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Search Results: 1 - 10 of 5629 matches for " Chandra Sekhar Reddy "
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A Study of the Cardiovascular Risk Factor Profile in Patients with Acute Coronary Syndrome with Particular Reference to Metabolic Syndrome  [PDF]
Mohammad Ali Sowdagar, Adikesava Naidu Otikunta, Y. V. Subba Reddy, Chandra Sekhar Pulala
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.611113
Abstract: Objectives: Cardiovascular risk factors for acute coronary syndrome (ACS) are on rise in people of Indian origin. Moreover, the prevalence of metabolic syndrome (MS) is higher in populations with ACS than in the general population. Thus, the aim of the study was to evaluate the cardiovascular risk factor profile of patients presenting with acute coronary syndrome and to study the prevalence and impact of metabolic syndrome in patients with acute coronary syndrome by using South Asian modified National cholesterol Education Program Adult Treatment Panel III definition. Methods: This study was conducted between October, 2010 and March, 2011 at Government General Hospital, Kurnool, India. A total of 100 patients with ST or non-ST segment elevation ACS and who had clinical, electrocardiographic and biochemical diagnosis within the first 24 hrs of clinical onset were enrolled in the study. The enrolled subjects were divided into two groups: those with MS and those without MS. Cardiovascular risk factors defined by components of MS were evaluated. Analysis was performed using SPSS software. Results: Sixty patients had MS along with ACS and 40 patients had ACS without MS. The most prevalent component of MS was increased waist circumference (83.3%), followed by increased triglycerides (78.3%) and increased fasting blood sugar (76.7%). Majority of patients (58.3%) had presence of three components of MS. Conclusion: The MS is a highly prevalent condition among the patients with ACS and is associated with severe coronary artery disease. The identification of MS imparts a high risk status to the patient in developing cardiovascular disease but at the same time provides abundant opportunities for intervention. Hence it is of paramount importance to aim for stricter goals and lower cut offs for intervention at all levels of prevention: primordial, primary and secondary.
Texture Classification Using Texton Co-Occurrence Matrix Derived From Texture Orientation
Sujatha.B,Chandra Sekhar Reddy,P Kiran Kumar Reddy
International Journal of Soft Computing & Engineering , 2013,
Abstract: The present paper derived a new co-occurrencematrix based on textons and texture orientation for rotationinvariant texture classification of 2D images. The newco-occurrence matrix is called as Texton and Texture OrientationCo-occurrence Matrix (T&TO-CM). The Co-occurrence Matrix(CM) characterizes the relationship between the values ofneighboring pixels, while the histogram based techniques havehigh indexing performance. If the CM is used to represent imagefeatures directly, then the dimension will be high and theperformance is decreased. On the other hand, if histogram is usedto represent image features, the spatial information will be lost.Texture Classification based on T&TO-CM, integrates color,texture and edge features of an image. The proposed T&TO-CM isused to describe the spatial correlation of textons and textureorientation for texture classification. T&TO-CM can capture thespatial distribution of edges, and it is an efficient texturedescriptor for images with heavy textural presence. The proposedmethod is computationally attractive as it computes differentfeatures with limited number of selected pixels. The experimentalresults indicate the efficacy of the present method over the variousother methods.
Computational Characterization of Modes of Transcriptional Regulation of Nuclear Receptor Genes
Yogita Sharma, Chandra Sekhar Reddy Chilamakuri, Marit Bakke, Boris Lenhard
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088880
Abstract: Background Nuclear receptors are a large structural class of transcription factors that act with their co-regulators and repressors to maintain a variety of biological and physiological processes such as metabolism, development and reproduction. They are activated through the binding of small ligands, which can be replaced by drug molecules, making nuclear receptors promising drug targets. Transcriptional regulation of the genes that encode them is central to gaining a deeper understanding of the diversity of their biochemical and biophysical roles and their role in disease and therapy. Even though they share evolutionary history, nuclear receptor genes have fundamentally different expression patterns, ranging from ubiquitously expressed to tissue-specific and spatiotemporally complex. However, current understanding of regulation in nuclear receptor gene family is still nascent. Methodology/Principal Findings In this study, we investigate the relationship between long-range regulation of nuclear receptor family and their known functionality. Towards this goal, we identify the nuclear receptor genes that are potential targets based on counts of highly conserved non-coding elements. We validate our results using publicly available expression (RNA-seq) and histone modification (ChIP-seq) data from the ENCODE project. We find that nuclear receptor genes involved in developmental roles show strong evidence of long-range mechanism of transcription regulation with distinct cis-regulatory content they feature clusters of highly conserved non-coding elements distributed in regions spanning several Megabases, long and multiple CpG islands, bivalent promoter marks and statistically significant higher enrichment of enhancer mark around their gene loci. On the other hand nuclear receptor genes that are involved in tissue-specific roles lack these features, having simple transcriptional controls and a greater variety of mechanisms for producing paralogs. We further examine the combinatorial patterns of histone maps associated with dynamic functional elements in order to explore the regulatory landscape of the gene family. The results show that our proposed classification capturing long-range regulation is strongly indicative of the functional roles of the nuclear receptors compared to existing classifications. Conclusions/Significanc We present a new classification for nuclear receptor gene family capturing whether a nuclear receptor is a possible target of long-range regulation or not. We compare our classification to existing structural (mechanism of action) and
The Study State Analysis of Tandem Queue with Blocking and Feedback
C. Chandra Sekhar Reddy,K. Ramakrishna Prasad,Mamatha
Computer Science , 2010,
Abstract: Computer system models provide detailed answer to system performance.In this paper a two stage tandem network system with Blocking and Feedback is considered and it performance has been analyzed by spectral expansion method.The study state system with balance equations has been discussed.
Tetramethyl guanidine (TMG) catalyzed synthesis of novel a -amino phosphonates by one-pot reaction
M. Veera Narayana Reddy,S. Annar,A. Bala Krishna,G. Chandra Sekhar Reddy
Organic Communications , 2010,
Abstract: An efficient method has been developed for the synthesis of a -amino phosphonates (4a-j) by the three component one-pot reaction of equimolar quantities of 2-amino methyl furan (1), dimethyl / diethyl phosphite (2) and various aldehydes (3a-j) in dry toluene at reflux conditions via Kabachnik – Fields reaction in high yields (70-80%) in the presence of tetramethyl guanidine (TMG) as catalyst. The TMG can be easily recovered from the reaction mixture after completion of the reaction and can be reused. Their antimicrobial activity has also been evaluated.
Synthesis, spectral characterization and anti-microbial activity of 6- Substituted [(2-aminoethyl)amino]-6λ 5-dibenzo [d, h] [1, 3,6,2]oxathiaza- phosphonin-6-ones
Chinta Raveendra Reddy,Katla Venkata Ramana,Chinthaparthi Radha Rani,Gangireddy Chandra Sekhar Reddy
Organic Communications , 2011,
Abstract: Synthesis of a series of a new class of phosphorus macrocycles was accomplished in two steps by condensation of (Z)-2-((2-mercaptophenylimino) methyl) phenol (1) with phosphorus oxychloride (2) in dry THF in the presence of triethylamine at 0-5 °C. In the second step ethylene diols/ amino alcohols/ diamine/ aminothiols/ phenols were reacted at room temperature in THF to afford the title compounds (5a-l). The chemical structures of the title products were characterized by IR, 1H, 13C, 31P-NMR, mass spectral studies and elemental analysis. All the title compounds were evaluated for antimicrobial activity to determine their efficacy and they were found role effective in suppressing the growth of bacteria and fungi.
Texton Based Shape Features on Local Binary Pattern for Age Classification
B.Eswara Reddy,P.Chandra Sekhar Reddy,V.Vijaya Kumar
International Journal of Image, Graphics and Signal Processing , 2012,
Abstract: Classification and recognition of objects is interest of many researchers. Shape is a significant feature of objects and it plays a crucial role in image classification and recognition. The present paper assumes that the features that drastically affect the adulthood classification system are the Shape features (SF) of face. Based on this, the present paper proposes a new technique of adulthood classification by extracting feature parameters of face on Integrated Texton based LBP (IT-LBP) images. The present paper evaluates LBP features on facial images. On LBP Texton Images complex shape features are evaluated on facial images for a precise age classification.LBP is a local texture operator with low computational complexity and low sensitivity to changes in illumination. Textons are considered as texture shape primitives which are located with certain placement rules. The proposed shape features represent emergent patterns showing a common property all over the image. The experimental evidence on FGnet aging database clearly indicates the significance and accuracy of the proposed classification method over the other existing methods.
Biogeochemical study of aquatic mosses in chromite mineralized zone of Byrapur, Karnata, India
K.V. Ramana Reddy,L.Chandra Sekhar Reddy,B.Damodaram
Indian Streams Research Journal , 2012,
Abstract: In view of the ecological, mineral exploration and environmental significance of aquatic mosses, a biogeochemical study of mosses was undertaken in the chromite mineralized zone of Byrapur area, Karnataka. The objective of the present work is to determine the metal accumulation in the aquatic mosses for Cr and other associated metals. Samples of aquatic mosses from mine pits in chromite mineralized zone were collected. The aquatic mosses were analyzed for mineral elements namely Cr, Co, Ni, Pb, Zn, Cu, Mo, Mn, V and Fe. Analysis of aquatic mosses show that the concentration of Cr ranges from 1820 ppm to 2564 ppm; Zn ranges from 430 ppm to 620 ppm; Co ranges from 24 ppm to 59 ppm; and for the Vanadium it ranges from 20 ppm to 48 ppm, whereas other metals are not in much higher concentration.
Detection and Removal of Non-responsive Channels and Trials in Evoked Potentials using Median test
V. Adinarayana Reddy,P. Chandra Sekhar Reddy,G. Hemalatha,B. Anuradha
Signal & Image Processing , 2012,
Abstract: The primary goal of this research work is to detect and remove non responsive channels and trials inevoked potentials by tracing out the signals with very low energy. This is done by calculating the energy ofthe average evoked potential of each channel, and the energy of the average evoked potential of each trial.Then channel wise and trial wise median test is conducted to detect and remove non-responsive channelsand trials. An attempt has been made to apply these techniques to 14-channel visual evoked potentials(VEPs) obtained from four different subjects.
Cross-Genome Comparisons of Newly Identified Domains in Mycoplasma gallisepticum and Domain Architectures with Other Mycoplasma species
Chandra Sekhar Reddy Chilamakuri,Adwait Joshi,Sane Sudha Rani,Bernard Offmann,R. Sowdhamini
Comparative and Functional Genomics , 2011, DOI: 10.1155/2011/878973
Abstract: Accurate functional annotation of protein sequences is hampered by important factors such as the failure of sequence search methods to identify relationships and the inherent diversity in function of proteins related at low sequence similarities. Earlier, we had employed intermediate sequence search approach to establish new domain relationships in the unassigned regions of gene products at the whole genome level by taking Mycoplasma gallisepticum as a specific example and established new domain relationships. In this paper, we report a detailed comparison of the conservation status of the domain and domain architectures of the gene products that bear our newly predicted domains amongst 14 other Mycoplasma genomes and reported the probable implications for the organisms. Some of the domain associations, observed in Mycoplasma that afflict humans and other non-human primates, are involved in regulation of solute transport and DNA binding suggesting specific modes of host-pathogen interactions.
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