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Search Results: 1 - 8 of 8 matches for " Chalom "
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Representation Type Of One Point Extensions Of Iterated Tubular Algebras
Gladys Chalom,Sonia Trepode
Boletim da Sociedade Paranaense de Matemática , 2005,
Abstract: The purpose of this work is to show that if Λ a strongly simplyconnected semi-regular iterated tubular algebra and M is an indecomposable Λ-module then Λ[M] is tame if and only if q_{Λ[M]} is weakly non negative.
Pediatric patient with systemic lupus erythematosus & congenital acquired immunodeficiency syndrome: An unusual case and a review of the literature
Elizabeth C Chalom, Fariba Rezaee, Joel Mendelson
Pediatric Rheumatology , 2008, DOI: 10.1186/1546-0096-6-7
Abstract: The coexistence of HIV in patients with lupus is extremely rare, especially in the pediatric population. Case reports generally describe patients with HIV who subsequently develop rheumatologic complaints. In children, there have only been five reported pediatric cases of SLE and HIV [1-4]. In all of five, the children had known congenital HIV and then developed SLE. In four of those cases, the child developed lupus nephritis, but no other clinical manifestation of SLE [1-3]. The fifth was a case report of lupus vasculitis without nephritis in a child with congenital HIV [4]. The case we are presenting is exceedingly rare among pediatric cases and we could not find a similar one in the literature. Our patient first presented with SLE and subsequently showed the manifestations of congenital human immunodeficiency syndrome.Patient was a 9 year old African American female who presented with fevers, polyarthritis, and morning stiffness. She had no rash or significant adenopathy. Her height was at the 25th percentile for age and her weight was just below the 50th percentile. Laboratory investigations revealed WBC = 2,800 cells/mm3 (58% neutrophils, 38% lymphocytes), hemoglobin = 10.4 g/dL, platelets = 167,000/mm3, erythrocyte sedimentation rate(ESR) = 56 mm/h, ANA titer = 1:1280, C4 complement <10 mg/dl, and anti-double stranded DNA (dsDNA) = 1051 IU/ml. Urinalysis was within normal limits. She was diagnosed with SLE and treated with prednisone, naproxen, and hydroxycholoroquine Over the next ten months, the prednisone was tapered and discontinued. The naproxen was later changed to rofecoxib and she did well on a combination rofecoxib and hydroxychloroquine for two years. She was then lost to follow-up for 13 months and did not take her medications. She then returned, complaining of arthralgias. She had no arthritis on exam and laboratory studies showed anemia with a hemoglobin of 9.9, WBC = 2.1 cells/mm3 (51%neutrophils, 23% lymphocytes, 21% monocytes and 5% basophils)
Gr?bner Basis in Algebras Extended by Loops
Chalom,G.; Marcos,E.; Oliveira,P.;
Revista de la Uni?3n Matem??tica Argentina , 2007,
Abstract: in this work we extend, to the path algebras context, some results obtained in the commutative context, [2]. the main result is that one can extend the gr?bner bases of an ungraded ideal to one possible definition of homogenization for the non commutative case.
Uncertainty analysis and composite hypothesis under the likelihood paradigm
André Chalom,Paulo Inácio de Knegt López de Prado
Quantitative Biology , 2015,
Abstract: The correct use and interpretation of models depends on several steps, two of which being the calibration by parameter estimation and the analysis of uncertainty. In the biological literature, these steps are seldom discussed together, but they can be seen as fitting pieces of the same puzzle. In particular, analytical procedures for uncertainty estimation may be masking a high degree of uncertainty coming from a model with a stable structure, but insufficient data. Under a likelihoodist approach, the problem of uncertainty estimation is closely related to the problem of composite hypothesis. In this paper, we present a brief historical background on the statistical school of Likelihoodism, and examine the complex relations between the law of likelihood and the problem of composite hypothesis, together with the existing proposals for coping with it. Then, we propose a new integrative methodology for the uncertainty estimation of models using the information in the collected data. We argue that this methodology is intuitively appealing under a likelihood paradigm.
Parameter space exploration of ecological models
André Chalom,Paulo Inácio de Knegt López de Prado
Quantitative Biology , 2012,
Abstract: In recent years, we are seeing the formulation and use of elaborate and complex models in ecological studies. The questions related to the efficient, systematic and error-proof exploration of parameter spaces are of great importance to better understand, estimate confidences and make use of the output from these models. In this work, we investigate some of the relevant questions related to parameter space exploration, in particular using the technique known as Latin Hypercube Sampling and focusing in quantitative output analysis. We present the analysis of a structured population growth model and contrast our findings with results from previously used techniques, known as sensitivity and elasticity analyses. We also assess how are the questions related to parameter space analysis being currently addressed in the ecological literature.
Minimal Binary Abelian Codes of length $p^m q^n$
Gladys Chalom,Raul Ant?nio Ferraz,Marinês Guerreiro,César Polcino Milies
Mathematics , 2012,
Abstract: We consider binary abelian codes of length $p^m q^n$, where $p$ and $q$ are prime rational integers under some restrictive hypotheses. In this case, we determine the idempotents generating minimal codes and either the respective weights or bounds of these weights. We give examples showing that these bounds are attained in some cases.
Developing a standardized approach to the assessment of pain in children and youth presenting to pediatric rheumatology providers: a Delphi survey and consensus conference process followed by feasibility testing
Jennifer N Stinson, Mark Connelly, Lindsay A Jibb, Laura E Schanberg, Gary Walco, Lynn R Spiegel, Shirley ML Tse, Elizabeth C Chalom, Peter Chira, Michael Rapoff
Pediatric Rheumatology , 2012, DOI: 10.1186/1546-0096-10-7
Abstract: In Phase 1, a 2-stage Delphi technique (pediatric rheumatologists and allied professionals) and consensus meeting (pediatric pain and rheumatology experts) were used to develop the self- and proxy-report pain measures. In Phase 2, 24 children aged 4-7 years (and their parents), and 77 youth, aged 8-18 years, with pain, were recruited during routine rheumatology clinic appointments and completed the pain measure using each medium (order randomly assigned). The participant's rheumatologist received a summary report prior to clinical assessment. Satisfaction surveys were completed by all participants. Descriptive statistics were used to describe the participant characteristics using means and standard deviations (for continuous variables) and frequencies and proportions (for categorical variables)Completing the measure using the handheld device took significantly longer for youth (M = 5.90 minutes) and parents (M = 7.00 minutes) compared to paper (M = 3.08 and 2.28 minutes respectively p = 0.001) and computer (M = 3.40 and 4.00 minutes respectively; p < 0.001). There was no difference in the number of missed responses between mediums for children or parents. For youth, the number of missed responses varied across mediums (p = 0.047) with the greatest number of missed responses occurring with the handheld device. Most children preferred the computer (65%, p = 0.008) and youth reported no preference between mediums (p = 0.307). Most physicians (60%) would recommend the computer summary over the paper questionnaire to a colleague.It is clinically feasible to implement a newly developed consensus-driven pain measure in pediatric rheumatology clinics using electronic or paper administration. Computer-based administration was most efficient for most users, but the medium employed in practice may depend on child age and economic and administrative factors.Pain in children and youth with rheumatic conditions such as arthritis is common [1,2]. Currently, there is no standardize
Transmission Patterns of HIV-Subtypes A/AE versus B: Inferring Risk-Behavior Trends and Treatment-Efficacy Limitations from Viral Genotypic Data Obtained Prior to and during Antiretroviral Therapy
Boaz Avidor, Dan Turner, Zohar Mor, Shirley Chalom, Klaris Riesenberg, Eduardo Shahar, Shimon Pollack, Daniel Elbirt, Zev Sthoeger, Shlomo Maayan, Karen Olshtain-Pops, Diana Averbuch, Michal Chowers, Valery Istomin, Emilia Anis, Ella Mendelson, Daniela Ram, Itzchak Levy, Zehava Grossman
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057789
Abstract: Background HIV subtypes A and CRF01_AE (A/AE) became prevalent in Israel, first through immigration of infected people, mostly intravenous-drug users (IVDU), from Former Soviet-Union (FSU) countries and then also by local spreading. We retrospectively studied virus-transmission patterns of these subtypes in comparison to the longer-established subtype B, evaluating in particular risk-group related differences. We also examined to what extent distinct drug-resistance patterns in subtypes A/AE versus B reflected differences in patient behavior and drug-treatment history. Methods Reverse-transcriptase (RT) and protease sequences were retrospectively analyzed along with clinical and epidemiological data. MEGA, ClusalX, and Beast programs were used in a phylogenetic analysis to identify transmission networks. Results 318 drug-naive individuals with A/AE or patients failing combination antiretroviral therapy (cART) were identified. 61% were IVDU. Compared to infected homosexuals, IVDU transmitted HIV infrequently and, typically, only to a single partner. 6.8% of drug-naive patients had drug resistance. Treatment-failing, regimen-stratified subtype-A/AE- and B-patients differed from each other significantly in the frequencies of the major resistance-conferring mutations T215FY, K219QE and several secondary mutations. Notably, failing boosted protease-inhibitors (PI) treatment was not significantly associated with protease or RT mutations in either subtype. Conclusions While sizable transmission networks occur in infected homosexuals, continued HIV transmission among IVDU in Israel is largely sporadic and the rate is relatively modest, as is that of drug-resistance transmission. Deviation of drug-naive A/AE sequences from subtype-B consensus sequence, documented here, may subtly affect drug-resistance pathways. Conspicuous differences in overall drug-resistance that are manifest before regimen stratification can be largely explained in terms of treatment history, by the different efficacy/adherence limitations of older versus newer regimens. The phenomenon of treatment failure in boosted-PI-including regimens in the apparent absence of drug-resistance to any of the drugs, and its relation to adherence, require further investigation.
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