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Search Results: 1 - 10 of 63160 matches for " Che-Yi Lin "
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New Anti-Inflammatory Aromatic Components from Antrodia camphorata
Yu-Chang Chen,His-Lin Chiu,Che-Yi Chao,Wen-Hsin Lin,Louis Kuoping Chao,Guan-Jhong Huang,Yueh-Hsiung Kuo
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14034629
Abstract: Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol ( 1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl ( 2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl ( 3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol ( 4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol ( 5), were isolated from Antrodia camphorata. Our results support that compounds 1– 5 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC 50 values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
Zebrafish Krüppel-Like Factor 4a Represses Intestinal Cell Proliferation and Promotes Differentiation of Intestinal Cell Lineages
I-Chen Li,Chein-Tso Chan,Yu-Fen Lu,Yi-Ting Wu,Yi-Chung Chen,Guo-Bin Li,Che-Yi Lin,Sheng-Ping L. Hwang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020974
Abstract: Mouse krüppel-like factor 4 (Klf4) is a zinc finger-containing transcription factor required for terminal differentiation of goblet cells in the colon. However, studies using either Klf4?/? mice or mice with conditionally deleted Klf4 in their gastric epithelia showed different results in the role of Klf4 in epithelial cell proliferation. We used zebrafish as a model organism to gain further understanding of the role of Klf4 in the intestinal cell proliferation and differentiation.
Low Temperature Mitigates Cardia Bifida in Zebrafish Embryos
Che-Yi Lin, Cheng-Chen Huang, Wen-Der Wang, Chung-Der Hsiao, Ching-Feng Cheng, Yi-Ting Wu, Yu-Fen Lu, Sheng-Ping L. Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069788
Abstract: The coordinated migration of bilateral cardiomyocytes and the formation of the cardiac cone are essential for heart tube formation. We investigated gene regulatory mechanisms involved in myocardial migration, and regulation of the timing of cardiac cone formation in zebrafish embryos. Through screening of zebrafish treated with ethylnitrosourea, we isolated a mutant with a hypomorphic allele of mil (s1pr2)/edg5, called s1pr2as10 (as10). Mutant embryos with this allele expressed less mil/edg5 mRNA and exhibited cardia bifida prior to 28 hours post-fertilization. Although the bilateral hearts of the mutants gradually fused together, the resulting formation of two atria and one tightly-packed ventricle failed to support normal blood circulation. Interestingly, cardia bifida of s1pr2as10 embryos could be rescued and normal circulation could be restored by incubating the embryos at low temperature (22.5°C). Rescue was also observed in gata5 and bon cardia bifida morphants raised at 22.5°C. The use of DNA microarrays, digital gene expression analyses, loss-of-function, as well as mRNA and protein rescue experiments, revealed that low temperature mitigates cardia bifida by regulating the expression of genes encoding components of the extracellular matrix (fibronectin 1, tenascin-c, tenascin-w). Furthermore, the addition of N-acetyl cysteine (NAC), a reactive oxygen species (ROS) scavenger, significantly decreased the effect of low temperature on mitigating cardia bifida in s1pr2as10 embryos. Our study reveals that temperature coordinates the development of the heart tube and somitogenesis, and that extracellular matrix genes (fibronectin 1, tenascin-c and tenascin-w) are involved.
Comparing Risk of New Onset Diabetes Mellitus in Chronic Kidney Disease Patients Receiving Peritoneal Dialysis and Hemodialysis Using Propensity Score Matching
Che-Yi Chou, Chih-Chia Liang, Huey-Liang Kuo, Chiz-Tzung Chang, Jiung-Hsiun Liu, Hsin-Hung Lin, I.-Kuan Wang, Ya-Fei Yang, Chiu-Ching Huang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087891
Abstract: Chronic kidney disease (CKD) patients are at risk for developing new-onset diabetes mellitus (NODM) even after hemodialysis (HD) and peritoneal dialysis (PD) treatment. It is not clear if the incidence for NODM is different in CKD patients receiving HD and PD. This study compared the risk of NODM in PD patients and HD patients. Methods All HD and PD patients in Taiwan Renal Registry Database from 1997 to 2005 were included and all patients were followed to December 31, 2008. The risk of NODM was analyzed in PD patients and propensity score matched HD patients using logistic regression for early type NODM (< = 6 months after dialysis) and Cox regression for late type NODM (>6 months after dialysis). Results A total of 2548 PD patients and 10192 HD patients who had no diabetes on the initiation of dialysis were analyzed. The incidence for NODM was 3.7 per 100 patient/year for HD and 2.4 for PD patients. HD patients are more at risk for developing early type NODM (p<0.001) with an adjusted odds ratio of 1.41 [95% confidence interval (CI) 1.12–1.78)]. HD patients are more at risk for late type NODM (p<0.001) with an adjusted hazard ratio of 2.01 (95% CI: 1.77–2.29). Patient’s age was negatively associated with risk of early type of NODM (p<0.001) but positively associated with risk of late type NODM (p<0.001). Conclusions Chronic kidney disease patients receiving hemodialysis are more at risk for developing new-onset diabetes mellitus compared to those receiving peritoneal dialysis.
One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim.
Chi-Ren Liao,Yu-Ling Ho,Guan-Jhong Huang,Chang Syun Yang,Che-Yi Chao,Yuan-Shiun Chang,Yueh-Hsiung Kuo
Molecules , 2013, DOI: 10.3390/molecules181113218
Abstract: One lignanoid compound, isoamericanol B ( 1), along with four triterpenoid compounds— cis -3- O - p -hydroxycinnamoyloleanolic acid ( 2 ), trans -3- O - p -hydroxy cinnamoyloleanolic acid ( 3 ), cis -3- O - p -hydroxycinnamoylursolic acid ( 4 ), trans -3- O - p -hydroxycinnamoylursolic acid ( 5 ) have been isolated for the first time from the leaves of Elaeagnus oldhamii Maxim. Compounds 1– 4 significantly inhibited the expression of NO (nitric oxide) produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 value for inhibition of nitrite production of compound 1 was about 10.3 ± 0.4 μg/mL. In the cell viability test, however, among compounds 1– 4 compound 1 did not significantly change cell viability. Therefore, in this study compound 1 possessed anti-inflammatory effects. The result suggests compound 1 as a potential lead compound for the treatment of inflammatory diseases.
Peptic Ulcer Disease Risk in Chronic Kidney Disease: Ten-Year Incidence, Ulcer Location, and Ulcerogenic Effect of Medications
Chih-Chia Liang, Chih-Hsin Muo, I-Kuan Wang, Chiz-Tzung Chang, Che-Yi Chou, Jiung-Hsiun Liu, Tzung-Hai Yen, Chiu-Ching Huang, Chi-Jung Chung
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087952
Abstract: Objectives We aimed at determining peptic ulcer disease (PUD) incidence among chronic kidney disease (CKD) patients during 1998–2008, compared to patients without CKD, and at examining associations between CKD and PUD. Methods Data for 1998–2008 were extracted from the National Health Insurance Research Database in Taiwan. The annual PUD incidence (cases per thousand persons per year) was calculated separately for patients with and without CKD. Characteristics of patients with newly diagnosed PUD (n = 16322) were compared to those of a control group without PUD (n = 32644). The 2 groups were matched for age, sex, and index year. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression. Results Over the 10-year period, the PUD incidence was ~10–12 times higher in CKD patients than in those without CKD. Its incidence in elderly CKD patients increased rapidly over time. For CKD patients, most PUD events (>95%) were managed during hospitalization. Peptic ulcer risk, adjusted for all potential confounders, was much higher in CKD patients undergoing hemodialysis (adjusted OR, 9.74; 95% CI, 7.11–13.31). Maintenance hemodialysis patients were 2 times more likely to have gastric ulcers than duodenal ulcers, while CKD patients not on dialysis had similar risks for both. There were no significant interactions between medications and CKD status on the peptic ulcer risk. Unlike CKD patients on nonsteroidal anti-inflammatory drugs and clopidogrel, those on aspirin did not have a higher peptic ulcer risk (adjusted OR, 0.88; 95% CI, 0.44–1.77). Conclusions CKD patients have a substantially increased PUD risk, and the majority of CKD patients with PUD require hospital management. Further, peptic ulcer risk is affected by hemodialysis therapy, patient status (inpatient vs. outpatient), and ulcerogenic medications.
Identification of Grown-In Defects in CZ Silicon after Cu Decoration  [PDF]
Kun-Lin Lin, Yi-Ling Jian, Che-Yu Lin, Chien-Cheng Lin, Yih-Rong Luo, Chien-Chia Tseng
Microscopy Research (MR) , 2017, DOI: 10.4236/mr.2017.52002
Abstract: Bulk Czochralski silicon crystals were decorated with Cu and characterized by transmission electron microscopy (TEM) with energy-dispersive spectroscopy (EDS), atomic force microscopy (AFM), optical microscopy (OM), scanning electron microscopy (SEM), and photoluminescence spectroscopy (PL). The vacancy-type core, oxidation-induced stacking faults (OISF) ring, nearly defect-free ring, and self-interstitial-type rich outer ring were delineated in the Si crystal wafer. At the surface of the Si crystal, vertical-horizontal line (V-H line) defects and windmill defects (W-defects) were formed instead of OISF. The families of growth planes and directions were expressed as {011} and <110> for the V-H line and {010} and <010> for W-defects, respectively. In addition to V-H line defects and W-defects, pits or voids and Si oxide with dissolved Cu were found in the Si crystal wafer.
Air quality model parallel computation optimized research using 64 bit Linux platform

ZHU Yun,LIN Che jen,CHEN Chun yi,JANG Carey,ZHONG Yi long,
,LIN Che jen,陈春贻,JANG Carey,钟义龙

计算机应用研究 , 2009,
Abstract: The computational efficiency and simulation results of community multiscale air quality(CMAQ) model developed by U.S.EPA were analyzed using a variety of parallel CPU cores under two 64 bit Linux OS platforms.The results show that the parallel computing can significantly reduce the CMAQ run time,and 16 appear to be the optimal performance comparing hardware investment parallel CPU cores number.The average simulation time per day was reduced to less than 16 minutes using the 16 parallel cores,compared to up ...
How to Design the Control Group in Randomized Controlled Trials of Acupuncture?
Jaung-Geng Lin,Chao-Hsun Chen,Yu-Che Huang,Yi-Hung Chen
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/875284
Abstract: In evidence-based medicine, randomized controlled trials (RCTs) are the preferred method for evaluating the efficacy of interventions. In regard to acupuncture RCTs, the most difficult issues are the design of the control group and implementation of the principle of “double-blinding.” We compared the advantages and limitations associated with different control group designs in acupuncture RCTs, to assist researchers in this field.
Transcription of the rat testis-specific Rtdpoz-T1 and -T2 retrogenes during embryo development: co-transcription and frequent exonisation of transposable element sequences
Chiu-Jung Huang, Wan-Yi Lin, Che-Ming Chang, Kong-Bung Choo
BMC Molecular Biology , 2009, DOI: 10.1186/1471-2199-10-74
Abstract: We show here that the T1 and T2 genes are also expressed in the rat embryo up to days 16–17 of development when the genes are silenced until being re-activated in the adult testis. On database interrogation, we find that some T1/T2 exons are chromosomally duplicated as cassettes of 2 or 3 exons consistent with retro-duplication. The embryonic T1/T2 transcripts, characterised by RT-PCR-cloning and rapid amplification of cDNA ends, are further found to have acquired one or more noncoding exons in the 5'-untranslated region (5'-UTR). Most importantly, the T1/T2 locus is embedded within a dense field of relics of transposable element (TE) derived mainly from LINE1 and ERV sequences, and the TE sequences are frequently exonised through alternative splicing to form the 5'-UTR sequences of the T1/T2 transcripts. In a case of T1 transcript, the 3'-end is extended into and terminated within an L1 sequence. Since the two genes share a common exon 1 and are, therefore, regulated by a single promoter, a T2-to-T1 co-transcription model is proposed. We further demonstrate that the exonised 5'-UTR TE sequences could lead to the creation of upstream open reading frames resulting in translational repression.Exonisation of TE sequences is a frequent event in the transcription of retrogenes during embryonic development and in the testis and may contribute to post-transcriptional regulation of expression of retrogenes.Retrotransposition is an important evolutionary driving force for the creation of new genes with novel lineage- and species-specific phenotypic traits. New genes created through retrotransposition are retrogenes that are devoid of introns. Furthermore, paralogues are subsequently created through segmental duplications and sequence modifications. Retrogenes could be re-activated by putative promoters and other transcription regulatory elements suitably located upstream of the retrogene insertion sites [1-3]. In the process of transcriptional re-activation, the newly arisen
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