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Search Results: 1 - 10 of 71174 matches for " Cheng-Xiong Xu "
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The Combination of RAD001 and NVP-BEZ235 Exerts Synergistic Anticancer Activity against Non-Small Cell Lung Cancer In Vitro and In Vivo
Cheng-Xiong Xu,Yikun Li,Ping Yue,Taofeek K. Owonikoko,Suresh S. Ramalingam,Fadlo R. Khuri,Shi-Yong Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020899
Abstract: The phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit PI3K, mTOR or both are currently under development. The mTOR allosteric inhibitor, RAD001, and the PI3K/mTOR dual kinase inhibitor, BEZ235, are examples of these agents. We were interested in developing strategies to enhance mTOR-targeted caner therapy. In this study, we found that BEZ235 alone effectively inhibited the growth of rapamycin-resistant cancer cells. Interestingly, the combination of sub-optimal concentrations of RAD001 and BEZ235 exerted synergistic inhibition of the growth of human lung cancer cells along with induction of apoptosis and G1 arrest. Furthermore, the combination was also more effective than either agent alone in inhibiting the growth of lung cancer xenografts in mice. The combination showed enhanced effects on inhibiting mTOR signaling and reducing the expression of c-Myc and cyclin D1. Taken together, our results suggest that the combination of RAD001 and BEZ235 is a novel strategy for cancer therapy.
Off-pump coronary artery bypass grafting using a bilateral internal mammary artery Y graft
Cheng-Xiong Gu,Jun-Feng Yang,Hong-Chao Zhang,Hua Wei
老年心脏病学杂志(英文版) , 2012,
Abstract: ObjectiveTo evaluate the outcome of off-pump coronary artery bypass grafting (OPCABG) using a bilateral internal mammary artery (BIMA) Y configuration graft to achieve total arterial myocardial revascularization. Methods From October 2002 to December 2008, 208 patients (196 males and 12 females) underwent OPCABG using a BIMA Y configuration graft. The average age of the patients was 56.5 ± 11.3 years, with an age range of 33–78 years. A total of 167 (80.2%) cases had triple-vessel disease. Left main stem disease was found in 33 (15.9%) cases, and double-vessel disease was found in 8 (3.9%) cases. The semi-skeletonization technique was used to harvest the two internal mammary arteries (IMAs), and then the free right internal mammary artery was connected end-to-side to the left internal mammary artery (LIMA) in situ to complete the Y configuration graft. Off-pump and sequential anastomosis methods were used to perform coronary artery bypass surgery in all patients. Graft patency was assessed intra-operatively with the HT311 transit time flowmeter. Results A total of 728 distal anastomoses were performed in 208 patients, with the average being 3.5 ± 1.3 per person. No one died or experienced recurrent angina within 30 days after the operation. Conclusions OPCABG using the BIMA Y graft was safe and effective to achieve total arterial revascularization. This method avoids surgical operation on the ascending aorta and other incisions.
Outcomes of Middle Cardiac Vein Arterialization via Internal Mammary/Thoracic Artery Anastomosis
Yang Yu, Hai-tao Li, Ming-xin Gao, Fan Zhang, Cheng-xiong Gu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080963
Abstract: Objective Cardiac vein arterialization is seldom applied for treating right coronary artery disease. This study aimed to improve outcomes of cardiac vein arterialization in a porcine model using intramammary artery anastomosis. Methods A chronic, stenotic coronary artery model was established in 12 of 14 Chinese experimental miniature pigs of either sex, which were randomly divided into equal control (n = 6) and experimental (n = 6) groups. In experimental animals, blood flow was reconstructed in the right coronary artery using intramammary artery. Arterialization involved dissection of right internal mammary artery from bifurcation to apex of thorax followed by end-to-side anastomosis of internal mammary artery and middle cardiac vein plus posterior descending branch of right coronary artery. Intraoperative heart rate was maintained at 110 beats/min. Graft flow assessment and echocardiography were performed when blood pressure and heart rate normalized. Results The experimental group had significantly higher mean endocardial and epicardial blood flow postoperatively than control group (mean endocardial blood flow: 0.37 vs. 0.14 ml/(g*min), p<0.001; mean epicardial blood flow: 0.29 vs. 0.22, p = 0.014). Transmural blood flow was also higher in experimental group than in control group (0.33 vs. 0.19, p<0.001); ejection fraction increased from 0.46% at baseline to 0.51% (p = 0.0038) at 6 hours postoperatively, and mean blood flow of internal mammary artery was 44.50, perfusion index 0.73 at postoperative 6 months, 43.33 and 0.80 at 3 months. Conclusion Successful cardiac vein arterialization via intramammary artery in a porcine model suggests that this may be a viable method for reconstructing blood flow in chronic, severe coronary artery disease.
Harmonic Propagation and Interaction Evaluation between Small-Scale Wind Farms and Nonlinear Loads
Guang-Long Xie,Bu-Han Zhang,Yan Li,Cheng-Xiong Mao
Energies , 2013, DOI: 10.3390/en6073297
Abstract: Distributed generation is a flexible and effective way to utilize renewable energy. The dispersed generators are quite close to the load, and pose some power quality problems such as harmonic current emissions. This paper focuses on the harmonic propagation and interaction between a small-scale wind farm and nonlinear loads in the distribution grid. Firstly, by setting the wind turbines as P – Q( V) nodes, the paper discusses the expanding Newton-Raphson power flow method for the wind farm. Then the generalized gamma mixture models are proposed to study the non-characteristic harmonic propagation of the wind farm, which are based on Gaussian mixture models, improved phasor clustering and generalized Gamma models. After the integration of the small-scale wind farm, harmonic emissions of nonlinear loads will become random and fluctuating due to the non-stationary wind power. Furthermore, in this paper the harmonic coupled admittance matrix model of nonlinear loads combined with a wind farm is deduced by rigorous formulas. Then the harmonic propagation and interaction between a real wind farm and nonlinear loads are analyzed by the harmonic coupled admittance matrix and generalized gamma mixture models. Finally, the proposed models and methods are verified through the corresponding simulation models in MATLAB/SIMULINK and PSCAD/EMTDC.
Off-pump coronary artery bypass grafting using a bilateral internal mammary artery Y graft

Cheng-Xiong Gu,Jun-Feng Yang,Hong-Chao Zhang,Hua Wei,Ling-Ke Li,

老年心脏病学杂志(英文版) , 2012,
CFD Application to Hydrogen Risk Analysis and PAR Qualification
Jinbiao Xiong,Yanhua Yang,Xu Cheng
Science and Technology of Nuclear Installations , 2009, DOI: 10.1155/2009/213981
Abstract: A three dimensional computation fluid dynamics (CFD) code, GASFLOW, is applied to analyze the hydrogen risk for Qinshan-II nuclear power plant (NPP). In this paper, the effect of spray modes on hydrogen risk in the containment during a large break loss of coolant accident (LBLOCA) is analyzed by selecting three different spray strategies, that is, without spray, with direct spray and with both direct and recirculation spray. A strong effect of spray modes on hydrogen distribution is observed. However, the efficiency of the passive auto-catalytic recombiners (PAR) is not substantially affected by spray modes. The hydrogen risk is significantly increased by the direct spray, while the recirculation spray has minor effect on it. In order to simulate more precisely the processes involved in the PAR operation, a new PAR model is developed using CFD approach. The validation shows that the results obtained by the model agree well with the experimental results.
Performance Analysis of Trench Power MOSFETs in High-Frequency Synchronous Buck Converter Applications
Yali Xiong,Xu Cheng,Xiangcheng Wang,Pavan Kumar,Lina Guo,Z. John Shen
Advances in Power Electronics , 2008, DOI: 10.1155/2008/412175
Abstract: This paper investigates the performance perspectives and theoretical limitations of trench power MOSFETs in synchronous rectifier buck converters operating in the MHz frequency range. Several trench MOSFET technologies are studied using a mixed-mode device/circuit modeling approach. Individual power loss contributions from the control and synchronous MOSFETs, and their dependence on switching frequency between 500 kHz and 5 MHz are discussed in detail. It is observed that the conduction loss contribution decreases from 40% to 4% while the switching loss contribution increases from 60% to 96% as the switching frequency increases from 500 KHz to 5 MHz. Beyond 1 MHz frequency there is no obvious benefit to increase the die size of either SyncFET or CtrlFET. The RDS(ON)×QG figure of merit (FOM) still correlates well to the overall converter efficiency in the MHz frequency range. The efficiency of the hard switching buck topology is limited to 80% at 2 MHz and 65% at 5 MHz even with the most advanced trench MOSFET technologies.
Identification of hsa-miR-335 as a Prognostic Signature in Gastric Cancer
Zhi Yan, Yimin Xiong, Weitian Xu, Juan Gao, Yi Cheng, Zhigang Wang, Fang Chen, Guorong Zheng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040037
Abstract: Background Gastric cancer (GC) is one of the most common malignancy and primary cause of death in Chinese cancer patients. Recurrence is a major factor leading to treatment failure and low level of 5-year survival rate in GC patients following surgical resection. Therefore, identification of biomarkers with potential in predicting recurrence risk is the key problem of the prognosis in GC patients. Patients and Methods A total of 74 GC patients were selected for systematic analysis, consisting of 31 patients with recurrence and 43 patients without recurrence. Firstly, miRNAs microarray and bioinformatics methods were used to characterize differential expressed miRNAs from primary tumor samples. Following, we used a ROC method to select signature with best sensitivity and specificity. Finally, we validated the signature in GC samples (frozen fresh and blood samples) using quantitative PCR. Results We have identified 12 differential miRNAs including 7 up-regulated and 5 down-regulated miRNAs in recurrence group. Using ROC method, we further ascertained hsa-miR-335 as a signature to recognize recurrence and non-recurrence cases in the training samples. Moreover, we validated this signature using quantitative PCR method in 64 test samples with consistent result with training set. A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-335 (P<0.001). In addition, we evaluated that hsa-miR-335 were involved in regulating target genes in several oncogenic signal-pathways, such as p53, MAPK, TGF-β, Wnt, ERbB, mTOR, Toll-like receptor and focal adhesion. Conclusion Our results indicate that the hsa-miR-335 has the potential to recognize the recurrence risk and relate to the prognosis of GC patients.
Simulation of Photocurrents of Terahertz Quantum-Well Photodetectors

XIONG Feng,GUO Xu-Guang,CAO Jun-Cheng,

中国物理快报 , 2008,
Abstract: We theoretically simulate the influence of the scattering processes of the electrons in the continuum states on the shapes of the photocurrent spectra of THz quantum well photodetectors. The width of the photocurrent peakshould be wider according to the uncertainty relation when these scattering processes lead to shorter relaxation time. We take a simple approximation model to include this influence and calculate the photocurrent spectra, which are in agreement with experimental results qualitatively.
Enterohemorrhagic Escherichia coli Specific Enterohemolysin Induced IL-1β in Human Macrophages and EHEC-Induced IL-1β Required Activation of NLRP3 Inflammasome
Xiaoai Zhang, Yuli Cheng, Yanwen Xiong, Changyun Ye, Han Zheng, Hui Sun, Hongqing Zhao, Zhihong Ren, Jianguo Xu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050288
Abstract: Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major foodborne pathogen causing hemorrhagic colitis and hemolytic-uremic syndrome. The role of EHEC O157:H7-enterohemolysin (Ehx) in the pathogenesis of infections remains poorly defined. In this study, we used gene deletion and complement methods to confirm its putative functions. Results demonstrated that, in THP-1 cells, EHEC O157:H7-Ehx is associated with greater production of extracellular interleukin (IL)-1β than other cytokines. The data also showed that EHEC O157:H7-Ehx contributed to cytotoxicity in THP-1 cells, causing the release of lactate dehydrogenase (LDH). Although we observed a positive correlation between IL-1β production and cytotoxicity in THP-1 cells infected with different EHEC O157:H7 strains, our immunoblot results showed that the majority of IL-1β in the supernatant was mature IL-1β and not the pro-IL-1β that can be released after cell death. However, EHEC O157:H7-Ehx had no detectable effect on biologically inactive pro-IL-1β at the mRNA or protein synthesis levels. Neither did it affect the expression of apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1, or NOD-like receptor family pyrin domain containing 3 (NLRP3). RNA interference experiments showed that EHEC O157:H7-induced IL-1β production required the involvement of ASC, caspase-1, and NLRP3 expression in THP-1 cells. Our results demonstrate that Ehx plays a crucial role in EHEC O157:H7-induced IL-1β production and its cytotoxicity to THP-1 cells. NLRP3 inflammasome activation is also involved in EHEC O157:H7-stimulated IL-1β release.
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