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CD163 Expression Was Associated with Angiogenesis and Shortened Survival in Patients with Uniformly Treated Classical Hodgkin Lymphoma
Young Wha Koh, Chan-Sik Park, Dok Hyun Yoon, Cheolwon Suh, Jooryung Huh
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087066
Abstract: Background Recent studies have reported the prognostic value of tissue-associated magrophages (TAMs) in classical Hodgkin lymphoma (cHL). In addition, TAMs are implicated in the tumor angiogenesis. In this study, we examined the prognostic relevance of TAMs in relation to vascular endothelial growth factor (VEGF) expression and angiogenesis in uniformly treated cases of cHL. Methods Diagnostic tissue from 116 patients with ABVD-treated cHL was evaluated retrospectively by immunohistochemical analysis for CD68, CD163 and VEGF expression and for CD31 expression as a measure of microvessel density (MVD). Results High CD163 expression (≥35% of cellularity) correlated with VEGF expression (Pearson’s Chi-square test, P = 0.008) and MVD (Spearman correlation coefficient 0.310, P<0.001). High CD163 expression was associated with inferior event-free survival (EFS, P = 0.005) and overall survival (OS, P<0.001) in univariate analysis. In multivariate analysis, high CD163 expression was strongly associated with inferior EFS (P = 0.043) and OS (P = 0.008). Patients with high MVD had a lower OS than those with low MVD, but the difference was not significant (P = 0.071, respectively). While high expression of CD68 was also associated with inferior EFS (P = 0.007), it showed no correlation with VEGF or MVD. Conclusions Our data confirms that CD163 expression provides independent prognostic information in cHL. The correlation of CD163 with VEGF expression and MVD suggests the role of CD163-positive cells in tumor angiogenesis of cHL.
Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib
Changhoon Yoo,Jeong-Eun Kim,Shin-Kyo Yoon,Song Cheol Kim,Jin-Hee Ahn,Tae Won Kim,Cheolwon Suh,Jae-Lyun Lee
Sarcoma , 2009, DOI: 10.1155/2009/360875
Abstract: A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angiosarcomas. When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.
Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)
Seok Kim, Chul Choi, Yeung-Chul Mun, Sung Oh, Hye Kang, Soon Lee, Jong Won, Min Kim, Jung Kwon, Jin Kim, Jae-Yong Kwak, Jung Kwon, In Hwang, Hyo Kim, Jae Lee, Sukjoong Oh, Keon Park, Cheolwon Suh, Won Kim
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-321
Abstract: We retrospectively analyzed 581 patients from 16 hospitals in Korea for primary intestinal NHL in this retrospective analysis. We compared clinical features and treatment outcomes according to the anatomic site of involvement and histologic subtypes.B-cell lymphoma (n = 504, 86.7%) was more frequent than T-cell lymphoma (n = 77, 13.3%). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (n = 386, 66.4%), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was the second most common subtype (n = 61, 10.5%). B-cell lymphoma mainly presented as localized disease (Lugano stage I/II) while T-cell lymphomas involved multiple intestinal sites. Thus, T-cell lymphoma had more unfavourable characteristics such as advanced stage at diagnosis, and the 5-year overall survival (OS) rate was significantly lower than B-cell lymphoma (28% versus 71%, P < 0.001). B symptoms were relatively uncommon (20.7%), and bone marrow invasion was a rare event (7.4%). The ileocecal region was the most commonly involved site (39.8%), followed by the small (27.9%) and large intestines (21.5%). Patients underwent surgery showed better OS than patients did not (5-year OS rate 77% versus 57%, P < 0.001). However, this beneficial effect of surgery was only statistically significant in patients with B-cell lymphomas (P < 0.001) not in T-cell lymphomas (P = 0.460). The comparison of survival based on the anatomic site of involvement showed that ileocecal regions had a better 5-year overall survival rate (72%) than other sites in consistent with that ileocecal region had higher proportion of patients with DLBCL who underwent surgery. Age > 60 years, performance status ≥ 2, elevated serum lactate dehydrogenase, Lugano stage IV, presence of B symptoms, and T-cell phenotype were independent prognostic factors for survival.The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might
Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma; Consortium for Improving Survival of Lymphoma (CISL) study
Ho-Young Yhim, Hye Kang, Yoon Choi, Seok Kim, Won Kim, Yee Chae, Jin Kim, Chul Choi, Sung Oh, Hyeon Eom, Jeong-A Kim, Jae Lee, Jong-Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Sung, Hyo Kim, Dae Lee, Cheolwon Suh, Jae-Yong Kwak
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-321
Abstract: We retrospectively analyzed data from 68 patients, newly diagnosed with DLBCL and breast involvement at 16 Korean institutions between January 1994 and June 2009.Median age at diagnosis was 48 years (range, 20-83 years). Forty-three (63.2%) patients were PBL according to previous arbitrary criteria, sixteen (23.5%) patients were high-intermediate to high risk of international prognostic index. The patients with one extranodal disease in the breast (OED) with or without nodal disease were 49 (72.1%), and those with multiple extranodal disease (MED) were 19 (27.9%). During median follow-up of 41.5 months (range, 2.4-186.0 months), estimated 5-year progression-free survival (PFS) was 53.7 ± 7.6%, and overall survival (OS) was 60.3 ± 7.2%. The 5-year PFS and OS was significantly higher for patients with the OED group than those with the MED group (5-year PFS, 64.9 ± 8.9% vs. 27.5 ± 11.4%, p = 0.001; 5-year OS, 74.3 ± 7.6% vs. 24.5 ± 13.0%, p < 0.001). In multivariate analysis, MED (hazard ratio [HR], 3.61; 95% confidence interval [CI], 1.07-12.2) and fewer than four cycles of systemic chemotherapy with or without local treatments (HR, 4.47; 95% CI, 1.54-12.96) were independent prognostic factors for worse OS. Twenty-five (36.8%) patients experienced progression, and the cumulative incidence of progression in multiple extranodal sites or other than breasts and central nervous system was significantly different between the OED group and the MED group (5-year cumulative incidence, 9.7 ± 5.4% vs. 49.0 ± 15.1%, p = 0.001).Our results show that the patients included in OED group, reflecting different treatment outcome, prognosis and pattern of progression, should be considered as PBL in the future trial. Further studies are warranted to validate our suggested criteria.Approximately one-third of non-Hodgkin lymphoma (NHL) arises primarily from sites other than lymph nodes; for this reason, they are usually named as primary extranodal lymphoma [1]. The definition of primary ext
Packet Compression Ratio Dependent Spanning Tree for Convergecast  [PDF]
Changjin Suh, Jisoo Shin
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.201027062
Abstract: A convergecast is a popular routing in sensor networks. It periodically forwards collected data at every sensor node along a configured routing path to the outside of a sensor network via the base station (BS). To extend the lifetime of energy-limited sensor networks, many previous researches proposed schemes for data compression. However, few researches investigated the relation between packet compression ratio and spanning trees. We propose packet Compression ratio dependent Spanning Tree (CST) which can provide effective routing paths in terms of the tree length for all ranges of compression ratio f. CST is equivalent to the Shortest Path spanning Tree (SPT) which is optimum in the case of no-compression (f = 0) and is equivalent to the Minimum Spanning Tree (MST) in the case of full-compression (f = 1). CST outperforms SPT and MST for any range of f (0 &lt; f &lt; 1). Through simulation we show CST provides shorter paths than MST and SPT in terms of the tree length by 34.1% and 7.8% respectively. We confirm CST is very useful in convergecasts.
Quantum Cosmology Explains the General Galaxy-Black Hole Correlation  [PDF]
Paul K. Suh
International Journal of Astronomy and Astrophysics (IJAA) , 2012, DOI: 10.4236/ijaa.2012.22014
Abstract: The symmetric quantum physics of the Universe demonstrates that the massive black holes developing in the post-inflation big-bang prompt the formation of the host galaxies around them. A general correlation between the variety of galaxies and black holes develops, a specific example of which is the celebrated (but not understood) mass correlation between the host elliptical galaxies and their core black holes. The elucidations and predictions in this exposition are inclusive and far-reaching, resolving a myriad of yet unsolved problems and quandaries in the evolving Universe, among which are: how the general galaxy-black hole correlations are established; what is the role of the dark matter and energy in the formation of galaxies and stars; how the spiral galaxies with less predominant black holes are formed; how the early star forming globular cluster emerged with sparse dark matter; why some galaxy mergers give rise to the starbursts, while other mergers switch the star flourishing galaxies off into grave yards; and how could the Universe have wound up as sheets and filaments of galaxy clusters encompassing great voids.
Cultural models of female breasts and breast cancer among Korean women  [PDF]
Eunyoung E. Suh
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.35055

Although a great many qualitative descriptions of the experience of having breast cancer exist, they overwhelmingly represent experiences of women in Western cultures and are based on assumptions that stem from Western individualism. This study explores and describes cultural models shared by a group of non-Western women, South Koreans, in reference to female breasts and breast cancer. The hermeneutic phenomenology-grounded qualitative study was conducted with 40 Korean women, between 23 and 81 years of age, half of whom were breast cancer survivors. The analysis elicited two cultural models, both characterized in terms of physical relationships to others (as opposed to the woman’s individual or independent view of her body): a breast-feeding mother to a child and an attractive wife to a husband. Female breasts are interpreted as a medium that connects women to roles as mothers and wives. Breast cancer can lead women to detach from their previous relational and role-oriented identities. Cultural traditions, cultural concepts, and culture-related health beliefs in Korea are interwoven deeply in the women’s stories about breasts, as a gendered organ, and its disease. The findings suggest that understanding indigenous cultural models should precede any supportive breast cancer care for women from non-Western cultural backgrounds. 

Information Theory of Matrix Completion
Changho Suh
Computer Science , 2014,
Abstract: Matrix completion is a fundamental problem that comes up in a variety of applications like the Netflix problem, collaborative filtering, computer vision, and crowdsourcing. The goal of the problem is to recover a k-by-n unknown matrix from a subset of its noiseless (or noisy) entries. We define an information-theoretic notion of completion capacity C that quantifies the maximum number of entries that one observation of an entry can resolve. This number provides the minimum number m of entries required for reliable reconstruction: m=kn/C. Translating the problem into a distributed joint source-channel coding problem with encoder restriction, we characterize the completion capacity for a wide class of stochastic models of the unknown matrix and the observation process. Our achievability proof is inspired by that of the Slepian-Wolf theorem. For an arbitrary stochastic matrix, we derive an upper bound on the completion capacity.
Comparison between the PlusoptiX and IScreen Photoscreeners in Detecting Amblyopic Risk Factors in Children  [PDF]
Jing Grace Wang, Donny W. Suh
Open Journal of Ophthalmology (OJOph) , 2013, DOI: 10.4236/ojoph.2013.31003

Purpose: To compare the accuracy of plusoptiX A08 photoscreener (PPS) and iScreen 3000 photoscreener (IPS) in objectively screening for amblyopic risk factors in children age 5 months to 13 years old. Methods: Cross-sectional study of 148 children who received photoscreenings via PPS and IPS and a comprehensive pediatric ophthalmic examination in our office. Patients were considered to have amblyogenic risk factors based on the AAPOS referral criteria guidelines. Results: 45 percent of patients undergoing a pediatric ophthalmology examination were found to have amblyopia or amblyogenic risk factors. In this study, PPS demonstrated an overall sensitivity of 75.4%, specificity of 68.0%, positive predictive value (PPV) of 67.1%, and negative predictive value (NPV) of 76.1%. However, IPS photoscreener had an overall sensitivity of 66.2%, specificity of 87.6%, PPV of 81.8%, and NPV of 75.5%. Discussion: The accuracy of PPS and IPS was compared in different age groups. The sensitivity and specificity were analyzed according to varied amblyogenic risk factors. The statistic results of this study were compared to those of previous studies, including Vision in Preschoolers (VIP) Study and the Iowa PhotoScreening Program. Conclusion: PPS and IPS proved to be useful tools in the objective vision screening in children. PPS was found to have a higher sensitivity, and IPS showed a higher specificity and PPV in detecting amblyopic risk factors. In conclusion, one device may be more beneficial over the other, depending on the patient population and office settings.

Inverted Takotsubo-Like Left Ventricular Dysfunction with Pulmonary Oedema Developed after Caesarean Delivery Complicated by Massive Haemorrhage in a Severe Preeclamptic Parturient with a Prolonged Painful Labour
Hyejin Jeong,Seongheon Lee,Cheolwon Jeong,Jongun Lee,Seongtae Jeong,Sungsu Chung,Kyungyeon Yoo
Case Reports in Anesthesiology , 2011, DOI: 10.1155/2011/164720
Abstract: Inverted takotsubo cardiomyopathy (TTC), a variant of stress-induced cardiomyopathy, features transient myocardial dysfunction characterized by a hyperdynamic left ventricular apex and akinesia of the base. Herein, we describe a 38-year-old primigravida with severe preeclampsia who had active labour for 4 h followed by an emergency caesarean delivery. She developed postpartum haemorrhage due to uterine atony complicated by pulmonary oedema, which was managed with large-volume infusion and hysterectomy. Her haemodynamic instability was associated with cardiac biomarkers indicative of diffuse myocardial injury and echocardiographic findings of an “inverted” TTC. The patient was almost fully recovered one month later. Our case shows that a reversible inverted TTC may result from a prolonged painful labour. TTC should be listed in the differential diagnosis of the patient presenting with pulmonary oedema of unknown origin, especially in patients with severe preeclampsia.
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