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Search Results: 1 - 10 of 3401 matches for " Cherry Lim "
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Using a Web-Based Application to Define the Accuracy of Diagnostic Tests When the Gold Standard Is Imperfect
Cherry Lim, Prapass Wannapinij, Lisa White, Nicholas P. J. Day, Ben S. Cooper, Sharon J. Peacock, Direk Limmathurotsakul
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079489
Abstract: Background Estimates of the sensitivity and specificity for new diagnostic tests based on evaluation against a known gold standard are imprecise when the accuracy of the gold standard is imperfect. Bayesian latent class models (LCMs) can be helpful under these circumstances, but the necessary analysis requires expertise in computational programming. Here, we describe open-access web-based applications that allow non-experts to apply Bayesian LCMs to their own data sets via a user-friendly interface. Methods/Principal Findings Applications for Bayesian LCMs were constructed on a web server using R and WinBUGS programs. The models provided (http://mice.tropmedres.ac) include two Bayesian LCMs: the two-tests in two-population model (Hui and Walter model) and the three-tests in one-population model (Walter and Irwig model). Both models are available with simplified and advanced interfaces. In the former, all settings for Bayesian statistics are fixed as defaults. Users input their data set into a table provided on the webpage. Disease prevalence and accuracy of diagnostic tests are then estimated using the Bayesian LCM, and provided on the web page within a few minutes. With the advanced interfaces, experienced researchers can modify all settings in the models as needed. These settings include correlation among diagnostic test results and prior distributions for all unknown parameters. The web pages provide worked examples with both models using the original data sets presented by Hui and Walter in 1980, and by Walter and Irwig in 1988. We also illustrate the utility of the advanced interface using the Walter and Irwig model on a data set from a recent melioidosis study. The results obtained from the web-based applications were comparable to those published previously. Conclusions The newly developed web-based applications are open-access and provide an important new resource for researchers worldwide to evaluate new diagnostic tests.
South Africa—Serious about Biodiversity Science
Michael Cherry
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0030145
Abstract:
Positron emission tomography and X-ray computed tomography: tools for mouse phenotyping?
SR Cherry
Breast Cancer Research , 2003, DOI: 10.1186/bcr671
Abstract:
Zur Parodie als Forschungsoption jenseits des Performativit ts-Metadiskurses Parody as a Performative Analytic: Beyond Performativity as Metadiscourse La parodia como analítica performativa: Mas allá de la performatividad como metadiscurso
Scott Cherry
Forum : Qualitative Social Research , 2008,
Abstract: Mittlerweile wird in verschiedenen Forschungsbereichen eine Wendung hin zum Konzept der Performativit t vollzogen, um zu verstehen, wie unterschiedliche Lebensweisen performativ hervorgebracht werden. Zugleich überrascht es, dass sich diese Wendung zu einem Verst ndnis einer performativ erzeugten Welt meist weiter auf Metadiskurse beschr nkt, die an ein positivistisches Wissenschaftsverst ndnis angelehnt bleiben. Diesem Vorgehen verpflichtete Untersuchungen lokalisieren das Performative als in der Welt existierendes Ph nomen, das dieser Welt vorg ngig ist und zugleich durch diese verfügbar wird. Solche Metadiskurs-Praktiken sind in ihrem Kern Strategien der Autorisierung der (Vor-) Existenz einer performativen Welt und bringen dann auch spezifische Grenzen hervor, innerhalb derer Performativit t fassbar werden soll. Auf diese Weise erscheint das Performative jedoch selbst als quasi naturalisiertes Objekt. Im Unterschied hierzu versuche ich zu zeigen, dass ein tats chlicher "performativer Turn" nur gelingen kann, wenn die eigenen (Forschungs- und Pr sentations-) Praktiken in einer Weise reorganisiert werden, dass sie kompatibel zur performativen Verfasstheit der Alltagswelt sind. Hierzu skizziere ich zun chst, wie das Konzept der "Performativit t" in der zeitgen ssischen Diskussion verwandt wird. Anschlie end stelle ich die "Parodie" als besondere, reflexive Variante von Perfomativit t vor, die Forschung im Zuge der Performanz erm glicht. URN: urn:nbn:de:0114-fqs0802258 Various domains of inquiry have engaged a shift to the concept of performativity as an organising principle for how forms of life are performatively brought into being. What appears surprising is that this move towards a performatively emergent world is displayed insensitively through metadiscourse practices inherited from positivist science. Performative inquiry locates "the performative" as a domain of phenomena "out-there" in the world, preceding it but only made available by it. This mode of metadiscourse practice is a strategy to authorise the prior existence of a performative world, which then sets specific boundaries within which "the performative" can be known. This approach to inquiry does not so much exemplify a performative world in its own performance of it, as describe it, offer accounts about it and remarks on it. Here, the domain of the performative becomes another naturalised object. This article proposes that, if this performative turn wishes to take seriously and engage a performative world, then it must reconfigure its own modes and forms of practice such that they too a
A field guide or a handbook?
Michael Cherry
South African Journal of Science , 2011, DOI: 10.4102/sajs.v107i11/12.964
Abstract:
Education and training need the involvement of all levels of government
Michael Cherry
South African Journal of Science , 2011, DOI: 10.4102/sajs.v107i7/8.850
Abstract:
Square Kilometre Array decision bodes well for South Africa
Michael Cherry
South African Journal of Science , 2012,
Abstract:
How should university research be funded?
Michael Cherry
South African Journal of Science , 2012,
Abstract:
New green paper on higher education lacks a clear vision
Michael Cherry
South African Journal of Science , 2012, DOI: 10.4102/sajs.v108i1/2.1101
Abstract:
The Higher Education Summit re-opens the debate on differentiation
Michael Cherry
South African Journal of Science , 2010, DOI: 10.4102/sajs.v106i7/8.368
Abstract:
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