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Search Results: 1 - 10 of 87774 matches for " Chen Zhen "
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Experimental study on effects of Shengmai Injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity
CHEN Zhen
Zhong Xi Yi Jie He Xue Bao , 2005,
Abstract: Objevtive: To observe the effects of Shengmai Injection on enhancing efficacy and reducing toxicity of 5-fluorouracil (5-FU). Methods: Fifty hepatoma 22 bearing mice were randomly divided into five groups: control group, 5-Fu group, Shengmai Injection (low, medium and high dose) combined with 5-FU groups. There were 10 mice in each group. Mice in the five groups were injected introperitoneally the same amount of normal saline, 5-FU (20 mg·kg-1·d-1) and Shengmai Injection (3.5 ml·kg-1·d-1, 7 ml·kg-1·d-1 and 14 ml·kg-1·d-1) combined with 5-FU respectively, once a day for 14 days. After that, all mice were killed and the tumor inhibiting rates, index of immunological function, liver and kidney function and the blood cells in the peripheral blood were observed. Results: The tumor inhibiting rates were higher in each Shengmai Injection combined with 5-FU group than that in the 5-FU group (P<0.05). The levels of CD3, CD4, CD4/CD8, IgG, IgM in 5-FU group were lower (P<0.05), while those in the three Shengmai Injection combined with 5-FU groups were higher than those in the control group (P<0.05). The level of serum alanine aminotransferase (ALT) was higher and the WBC and PLT counts in the peripheral blood were lower in 5-FU group than those in the control group (P<0.05). But the levels of serum ALT in the three Shengmai Injection combined with 5-FU groups were consistent with that in the control group and the amounts of WBC decreased slightly. Conclusion: Shengmai Injection can enhance the anti-tumor effect of 5-FU. It can also improve the immunological function and reduce the adverse reactions of chemotherapy.
Correlation between TXB2, 6-Keto-PGF1α and liver metastasis in rats model with blood stasis
CHEN Zhen (
Zhong Xi Yi Jie He Xue Bao , 2003,
Abstract: Objective: To observe the correlation between serum level of TXB2, 6-Keto-PGF1α and liver metastasis. Methods: The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB2 and 6-Keto-PGF1α were tested by radioimmunoassay. Results: Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF1α, TXB2, and TXB2/6-Keto-PGF1α were higher in the group with blood stasis. Conclusion: In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF1α, TXB2 and TXB2/6-Keto-PGF1α.
Effects of Monoclonal Antibody Cetuximab on Proliferation of Non-small Cell Lung Cancer Cell lines
Zhen CHEN,Zhiwei CHEN
Chinese Journal of Lung Cancer , 2010,
Abstract: Background and objective The epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab has been used widely in non-small cell lung cancer patients. The aim of this study is to explore the effect of lung cancer cells (A549, H460, H1299, SPC-A-1) which were treated by cetuximab in vitro. Methods We studied the effects of increasing concentrations of cetuximab (1 nmol/L-625 nmol/L) in four human lung cancer cell lines (A549, SPC-A-1, H460, H1229). CCK8 measured the inhibition of cell proliferation in each group. A549, SPC-A-1 were marked by PI and the statuses of apoptosis were observed. Western blot were used to detect the proliferation-related signaling protein and apoptosis-related protein in A549. Results The treatment with cetuximab resulted in the effect on cell proliferation and apoptosis in a time- and dosedependent manner. The expression of activated key enzymes (p-AKT, p-EGFR, p-MAPK) in EGFR signaling transduction pathway were down-regulated more obviously. Conclusion Cetuximab is an effective targeted drug in the treatment of lung cancer cell lines, tissues, most likely to contribute to the inhibition of key enzymes in EGFR signaling transduction pathway.
Adaptive Lag Synchronization of Lorenz Chaotic System with Uncertain Parameters  [PDF]
Yanfei Chen, Zhen Jia, Guangming Deng
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.36083
Abstract: The paper discusses lag synchronization of Lorenz chaotic system with three uncertain parameters. Based on adaptive technique, the lag synchronization of Lorenz chaotic system is achieved by designing a novel nonlinear controller. Furthermore, the parameters identification is realized simultaneously. A sufficient condition is given and proved theoreticcally by Lyapunov stability theory and LaSalle’s invariance principle. Finally, the numerical simulations are provided to show the effectiveness and feasibility of the proposed method.
Plasma Surface Treatment of BOPP Film by Dielectric Barrier Glow Discharge in Argon/Air  [PDF]
Longxi Chen, Xiangjia Meng, Zhen Mei
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.614205
Abstract: A plasma surface treatment of biaxially oriented polypropylene (BOPP) film was carried out with dielectric barrier glow discharge (DBGD) in Ar/air. The paper studied the effects of the ratios of Ar/air plasma on the BOPP surface modification. The results indicated that the efficiency of the plasma surface modification was improved with increasing treatment time and power density with DBGD in Ar/air. The water contact angle increased first and then decreased with the increase of the Ar/air mixture rate. The DBGD gives a better surface modification than filament discharge. The ageing behavior was influenced by the mixture rate of Ar/air, but the water contact angle of the treated sample was always less than that of un-treated sample.
Oscillation Criteria of Solution for a Second Order Difference Equation with Forced Term
Chen Huiqin,Jin Zhen
Discrete Dynamics in Nature and Society , 2010, DOI: 10.1155/2010/171234
Abstract: We will consider oscillation criteria for the second order difference equation with forced term ( ). We establish sufficient conditions which guarantee that every solution is oscillatory or eventually positive solutions converge to zero. In the last thirty years, there has been an increasing interest in the study of oscillation and asymptotic behavior of solutions of second order difference equations (see [1–11]). In [1], Arul and Thandapani considered the equation and gave some sufficient conditions for the existence of positive solutions. In [3], Saker considered the equation and gave some sufficient conditions which guarantee that every solution is oscillatory. Following this trend, we are concerned with oscillation criteria of solutions for a second order difference equation with forced term where is a positive sequence, is a nonnegative sequence and not identically zero for all large , is a real sequence, is a real number, and , are nonnegative integers, . A solution of (3) is said to be eventually positive if for all large and eventually negative if for all large . Equation (3) is said to be oscillatory if it is neither eventually positive nor eventually negative. In order to obtain our conclusions, we first give two lemmas. Lemma 0.1. If difference inequality is oscillation, then difference equation is oscillation. Otherwise, if (5) has eventually positive solution, then (4) has eventually positive solution; this is contradictory. Lemma 0.2. Suppose that is an eventually positive solution of (3), , and(i) , (ii) , (iii) . Set . Then and Proof. Suppose that is an eventually positive solution of (3), then there exists , such that , , and for , then for . By summing up (3) from to , we obtain From (6), we know that , where α is a positive limited number or . Thus , β is a limited number or . If ( is a constant), then there exist , for , so that which is contrary to . If , then there exist , for ; hence, therefore, ; thus, there exist , , and ( ) for . By summing up (3) from to, we obtain As , the right-hand side of (9) is bounded, but the left-hand side of (9) tends to ; this is contradictory. Then ; thus . This completes the proof. By means of Lemma 0.2, we obtain the following. Theorem 0.3. If conditions (i), (ii), and (iii) hold and is an eventually positive solution of (3), then . Proof. Making use of (6) and the conclusion of Lemma 0.2, we know so . If not, suppose that , then there exist ,? for . Now substitute for in (6), we obtain a contrary. This completes the proof. Theorem 0.4. If conditions (i), (ii), and (iii) hold, let and if is
Clinical Distribution and Molecular Basis of Traditional Chinese Medicine ZHENG in Cancer
Zhen Chen,Peng Wang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/783923
Abstract: In traditional Chinese medicine (TCM) clinical practice, ZHENG (also known as syndrome) helps to guide design of individualized treatment strategies. In this study, we investigated the clinical use of ZHENG in TCM-treated cancer patients by systematically analyzing data from all relevant reports in the Chinese-language scientific literature. We aimed to determine the clinical ZHENG distributions in six common cancers (lung, liver, gastric, breast, colorectal, and pancreatic) with the expectation of uncovering a theoretical basis for TCM ZHENG as a clinical cancer treatment. In addition, we also reviewed the molecular basis underlying Xue-Yu (blood stasis), Shi-Re (dampness-heat), Yin-Xu (Yin deficiency), and Pi-Xu (spleen deficiency) ZHENG that are commonly found in cancer patients. The results from our summary study provide insights into the potential utility of TCM ZHENG and may contribute to a better understanding of the molecular basis of TCM ZHENG in cancer.
Structural variation of melt-crystallized PTT during the heating process revealed by FTIR and SAXS
Zhen Chen,ShouKe Yan
Chinese Science Bulletin , 2013, DOI: 10.1007/s11434-012-5589-x
Abstract: Time-resolved FTIR, WAXD/SAXS and DSC have been used to investigate the structural variation of non-isothermally crystallized poly(trimethylene terephthalate) (PTT) during the heating process. The three-phase model: the lamellar phase, the mobile amorphous phase (MAP) and the rigid amorphous phase (RAP) between lamellae is suggested to describe the structure of melt-crystallized PTT. According to FTIR results, the conformation of RAP in the constrained state is different from that of MAP. The increased content of amorphous phase in the temperature range from 120 to 192°C is ascribed to the relaxation of RAP, rather than the melting of defective crystals. When the PTT is heated to a temperature above 192°C, the recrystallization/crystal perfection of original defective lamellae occurs without a pre-melting process, which leads to an increase in lamellar thickness and probably connects two adjacent lamellar stacks. This is responsible for an increase in crystallinity as well as a higher major melting temperature.
A Gradient Based Iterative Solutions for Sylvester Tensor Equations
Zhen Chen,Linzhang Lu
Mathematical Problems in Engineering , 2013, DOI: 10.1155/2013/819479
Abstract:
Survey of knowledge of cardiopulmonary resuscitation in nurses of community-based health services in Hainan province
CHEN Xiu-zhen
Al Ameen Journal of Medical Sciences , 2008,
Abstract: To assess the knowledge of cardiopulmonary resuscitation (CPR) among the nurses ( n= 302) of community-based health services in Hainan province of China, a survey was made by randomized stratified cluster sampling using self-designed questionnaires. The passing rate for qualification of the knowledge of CPR was found to be very low in Hainan province (23.18 %). A significant difference of regions and different educational level among the nurses were also noticed (P<0.01). It may be concluded from the study that nurses of community-based health services in Hainan province lack the basic knowledge of CPR, especially in rural region.
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