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Search Results: 1 - 10 of 11948 matches for " ChengZhi Xie "
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Mitochondrial DNA analysis of Bronze Age horses recovered from Chifeng region, Inner Mongolia, China
Cai Dawei,Han Lu,Xie Chengzhi,Li Shengnan,Zhou Hui,Zhu Hong,
Cai Dawei
,Han Lu,Xie Chengzhi,Li Shengnan,Zhou Hui and Zhu Hong

自然科学进展 , 2007,
Abstract: In this study, mitochondrial DNA (mtDNA) analysis was carried out on 9 Bronze Age horses recovered from Dashanqian and Jinggouzi archaeological sites in Chifeng region, Inner Mongolia, China to explore the origin of Chinese domestic horses. Both mtDNA 16S rRNA gene and control region (D-loop) fragments of ancient horses were amplified and sequenced. The analysis of the highly conservative 16S rRNA gene sequences indicated that the burial environment of Chifeng region is suitable for the preservation of ancient DNA (aDNA). Combing 465 mtDNA D-loop sequences representing different breeds from East Asia, Central Asia, Near East and Europe, we constructed a phylogenetic network to investigate the relationship between ancient and modern horses. The phylogenetic network showed that the 9 horses were distributed into different modern horse clusters which were closely related to them representing a certain geographical distribution. Our results showed that the maternal genetic line of the ancient horses in Chifeng region was highly diversified, which contributed to the gene pool of modern domestic horses and suggested a complex origin of domestic horses in China.
Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells
Xuelian Xu,Chengzhi Xie,Holly Edwards,Hui Zhou,Steven A. Buck,Yubin Ge
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017138
Abstract: Pediatric acute myeloid leukemia (AML) remains a challenging disease to treat even with intensified cytarabine-based chemotherapy. Histone deacetylases (HDACs) have been reported to be promising therapeutic targets for treating AML. However, HDAC family members that are involved in chemotherapy sensitivities remain unknown. In this study, we sought to identify members of the HDAC family that are involved in cytarabine sensitivities, and to select the optimal HDACI that is most efficacious when combined with cytarabine for treating children with AML.
Analysis of the matrilineal genetic structure of population in the early Iron Age from Tarim Basin, Xinjiang, China
YinQiu Cui,ShiZhu Gao,ChengZhi Xie,QuanChao Zhang,HaiJing Wang,Hong Zhu,Hui Zhou
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0647-8
Abstract: Ancient mtDNA data of human remains were analyzed from four early Iron Age Tarim Basin sites (Yuansha, Zaghunluq, Sampula and Niya) in the southern Silk Road region. Haplogroup distributions show that ancient Tarim Basin population was comprised of well-differentiated Western and Eastern matrilineal lineages. Some West lineage of Tarim Basin population originated from Near East and Iran region. Of the East lineages, North and Northeast Asia originated lineages were the main components, and a few Southeast Asian lineages also existed, which indicated a more extensive origin and a more complex admixture. The genetic structure of ancient Tarim Basin population is relatively close to the modern populations of Xinjiang, which implied that the early Iron Age is an important period during the formation of the modern Xinjiang population.
Soft X-ray in-line holographic experiment
Shaoguang Yang,Xingshu Xie,Chengzhi Jia,Yongfei Zhao,Shiping Jiang,Yuxuan Zhang,Xiaobin Shan,Xinyi Zhang
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02883564
Abstract: “Water window” soft X-ray has some advantages in the microimaging of biological specimens. Soft X-ray holography can give us three-dimensional images of biological cells in their natural condition. Quasi-monochromatic soft X-ray from the pdymonochromatic synchrotron radiation is obtained by a zone plate-pinhole linear monochromator at National Synchrotron Radiation Laboratory (NSRI,) at Hcfei. The pinhole is used to increase the temporal coherence of the soft X-ray. and also to increase the spatial coherence of it. An in-line holographic experiment has been finished with soft X-ray of main wavelength 4.5 nm and pinhole of diameter 0.03 mm. The magnified hologram is recowtructed with He-Ne laser. A smaller pinhole is wanted to be used to improve the cuherence of the soft X-ray so as to improve the quality of the hologram.
Mitochondrial DNA analysis of ancient Sampula population in Xinjiang

Xie Chengzhi,Li Chunxiang,Cui Yinqiu,Cai Dawei,Wang Haijing,Zhu Hong,Zhou Hui,

自然科学进展 , 2007,
Abstract: The archaeological site of Sampula cemetery was located about 14 km to the southwest of the Luo County in Xinjiang Khotan, China, belonging to the ancient Yutian kingdom. 14C analysis showed that this cemetery was used from 217 B.C. to 283 A.D. Ancient DNA was analyzed by 364 bp of the mitochondrial DNA hypervariable region I (mtDNA HVR-I), and by six restriction fragment length polymorphism (RFLP) sites of mtDNA coding region. We successfully extracted and sequenced intact stretches of maternally inherited mtDNA from 13 out of 16 ancient Sampula samples. The analysis of mtDNA haplogroup distribution showed that the ancient Sampula was a complex population with both European and Asian characteristics. Median joining network of U3 sub-haplogroup and multi-dimensional scaling analysis all showed that the ancient Sampula had maternal relationship with Ossetian and Iranian.
Governance and Financing of Chinese Higher Education
Chengzhi Wang
Education Policy Analysis Archives , 2000,
Abstract: With an introduction to the overall underdevelopment of higher education in China compared with the American counterpart, this article briefly examines the main trends of over two decades of development of the governance and financing systems of China's higher education sector. This article analyzes the resource allocation from governments and revenue generation in institutions under the reform policies of administrative decentralization and financing diversification. The new "Great Leap Forward" in higher education in 1999 and beyond, i.e., the radical and, to a certain extent, desperate mass higher education policy and practice of expanding enrollments in order to spur domestic consumption, is critically analyzed. By examining the ongoing institutional merging and "co-building" and the most recent enrollment expansion, the writer points out the economic significance for higher education of overcoming diseconomies of scale and inefficiencies. However, the long-range outcomes of the seemingly exciting investment in and consumption of mass higher education are difficult to predict.
Soft X-ray in-line holographic experiment

Shaoguang Yang,Xingshu Xie,Chengzhi Jia,Yongfei Zhao,Shiping Jiang,Yuxuan Zhang,Xiaobin Shan,Xinyi Zhang,

科学通报(英文版) , 1998,
Abstract: “Water window” soft X-ray has some advantages in the microimaging of biological specimens. Soft X-ray holography can give us three-dimensional images of biological cells in their natural condition. Quasi-monochromatic soft X-ray from the pdymonochromatic synchrotron radiation is obtained by a zone plate-pinhole linear monochromator at National Synchrotron Radiation Laboratory (NSRI,) at Hcfei. The pinhole is used to increase the temporal coherence of the soft X-ray. and also to increase the spatial coherence of it. An in-line holographic experiment has been finished with soft X-ray of main wavelength 4.5 nm and pinhole of diameter 0.03 mm. The magnified hologram is recowtructed with He-Ne laser. A smaller pinhole is wanted to be used to improve the cuherence of the soft X-ray so as to improve the quality of the hologram.
Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age
Chunxiang Li, Hongjie Li, Yinqiu Cui, Chengzhi Xie, Dawei Cai, Wenying Li, Victor H Mair, Zhi Xu, Quanchao Zhang, Idelisi Abuduresule, Li Jin, Hong Zhu, Hui Zhou
BMC Biology , 2010, DOI: 10.1186/1741-7007-8-15
Abstract: Mitochondrial DNA analysis showed that the Xiaohe people carried both the East Eurasian haplogroup (C) and the West Eurasian haplogroups (H and K), whereas Y chromosomal DNA analysis revealed only the West Eurasian haplogroup R1a1a in the male individuals.Our results demonstrated that the Xiaohe people were an admixture from populations originating from both the West and the East, implying that the Tarim Basin had been occupied by an admixed population since the early Bronze Age. To our knowledge, this is the earliest genetic evidence of an admixed population settled in the Tarim Basin.The Tarim Basin in western China, positioned at a critical site on the ancient Silk Road, has played a significant role in the history of human migration, cultural developments and communications between the East and the West. It became famous due to the discovery of many well-preserved mummies within the area. These mummies, especially the prehistoric Bronze Age 'Caucasoid' mummies, such as the 'Beauty of Loulan', have attracted extensive interest among scientists regarding who were these people and where did they come from.Based on analyses of human remains and other archaeological materials from the ancient cemeteries (dated from approximately the Bronze Age to the Iron Age), there is now widespread acceptance that the first residents of the Tarim Basin came from the West. This was followed, in stages, by the arrival of Eastern people following the Han Dynasty [1,2]. However, the exact time when the admixture of the East and the West occurred in this area is still obscure [3]. In 2000, the Xinjiang Archaeological Institute rediscovered a very important Bronze Age site, the Xiaohe cemetery, by utilizing a device employing the global positioning system. The rediscovery of this cemetery provided an invaluable opportunity to further investigate the migrations of ancient populations in the region.The Xiaohe cemetery (40°20'11"N, 88°40'20.3"E) is located in the Taklamakan Desert of north
Class I and Class II Histone Deacetylases Are Potential Therapeutic Targets for Treating Pancreatic Cancer
Guan Wang, Jing He, Jianyun Zhao, Wenting Yun, Chengzhi Xie, Jeffrey W. Taub, Asfar Azmi, Ramzi M. Mohammad, Yan Dong, Wei Kong, Yingjie Guo, Yubin Ge
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052095
Abstract: Background Pancreatic cancer is a highly malignant disease with an extremely poor prognosis. Histone deacetylase inhibitors (HDACIs) have shown promising antitumor activities against preclinical models of pancreatic cancer, either alone or in combination with chemotherapeutic agents. In this study, we sought to identify clinically relevant histone deacetylases (HDACs) to guide the selection of HDAC inhibitors (HDACIs) tailored to the treatment of pancreatic cancer. Methodology HDAC expression in seven pancreatic cancer cell lines and normal human pancreatic ductal epithelial cells was determined by Western blotting. Antitumor interactions between class I- and class II-selective HDACIs were determined by MTT assays and standard isobologram/CompuSyn software analyses. The effects of HDACIs on cell death, apoptosis and cell cycle progression, and histone H4, alpha-tubulin, p21, and γH2AX levels were determined by colony formation assays, flow cytometry analysis, and Western blotting, respectively. Results The majority of classes I and II HDACs were detected in the pancreatic cancer cell lines, albeit at variable levels. Treatments with MGCD0103 (a class I-selective HDACI) resulted in dose-dependent growth arrest, cell death/apoptosis, and cell cycle arrest in G2/M phase, accompanied by induction of p21 and DNA double-strand breaks (DSBs). In contrast, MC1568 (a class IIa-selective HDACI) or Tubastatin A (a HDAC6-selective inhibitor) showed minimal effects. When combined simultaneously, MC1568 significantly enhanced MGCD0103-induced growth arrest, cell death/apoptosis, and G2/M cell cycle arrest, while Tubastatin A only synergistically enhanced MGCD0103-induced growth arrest. Although MC1568 or Tubastatin A alone had no obvious effects on DNA DSBs and p21 expression, their combination with MGCD0103 resulted in cooperative induction of p21 in the cells. Conclusion Our results suggest that classes I and II HDACs are potential therapeutic targets for treating pancreatic cancer. Accordingly, treating pancreatic cancer with pan-HDACIs may be more beneficial than class- or isoform-selective inhibitors.
Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51
Chengzhi Xie, Christina Drenberg, Holly Edwards, J. Timothy Caldwell, Wei Chen, Hiroto Inaba, Xuelian Xu, Steven A. Buck, Jeffrey W. Taub, Sharyn D. Baker, Yubin Ge
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079106
Abstract: Acute myeloid leukemia (AML) remains a challenging disease to treat and urgently requires new therapies to improve its treatment outcome. In this study, we investigated the molecular mechanisms underlying the cooperative antileukemic activities of panobinostat and cytarabine or daunorubicin (DNR) in AML cell lines and diagnostic blast samples in vitro and in vivo. Panobinostat suppressed expression of BRCA1, CHK1, and RAD51 in AML cells in a dose-dependent manner. Further, panobinostat significantly increased cytarabine- or DNR-induced DNA double-strand breaks and apoptosis, and abrogated S and/or G2/M cell cycle checkpoints. Analogous results were obtained by shRNA knockdown of BRCA1, CHK1, or RAD51. Cotreatment of NOD-SCID-IL2Rγnull mice bearing AML xenografts with panobinostat and cytarabine significantly increased survival compared to either cytarabine or panobinostat treatment alone. Additional studies revealed that panobinostat suppressed the expression of BRCA1, CHK1, and RAD51 through downregulation of E2F1 transcription factor. Our results establish a novel mechanism underlying the cooperative antileukemic activities of these drug combinations in which panobinostat suppresses expression of BRCA1, CHK1, and RAD51 to enhance cytarabine and daunorubicin sensitivities in AML cells.
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