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Search Results: 1 - 10 of 462346 matches for " Chad A. LaGrange "
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Clinical features and outcomes of 25 patients with primary adenosquamous cell carcinoma of the prostate
Jue Wang,Fenwei Wang,Chad A. LaGrange,George P. Hemstreet
Rare Tumors , 2010, DOI: 10.4081/rt.2010.e47
Abstract: The aim of the present study was to examine the epidemiology, natural history, treatment and long-term survival of patients with adenosquamous cell carcinoma of the prostate. The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify ASCC of prostate cases between January 1973 and December 2006. Survival probabilities were estimated using the Kaplan-Meier methods and compared using the log-rank test. A total of 25 patients with adenosquamous cell carcinoma of the prostate were identified during the study period. The median age was 74 years (range 53-98). Twenty percent of study subjects presented with metastatic disease. Among those patients with known grade (n=16), 75% had poorly or undifferentiated histology. A total of 40% of study subjects received radical prostatectomy, while 24% of the patients had primary radiation therapy. The 1-, 3-, and 5-year cancer specific survival rates for the entire cohort were 55.2%, 37.8%, and 30.3%, respectively. For patients who underwent prostatectomy, the 1-, 3-, and 5-year survival rates were 78%, 78%, and 63%, respectively. For the patients who did not receive prostatectomy, the 1-year survival rates were 38.7% and none survived to three years. Adenosquamous cell carcinoma is a rare aggressive subtype of prostate cancer with poor cancer specific survival. The development of new therapeutic approaches for this aggressive tumor is urgently needed.
Clinically Undiagnosed Prostate Carcinoma Metastatic to Renal Oncocytoma
Adam J. Horn,Bari E. Fritz,Chad A. LaGrange,William W. West,Subodh M. Lele
Case Reports in Urology , 2012, DOI: 10.1155/2012/307813
Abstract: Tumors-to-tumor metastasis is an uncommon occurrence and can be a source of great diagnostic difficulty, especially when the donor tumor is undiagnosed. Here we report a case of a kidney resected for a primary neoplasm (oncocytoma) that harbored metastases from a clinically undiagnosed prostatic adenocarcinoma. The presence of the poorly differentiated metastasis within an otherwise typical oncocytoma in the absence of metastases in the surrounding nonneoplastic renal parenchyma resulted in a diagnostic dilemma. To our knowledge, this is the first report of a case in the English literature of a clinically undiagnosed prostatic adenocarcinoma metastatic to a renal oncocytoma identified on examination of the resected renal neoplasm.
Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases
Jue Wang,Fen Wei Wang,Chad A. LaGrange,George P. Hemstreet III,Anne Kessinger
Sarcoma , 2010, DOI: 10.1155/2010/454792
Abstract: Background. Urinary bladder sarcomatoid carcinoma (carcinosarcoma) is rare. The objective of this study was to examine the epidemiology, natural history, and prognostic factors of urinary bladder carcinosarcoma using population-based registry. Methods. The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify cases by tumor site and histology codes. The association between clinical and demographic characteristics and long-term survival was examined. Results. A total of 221 histology confirmed cases were identified between 1973 and 2004, this accounted for approximately 0.11% of all primary bladder tumors during the study period. Median age of the patients was 75 years (range 41–96). Of the patients with a known tumor stage (=204), 72.5% had a regional or distant stage; 98.4% of patients with known histology grade (=127), had poorly or undifferentiated histology. Multiple primary tumors were indentified in about 40% of study subjects. The majority of patients (95.9%) received cancer directed surgery, 35.8% had radical or partial cystectomy, 15.8% of patients received radiation therapy combination with surgery. The median overall survival was 14 months (95% CI 7–21 months). 1-, 5-, and 10-year cancer specific survival rate were 53.9%, 28.4% and 25.8%. In a multivariate analysis, only tumor stage was found to be a significant prognostic factor for disease-specific survival. Conclusions. Urinary bladder carcinosarcoma commonly presented as high grade, advanced stage and aggressive behavior with a poor prognosis. Emphasis on early detection, including identification of risk factors is needed to improve the outcome for patients with this malignancy.
Clinically Undiagnosed Prostate Carcinoma Metastatic to Renal Oncocytoma
Adam J. Horn,Bari E. Fritz,Chad A. LaGrange,William W. West,Subodh M. Lele
Case Reports in Urology , 2012, DOI: 10.1155/2012/307813
Abstract: Tumors-to-tumor metastasis is an uncommon occurrence and can be a source of great diagnostic difficulty, especially when the donor tumor is undiagnosed. Here we report a case of a kidney resected for a primary neoplasm (oncocytoma) that harbored metastases from a clinically undiagnosed prostatic adenocarcinoma. The presence of the poorly differentiated metastasis within an otherwise typical oncocytoma in the absence of metastases in the surrounding nonneoplastic renal parenchyma resulted in a diagnostic dilemma. To our knowledge, this is the first report of a case in the English literature of a clinically undiagnosed prostatic adenocarcinoma metastatic to a renal oncocytoma identified on examination of the resected renal neoplasm. 1. Introduction While tumor metastasis is a common occurrence, the tumor-to-tumor metastasis is quite rare, being first documented in 1902. The most common donor site is lung, followed by breast, prostate, and thyroid carcinomas [1]. The kidney (in particular, renal cell carcinoma) is the most common recipient, followed by sarcomas, meningiomas, thyroid, and pituitary adenomas [1, 2]. In addition to renal cell carcinoma, angiomyolipomas and renal oncocytomas have been described as being recipients [3, 4]. In this paper we present a case of renal oncocytoma harboring metastases from a previously undiagnosed prostatic adenocarcinoma. To the best of our knowledge, there has been no documented cases of prostatic adenocarcinoma with metastasis to a renal oncocytoma. 2. Case Report A 92-year-old man presented with complaints of low back pain. He had magnetic resonance imaging of the spine performed which incidentally revealed a mass in the left kidney. A CT scan confirmed this finding, demonstrating a 6?cm solid enhancing mass in the left kidney, in addition to multiple bilateral lung nodules and lesions in the spine worrisome for metastatic disease. He was presumed to have metastatic renal cell carcinoma and underwent a radical nephrectomy. Dissection of the radical nephrectomy specimen revealed a solitary tumor measuring ?cm, which was well circumscribed, tan-brown, and confined to the kidney. Microscopic examination of the renal tumor revealed areas typical of an oncocytoma with an archipelaginous architectural pattern near the center of the tumor (Figure 1). In addition to the oncocytic cells, a second population of cells arranged in small groups containing high nuclear/cytoplasmic ratios, nuclear hyperchromasia, occasional prominent nucleoli, and rare mitoses were noted (Figure 2). The nests were restricted to the oncocytic
Human Prostatic Acid Phosphatase: Structure, Function and Regulation
Sakthivel Muniyan,Nagendra K. Chaturvedi,Jennifer G. Dwyer,Chad A. LaGrange,William G. Chaney,Ming-Fong Lin
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140510438
Abstract: Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as a protein tyrosine phosphatase by dephosphorylating ErbB-2/Neu/HER-2 at the phosphotyrosine residues in prostate cancer (PCa) cells, which results in reduced tumorigenicity. Further, the interaction of cPAcP and ErbB-2 regulates androgen sensitivity of PCa cells. Knockdown of cPAcP expression allows androgen-sensitive PCa cells to develop the castration-resistant phenotype, where cells proliferate under an androgen-reduced condition. Thus, cPAcP has a significant influence on PCa cell growth. Interestingly, promoter analysis suggests that PAcP expression can be regulated by NF-κB, via a novel binding sequence in an androgen-independent manner. Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy.
Rapid Lab-Scale Microwave-Assisted Extraction and Analysis of Anthropogenic Organic Chemicals in River Sediments  [PDF]
Thomas J Brown, Chad A Kinney
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.23029
Abstract: An Ethos EZ Microwave Lab Station is employed in the development of a robust and efficient microwave extraction method for organic contaminants of anthropogenic origin in river sediments. The extraction method is designed for a small, representative set of target compounds encompassing a range of physicochemical properties. Listed in order of gas chromatography elution they are para-cresol, indole, 4-tert-octylphenol, phenanthrene, triclosan, bisphenol-A, carbamazepine, and benzo [a] pyrene. The sediments samples are extracted wet, which reduces preparation time, and allows the ambient moisture of the sediments to aid in microwave energy absorption and the extraction process. The microwave can hold up to 12 samples that can be simultaneously extracted allowing for rapid sample preparation. Utilizing the pressurized vessels, microwave energy, and a unique mixture of three organic solvents allows for multiple samples to be extracted rapidly with minimal solvent consumption. The final extracts are quantified by gas chromatography/mass spectrometry. Recoveries of the 8 target compounds in sediment range from 49% to 113%, and method detection limits range between 14 and 114 μg kg–1, which are comparable with other more time consuming methods.
The 2D surfaces that generate Newtonian and general relativistic orbits with small eccentricities
Chad A. Middleton
Physics , 2015,
Abstract: Embedding diagrams prove to be quite useful when learning general relativity as they offer a way of visualizing spacetime curvature through warped two dimensional (2D) surfaces. In this manuscript we present a different 2D construct that also serves as a useful conceptual tool for gaining insight into gravitation, in particular, orbital dynamics - namely the cylindrically symmetric surfaces that generate Newtonian and general relativistic orbits with small eccentricities. Although we first show that no such surface exists that can exactly reproduce the arbitrary bound orbits of Newtonian gravitation or of general relativity (or, more generally, of any spherically symmetric potential), surfaces do exist that closely approximate the resulting orbital motion for small eccentricities; exactly the regime that describes the motion of the solar system planets. These surfaces help to illustrate the similarities, as well as the differences, between the two theories of gravitation (i.e. stationary elliptical orbits in Newtonian gravitation and precessing elliptical-like orbits in general relativity) and offer, in this age of 3D printing, an opportunity for students and instructors to experimentally explore the predictions made by each.
A Class of Curves In Every Knot Type Where Chords of High Distortion are Common
Chad A. S. Mullikin
Mathematics , 2006,
Abstract: The distortion of a curve is the supremum, taken over distinct pairs of points of the curve, of the ratio of arclength to spatial distance between the points. Gromov asked in 1981 whether a curve in every knot type can be constructed with distortion less than a universal constant C. Answering Gromov's question seems to require the construction of lower bounds on the distortion of knots in terms of some topological invariant. We attempt to make such bounds easier to construct by showing that pairs of points with high distortion are very common on curves of minimum length in the set of curves in a given knot type with distortion bounded above and distortion thickness bounded below.
Mycobacteriosis in the compromised host
Lagrange, PH;Wargnier, A;Herrmann, JL;
Memórias do Instituto Oswaldo Cruz , 2000, DOI: 10.1590/S0074-02762000000700027
Abstract: the studies of rare genetic defects, the preliminary results of population-based studies, being validated by the experimental immunocompromised animal models and the current observations accumulated in immunocompromised patients with mycobacterial diseases provide us with insights into the importance of the macrophage activation pathway in controlling human infection with pathogenic and non pathogenic intracellular multiplying mycobacteria. initial cytokine production by infected macrophages and/or dendritic cells could be crucial in the overall regulation of self cure, acquired protection or immunopathological sequelae expressing the disease. knowledge of molecular and genetic cross-talks between phagocytic and specialized antigen presenting cells and different mycobacterial products associated with persistence or replication of the intracellular bacteria, could provide further informations on the global immune regulation of the early host responses to infection and the following events. it seems likely that the development of mycobacterial infections in humans will turn out to be as much dependent on the genetic make up of the host as or the virulence of the bacteria.
Mycobacteriosis in the compromised host
Lagrange PH,Wargnier A,Herrmann JL
Memórias do Instituto Oswaldo Cruz , 2000,
Abstract: The studies of rare genetic defects, the preliminary results of population-based studies, being validated by the experimental immunocompromised animal models and the current observations accumulated in immunocompromised patients with mycobacterial diseases provide us with insights into the importance of the macrophage activation pathway in controlling human infection with pathogenic and non pathogenic intracellular multiplying mycobacteria. Initial cytokine production by infected macrophages and/or dendritic cells could be crucial in the overall regulation of self cure, acquired protection or immunopathological sequelae expressing the disease. Knowledge of molecular and genetic cross-talks between phagocytic and specialized antigen presenting cells and different mycobacterial products associated with persistence or replication of the intracellular bacteria, could provide further informations on the global immune regulation of the early host responses to infection and the following events. It seems likely that the development of mycobacterial infections in humans will turn out to be as much dependent on the genetic make up of the host as or the virulence of the bacteria.
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