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Search Results: 1 - 10 of 1998 matches for " Chiara Angeletti "
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Short-Term Psychodynamic Psychotherapy in Patients with “Male Depression” Syndrome, Hopelessness, and Suicide Risk: A Pilot Study
Gloria Angeletti,Maurizio Pompili,Marco Innamorati,Chiara Santucci
Depression Research and Treatment , 2013, DOI: 10.1155/2013/408983
Hemodynamic Changes during Hepatic Vascular Exclusion: Use of Intraoperative Transesophageal Echocardiography a Case Series
Franco Marinangeli,Alessandra Ciccozzi,Chiara Angeletti,Cristiana Guetti
ISRN Anesthesiology , 2011, DOI: 10.5402/2011/278545
Tramadol Extended-Release for the Management of Pain due to Osteoarthritis
Chiara Angeletti,Cristiana Guetti,Antonella Paladini,Giustino Varrassi
ISRN Pain , 2013, DOI: 10.1155/2013/245346
Abstract: Current knowledge on pathogenesis of osteoarticular pain, as well as the consequent several, especially on the gastrointestinal, renal, and cardiovascular systems, side effects of NSAIDs, makes it difficult to perform an optimal management of this mixed typology of pain. This is especially observable in elderly patients, the most frequently affected by osteoarthritis (OA). Tramadol is an analgesic drug, the action of which has a twofold action. It has a weak affinity to mu opioid receptors and, at the same time, can result in inhibition of the reuptake of noradrenaline and serotonin in nociceptorial descending inhibitory control system. These two mechanisms, “opioidergic” and “nonopioidergic,” are the grounds for contrasting certain types of pain that are generally less responsive to opioids, such as neuropathic pain or mixed OA pain. The extended-release formulation of tramadol has good efficacy and tolerability and acts through a dosing schedule that allows a high level of patients compliance to therapies with a good recovery outcome for the patients' functional status. 1. Background Pain is the most common symptom of osteoarthritis (OA), and, as pain levels rise, patients experience a reduced range of motion with a consequent increase of disability [1]. Pain and function limitations substantially reduce the life quality of people affected by OA. The treatment planning for OA is designed to essentially provide pain relief, to prevent from complications such as muscle atrophy or joint deformities, and to maintain and/or improve the functional status with the final aim to produce a sensible life quality improvement [2]. The effectiveness of pain relief not only may result in a reduction of the intensity of pain itself but can also lead to an improvement of life aspects that are strictly related to pain. As has been widely documented, chronic persistent pain can sensibly reduce the health-related quality of life, causing reduced sleep, interference with social/family relationships [3], activity of daily living and productivity, and increased anxiety and depression [4]. There is, therefore, a general need for optimized pharmacologic treatment strategies in patients with chronic/persistent pain due to OA. A management strategy for such patients also should require individualized therapies that are able to ensure a positive risk/benefit profile. It should also provide analgesia outcomes covering an extended period of time. Tramadol is a centrally acting synthetic analgesic with two mechanisms of action. It involves weak -opioid receptors agonism and
GlideScope and Frova Introducer for Difficult Airway Management
Alessandra Ciccozzi,Chiara Angeletti,Cristiana Guetti,Roberta Papola,Paolo Matteo Angeletti,Antonella Paladini,Giustino Varrassi,Franco Marinangeli
Case Reports in Anesthesiology , 2013, DOI: 10.1155/2013/717928
Abstract: The introduction into clinical practice of new tools for intubation as videolaringoscopia has dramatically improved the success rate of intubation and the work of anesthesiologists in what is considered the most delicate maneuver. Nevertheless intubation difficulties may also be encountered with good anatomical visualization of glottic structures in videolaringoscopia. To overcome the obstacles that may occur both in a difficult provided intubation such as those unexpected, associated endotracheal introducer able to facilitate the passage of the endotracheal tube through the vocal cords into the trachea may be useful. We report 4 cases of difficult intubation planned and unplanned and completed successfully using the GlideScope videolaryngoscope associated with endotracheal Frova introducer. 1. Introduction Difficult airway management is a major task for anesthesiologists [1, 2]. Failure in airway management indeed, is a major cause of mortality and morbidity in the setting of anesthesiology and intensive care units [3, 4]. The GlideScope (GS) is a videolaryngoscope (VLS), the last generation of intubation devices available in clinical practice in the last decade. GS provides an indirect airway view, improves the assessment of Cormack-Lehane score, and does not require a specific training [5, 6]. Recent studies underline the advantages of VLS in the management of predicted difficult airway [7, 8] as well as prehospital emergencies [9]. Unfortunately, the direct laryngeal view provided by VLS does not always assure the correct insertion of endotracheal tube (ETT), due to the 60-degree angle in the distal portion of GS blade, that tends to hamper the passage of the ETT from oropharynx to trachea. To facilitate the placement of the ETT, a rigid stylet shaped with the same angle as the blade, the GlideRite stylet (GRs), has been made up. Recently, the most suitable characteristics of the introducer have been largely debated: gum elastic bougie, rigid stylet, malleable stylet, and several experiences have been published with different endotracheal introducer utilized in combination with VLS to facilitate intubation maneuver [10–14]. We report our clinical experience in 4 patients, three characterized by potential and one by unexpected difficult intubation, in whom videolaryngo-GlideScope (VLGS) combined with Frova bougie has been used to facilitate endotracheal intubation. 2. Case??1 A 61-year-old woman (BMI: 22.6?kg/m2) was urgently admitted to the anesthesiological evaluation before undergoing the intervention of spinal decompression of cervical C3–C6
Short-Term Psychodynamic Psychotherapy in Patients with “Male Depression” Syndrome, Hopelessness, and Suicide Risk: A Pilot Study
Gloria Angeletti,Maurizio Pompili,Marco Innamorati,Chiara Santucci,Valeria Savoja,Mark Goldblatt,Paolo Girardi
Depression Research and Treatment , 2013, DOI: 10.1155/2013/408983
Abstract: Objectives and Methods. This was an observational study of the efficacy of short-term psychodynamic psychotherapy (STPP) in a sample of 35 (30 women and 5 men) patients with moderate-to-severe “male depression” (Gotland Scale for Male Depression (GSMD)?≥?13) comorbid with unipolar mood disorder (dysthymia and major depression) or anxiety disorder. Outcome measures were GSMD and BHS (Beck Hopelessness Scale) score changes from baseline. Results. Patients had a strong response to STPP on the GSMD (estimated mean score change ; partial eta squared?? ), but not on the BHS (estimated mean score change ; partial eta squared ? ). BHS score changes were significantly associated with GSMD score changes (Pearson's ; ), even when controlling for the severity of hopelessness at the baseline (partial ; ). Conclusions. STPP proved to be effective in patients suffering from “male depression” although hopelessness was only marginally reduced by this treatment which points to the need to better understand how STPP can be involved in the reduction of suicide risk. 1. Introduction The term “depression” encompasses a wide range of conditions that may occur along a continuum, ranging from milder forms of discomfort to more severe and persistent form, as in the case of major depression. Depression is the leading cause of disability and the 4th leading contributor to the global burden of disease [1, 2] and by the year 2020, it is projected to become the 2nd leading contributor to the global burden of disease in all ages and both sexes [1]. Major depression is the most frequent mental illness in the world [3–6]. For example, in the US, the Epidemiological Catchment Area (ECA) Study indicated a one-month prevalence between 1.7% and 3.4% [7], and more recently, the National Comorbidity Survey Replication (NCS-R) estimated a 12-month prevalence of 6.6% [8]. Nevertheless, prevalence of moderate- to- severe depressive symptoms could be much higher [9–11]. In 2010, the British National Institute for Health and Clinical Excellence (NICE) commissioned the development of an updated version of the guideline on the treatment and management of depression in adults [12]. The NICE guideline pointed out that people who suffer from depression usually prefer psychological treatments to medication [13] and value outcomes beyond symptom reduction [14]. The NICE guideline indicated that it was not possible to demonstrate a consistent picture of any clinically important benefit for short-term psychodynamic psychotherapy (STPP) in depression. While cognitive-behavioral therapy and interpersonal
La nuova intesa con l’Unione Buddhista Italiana: una doppia conforme per il Sangha italiano
Silvia Angeletti
Stato, Chiese e Pluralismo Confessionale , 2011,
Abstract: SOMMARIO: 1. Nuovi accordi e aggiornamenti nel quadro delle intese - 2. Le novità in tema di obbligatorietà del servizio militare - 3. L’insegnamento religioso nella scuola pubblica - 4. Il diritto di istituire scuole e istituti di educazione - 5. L’interesse all’intesa, tra tempi della politica ed esigenze confessionali.
A Systemic Approach to the Compensation of Rain Attenuation in Ka-Band Communication Satellites
Piero Angeletti,Marco Lisi
International Journal of Microwave Science and Technology , 2012, DOI: 10.1155/2012/791635
Abstract: Rain attenuation at Ka-band is a severe phenomenon that drastically impairs satellite communications at these frequencies. Several adaptive compensation techniques have been elaborated to counteract its effects and most often applied one at a time. The present paper proposes the contemporary exploitation of different techniques in a combined approach. Such an integrated approach is thoroughly analyzed in a simplified scenario and will be shown to achieve a very effective solution, making the Ka-band spectrum fully available for broadband satellite applications and network-centric systems. 1. Introduction The advent of Ka-band (The frequency bands 17.7–21.2?GHz (space to Earth) and 27.5–31?GHz (Earth to space) have been allocated by the International Telecommunication Union (ITU) for the use of Fixed Satellite Services (FSS)) satellite communications is driven by the diffusion of consumer applications (such as High Definition Television broadcasting) and by the increased demand for broadband networks in network-centric systems. The network-centric architecture, originally conceived for military applications, is becoming a paradigm for large integrated systems, or “systems of systems”, able to collect and to convey data seamlessly throughout a number of different possible media and to deliver useful information after a data fusion process. Ka-band space segment and ground segment technologies, after a pioneering phase (Italsat [1, 2], ACTS [3]) and a successive consolidation, are now mature for cost-effective and reliable commercial missions. One the major drawbacks still affecting Ka-band satellite communications is that related to rain attenuation. Rain attenuation in satellite communication systems operating at Ka-band frequencies is much more severe than that usually experienced at lower frequency bands: rain attenuation at 20?GHz (Ka-band down-link), for instance, is almost three times that at 11?GHz (Ku-band down-link) [4, page 125]. This fact makes rain attenuation one of the most important limiting factors to be taken into account in the design of a 20/30?GHz satellite communication system. A number of mitigation techniques has been envisioned and experimented over the years, in the attempt to overcome the problem and to make Ka-band satellite applications as commercially viable as those at Ku band [5, Chapter 8]. One first classification of such techniques is between ground-based and space-based solutions. Ground-based techniques are those basically operated on ground (either in open- or closed-loop configurations) and only indirectly affecting
Diffusions conditioned on occupation measures
Florian Angeletti,Hugo Touchette
Physics , 2015,
Abstract: A Markov process fluctuating away from its typical behavior can be represented in the long-time limit by another Markov process, called the effective or driven process, having the same stationary states as the original process conditioned on the fluctuation observed. We construct here this driven process for diffusions spending an atypical fraction of their evolution in some region of state space, corresponding mathematically to stochastic differential equations conditioned on occupation measures. As an illustration, we consider the Langevin equation conditioned on staying for a fraction of time in different intervals of the real line, including the positive half-line which leads to a generalization of the Brownian meander problem. Other applications related to quasi-stationary distributions, metastable states, noisy chemical reactions, queues, and random walks are discussed.
Pain after earthquake
Chiara Angeletti, Cristiana Guetti, Roberta Papola, Emiliano Petrucci, Maria Laura Ursini, Alessandra Ciccozzi, Francesca Masi, Maria Rosaria Russo, Salvatore Squarcione, Antonella Paladini, Joseph Pergolizzi, Robert Taylor, Giustino Varrassi, Franco Marinangeli
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2012, DOI: 10.1186/1757-7241-20-43
Abstract: This observational retrospective study evaluated the prevalence and drug treatment of pain in the five weeks following the L'Aquila earthquake (April 6, 2009).958 triage documents were analysed for patients pain severity, pain type, and treatment efficacy.A third of pain patients reported pain with a prevalence of 34.6%. More than half of pain patients reported severe pain (58.8%). Analgesic agents were limited to available drugs: anti-inflammatory agents, paracetamol, and weak opioids. Reduction in verbal numerical pain scores within the first 24 hours after treatment was achieved with the medications at hand. Pain prevalence and characterization exhibited a biphasic pattern with acute pain syndromes owing to trauma occurring in the first 15 days after the earthquake; traumatic pain then decreased and re-surged at around week five, owing to rebuilding efforts. In the second through fourth week, reports of pain occurred mainly owing to relapses of chronic conditions.This study indicates that pain is prevalent during natural disasters, may exhibit a discernible pattern over the weeks following the event, and current drug treatments in this region may be adequate for emergency situations.
Viral trans-factor independent replication of human papillomavirus genomes
Daraporn Pittayakhajonwut, Peter C Angeletti
Virology Journal , 2010, DOI: 10.1186/1743-422x-7-123
Abstract: Here we report that multiple HPV16 mutants, lacking either or both E1 and E2 open reading frame (ORFs) and the long control region (LCR), still support extrachromosomal replication. Our data clearly indicate that HPV16 has a mode of replication, independent of viral trans-factors, E1 and E2, which is achieved by origin activity located outside of the LCR.Papillomaviruses (PVs) infect the basal layers of epithelial cells and maintain their genomes at constant, but relatively low-copy number in basal epithelial cells. These viruses replicate their genomes as nuclear plasmids in their natural mammalian host cells. Understanding of Human papillomavirus (HPV) replication has lagged behind that of other DNA viruses due to the need for development of efficient cell culture systems [1-3]. Most of our knowledge of HPV replication is derived from extensive studies of BPV1 in established rodent cell lines (C127), since BPV1 was found to transform and replicate episomally in these cells. Short-term replication assays were performed in transformed cells, in order to identify the cis- and trans-elements that were required for replication of PVs [4]. Using this approach, with BPV1, the early proteins E1 and E2 were found to be required for viral DNA replication [5-7]. These viral proteins interact with their cognate binding sites, located within the LCR, referred to as the origin of replication (ori). More detailed analyses have shown that the minimal BPV origin includes multiple E2BSs, an E1BS, and also an AT-rich region [8].Genetic analysis of HPV11 and 18 transient replication also suggested that both viral proteins E1 and E2, as well as the origin of replication containing one or more E2BS and putative E1BS and AT-rich region, were essential for HPV DNA replication [7,9-12]. Several experiments, including those performed by cell-free DNA replication, revealed that E1 had ATP-dependent helicase activity and recruits DNA polymerase α to the viral ori to initiate replication. Eff
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