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Search Results: 1 - 10 of 18897 matches for " Chee-Fu Yung "
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Comparing the Immunogenicity of AS03-Adjuvanted 2009 Pandemic H1N1 Vaccine with Clinical Protection in Priority Risk Groups in England
Chee-Fu Yung, Nick Andrews, Katja Hoschler, Elizabeth Miller
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056844
Abstract: In England, during pandemic 2009 H1N1, vaccine efficacy and immunogenicity population studies in priority groups were rolled out in parallel to evaluate the pandemic vaccination programme. This provided a unique opportunity to compare immunogenicity and clinical protection in the same population and thus provide insights into the correlates of protection for the pandemic H1N1 2009 vaccine in risk groups. While clinical protection from AS03-adjuvanted pandemic 2009 H1N1 vaccine was high in those aged <25 years and pregnant women, effectiveness in older adults with chronic conditions has been found to be surprisingly poor. Here we present results from the immunogenicity study derived from the same population. Individuals from priority groups eligible for pandemic vaccination attending participating general practices were recruited. Pre and post-vaccination blood samples were collected and HI antibody testing to assess immune response to vaccination performed. The final cohort consisted of 610 individuals: 60 healthy children aged <5 years; 32 healthy pregnant women; 518 individuals from risk groups. Seroconversion rate in healthy children aged <5 years (87%, 95% CI: 75% to 94%) was higher than that of risk groups combined (65%, 95% CI: 61% to 69%) (p<0.001). Multivariable analysis of risk groups showed that the size of response in those who did seroconvert was lower in those who received the 2009/10 seasonal TIV (Fold effect: 0.52, 0.35 to 0.78). Predicted immunological boosting from higher pre-vaccine titres after 2009 pandemic H1N1 vaccination only occurred in children (seroconversion rate = 92%) and not in individuals aged 10 to 39 from risk groups (seroconversion rate = 74%). The lack of clinical protection identified in the same population in older adults from risk groups could be attributed to these lower seroresponses. Current immunogenicity licensing criteria for pandemic influenza vaccine may not correlate with clinical protection in individuals with chronic disease or immunocompromised.
Utilities and Limitations of the World Health Organization 2009 Warning Signs for Adult Dengue Severity
Tun-Linn Thein equal contributor ,Victor C. Gan equal contributor,David C. Lye,Chee-Fu Yung,Yee-Sin Leo
PLOS Neglected Tropical Diseases , 2013, DOI: 10.1371/journal.pntd.0002023
Abstract: Background In 2009, the World Health Organization (WHO) proposed seven warning signs (WS) as criteria for hospitalization and predictors of severe dengue (SD). We assessed their performance for predicting dengue hemorrhagic fever (DHF) and SD in adult dengue. Method DHF, WS and SD were defined according to the WHO 1997 and 2009 dengue guidelines. We analyzed the prevalence, sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of WS before DHF and SD onset. Results Of 1507 cases, median age was 35 years (5th–95th percentile, 17–60), illness duration on admission 4 days (5th–95th percentile, 2–6) and length of hospitalization 5 days (5th–95th percentile, 3–7). DHF occurred in 298 (19.5%) and SD in 248 (16.5%). Of these, WS occurred before DHF in 124 and SD in 65 at median of two days before DHF or SD. Three commonest warning signs were lethargy, abdominal pain/tenderness and mucosal bleeding. No single WS alone or combined had Sn >64% in predicting severe disease. Specificity was >90% for both DHF and SD with persistent vomiting, hepatomegaly, hematocrit rise and rapid platelet drop, clinical fluid accumulation, and any 3 or 4 WS. Any one of seven WS had 96% Sn but only 18% Sp for SD. Conclusions No WS was highly sensitive in predicting subsequent DHF or SD in our confirmed adult dengue cohort. Persistent vomiting, hepatomegaly, hematocrit rise and rapid platelet drop, and clinical fluid accumulation, as well as any 3 or 4 WS were highly specific for DHF or SD.
Visualization Techniques in Smart Grid  [PDF]
Dao Viet Nga, Ong Hang See, Do Nguyet Quang, Chee Yung Xuen, Lai Lee Chee
Smart Grid and Renewable Energy (SGRE) , 2012, DOI: 10.4236/sgre.2012.33025
Abstract: Visualization is an established methodology in scientific computing. It has been used in many fields because of its strong capability in large data management and information display. However, its applications in power systems, especially in Smart Grid are still in infancy stage. Besides, while there were a lot of researches working on visualizing data in transmission power system, the study on displaying distribution power system data was limited. Therefore, in this paper, author proposed some techniques to visualize the Smart Grid data at distribution. They are classified in three categories, which are low dimensional techniques, multivariate high dimensional techniques and Geographical Information System (GIS) techniques.
The effect of service constraint on EPQ model with random defective rate
Yung-Fu Huang
Mathematical Problems in Engineering , 2006, DOI: 10.1155/mpe/2006/79028
Abstract: Chiu studied the effect of service-level constraint on the economic production quantity (EPQ) model with random defective rate. In this note, we will offer a simple algebraic approach to replace his differential calculus skill to find the optimal solution under the expected annual cost minimization.
The effect of service constraint on EPQ model with random defective rate
Yung-Fu Huang
Mathematical Problems in Engineering , 2006,
Abstract: Chiu studied the effect of service-level constraint on the economic production quantity (EPQ) model with random defective rate. In this note, we will offer a simple algebraic approach to replace his differential calculus skill to find the optimal solution under the expected annual cost minimization.
Retailer’s replenishment policies under conditions of permissible delay in payments
Huang Yung-Fu
Yugoslav Journal of Operations Research , 2004, DOI: 10.2298/yjor0402231h
Abstract: Goyal (1985) is frequently cited when the inventory systems under conditions of permissible delay in payments are discussed. Goyal implicitly assumed that: 1. The unit selling price and the unit purchasing price are equal; 2. At the end of the credit period, the account is settled. The retailer starts paying for higher interest charges on the items in stock and returns money of the remaining balance immediately when the items are sold. But these assumptions are debatable in real-life situations. The main purpose of this paper is to modify Goyal’s model to allow the unit selling price and the unit purchasing price not necessarily be equal to reflect the real-life situations. Furthermore, this paper will adopt different payment rule. We assume that the retailer uses sales revenue during the permissible credit period to make payment to the supplier at the end of the credit period. If it is not enough to pay off the purchasing cost of all items, the retailer will pay off the remaining balance by taking loan from the bank. So, the retailer starts paying for the interest charges on the amount of loan from the bank after the account is settled. Then the retailer will return money to the bank at the end of the inventory cycle. Under these conditions, we model the retailer’s inventory system as a cost minimization problem to determine the retailer’s optimal cycle time and optimal order quantity. Four cases are developed to efficiently determine the optimal cycle time and the optimal order quantity. Numerical examples are given to illustrate these cases. Comparing with Goyal’s model, we also find that the optimal cycle times in this paper are not longer than those of Goyal’s model.
Algebraic Improvement on Effects of Random Defective Rate and Imperfect Rework Process on Economic Production Quantity Model
Yung-Fu Huang
Journal of Applied Sciences , 2006,
Abstract: The present note studied the effect of random defective rate and imperfect rework process on the Economic Production Quantity (EPQ) model. They demonstrate that the optimal lot size can be solved algebraically and the expected inventory cost can be derived immediately as well. In this note, we will offer a simple algebraic approach to replace their algebraic skill to find the optimal solution under the expected annual cost minimized.
An Algebraically Derived Minimal Cost Solution Technique of the EOQ Model Under Conditional Trade Credit
Yung-Fu Huang
Journal of Applied Sciences , 2006,
Abstract: In this study the restrictive assumptions of the trade credit independent of the order quantity and the retailer`s unit selling price equaled to the purchasing price per unit are relaxed to fit real business situations. This study investigates the retailer`s inventory problem under trade credit dependent of the order quantity and the retailer`s unit selling price not necessarily equals to the purchasing price per unit within the Economic Order Quantity (EOQ) framework. In addition, we adopt the algebraic procedure to determine the retailer`s optimal ordering policy under minimizing the annual total variable cost. This algebraic approach could therefore be used easily to introduce the basic inventory theories to younger students who lack the knowledge of calculus. Then, two theorems are developed to efficiently determine the optimal cycle time and optimal order quantity for the retailer. Finally, numerical examples are given to illustrate these theorems and obtain a lot of managerial insights.
Optimal Cycle Time and Optimal Payment Time under Supplier Credit
Yung-Fu Huang
Journal of Applied Sciences , 2004,
Abstract: This study investigate the retailer`s optimal cycle time and optimal payment time under supplier`s trade credit policy and cash discount policy. Mathematical models have been derived for obtaining the optimal cycle time and optimal payment policy for item under supplier`s trade credit and cash discount so that the annual total relevant cost is minimized. Furthermore, numerical examples have given to illustrate the results developed in this study and a lot of managerial insights have obtained.
A Note on Retailer`s Ordering Policy and Payment Policy under Trade Credit and Cash Discount
Yung-Fu Huang
Journal of Applied Sciences , 2004,
Abstract: In present study, the model of Huang has been modified and discussed with retailer`s ordering policy under conditions of cash discount and trade credit. Mathematical model has been modified for obtaining the optimal cycle time and optimal payment policy for item under cash discount and trade credit so that the annual total cost is minimized. Then, a theorem is provided to efficiently determine the optimal cycle time and optimal payment policy. Finally, a numerical example is solved to illustrate the results obtained.
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