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Search Results: 1 - 10 of 56582 matches for " Chiao-Min Lin "
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A Bibliometric Analysis on the Literature of Information Organization in Taiwan
Chiao-Min Lin
Journal of Library and Information Studies , 2009,
Abstract: The purpose of this study is to explore the characteristics of the literature on information organization in Taiwan. A total of 610 articles from 1882 to 2008 and 113 theses and dissertations from 1971 to 2008 were identified and analyzed. The growth of literature, research subjects, author productivity, the distribution of journals and organizations are addressed. The results of this study reveal that the journal articles in Taiwan had been up-growing except after 2003, but the theses and dissertations had been growing stably. The major research subject of journal articles is classification theory and descriptive cataloging, but the theses and dissertations are knowledge organization. The zone analysis from Bradford’s law is not applicable to journal productivity. Productivity is mainly focused on single author and toward coauthor. The Journal of Educational Media and Library Sciences is the major journal that publishes information organization articles. The National Taiwan University is the most productive schools of theses and dissertations, but various schools have their characteristics of research subjects. [Article content in Chinese]
台灣電子文件發展策略之分析研究 The Analysis and Study of the Development Strategies of Electronic Records in Taiwan
Li-Kuei Hsueh,Chiao-Min Lin
Journal of Educational Media & Library Sciences , 2006,
Abstract: 電子文件的發展已成為世界各國評估電子化政府的指標之一,各政府機關產生的公文書也逐漸由電子形式所取代,各先進國家多已針對電子文件的發展制訂未來數年之發展策略,做為規劃與發展之藍圖。本研究透過機關訪談及焦點座談方式,了解台灣政府機關電子文件管理之現況與問題,進而參酌國外經驗與國內機關需求,提出建立台灣電子文件管理策略的結論與相關建議。 The development of electronic records has been an indicator of modern government all over the world. The format of public records of government agencies has been gradually transformed to digital form. Most of progressive countries have the development strategies of electronic records as the guideline. In this paper, Interview and panel discussion are taken so as to understand the opinions of our government agencies. Conclusions and suggestions are proposed as the reference for Taiwan’s government.
The Development Strategies of Electronic Records: United States, Canada, United Kingdom and Australia as Examples
Li-Kuei Hsueh,Chiao-Min Lin
Journal of Library and Information Studies , 2004,
Abstract: The development of electronic records have been an indicator of modern government all over the world. The format of public records of government agencies have been gradually transformed to digitalform. How to manage the life cycle of electronic records have became an important issue. In this paper, the development strategies in electronic records of the United States, Canada, United Kingdom and Australia are taken as examples to explain their state-of-the-art. Several suggestions are proposed as the reference for Taiwan’s government. [Article content in Chinese]
The N-Terminal Amphipathic Helix of the Topological Specificity Factor MinE Is Associated with Shaping Membrane Curvature
Yu-Ling Shih, Kai-Fa Huang, Hsin-Mei Lai, Jiahn-Haur Liao, Chai-Siah Lee, Chiao-Min Chang, Huey-Ming Mak, Cheng-Wei Hsieh, Chu-Chi Lin
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021425
Abstract: Pole-to-pole oscillations of the Min proteins in Escherichia coli are required for the proper placement of the division septum. Direct interaction of MinE with the cell membrane is critical for the dynamic behavior of the Min system. In vitro, this MinE-membrane interaction led to membrane deformation; however, the underlying mechanism remained unclear. Here we report that MinE-induced membrane deformation involves the formation of an amphipathic helix of MinE2–9, which, together with the adjacent basic residues, function as membrane anchors. Biochemical evidence suggested that the membrane association induces formation of the helix, with the helical face, consisting of A2, L3, and F6, inserted into the membrane. Insertion of this helix into the cell membrane can influence local membrane curvature and lead to drastic changes in membrane topology. Accordingly, MinE showed characteristic features of protein-induced membrane tubulation and lipid clustering in in vitro reconstituted systems. In conclusion, MinE shares common protein signatures with a group of membrane trafficking proteins in eukaryotic cells. These MinE signatures appear to affect membrane curvature.
Quasi-Lumped Design of Bandpass Filter Using Combined CPW and Microstrip
Mingchih Chen;Yi-Chiao Lin;Min-Hua Ho
PIER Letters , 2009, DOI: 10.2528/PIERL09042201
Abstract: A bandpass filter (BPF) using CPW combined with microstrip is proposed. The target BPF is composed of two element filters built from combined CPW and microstrip structure. The design of element filter is based on the lumped elements approach with each circuit component built from a CPW or microstrip. In the circuit model, transmission zeros are created by the passband edges to enhance the signal selectivity. The element filter's characteristics are analyzed by the lumped L-C circuit model. Experiment is conducted, and a good agreement is observed between the measurement and simulation.
The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study
Tse-Min Lu, Shing-Jong Lin, Ming-Wei Lin, Chiao-Po Hsu, Ming-Yi Chung
Cardiovascular Diabetology , 2011, DOI: 10.1186/1475-2840-10-16
Abstract: From July 2006 to June 2009, we assessed the association between polymorphisms in DDAH1 and type 2 diabetes in 814 consecutive unrelated subjects, including 309 type 2 diabetic patients and 505 non-diabetic individuals. Six single nucleotide polymorphisms (SNPs) in DDAH1, rs233112, rs1498373, rs1498374, rs587843, rs1403956, and rs1241321 were analyzed. Plasma ADMA levels were determined by high performance liquid chromatography. Insulin sensitivity was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR).Among the 6 SNPs, only rs1241321 was significantly associated with a decreased risk of type 2 diabetes (AA vs GG+AG, OR = 0.64, 95% CI 0.47-0.86, p = 0.004). The association remained unchanged after adjustment for plasma ADMA level. The fasting plasma glucose and log HOMA-IR tended to be lower in subjects carrying the homozygous AA genotype of rs1241321 compared with the GG+AG genotypes. Over a median follow-up period of 28.2 months, there were 44 all-cause mortality and 50 major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal myocardial infarction and stroke). Compared with the GG and AG genotypes, the AA genotype of rs1241321 was associated with reduced risk of MACE (HR = 0.31, 95% CI: 0.11-0.90, p = 0.03) and all-cause mortality (HR = 0.18, 95% CI: 0.04-0.80, p = 0.02) only in subgroup with type 2 diabetes. One common haplotype (GGCAGC) was found to be significantly associated with a decreased risk of type 2 diabetes (OR = 0.67, 95% CI = 0.46-0.98, p = 0.04).Our results provide the first evidence that SNP rs1241321 in DDAH1 is associated with type 2 diabetes and its long-term outcome.Endothelial dysfunction is present from the onset of type 2 diabetes and strongly related to its outcomes [1], and itself may lead to the development of insulin resistance and diabetes [2,3]. Derangement of the L-arginine-nitric oxide (NO) pathway by asymmetric dimethylarginine (ADMA) has been implicated as an important contribut
Kinetics of T Helper Subsets and Associated Cytokines Correlate Well with the Clinical Activity of Graft-Versus-Host Disease
Su-Peng Yeh, Yu-Min Liao, Wen-Jyi Lo, Chiao-Lin Lin, Li-Yuan Bai, Chen-Yuan Lin, Ching-Yun Hsieh, Yu-Chien Chang, Yu-Ting Huang, Chang-Fang Chiu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044416
Abstract: Background CD4+interferon (IFN)-γ+ T cell (Th1) and CD4+interleukin (IL)-4+ T cell (Th2) polarizations are crucial in the pathogenesis of graft-versus-host disease (GVHD). However, this hypothesis is largely based on animal experiments of Parent-into-F1 GVHD model. The causal relationship between kinetics of Th1, Th2 and associated cytokines and the clinical activity of GVHD in a real world situation remains unknown. Methodology Peripheral blood was collected every week prospectively from Day 0 to Day 210 (patients without GVHD) or Day 300 (patients with chronic GVHD) after allogeneic peripheral blood stem cell transplantation in consecutive 27 patients. The frequencies of Th1 and Th2 within CD4+ T cells were determined by flow cytometry and pplasma IFN-γ, IL-12, IL-4, and IL-10 were determined by ELISA. Principal Findings Kinetics of Th1, Th2 frequency, and the plasma IL-10 and IFN-γ more commonly coincided with, rather than predicted, the activity of GVHD. These markers are significantly higher when acute or chronic GVHD developed. The kinetics of IL-10 is especially correlated well with the activity of GVHD during clinical course of immunosuppressive treatment. For patients with hepatic GVHD, there is a positive correlation between plasma IL-10 levels and the severity of hepatic injury. The frequency of Th2 is also significant higher in acute GVHD and tends to be higher in chronic GVHD. Interestingly, there is a very good positive correlation between the frequency of Th1 and Th2 (r = 0.951, p<0.001). The plasma level of IL-4 and IL-12 are not associated with the activity of GVHD. Conclusions The frequency of Th1, Th2 within CD4+ T cells and plasma IL-10 and IFN-γ are good biomarkers of GVHD. Plasma IL-10 can also be used to monitor the therapeutic responsiveness. Furthermore, both Th1 and Th2 likely contribute to the pathogenesis of GVHD.
Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway
Chih-Yu Peng,Hui-Wen Yang,Yin-Hung Chu,Yu-Chao Chang,Ming-Ju Hsieh,Ming-Yung Chou,Kun-Tu Yeh,Yueh-Min Lin,Shun-Fa Yang,Chiao-Wen Lin
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/732578
Abstract: Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities. However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated. In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells. Results showed that CAPE attenuated SCC-9 cell migration and invasion at noncytotoxic concentrations (0?μM to 40?μM). Western blot and gelatin zymography analysis findings further indicated that CAPE downregulated matrix metalloproteinase-2 (MMP-2) protein expression and inhibited its enzymatic activity. CAPE exerted its inhibitory effects on MMP-2 expression and activity by upregulating tissue inhibitor of metalloproteinase-2 (TIMP-2) and potently decreased migration by reducing focal adhesion kinase (FAK) phosphorylation and the activation of its downstream signaling molecules p38/MAPK and JNK. These data indicate that CAPE could potentially be used as a chemoagent to prevent oral cancer metastasis. 1. Introduction Oral cancer is associated with a high degree of local invasiveness and a high rate of metastasis to regional cervical lymph nodes. Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer and is characterized by poor prognosis and low survival rate [1]. Metastasis is the major cause of cancer death and involves multiple processes including the remodeling and degradation of the extracellular matrix (ECM) [2]. Various proteinases, such as the matrix metalloproteinases (MMPs), cathepsins, and plasminogen activator (PA), are involved in the interactions between cancer cells and the ECM [3, 4]. The MMPs function in the degradation of structural proteins in the ECM and regulate several cellular functions including growth, invasion, metastasis, and angiogenesis [5]. Among the various MMPs thought to be involved in human disease, investigators have intensively investigated the gelatinases (MMP-2 and MMP-9). Matrix metalloproteinase-2 and MMP-9 are the principal enzymes involved in the degradation of the major structural component of the basement membrane, type IV collagen [6, 7]. Several studies have shown that the gelatinases are overexpressed in several types of human cancer, such as breast [8], pancreas [9], prostate [10], lung [11], and oral [12] cancers. Previous studies have also identified significantly increased urine and plasma MMP-2 concentrations in cancer patients [13, 14], with MMP-2 and MMP-9 being considered as predictors of risk or
Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
Agnes L.-F. Chan,Wen-Shin Chang,Li-Min Chen,Chi-Ming Lee,Chiao-En Chen,Chun-Mao Lin,Jau-Lang Hwang
Molecules , 2009, DOI: 10.3390/molecules14041342
Abstract: Evodiamine (EVO), an alkaloidal compound isolated from Evodia rutaecarpa (Juss.), has been reported to affect many physiological functions. Topoisomerase inhibitors have been developed in a variety of clinical applications. In the present study, we report the topoisomerase I (TopI) inhibitory activity of EVO, which may have properties that lead to improved therapeutic benefits. EVO is able to inhibit supercoiled plasmid DNA relaxation catalyzed by TopI. Upon treatment 0~10 μM EVO TopI was depleted in MCF-7 breast cancer cells in a concentration-dependent and time-dependent manner in 0~120 min. A K-SDS precipitation assay was performed to measure the extent of Top I-trapped chromosomal DNA. The ability of EVO to cause the formation of a TopI-DNA complex increased in a concentration-dependent manner, in that the DNA trapped increased by 24.2% in cells treated with 30 μM. The results suggest that EVO inhibits TopI by stabilizing the enzyme and DNA covalent complex.
Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis
Chiao-Ming Lin, Pei-Yi Lin, Yu-Chiao Li, Jui-Chou Hsu
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-46
Abstract: Loss-of-function mutant clones were generated using the MARCM or EGUF system whereas overexpression clones were generated using the Flip-out system. Immunostaining were then performed in eye imaginal discs with clones. FRAP was performed in cultured eye discs.Here, we compared their loss-of-function phenotype at single-cell resolution, using a sheet of epithelial cells in the Drosophila eye imaginal disc as a model system. Surprisingly, we found that capt and ssh, but not tsr, mutant cells within and posterior to the morphogenetic furrow (MF) shared similar phenotypes. The capt/ssh mutant cells possessed: (1) hexagonal cell packing with discontinuous adherens junctions; and (2) largely complementary accumulation of excessive phosphorylated myosin light chain (p-MLC) and F-actin rings at the apical cortex. We further showed that the capt/ssh mutant phenotypes depended on the inactivation of protein kinase A (PKA) and activation of Rho.Although Capt, Ssh and Tsr were reported to negatively regulate actin polymerization, we found that Capt and Ssh, but not Tsr, share overlapping functions during eye morphogenesis.
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