Mathematical simulation method can be adopted to check flight characteristic of UAV, also can be adopted to simulate hardware experiments of unmanned aerial vehicle (UAV), then related flight experiments can be performed. The simulation method can reduce the flight periods, cost and risk. UAV flight model research play an important role in simulation and modeling in initialize periods of the UAV producing. The study of the paper focuses on the aerodynamic force modeling work of UAV based on Simulink. The designed model not only can afford mathematics simulation experiment but also will do benefits to the research of flight control, navigation guidance of UAV.