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Search Results: 1 - 10 of 127253 matches for " Charles T. Prickett "
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Automated electronic medical record sepsis detection in the emergency department
Su Q. Nguyen,Edwin Mwakalindile,James S. Booth,Vicki Hogan,Jordan Morgan,Charles T. Prickett,John P. Donnelly,Henry E. Wang
PeerJ , 2015, DOI: 10.7717/peerj.343
Abstract: Background. While often first treated in the emergency department (ED), identification of sepsis is difficult. Electronic medical record (EMR) clinical decision tools offer a novel strategy for identifying patients with sepsis. The objective of this study was to test the accuracy of an EMR-based, automated sepsis identification system.
Use of GenMAPP and MAPPFinder to analyse pathways involved in chickens infected with the protozoan parasite Eimeria
Prickett Dennis,Watson Michael
BMC Proceedings , 2009, DOI: 10.1186/1753-6561-3-s4-s7
Abstract: Background Microarrays allow genome-wide assays of gene expression. There is a need for user-friendly software to visualise and analyse these data. Analysing microarray data in the context of biological pathways is now common, and several tools exist. Results We describe the use of MAPPFinder, a component of GenMAPP to characterise the biological pathways affected in chickens infected with the protozoan parasite Eimeria. Several pathways were significantly affected based on the unadjusted p-value, including several immune-system pathways. Conclusion GenMAPP/MAPPFinder provides a means to rapidly visualise pathways affected in microarray studies. However, it relies on good genome annotation and having genes reliably linked to pathway objects. We show that GenMAPP/MAPPFinder can produce useful results, and as the annotation of the chicken genome improves, so will the level of information gained.
Assessment of a short phylogenetic marker based on comparisons of 3’ end 16S rDNA and 5’ end 16S-23S ITS nucleotide sequences of the Bacillus cereus group  [PDF]
Sabarimatou Yakoubou, Jean-Charles C?té
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.210138
Abstract: A short phylogenetic marker previously used in the reconstruction of the Order Bacillales and the genus Bacillus was assessed here at a lower taxa level: species in the Bacillus cereus group: B. anthracis, B. cereus, B. thuringiensis and B. weihenstephanensis. This maker is 220 bp in length. It is a combination of 150 bp at the 3’ end of the 16S rDNA and 70 bp at the 5’ end of the 16S-23S ITS sequence. Three additional Bacillus species, B. halodurans, B. licheniformis and B. subtilis, and Clostridium tetani were included for comparison purposes. A total of eight bacterial species and 12 strains were analyzed. A boot- strapped neighbor-joining tree was inferred from comparative analyses of all allelic sequences of the bacterial species and strains under study. Based on its topology, four major Groups were revealed at the 90% nucleotide sequence identities, Group I to IV. Group I contains all al-leles of the Bacillus cereus group. Group II con-tains all alleles of B. halodurans. Group III con-tains all alleles of B. licheniformis and B. subtilis. Group IV contains all alleles of Clostridium tetani. The 220 bp phylogenetic marker used here could resolve different species from different genera. At the genus level, distant species could be dis-tinguished. Very closely-related species, however, were undistinguishable. Species in the B. cereus group, most notably B. cereus, B. anth- racis and B. thuringiensis, could not be distin- guished. After successfully inferring the phylo- genies of the Order Bacillales and the genus Bacillus, we have met the resolving limit of this short phy-logenetic marker: B. cereus, B. anthracis and B. thuringiensis.
Assessment of a short phylogenetic marker based on comparisons of 3' end 16S rDNA and 5' end 16S-23S ITS nucleotide sequences on the genus Xanthomonas  [PDF]
Sabarimatou Yakoubou, Jean-Charles C?té
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.212167
Abstract: A short phylogenetic marker previously used in the reconstruction of the Class γ-proteobacteria was assessed here at a lower taxa level, species in the genus Xanthomonas. This maker is 224 nucleotides in length. It is a combination of a 157 nucleotide sequence at the 3' end of the 16S rRNA gene and a 67 nucleotide sequence at the 5' end of the 16S-23S ITS sequence. A total of 23 Xanthomonas species were analyzed. Species from the phylogenetically related genera Xylella and Stenotrophomonas were included for com- parison purposes. A bootstrapped neighbor- joining phylogenetic tree was inferred from comparative analyses of the 224 bp nucleotide sequence of all 30 bacterial strains under study. Four major Groups were revealed based on the topology of the neighbor-joining tree, Group I to IV. Group I and II contained the genera Steno-trophomonas and Xylella, respectively. Group III included five Xanthomonas species: X. theicola, X. sacchari, X. albineans, X. transluscens and X. hyacinthi. This group of Xanthomonas species is often referred to as the hyacinthi group. Group IV contained the other 18 Xanthomonas species. The overall topology of the neighbor-joining tree was in agreement with currently accepted phylogenetic. The short phylogenetic marker used here could resolve species from three dif-ferent Xanthomonadacea genera: Stenotro-phomonas, Xylella and Xanthomonas. At the level of the Xanthomonas genus, distant spe-cies could be distinguished, and whereas some closely-related species could be distinguished, others were undistinguishable. Pathovars could not be distinguished. We have met the resolving limit of this marker: pathovars and very closely related species from same genus.
Microcontroller-Based Process Monitoring Using Petri-Nets
Frankowiak MarcosR,Grosvenor RogerI,Prickett PaulW
EURASIP Journal on Embedded Systems , 2009,
Abstract: This paper considers the development of a Petri-net-based modelling tool as a mechanism for process and system monitoring. The use of Petri-nets, which has previously been largely based in the areas of systems modelling and simulation, is shown here to have great potential for deployment as a process monitoring and management application. Interfacing with real-world processes has been achieved in part by introducing a specific set of extensions to the original Petri-net concept. This work has resulted in the engineering of a tool that can be embedded within the process using a microcontroller platform. The potential for such systems to provide low cost, yet powerful process management tools, is becoming increasingly evident, particularly given the ever-improving capabilities of microcontrollers.
The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates
Charles T. Hanifin
Marine Drugs , 2010, DOI: 10.3390/md8030577
Abstract: Tetrodotoxin (TTX) is widely distributed in marine taxa, however in terrestrial taxa it is limited to a single class of vertebrates (Amphibia). Tetrodotoxin present in the skin and eggs of TTX-bearing amphibians primarily serves as an antipredator defense and these taxa have provided excellent models for the study of the evolution and chemical ecology of TTX toxicity. The origin of TTX present in terrestrial vertebrates is controversial. In marine organisms the accepted hypothesis is that the TTX present in metazoans results from either dietary uptake of bacterially produced TTX or symbiosis with TTX producing bacteria, but this hypothesis may not be applicable to TTX-bearing amphibians. Here I review the taxonomic distribution and evolutionary ecology of TTX in amphibians with some attention to the origin of TTX present in these taxa.
The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness
Charles T Esmon
Critical Care , 2001, DOI: 10.1186/cc1333
Abstract: The initiation of coagulation, especially in severe sepsis, is probably mediated by the induction of tissue factor (TF) expression by endotoxin. This leads to the activation of factor X, which then combines with factor Va to convert prothrombin to thrombin. Although thrombin is usually considered to have purely procoagulant activity, it is in fact a multifunctional protein that has some important homeostatic anticoagulant effects (Fig. 1) [1]. One of its main functions is to bind to thrombomodulin, which is expressed on the endothelial cell surface. Thrombomodulin is the major physiologic buffer for the procoagulant effects of thrombin in normal vessels [2,3]. Because thrombomodulin binds to the same site on thrombin that would normally bind to fibrinogen, platelets or factor V, all of these functions are blocked. Instead, the thrombin-thrombomodulin complex activates Protein C (through a different site on the thrombin molecule), resulting in initiation of the Activated Protein C pathway [3]. This process is augmented by the EPCR [4,5]. Activated Protein C must dissociate from EPCR before it can bind to Protein S and function as an effective anticoagulant through the inactivation of factor Va.Activated Protein C is particularly important in the microcirculation [3]. Although the number of thrombomodulin molecules per endothelial cell is approximately constant, the local concentration of thrombomodulin is determined by the number of endothelial cells that are in contact with the blood. Because the endothelial cell surface area per unit blood volume is much greater in the microcirculation (approximately 3000-5000 cm2 of endothelium/ml blood) than in larger blood vessels (approximately 1.5 cm2/ml) (Fig. 2) [6], there is a correspondingly high concentration of thrombomodulin in the normal microvasculature (approximately 500 nmol/l) as compared with the larger vessels (approximately 0.1-0.2 nmol/l). As a result, thrombin is rapidly removed from the microcirculation as it
From substantival to functional vitalism and beyond: animas, organisms and attitudes
Wolfe,Charles T.;
Eidos , 2011,
Abstract: abstract i distinguish between 'substantival' and 'functional' forms of vitalism in the eighteenth century. substantival vitalism presupposes the existence of a (substantive) vital force which either plays a causal role in the natural world as studied scientifically, or remains an immaterial, extra-causal entity. functional vitalism tends to operate 'post facto', from the existence of living bodies to the search for explanatory models that will account for their uniquely 'vital' properties better than fully mechanistic models can. i discuss representative figures of the montpellier school (bordeu, ménuret, fouquet) as functional rather than substantival vitalists, and suggest an additional point regarding the reprisal of vitalism(s) in the 20th century, from driesch to canguilhem: that in addition to the substantival and functional varieties, we encounter a third species of vitalism, which i term 'attitudinal', as it argues for vitalism as a kind of attitude.
The external dimension of the Spanish transition
Charles T. Powell
Revista CIDOB d'Afers Internacionals , 1993,
Abstract: The author intends to go beyond the unanimous opinion that the processes of political transition must be explained, almost exclusively, in terms of national forces and calculations. In the case of the Spanish transition he intends to demonstrate how thestrategies of the national actors (crown, government and parties) were moulded largely by the pressure of regulations and structures drawn up outside its frontiers. Firstly, by the United States’ discreet support (always putting forward first her strategic interests) of the political evolution whilst it did not put in danger the Spanish contribution to the western defensive system (while the USSR hardly played any role). The Spanish transition did not offer a threat to the alliance system from the beginning and with which the result was practically guaranteed. The European governments for their part, worried least about security and more about the political dimension pressurizing the regime and supporting the leaders of the democratic opposition more and more. The European institutions, withtheir veto, ended up legitimizing the Spanish process of democratization while the different Internationals came together and helped their coreligionists in Spain. Their political and diplomatic pressure were complemented, with the paradigm in the case of PSOE, with the contribution of means and resources by the political foundations, largely German, whose highly visible participation did not lessen the credibiity of those it protected.
A Note on the Genus Pelecinus
Charles T. Brues
Psyche , 1928, DOI: 10.1155/1928/47573
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