Posizionamento di Y-stent autoespandibile in nitiol: case report
Salio M.,Barisione E.,Ferretti G.
Working Paper of Public Health , 2012,
Abstract: Maschio di 66 anni, ex impiegato, ex forte fumatore. In anamnesi ipertensione arteriosa e pregressi episodi di flutter atriale, l’ultimo nel 2008 trattato con ablazione.In data 21/04/2009 abbiamo eseguito broncoscopia flessibile per neoformazione ilare sinistra con adenopatie mediastiniche. L’esame evidenziava paralisi della corda vocale di sinistra e compressione estrinseca del III inferiore della trachea, la TBNA in 4L ha permesso di porre diagnosi di adenocarcinoma polmonare.Nei mesi successivi è stata somministrata una prima linea terapeutica con CHOP + docetaxel, sospesa dopo due cicli per mancata risposta, utilizzata una seconda linea con erlotinib, anche quest’ultimo sospeso per progressione di patologia.
Time Competition. The New Strategic Frontier  [PDF]
Chiara Demartini, Piero Mella
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.32020
Abstract: The acceleration of change necessitates strategies to control time, considered not only as a variable that influences the temporal evolution of phenomena but as one that directly influences phenomena itself. This study tries to present the logic of time compression and time to market, as well as the main instruments for the formulation of time-based strategies, not only by observing how the value of time is perceived as a contraction of production and distribution lead times but also by considering the choice of the most opportune moment to start a business and introduce (or withdraw) a new product. Starting from a discussion of time-based competition managerial approaches, this study develops a theoretical framework showing different time-based methodologies (JIT, MRP, OPT, FMS, PERT, HSM) that help management to adopt time-based strategies. It also puts forward a taxonomy of time-based strategies as well as a logical strategic path to time value.
Reducing seismic risk by understanding its cultural roots: Inference from an Italian case history  [PDF]
Francesco Stoppa, Chiara Berti
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.58A1010

The paper discusses how to approach the problem of the social mitigation of seismic risk, in order to reduce damage and grief consequent to earthquakes. An alert protocol, intended as a working hypothesis, is proposed based on the experience gained from analysis of the behaviour and social response to the threat before and after the great disaster of the L’Aquila earthquake on 6th April 2009. Authors propose a protocol addressing four levels of increasing alert based on signs of earthquake preparation and social concerns. In this sense, it works as an intensity scale and does not strictly relate to earthquake size (magnitude) or seismic hazard. The proposed alert protocol provides sensible measures for reducing vulnerability, which is the only factor that can be more or less efficiently controlled, based on structural and behavioural adjustments. Factors indicating the difficult relationship between politicians, scientific community and citizens are considered: 1) a serious gap between researchers and citizens; 2) measures adopted by local administrators and the National Civil Protection Service not agreed by the population; 3) misunderstanding originated from a lack of clarity of communication about scientific terminology; and 4) the lack of an alert procedure protocol. In the current situation, all these problems are crucial and contribute to the unpreparedness to face a seismic event, and thus greatly increase the risk. The adoption and implementation of an alert procedure protocol requires a preliminary assessment of the context and should be adapted to the local sensibility and culture. The application of a protocol may reduce the contrasts between preventive measures and individual responsibilities, making mitigation measures more feasible and socially acceptable. In this paper, risk evaluation is not strictly related to probabilistic or deterministic predictions. In fact, this is a result of a project that comes from the general analysis of risk and is not intended to give an alternative hazard estimate method. This paper proposes an alert protocol addressing four levels of increasing alert based on signs of earthquake generating preparation and social concerns. Finally, there is a suggestion on how to gradually communicate the threat and get citizens involved in the risk mitigation process.

Mental health literacy and the anxiety disorders  [PDF]
Adrian Furnham, Chiara Lousley
Health (Health) , 2013, DOI: 10.4236/health.2013.53A071

Context: This study set out to investigate the mental health literacy (MHL) about eight anxiety disorders (ADs), using vignette methodology. Methods: In all 317 British Adult participants completed a questionnaire with vignettes describing eight anxiety disorders including OCD, PTSD, Agoraphobia, Specific Phobias, Social Phobia, Separation Anxiety Disorder, GAD and Panic Disorder. Recognition, beliefs about treatments and perceived life adjustment (happiness, success at work) of specific people with these disorders were assessed. Results: Literacy levels varied across anxiety disorders, with high recognition of OCD (64.67%), but very poor for panic disorder (1.26%), GAD (2.84%) and separation anxiety disorder (5.99%). There were few significant effects of vignette gender on literacy levels. MHL for most anxiety disorders was relatively low; particularly panic disorder, GAD and separation anxiety disorder. Social Phobics were judged as least happy and adjusted and agoraphobics least successful at work and would benefit most from psychological help. Conclusions: Overall recognition of the anxiety disorders was poor. Beliefs about adjustment and treatment varied widely as a function of each disorder. Implications of the research for education of the public and limitations of this research are considered.

Verificación de los pronosticos del modelo BRAMS centrado en la region subtropical de Sudamerica BRAMS forecast verification over a region of subtropical Southamerica
Yanina García Skabar,Paola Salio,Matilde Nicolini
Revista Brasileira de Meteorologia , 2012, DOI: 10.1590/s0102-77862012000300004
Abstract: El objetivo del presente trabajo es realizar una verificación de los pronósticos generados en el Departamento de Ciencias de la Atmósfera y los Océanos de la Universidad de Buenos Aires con el modelo Brazilian Regional Atmospheric Modeling System(BRAMS). Utilizando dicho modelo, desde 2006, se realizan dos pronósticos al día por un plazo de 72 horas en dos retículas anidadas con una resolución horizontal de 80 y 20km. La retícula de mayor resolución abarca Paraguay, Uruguay, Sur de Brasil y Bolivia y el centro y norte de Argentina y Chile. En este trabajo se realiza la verificación sobre el dominio de mayor resolución para el período desde abril de 2006 a diciembre de 2008. El interés se centra en verificar los pronósticos de precipitación, y de los perfiles verticales de temperatura, humedad y viento en las localidades donde se dispone de datos de radiosondeos. La verificación de los pronósticos de precipitación se realiza mediante estadísticos calculados frente a las observaciones convencionales disponibles y frente a estimaciones de precipitación CMORPH. Los resultados son similares a los obtenidos en la región con modelos de aproximadamente la misma resolución. Además se identifican las deficiencias principales de los pronósticos lo que permitirá realizar ajustes en la configuración del mismo para mejorar su desempe o. The aim of this work is to verify the forecasts generated in the Department of Atmospheric Sciences and Ocean, University of Buenos Aires with the Brazilian model Regional Atmospheric Modeling System (BRAMS). Since year 2006, every day two different forecasts that extend for 72 hours have been performed using two nested grids with an horizontal resolution of 80 and 20 km. The higher resolution domain covers Paraguay, Uruguay, southern Brazil and Bolivia and the central and northern part of Argentina and Chile. This paper presents the results of the verification of the model in the higher resolution domain for the period April 2006 to December 2008. The focus is in the precipitation and vertical profiles of temperature and wind forecasts in the locations where soundings are available. Verification of precipitation forecast is based on statistics computed against observations and precipitation estimates from CMORPH. The results are close to those obtained in the region with models of similar resolution. It is also possible to identify the main forecast deficiencies, contributing to future adjustments in its configuration to improve the model performance.
Nevadas en el Sudeste Bonaerense: climatología sinóptica y un caso de estudio
Paola Salio,Claudia Campetella,Juan Ruiz,Yanina Garcia Skabar
Meteorologica , 2006,
Abstract: Este trabajo realiza una estadística de la frecuencia de las nevadas ocurridas sobre el sudeste de la provincia de Buenos Aires durante un período de 35 a os (1960-2004). Utilizando información de tiempo presente se detectaron 32 eventos de nevada, 7 de los cuales produjeron nieve en más de una estación sinóptica. A fin de comprender los patrones de circulación, se realiza una climatología sinóptica de las incursiones de aire frío que son responsables de nevadas en la región de estudio. Dichos patrones se caracterizan por anomalías extremas en las vaguadas asociadas a frentes fríos y en las cu as posfrontales que denotan la intensidad de dichos sistemas. El campo de anomalías de altura geopotencial muestra en los casos de nieve generalizada un mínimo sobre la vaguada frontal que duplica la intensidad de la obtenida en los casos de nieve aislada. El intenso régimen ciclónico favorece la convergencia en niveles bajos y el fuerte enfriamiento, evidente en las anomalías del campo térmico en niveles medios, indicando la inestabilidad generada en la masa de aire que es conducida hacia el norte sobre la costa patagónica y el Mar Argentino. En un caso particular de nevada generalizada, asociada a una fuerte incursión de aire frío ocurrida el 10 de julio de 2004 sobre el sudeste de la costa bonaerense, se analiza la situación sinóptica utilizando el modelo "Sistema de Modelado Atmosférico Regional" (RAMS) como herramienta de diagnóstico y se la relaciona con las muestras previamente encontradas, caracterizando la masa de aire polar y su evolución. La nevada se asocia a una inestabilización sostenida de la masa de aire, favorecida por calentamiento y humedecimiento en una trayectoria dominantemente marítima y por convergencia en un régimen ciclónico en niveles bajos. This paper presents a statistic of the frequency of snow-fall occurred over the southeast of Buenos Aires province over a 35 year period (1960-2004). Considering present weather information 32 events were found and only 7 events show snow over more than one synoptic station. A synoptic climatology of the cold air incursions that are responsible for snow-fall in the study region is shown in order to understand the circulation patterns. Atmospheric circulation patterns are characterized by extreme anomalies linked to the trough associated to cold front and the ridge in post-frontal areas that denote the intensity of these systems,. The anomalies field of geopotencial height shows a negative extreme over the frontal trough in the cases of generalized snow duplicate the intensity in cases with isolated s
Dieulafoy’s disease of the bronchus: a possible mistake
Barisione E.,Ravera S.,Ferretti G.,Salio M.
Working Paper of Public Health , 2012,
Abstract: We present a case of a 57 year old woman who suffered from massive hemoptysis; she was sent to us for a suspect neoformant lesion. We assumed it might be Dielafoy’s disease and proceeded with an imaging study that confirmed the diagnosis; after embolization, the patient no longer showed signs of bleeding. In brief, we concluded that whenever there is a suspect Dielafoy’s disease, the biopsy has to be avoided.
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