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Search Results: 1 - 10 of 37642 matches for " Chi Chu Ming "
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Effect of Humidity on Thermal Comfort in the Humid Tropics  [PDF]
Harimi Djamila, Sivakumar Kumaresan, Chi-Ming Chu
Journal of Building Construction and Planning Research (JBCPR) , 2014, DOI: 10.4236/jbcpr.2014.22010
Abstract: This paper presents the main findings of the effect of indoor humidity on occupants’ thermal comfort in the humid tropics of Malaysia. An extensive field investigation was carried out in Kota Kinabalu city and the surrounding areas, located in East Malaysia. A total of 890 individuals were asked to complete a questionnaire. Measured indoor climates were also recorded. The survey was designed as cross sectional data collection. The present investigation found that the occupants were thermally comfortable at wide relative humidity range. The mean relative humidity corresponding to the optimum comfort temperature was close to 73%. Regression models failed to predict accurately the effect of relative humidity on occupants’ thermal perceptions. In addition, a quadratic regression model was developed for the prediction of the mean indoor relative humidity based on indoor temperature. The suggested regression model can be used for an approximate prediction of indoor relative humidity when required.
A Conceptual Review on Residential Thermal Comfort in the Humid Tropics
Djamila Harimi,Chi Chu Ming,Sivakumar Kumaresan
International Journal of Engineering Innovations and Research , 2012,
Abstract: In the era of increasingly expensive fuel and with the theoretical complication and the limitation of comfort prediction in naturally ventilated buildings based on thermal balance approach, researchers were motivated to go beyond heat balance approach to predict occupants’ thermal comfort using statistical approach known by adaptive models. The most established recognized model was developed mostly from the worldwide database recorded in office buildings. This poses validity problem when the model is applied for residential buildings. From a practical point of view using this model for the determination of neutral temperature in residences is likely to leads to errors in prediction which in turns are likely to have detrimental effect on occupants’ satisfaction, not to mention the potential effect in terms of energy consumption. This paper presents a conceptual review on indoor thermal comfort based on heat balance and adaptive models. The validity of international thermal comfort standards for residential buildings for neutral temperature prediction specifically in the hot-humid tropics is addressed. The need of database from field studies in residential buildings is emphasized.
Liquid Phase Adsorption of α-Tocopherol by Activated Carbon
Awang Bono,Chu Chi Ming,Murni Sundang
Journal of Applied Sciences , 2007,
Abstract: α-Tocopherol or commonly called vitamin E can be found in major commercial vegetable oils such as soya oil and palm oil. However the existence in these oil is in low concentration. The recovery of low concentration of α-tocopherol from palm oils is increasingly popular. Adsorption technique for the recovery of α-tocopherol from palm oil is believed to be much lower in cost and more effective. As a case study in this work, activated carbon is chosen as the adsorbent and ethanol as the solvent. The adsorption equilibria of α-tocopherol onto activated carbon was conducted in batch and the concentration of α-tocopherol was identified by LCMS. Langmuirian monolayer adsorption theory was used for the analysis of the isotherm equilibria. The adsorptivity of α-tocopherol onto activated carbon was identified. The adsorption equilibria at low concentration found to be linear. The breakthrough curve was then generated using model assuming isothermal, single transition trace component with intraparticle diffusion. Sensitivity test on the curve indicated that the system is very sensitive to changes in diffusitivity and passive to changes on the equilibrium constant.
Temperature Profile Data in the Zone of Flow Establishment above a Model Air-cooled Heat Exchanger with 0.56 m2 Face Area Operating under Natural Convection
Md. Mizanur Rahman,Sivakumar Kumaresan,Chu Chi Ming
Journal of Applied Sciences , 2010,
Abstract: The aim of this study was to analyze the temperature profile in the Zone of Flow Establishment (ZFE) above a 0.56 m2 hot screen placed at different height above an electrically heated model air-cooled heat exchanger operating under natural convection. Installation of screens increased the temperature difference from 30 to 140 K with respect to ambient that resulted in the air velocity increased at the inlet of the special duct from 0.67 m sec-1 to more than 2.0 m sec-1 under different heat loads ranging from 1 to 2.5 kW. The investigation of temperature profile was done above the hot screens placed at 0.35, 0.65, 0.95 and 1.25 m height over the electrically heated model air-cooled heat exchanger. The results show that the exit air temperature near to the electric heater and above the hot screens did not differ significantly but at heights of 0.09 m and upward the temperature difference differed by 2 to 6 K depending on the height of the hot screens. Maximum temperature difference was observed for hot screen placed at 0.65 and 0.95 m. Although, the temperatures at the beginning of the zone of flow establishment were almost the same for every heat load, the radial profile of temperature turned from parabolic in shape to uniformly flat for the configuration without screen and with screen respectively. This indicates turbulence increase above the hot screens.
Involvement of DNA-PKcs in the IL-6 and IL-12 Response to CpG-ODN Is Mediated by Its Interaction with TRAF6 in Dendritic Cells
Chi Ma, Marianna Muranyi, Catherine H. Chu, Jianhua Zhang, Wen-Ming Chu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058072
Abstract: CpG-ODN stimulates dendritic cells (DCs) to produce cytokines, which are important for pathogenesis of autoimmune disorders and vaccine strategy for cancer. CpG-ODN activates the TLR9/MyD88/TRAF6 cascade leading to activation of IKK-NF-κB and JNK, which are critical for production of pro-inflammatory cytokines. However, whether other molecules are involved in activation of CpG-ODN signaling is still not clear. Here we report that the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is involved in this activation process. DNA-PKcs-deficient DCs exhibited a defect in the IL-6 and IL-12 response to CpG-ODN in a dose- and time- dependent manner. Loss of DNA-PKcs impaired phosphorylation of IKK, IκBα, NF-κB and JNK in response to CpG-ODN. Interestingly, CpG-ODN was able to bind DNA-PKcs and induce its association and co-localization with TRAF6 in the absence of TLR9. Our data suggest that DNA-PKcs is a player in CpG-ODN signaling and may explain why DNA-PKcs is implicated in the pathogenic process of autoimmune disease.
Albumin fibrillization induces apoptosis via integrin/FAK/Akt pathway
Chun-Yung Huang, Chi-Ming Liang, Chiao-Li Chu, Shu-Mei Liang
BMC Biotechnology , 2009, DOI: 10.1186/1472-6750-9-2
Abstract: We induced BSA, a non-cytotoxic globular protein, to become fibril by a novel process involving Superdex-200 column chromatography in the presence of anionic or zwittergenic detergent(s). The column pore size was more important than column matrix composite in fibril formation. The fibrillar BSA induced apoptosis in BHK-21 cell as well as breast cancer cell line T47D. Pre-treating cells with anti-integrin antibodies blocked the apoptotic effect. Fibrillar BSA, but not globular BSA, bound to integrin, dephosphorylated focal adhesion kinase (FAK), Akt and glycogen synthase kinase-3β (GSK-3β).We report on a novel process for converting globular proteins into fibrillar form to cause apoptosis by modulating the integrin/FAK/Akt/GSK-3β/caspase-3 signaling pathway. Our findings may be useful for understanding the pathogenesis of amyloid-like fibrils and applicable for the development of better therapeutic agents that target the underlying mechanism(s) of the etiologic agents.After glycation [1], sonication [2], or incubation at high temperature [3-7], numerous proteins can be converted to amyloid-like fibrils with common properties such as more notable β-structure, fibrillar morphology, protofilament substructure, cross-β diffraction pattern, and binding to Congo red or amyloid-specific dye thioflavin T (ThT) [8-12]. The formation of amyloid fibrils can be promoted by the presence of ethanol [7,13], sodium dodecyl sulfate (SDS) [14-16], or other anionic detergents [17]. However, these methods generally require a high concentration of protein, vigorous shaking, or the addition of fibril seed and are not easy to isolate fibrillar protein from others such as oligomers, protofibrils or non-fibrillar proteins that may also exist in the solution [1,2,7,15,16,18,19].Amyloid fibrils are cytocytotoxic [20-23], however, it is still debatable as to whether oligomers, mature fibrils, protofibrils or target cellular types are the most critical factors in dictating cellular damage [24-27
A population-based cohort study of symptomatic gallstone disease in diabetic patients
Chi-Ming Liu,Chung-Te Hsu,Chung-Yi Li,Chu-Chieh Chen
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i14.1652
Abstract: AIM: To investigate the prevalence of gallstone disease (GSD) and to evaluate the risk of symptomatic GSD among diabetic patients. METHODS: The study was conducted by analyzing the National Health Research Institutes (NHRI) dataset of ambulatory care patients, inpatient claims, and the updated registry of beneficiaries from 2000 to 2008. A total of 615 532 diabetic patients without a prior history of hospital treatment or ambulatory care visits for symptomatic GSD were identified in the year 2000. Age- and gender-matched control individuals free from both GSD and diabetes from 1997 to 1999 were randomly selected from the NHIR database (n = 614 871). The incidence densities of symptomatic GSD were estimated according to the subjects’ diabetic status. The distributions of age, gender, occupation, income, and residential area urbanization were compared between diabetic patients and control subjects using Cox proportion hazards models. Differences between the rates of selected comorbidities were also assessed in the two groups. RESULTS: Overall, 60 734 diabetic patients and 48 116 control patients developed symptomatic GSD and underwent operations, resulting in cumulative operation rates of 9.87% and 7.83%, respectively. The age and gender distributions of both groups were similar, with a mean age of 60 years and a predominance of females. The diabetic group had a significantly higher prevalence of all comorbidities of interest. A higher incidence of symptomatic GSD was observed in females than in males in both groups. In the control group, females under the age of 64 had a significantly higher incidence of GSD than the corresponding males, but this difference was reduced with increasing age. The cumulative incidences of operations for symptomatic GSD in the diabetic and control groups were 13.06 and 9.52 cases per 1000 person-years, respectively. Diabetic men exhibited a higher incidence of operations for symptomatic GSD than did their counterparts in the control group (12.35 vs 8.75 cases per 1000 person-years). CONCLUSION: The association of diabetes with increased symptomatic GSD may provide insight to the treatment or management of diabetes in clinical settings.
Rheology and Gelling Behavior of Boehmite Sols
M.A. Islam,Chu Chi Ming,Pogaku Ravindra,Eng-Seng Chan
Journal of Applied Sciences , 2011,
Abstract: Rheological studies of boehmite sols based on pH was (1) to study the nature of flow properties of the boehmite sols and (2) to identify the sol-gel transition of boehmite sols with the change of pH of the liquid. It is evident that the shear rate and viscosity of the liquid exhibit a pseudoplastic (shear thinning) flow behavior for all pH level. The transformation of sol-gel at low pH probably due to the hydrogen bond between the layers of the boehmite structure. The temperature has an appreciable effect on the activation energy during the sol-gel transition. The flow activation energies ?E? are in the range of 1.75 to 6.25 J mol-1 at temperature 298-384 K. Based on these results, the flow activation energy of boehmite sols sharply decreases with decreasing the pH. The flocculation of the suspension at pH 4 to 1 showed to be favourable in term of enhanced density of boehmite.
Effects of Black Soybean on Atherogenic Prevention in Hypercholesterolemic Rabbits and on Adhesion Molecular Expression in Cultured HAECs  [PDF]
Pi-Yu Chao, Yuh-Lien Chen, Yi-Chu Lin, Ju-Ing Hsu, Kuan-Hung Lin, Yi-Fa Lu, Tien-Joung Yiu, Meng-Yuan Huang, Chi-Ming Yang
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.48A002

The aim of the study was to investigate the effect of black soybean (BS) on the susceptibility of low-density lipoprotein (LDL) in hypercholesterolemic New Zealand white rabbits. Effects of the BS extract (BSE) and its components on monocyte adhesion of human aortic endothelial cells (HAECs), and adhesion molecule were investigated. Rabbits were divided into four groups, including control, 0.5% cholesterol with 20% casein (either with or without 0.5% vitamin E), and BS groups, all fed for 8 weeks. LDL was treated with 10 μM Cu2+ in vitro to determine the LDL lag time, and the vitamin E content of LDL was determined. The thickness of the tunica intima was measured on paraffin sections of thoracic aortas and aortic arches stained with Movat’s pentachrome. HAECs were pretreated with 100 μg/ml of BSE, and 10 μM of genistein, daidzein, cyanidin, and aspirin for 18 h, followed by tumor necrosis factor (TNF)-α (2 ng/ml) for 6 h, after which U937 cell adhesion was determined. Adhesion molecule expression was examined using ELISAs. The LDL lag time in the BS group was similar to that in the vitamin E group, while its lag time was significantly longer than those in the control and casein groups. The ratio of the intimal area/medial area of the aortic arch of the casein group was significantly higher than those in the control, BS, and vitamin E groups. The vitamin E group had the lowest value, and was closest to the control group. The BS group exhibited a significantly decreased atheroma region in the aortic arch compared to the casein group. Pre-incubation with BSE, genistein, daidzein, cyanidin, and aspirin significantly decreased adhesion by U937 monocytic cells to TNF-α stimulated HAECs. Genistein, daidzein, cyanidin, and aspirin significantly suppressed the expression of vascular cell adhesion molecule (VCAM)-1. Only genistein and aspirin significantly decreased intracellular adhesion molecule (ICAM)-1 expression compared to TNF-α treatment, while no treatments had any effect on E-selectin expression. BS significantly prolonged the LDL lag time and decreased the atheroma region of the aortic arch in hypercholesterolemic rabbits, thereby exerting an antiatherosclerotic effect. Presumably, the BSE downregulate intracellular redox-dependent signaling pathways in HAECs upon TNF-

The Effects of Social Interaction and Psychological Bias on Trading Behavior: Evidence from a Laboratory Experiment  [PDF]
Chi Ming Ho
Journal of Mathematical Finance (JMF) , 2018, DOI: 10.4236/jmf.2018.81014
Abstract: This paper details an experiment designed to explore the trading behaviors of investors that result from psychological biases and social interactions. In total, 88 investors were tracked for 6 months and 40,795 transactions were recorded. The research conducted an experimental survey and estimated a system analysis model to generate several important conclusions. First, the degree of regret bias and the disposition effects are unrelated, probably because the professional training of investors and the disposition effects are not significantly related. Second, if investors are affected by contradictions arising from their decisions, then the likelihood that they will sell a stock will decrease as the investor relationships in the community improve and the regret bias increases. Third, male investors prefer to trade derivatives, and even after controlling for the degree of regret bias, this preference is still significant.
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