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Search Results: 1 - 10 of 103144 matches for " Chen Xi-xin "
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A SVD-Based Approach of Suppressing Transient Interference in High-Frequency Radar
基于矩阵奇异值分解的高频雷达瞬态干扰抑制

Chen Xi-xin,Huang Yin-he,
陈希信
,黄银河

电子与信息学报 , 2005,
Abstract: The transient interferences, such as lightening impulse, meteor trail echoes and so on, have to be suppressed since they severely degrade the detection capability of High Frequency (HF) radar. An approach of suppressing the transient interference based on Singular Value Decomposition (SVD) is presented in this paper. In this approach, the HF radar echo is segmented and all segments constitute the columns of some matrix with its SVD computed. Firstly, it can be preliminarily judged whether the transient interference exists in the HF radar echo from the valid rank of the built matrix. Secondly, the orthogonal decomposition of the HF radar echo is obtained using the orthogonality of SVD, thus the transient interference is separated from the radar echo and so easily detected. Finally, the radar echo segment polluted by the transient interference is estimated by building the all-pole autoregressive linear prediction model. The effectiveness of this approach is demonstrated by examples of measured HF radar echo.
The Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy for Advanced Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis
Shi Guang Li, Hai Yong Chen, Chen Sheng Ou-Yang, Xi-Xin Wang, Zhen-Jiang Yang, Yao Tong, William C.S. Cho
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057604
Abstract: Many published studies reflect the growing application of complementary and alternative medicine, particularly Chinese herbal medicine (CHM) use in combination with conventional cancer therapy for advanced non-small cell lung cancer (NSCLC), but its efficacy remains largely unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with conventional chemotherapy (CT) in the treatment of advanced NSCLC. Publications in 11 electronic databases were extensively searched, and 24 trials were included for analysis. A sum of 2,109 patients was enrolled in these studies, at which 1,064 patients participated in CT combined CHM and 1,039 in CT (six patients dropped out and were not reported the group enrolled). Compared to using CT alone, CHM combined with CT significantly increase one-year survival rate (RR = 1.36, 95% CI = 1.15–1.60, p = 0.0003). Besides, the combined therapy significantly increased immediate tumor response (RR = 1.36, 95% CI = 1.19–1.56, p<1.0E?5) and improved Karnofsky performance score (KPS) (RR = 2.90, 95% CI = 1.62–5.18, p = 0.0003). Combined therapy remarkably reduced the nausea and vomiting at toxicity grade of III–IV (RR = 0.24, 95% CI = 0.12–0.50, p = 0.0001) and prevented the decline of hemoglobin and platelet in patients under CT at toxicity grade of I–IV (RR = 0.64, 95% CI = 0.51–0.80, p<0.0001). Moreover, the herbs that are frequently used in NSCLC patients were identified. This systematic review suggests that CHM as an adjuvant therapy can reduce CT toxicity, prolong survival rate, enhance immediate tumor response, and improve KPS in advanced NSCLC patients. However, due to the lack of large-scale randomized clinical trials in the included studies, further larger scale trials are needed.
Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China
Peng-jun Zhang, Xiao-li Li, Bin Cao, Shi-gui Yang, Li-rong Liang, Li Gu, Zhen Xu, Ke Hu, Hong-yuan Zhang, Xi-xin Yan, Wen-bao Huang, Wei Chen, Jing-xiao Zhang, Lan-juan Li, Chen Wang, for the National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group of China
BMC Infectious Diseases , 2012, DOI: 10.1186/1471-2334-12-29
Abstract: Retrospective observational study in 394 severe or critical pregnant women admitted to a hospital with pH1N1 influenza from Sep. 1, 2009 to Dec. 31, 2009. rRT-PCR testing was used to confirm infection. In-hospital mortality was the primary endpoint of this study. Univariable logistic analysis and multivariate logistic regression analysis were used to investigate the potential factors on admission that might be associated with the maternal and neonatal mortality.394 pregnant women were included, 286 were infected with pH1N1 in the third trimester. 351 had pneumonia, and 77 died. A PaO2/FiO2 ≤ 200 (odds ratio (OR), 27.16; 95% confidence interval (CI), 2.64-279.70) and higher BMI (i.e. ≥ 30) on admission (OR, 1.26; 95% CI, 1.09 to 1.47) were independent risk factors for maternal death. Of 211 deliveries, 146 neonates survived. Premature delivery (OR, 4.17; 95% CI, 1.19-14.56) was associated neonatal mortality. Among 186 patients who received mechanical ventilation, 83 patients were treated with non-invasive ventilation (NIV) and 38 were successful with NIV. The death rate was lower among patients who initially received NIV than those who were initially intubated (24/83, 28.9% vs 43/87, 49.4%; p = 0.006). Septic shock was an independent risk factor for failure of NIV.Severe hypoxemia and higher BMI on admission were associated with adverse outcomes for pregnant women. Preterm delivery was a risk factor for neonatal death among pregnant women with pH1N1 influenza infection. NIV may be useful in selected pregnant women without septic shock.Pregnant women are at an increased risk for contracting influenza and its complications associated with influenza [1]. Like previous epidemic and pandemic diseases, 2009 pandemic H1N1 (pH1N1) influenza posed an increased risk of severe illness among pregnant women [2-9]. A report from the first month of the pH1N1 outbreak noted that the rate of hospitalization among pregnant women was approximately four times the rate in the general pop
Construction of Nucleic Acid Vaccine of Porcine Parvovirus and Research on Immunogenicity
猪细小病毒核酸疫苗的构建及其对小鼠免疫原性的研究

WEI Zhan-yong,WANG Xue-bin,CUI Bao-an,HUANG Ke-he,JIN Xi-xin,WANG Ya-bin,CHEN Hong-ying,
魏战勇
,王学斌,崔保安,黄克和,金喜新,王亚宾,陈红英

中国生物工程杂志 , 2006,
Abstract: To construct gene vaccine of Porcine parvovirus (PPV) and to investigate its immune response in mice, the recombinant eukaryotic expression plasmid of pCIneo-VP_2 was constructed and transfected into PK-15 cells by lipofectamine, the expressed product was detected by immunofluorescence assay. To study the immune responses of DNA vaccine in vivo, the recombinant plasmid pCIneo-VP_2, the control pCI-neo and the PPV live vaccine were immunized by intramuscular injection in mice. Anti-PPV antibodies were measured by ELISA. lymphocyte proliferation activity was detected using MTT method, and the specific CTL were assayed too. The results show that the immunized mice produced PPV antibody after one week, and reached to the highest level after four weeks. Compared with the control group, the pCIneo-VP_2 immunized group produced significant differences in the antibody titers, the lymphocyte proliferation activity and the specific killing activities of CTL. The pCIneo-VP_2 induced humora and cellular immune responses similarly to that the live vaccine induced. These results manifested that the PPV DNA vaccine successfully induced humoral and cellular immune response in mice.
Antiviral Therapy and Outcomes of Patients with Pneumonia Caused by Influenza A Pandemic (H1N1) Virus
Shi-gui Yang, Bin Cao, Li-rong Liang, Xiao-li Li, Yong-hong Xiao, Zhi-xin Cao, Hong-yu Jia, Hong-jie Yu, Zhen Xu, Li Gu, Yi-da Yang, Yu Chen, Wei-bo Du, Xi-xin Yan, Zong-an Liang, Wei Zhang, Chang-le Zhang, Wei Chen, Cai-ping Guo, Xun-liang Jiang, Ming Yang, Guang-ming Deng, Kai-jiang Yu, Ke Hu, Qi Zou, Lan-juan Li, Chen Wang, for the National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group of China
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029652
Abstract: Background There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. Methods During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. Results 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy (18.2%) than those with who received oseltamivir ≤ 2days (2.9%), between 2–5 days (4.6%) and >5 days after illness onset (4.9%), p<0.01. A similar trend was observed in pediatric patients. Cox regression showed that at 60 days after symptoms onset, 11 patients (10.8%) who did not receive antivirals died versus 4 (1.8%), 18 (3.3%), and 23 (3.7%) patients whose oseltamivir treatment was started ≤ 2days, between 2–5days, and >5 days, respectively. For males patients, aged ≥ 14 years and baseline PaO2/FiO2<200, oseltamivir administration reduced the mortality risk by 92.1%, 88% and 83.5%, respectively. Higher doses of oseltamivir (>3.8 mg/kg/d) did not improve clinical outcome (mortality, higher dose 2.5% vs standard dose 2.8%, p>0.05). Conclusions Antiviral therapy might reduce mortality of patients with pH1N1 pneumonia, even when initiated more than 48 hours after onset of illness. Greater protective effects might be in males, patients aged 14–60 years, and patients with PaO2/FiO2<200.
Some Frontier Problems on Land Subsidence Research
关于城市地面沉降研究的几个前沿问题

ZHENG Xi-xin,WU Qiang,HOU Yan-sheng,YING Yu-fei,
郑铣鑫
,武强,侯艳声,应玉飞

地球学报 , 2002,
Abstract: 地面沉降涉及资源、环境、经济和社会等各个方面,影响城市和地区的可持续发展,已成为21世纪国内外城市主要地质灾害。文章概述了国内外地面沉降状况,对目前城市地面沉降研究存在的问题进行了分析,并提出了城市地面沉降研究值得关注的几个前沿问题。
Construction of the Eukaryotic Expression Vector with IL-2 Gene and VP2 Gene of PPV and Research on Immunogenicity
IL-2与猪细小病毒VP2基因双表达载体的构建及免疫原性的研究

CUI Bao-An,WEI Zhan-Yong,WANG Xue-Bin,HUANG Ke-He,JIN Xi-Xin,DONG Zhen-Jie,ZHENG Lan-Lan,
崔保安
,魏战勇,王学斌,黄克和,金喜新,董振杰,郑兰兰

生物工程学报 , 2006,
Abstract: To construct gene vaccine of PPV and to investigate the effects of interleukin 2 (IL-2) as an adjuvant on immune responses in mouse, the recombinant expression plasmid of pCIneo-IL_2-VP_2 was constructed and transfected into PK-15 cells by lipofectamine, the expressed product was detected by immunofluore assay. To study the immune effects of DNA vaccine in vitro and in vivo, mice were used as the animal model. The recombinant plasmid pCIneo-IL_2-VP_2, the control plasmid pCI-neo and the PPV live vaccine were immunized by intramuscular injection. Anti-PPV antibodies were measured by ELISA, lymphocyte proliferation activity was detected using MTT method, and the specific killing activities of CTL were assayed too. The results show that the immunized mice produced PPV antibody after one week, and reached to highest after four weeks. Compared with the control group, the pCIneo-IL_2-VP_2 immunized group produced significant differences in the antibody titers, the lymphocyte proliferation activity and the specific killing activities of CTL. The pCIneo-IL_2-VP_2 induced humoral and cellular immunity responses similarly to that the live vaccine induced. These results manifested that the PPV DNA vaccine successfully induced humoral and cellular immunity response in mice with the IL-2 gene as an adjuvant.
Prokaryotice expression of the NS1 gene of PPV and renaturationof the recombinant protein
猪细小病毒NS1基因的原核表达及重组蛋白的复性

JIN Xi-xin,CUI Bao-an,WEI Zhan-yong,LIU Zhan-tong,WANG Xue-bin,TIAN Yong-jun,
金喜新
,崔保安,魏战勇,刘占通,王学斌,田永军

微生物学报 , 2007,
Abstract: The antigen of NS1 gene of PPV was amplified by PCR, and the amplified fragments were cloned into the prokaryotic expression vector pGEX-4T-1. The insert position, the size and the frame were identified by PCR, restriction enzyme digestion and the sequence analysis of the recombinant plasmids. The sequence analysis results of pGEX-NS1-HN1 showed that the prokaryotic expression vector was successfully constructed. The target gene was successfully expressed in the host cell BL21 when induced with IPTG. The expression was optimized with proper inducing conditions of 1.0mmol/L IPTG, 10 hours and 37 degree C induction. The expression of the target protein added up to 29.8% of the total bacterial protein. The results of SDS-PAGE indicated that molecular weight of the expressed protein was about 52kDa and the expressed protein mainly existed in the inclusion body. Western blot analysis proved the recombinant protein has good reactive ability against PPV positive serum. The pGEX-NS1-HN1 inclusion body was dissolved with 8mol/L urea. Then the expressed protein was renatured by dilution method and the systems of GSH and GSSG. ELISA detection proved the renaturation protein has good biological activity.
Differentiation of Mesenchymal Stem Cells into Hepatocyte-Like Cells by Autologous Serum after Radiofrequency Ablation of Liver Tumor  [PDF]
Yi Yang, Xi Chen, Tao Wu, Xin Xu, Gang Cao, Hua Li, Yiming Li
Stem Cell Discovery (SCD) , 2014, DOI: 10.4236/scd.2014.44011
Abstract: Mesenchymal stem cells (MSCs) have been shown to differentiate into liver cells in serum of part-resection liver, but it was hardly feasible in clinical use. Our studies revealed that MSCs could differentiate into hepatocyte-like cells in autologous serum after radiofrequency ablation (RFA) therapy of the liver tumor. Rabbits with liver tumor subsequently treated with RFA therapy. Serum was collected from those rabbits before RFA therapy and 72 hours after RFA therapy. MSCs were isolated from each rabbit’s bone marrow and cultured in DMEM medium containing the following different supplements: 30% fetal calf serum (FCS group), 30% rabbit autologous serum (AS group) or 30% autologous serum after RFA treatment of the liver tumor (ASRF group), observed by electron microscopy, flow cytometry, immunofluorescence. Seven days later, most of the spindle-shaped MSCs in the ASRF group transformed into polygon or round-shaped cells resembling hepatocytes, and the percentage in S/G2/M phase was higher than in the FCS or AS groups. Fourteen days later, slender microvilli, cell-cell junction structures and cholangiole emerged in the cells belonging to the ASRF group, the expression of albumin and CK18 was observed only in the differentiated cells from the ASRF group. These changes were not observed in the FCS group or the AS group. This study may provide a potential cell source and culture process for clinical application in liver injury treatment.
A simple derivation of level spacing of quasinormal frequencies for a black hole with a deficit solid angle and quintessence-like matter
Ping Xi,Xi-chen Ao,Xin-zhou Li
Physics , 2010, DOI: 10.1007/s10509-010-0410-2
Abstract: In this paper, we investigate analytically the level space of the imaginary part of quasinormal frequencies for a black hole with a deficit solid angle and quintessence-like matter by the Padmanabhan's method \cite{Padmanabhan}. Padmanabhan presented a method to study analytically the imaginary part of quasinormal frequencies for a class of spherically symmetric spacetimes including Schwarzschild-de Sitter black holes which has an evenly spaced structure. The results show that the level space of scalar and gravitational quasinormal frequencies for this kind of black holes only depend on the surface gravity of black-hole horizon in the range of -1 < w < -1/3, respectively . We also extend the range of $w$ to $w \leq -1$, the results of which are similar to that in -1 < w < -1/3 case. Particularly, a black hole with a deficit solid angle in accelerating universe will be a Schwarzschild-de Sitter black hole, fixing $w = -1$ and $\epsilon^2 = 0$. And a black hole with a deficit solid angle in the accelerating universe will be a Schwarzschild black hole,when $\rho_0 = 0$ and $\epsilon^2 = 0$. In this paper, $w$ is the parameter of state equation, $\epsilon^2$ is a parameter relating to a deficit solid angle and $\rho_0$ is the density of static spherically symmetrical quintessence-like matter at $r = 1$.
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