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Search Results: 1 - 10 of 228208 matches for " Charles C. Okoli "
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EXPERIMENTAL EVIDENCE FOR THE ANTIDIABETIC ACTIVITY OF CAJANUS CAJAN LEAVES IN RATS
Adaobi C. Ezike,Peter A. Akah,Charles C. Okoli,Chinwe B. Okpala
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: The antidiabetic activity of methanol leaves extract of Cajanus cajan (L.) Millsp.(Fabaceae) was studied in alloxan-diabetic and in oral glucose loaded rats. The acute toxicity and lethality (LD50) and the phytochemical analysis of the extract were also evaluated. The results showed that the extract (400 and 600 mg/kg) significantly (P<0.05) reduced fasting blood sugar of alloxan diabetic rats in a dose-related manner, with maximum hypoglycemic effect at 4 – 6 h. The extract (400 and 600 mg/kg) also significantly (P<0.05) suppressed the peak postprandial rise in blood glucose of normal rats by 101.8 and 57.40 % respectively. Acute toxicity and lethality test of the extract in rats gave an oral LD50 greater than 5 g/kg. The findings indicate that the leaves of C. cajan may be beneficial as an antidiabetic therapy.
Acanthus montanus: An experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles
Charles O Okoli, Peter A Akah, Nkemjika J Onuoha, Theophine C Okoye, Anthonia C Nwoye, Chukwuemeka S Nworu
BMC Complementary and Alternative Medicine , 2008, DOI: 10.1186/1472-6882-8-27
Abstract: The aqueous root extract (obtained by hot water maceration of the root powder) was studied for effects on the growth of clinically isolated strains of Pseudomonas aeruginosa and Staphylococcus aureus. The anti-inflammatory activity was investigated using acute topical edema of the mouse ear induced by xylene, acute paw edema induced by agar in rats, formaldehyde arthritis in rats, vascular permeability induced by acetic acid in mice and heat- and hypotonicity-induced haemolysis of ox red blood cells (RBCs). Also evaluated were the effects on in vivo leukocyte migration induced by agar, phagocytic activity of macrophages on Candida albicans and specific cell-mediated immune responses (delayed type hypersensitivity reaction (DTHR) induced by sheep red blood cell (SRBC)). The acute toxicity and lethality (LD50) in mice and phytochemical constituents of the extract were also determined.The extract moderately inhibited the growth of the test organisms and significantly (P < 0.05) inhibited (57%) topical acute edema in the mouse ear. It significantly (P < 0.05) suppressed the development of acute edema of the rat paw in a non-dose-related manner and was not effective in inhibiting the global edematous response to formaldehyde arthritis. It also inhibited vascular permeability induced by acetic acid in mice and the haemolysis of ox RBCs induced by heat- and hypotonicity. The extract increased total leukocyte and neutrophil counts and caused a significant (P < 0.05) dose-related increase in the total number of macrophages at the 800 mg/kg dose. On phagocytic activity, the extract evoked a significant (P < 0.05) increase in the number of macrophages with ingested C. albicans at 800 mg/kg dose, and significantly (P < 0.05) inhibited DTHR in a dose-related manner. Phytochemical tests on the extract revealed an abundant presence of alkaloids and carbohydrates while saponins, glycosides, and terpenoids occurred in trace amounts. Acute toxicity test established an oral and intrap
Emerging treatments for essential thrombocythemia
Okoli S, Harrison C
Journal of Blood Medicine , 2011, DOI: http://dx.doi.org/10.2147/JBM.S19053
Abstract: ging treatments for essential thrombocythemia Review (3632) Total Article Views Authors: Okoli S, Harrison C Published Date December 2011 Volume 2011:2 Pages 151 - 159 DOI: http://dx.doi.org/10.2147/JBM.S19053 Steven Okoli, Claire Harrison Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK Abstract: In 1934, Epstein and Goedel used the term hemorrhagic thrombocythemia to describe a disorder characterized by permanent elevation of a platelet count to more than three times normal, hyperplasia of megakaryocytes, and the tendency for venous thrombosis and spontaneous hemorrhage. Over the last 75 years, and particularly in the past 6 years, major progress has been made in our understanding of essential thrombocythemia (ET) and its pathogenesis with the identification of the highly prevalent JAK-2 V617F and other mutations. Current management of this condition is based upon historical data and with treatments that have not changed significantly for nearly two decades. This study discusses this and recent progress, highlighting exciting new data with old and new drugs, as well as which patients in particular should be evaluated for these new therapies.
Emerging treatments for essential thrombocythemia
Okoli S,Harrison C
Journal of Blood Medicine , 2011,
Abstract: Steven Okoli, Claire HarrisonDepartment of Haematology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UKAbstract: In 1934, Epstein and Goedel used the term hemorrhagic thrombocythemia to describe a disorder characterized by permanent elevation of a platelet count to more than three times normal, hyperplasia of megakaryocytes, and the tendency for venous thrombosis and spontaneous hemorrhage. Over the last 75 years, and particularly in the past 6 years, major progress has been made in our understanding of essential thrombocythemia (ET) and its pathogenesis with the identification of the highly prevalent JAK-2 V617F and other mutations. Current management of this condition is based upon historical data and with treatments that have not changed significantly for nearly two decades. This study discusses this and recent progress, highlighting exciting new data with old and new drugs, as well as which patients in particular should be evaluated for these new therapies.Keywords: essential thrombocythemia, interferon, JAK inhibitor
Huh-7 Human Liver Cancer Cells: A Model System to Understand Hepatocellular Carcinoma and Therapy  [PDF]
Anna C. Krelle, Arinze S. Okoli, George L. Mendz
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.42078
Abstract:

In the last decades, the use of in vitro systems in liver research has grown exponentially. Important reasons promoting this work are the high throughput and ease of genetic manipulations afforded by these experiments relative to in vivo experiments. Thousands of investigations of hepatocellular carcinoma have been performed employing the human hepatoma Huh-7 cell line. The extensive body of knowledge produced attests to the importance and value of this in vitro cell system to study the characteristics of hepatomas and the potential of natural and synthetic compounds to prevent and eliminate this liver cancer. The necessarily brief summary provided here attempts to summarise some of the most recent achievements and limitations of investigations with Huh-7 cells and derivatives.

Detection of HIV-1 and -2 Antibodies among Selected Secondary Schools in Udenu L.G.A. of Enugu State, South East, Nigeria  [PDF]
Onwuchekwa Augustine Okoli, Charles Chibueze Ezekoye, Ogochukwu Ochiabuto, Clemtina Ngozi Nwafor, Stella Ukamaka Ugwu
Open Journal of Medical Microbiology (OJMM) , 2013, DOI: 10.4236/ojmm.2013.34039
Abstract: This study was carried out to determine the prevalence of HIV-1 and -2 among three selected secondary schools in Udenu Local Government Area of Enugu State, Nigeria. Three hundred students were recruited for this study representing 120 males (40%) and 180 females (60%) with their age ranging from 12 to 20 years from September to November, 2010. Samples of blood were collected and processed using standard laboratory procedures. All the students were screened for the presence of antibodies to HIV-1 and -2 using 2 enzyme-linked immunosorbent assay (ELISA) rapid screening kits, based on WHO systems-2 for detecting antibodies to HIV-1 and -2. The diagnosis of HIV infection was further confirmed by Western blot. The results showed that out of the 300 students who were enrolled into the study, 6 (2%) were positive for HIV-1 and -2 antibodies including two males (0.7%) and four females (1.3%). Statistically, there is a significant difference in the distribution of HIV infections by gender (P < 0.05). It showed that students aged 12 years and below 20 years had lower infection rate for HIV. Statistically, there is no significant difference in the distribution of infections with respect to age (P > 0.05). Although its prevalence is low, the presence of HIV-1 and -2 antibodies in Secondary School students of Udenu L.G.A. of Enugu State should be worrisome because it can easily be transmitted to other healthy individuals in the nearest future. Therefore, this calls for a concerted and synergistic effort to nip the spread in the bud so that it cannot spread to other teenagers and the larger community.
Environmental and Public Health Issues of Animal Food Products Delivery System in Imo State, Nigeria
Okoli Chidi Grace,Okoli Ifeanyi Charles,Okorondu Ugochukwu Victor,Opara Maxwell Nwachukwu
Online Journal of Health & Allied Sciences , 2006,
Abstract: Information on livestock movement, animal food products processing facilities, meat inspection methods, official meat inspection records and distribution and marketing systems for processed products in Imo state, Nigeria needed for policy development interventions in the sector are not fully understood. The primary data generated with the aid of personal interviews, field observations and secondary data obtained from records accumulated by the department of veterinary services Imo state from 2001 to 2004 were used to investigate the environmental and public health issues of animal food products delivery system in state. Majority of trade animals supplied to the state originated from the northern states of the country and were brought in with trucks by road. Only two veterinary control posts served the whole state thus resulting in non-inspection and taxing of a large proportion of trade animals. Official record of trade animals supplied to the state from 2001 to 2004 ranged from 45000 – 144000 for cattle, 23000 – 96000 for goats and 11000 – 72000 for sheep per annum, with supplies increasing steadily across the years. Official slaughter points in the state were principally low-grade quality slaughter premises consisting of a thin concrete slab. Meat handling was very unhygienic with carcasses dressed beside refuse heaps of over 2 years standing. Carcasses were dragged on the ground and transported in taxi boots and open trucks. Meat inspection at these points was not thorough because of stiff resistance of butchers to carcass condemnation. Official meat inspection records for the state from 2001 to 2004 revealed that overall totals of 159,000 cattle, 101,000 goats and 67,000 sheep were slaughtered. This accounted for about 56, 57 and 57% shortfall of cattle, goat and sheep respectively supplied to the state and represents the volume of un-inspected animals during the study period. Fascioliasis and tuberculosis were the most common infections encountered in cattle and recorded percentage occurrences of 16.7 and 7.5 respectively, whereas mastitis was common in goats and sheep at percentage occurrences of 5.8 and 5.0 respectively. Overall prevalence rates of 4.4, 8.0, 3.2, 3.3 and 1.5% were recorded for tuberculosis, fascioliasis, streptotricosis, mastitis and worms respectively. Animal food products delivery in Imo state needs to be improved upon in order to safeguarded the health of consumers
Proximal Input of Polynuclear Aromatic Hydrocarbons (PAHs) in Groundwater Sources of Okrika Mainland, Nigeria  [PDF]
C. G. Okoli, D. H. Ogbuagu, C. L. Gilbert, S. Madu, R. F. Njoku-Tony
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.26096
Abstract: The Port Harcourt Refinery Company situated at Okrika Mainland discharges its effluent into the Creeks surrounding this coastal land. The current study examined the presence of polynuclear aromatic hydrocarbons in groundwater sources of the coastal settlement. Ten replicate samples were collected from 10 boreholes in the settlement using sterilized amber glass bottles and fixed with concentrated H2SO4. They were later analyzed using Gas chromatography (GC). The Pearson product moment correlation coefficient (r) was used to determine the interactions of the PAHs detected while the One-way ANOVA was used to determine spatial variance equality in means of the PAHs components at P < 0.05. Further structure detection was made with means plots, utilizing pH as a predictor variable. High concentrations of PAHs which exceeded the WHO maximum permissible limit for the PAHs in drinking water (0.002 mg/L) were recorded from the borehole samples. Acenaphthene had the highest concentration of 0.88317 (0.202494 ± 0.0652) mg/L, while acenaphthylene had the least maximum concentration of 0.18837 (0.04978 ± 0.0123). However, naphthalene recorded concentrations of between 0.00058 and 0.52510 (0.0874576 ± 0.03472) mg/L, fluorene 0.00018 and 0.20438 (0.0527435 ± 0.01564) mg/L, phenanthrene 0.00041 and 0.26732 (0.0603780 ± 0.018634) mg/L, and anthracene between 0.00029 and 0.25084 (0.0692785 ± 0.0176569) mg/L. There was significant variance inequality in means of the PAHs measured across the sampling locations at P < 0.05 [F(971.1318) > Fcrit(3.85563)]. A further structure detection revealed that the inequalities were contributed by all the PAH components, especially between BH 3 and BH 1, BH 4 and BH 2 and 5, as well as between BH 6 and BH 10. Very strong associations were observed between the PAH components at P < 0.01. BH 8 recorded the highest contamination level of the various PAHs due basically to its proximity to the refinery’s effluent discharge point (Ekerekana Creek) and channel. Hence the source of these pollutants could best be fingerprinted to the nearby Port Harcourt Refinery Company’s effluent discharges. These PAHs are not only ingested by drinking contaminated waters, but are further consumed when this water is used to prepare foods. This creates a great cause for public health concerns especially as several PAHs are known carcinogens. It is therefore, recommended that technologically advanced techniques of water treatment be
Formulation and Evaluation of Cookies Containing Germinated Pigeon Pea, Fermented Sorghum and Cocoyam Flour Blends using Mixture Response Surface Methodology
Laura C. Okpala,Eric C. Okoli
Advance Journal of Food Science and Technology , 2011,
Abstract: Cookies were produced from blends of germinated pigeon pea, fermented sorghum and cocoyam flours. The study was carried out to evaluate the effects of varying the proportions of these components on the sensory and protein quality of the cookies. The sensory attributes studied were colour, taste, texture, crispiness and general acceptability while the protein quality indices were Biological Value (BV) and Net Protein Utilization (NPU). Mixture response surface methodology was used to model the sensory and protein quality with single, binary and ternary combinations of germinated pigeon pea, fermented sorghum and cocoyam flours. The sum of the component proportions was always equal to 100%. Results showed that BV and NPU of most of the cookies were above minimum recommended levels. With the exception of cookies containing high levels of pigeon pea flour, cookies had acceptable sensory scores. Increase in pigeon pea flour resulted in increase in the BV and NPU. Regression equations suggested that the ternary blends produced the highest increase in all the sensory attributes (with the exception of colour).
Experimental Evaluation of Temperature Effects on Detarium microcarpum, Brachystegia eurycoma and Pleurotus Biomaterial Mud  [PDF]
K. C. Igwilo, G. O. Osueke, S. T. A. Okolie, P. A. L. Anawe, Okoli Nnanna
Open Journal of Yangtze Oil and Gas (OJOGas) , 2017, DOI: 10.4236/ojogas.2017.22007
Abstract: Three sets of drilling fluids were formulated from biomaterials such as Detarium microcarpum, Brachystegia eurycoma and Pleurotus. The laboratory measurements were carried out on plastic viscosity, yield point and fluid loss exposed at required temperatures and then evaluated. The field Polyanionic cellulose additive that is currently in use was also formulated and used as a control sample to biomaterial products. Xanthan gumpolymer on equal concentration was added to both muds. The three sets of muds comprises the one without weighting material and the ones weighted up with calcium carbonate and barite respectively for both biomaterial mud and Polyanionic mud were examined as per American Petroleum Institute Standard. The graphs of the rheological properties and fluid loss against temperature were plotted. It was shown from the plots that the yield point and plastic viscosity decreased with increase in temperature while fluid loss increased with increase in temperature for both biomaterial mud and Polyanionic mud. It was also shown from the tables that the plastic viscosity and yield point are slightly better than the Polyanionic mud but less active in fluid loss than the Polyanionic mud.
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