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Search Results: 1 - 10 of 5067 matches for " Ch. Grieb "
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Anatomy of bispectra in general single-field inflation -- modal expansions
Thorsten Battefeld,Jan Grieb
Physics , 2011, DOI: 10.1088/1475-7516/2011/12/003
Abstract: We discuss bispectra of single-field inflationary models described by general Lorentz invariant Lagrangians that are at most first order in field derivatives, including the fast-roll models investigated by Noller and Magueijo. Based on a factor analysis, we identify the least correlated basic contributions to the general shape and show quantitatively which templates provide a good approximation. We compute how relative contributions of basic shapes to the total bispectrum scale as slow roll is relaxed. To enable future comparison with CMB observations, we provide a modal expansion of these non-separable bispectra in Fourier space, employing the formalism by Shellard et al. Convergence is rapid, usually better than ninety-five percent with less than thirty modes, due to the smoothness of these primordial shapes. Truncated polynomial modal expansions have restrictions, which we highlight using an example with slow convergence. The particular shape originates from particle production during inflation (common in trapped inflation) and entails both localized and oscillatory features. We show that this shape can be recovered efficiently using a Fourier basis and outline the prospect of future model parameter extraction and N-body simulations based on modal techniques.
DWARF – a data warehouse system for analyzing protein families
Markus Fischer, Quan K Thai, Melanie Grieb, Jürgen Pleiss
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-495
Abstract: The data warehouse system DWARF integrates data on sequence, structure, and functional annotation for protein fold families. The underlying relational data model consists of three major sections representing entities related to the protein (biochemical function, source organism, classification to homologous families and superfamilies), the protein sequence (position-specific annotation, mutant information), and the protein structure (secondary structure information, superimposed tertiary structure). Tools for extracting, transforming and loading data from public available resources (ExPDB, GenBank, DSSP) are provided to populate the database. The data can be accessed by an interface for searching and browsing, and by analysis tools that operate on annotation, sequence, or structure. We applied DWARF to the family of α/β-hydrolases to host the Lipase Engineering database. Release 2.3 contains 6138 sequences and 167 experimentally determined protein structures, which are assigned to 37 superfamilies 103 homologous families.DWARF has been designed for constructing databases of large structurally related protein families and for evaluating their sequence-structure-function relationships by a systematic analysis of sequence, structure and functional annotation. It has been applied to predict biochemical properties from sequence, and serves as a valuable tool for protein engineering.In the last decades large amounts on biological data were accumulated and the high-throughput methods in the fields of genomics and proteomics create an ever-increasing rate of high dimensional data on sequence, structure, and function of biological systems. The systematic analysis of these data provides the opportunity to gain a novel level of the understanding of complex biological systems. However the data are highly diverse and widely scattered across hundreds of databases and thus are difficult to exploit. Therefore methods have to be developed that allow the integration of these diverse
Convergence of children′s depression rating scale-revised scores and clinical diagnosis in rating adolescent depressive symptomatology
Paul L. Plener,Jasmin Grieb,Nina Sproeber,Joana Straub
Mental Illness , 2012, DOI: 10.4081/mi.2012.e7
Abstract: The Children′s Depression Rating Scale- Revised (CDRS-R) is a widely used instrument for research on depression in minors. A raw score of ≥40 has often been used as indicator of depressive symptomatology. As a validated German version of the CDRS-R has recently became available, we assessed CDRS-R raw summary scores of a video taped interview session in two different rater groups and compared them with clinical ratings of International Classification of Diseases (ICD- 10) depression diagnosis as observed by a third independent group. We found that for the German version a raw score between 35 and 40 is indicative for mild depressive symptomatology as described by the ICD-10. CDRS-R scores show potential clinical applicability to deduct levels of depression.
Calciphylaxis – a challenging & solvable task for plastic surgery? A case report
Tsolakidis Savas,Grieb Gerrit,Piatkowski Andrzej,Alharbi Ziyad
BMC Dermatology , 2013, DOI: 10.1186/1471-5945-13-1
Abstract: Background Calciphylaxis (calcific uremic arteriolopathy) is rare and its pathogenesis is not fully understood. Indeed, Calciphylaxis presents a challenge through the course of its management which involve different specialities but unfortunately this disease so far has a poor prognosis. We herein present, in this case report, a multidisciplinary approach involving plastic surgeons with special regards to reconstructive approach after debridement procedures. Case presentation We present a 21 years old male with a BMI of 38,2, who was transferred to our department from another hospital. Calciphylaxis has been diagnosed after receiving anticoagulation with phenprocoumon after a single event of pulmonary embolism. The INR on admission was 1,79. He had necrotic spots on both sides of the abdominal wall and on both thighs medially. During this time he underwent several reconstructive procedures in our department. Conclusion It can be suggested that this agonizing disease needs indeed a multidisciplinary approach involving Nephrologists, Dermatologists, Intensive Care Physicians and Plastic Surgeons, taking into consideration that surgical correction can achieve further improvement in a specialized centre. Notwithstanding, further cohort studies should be approached clinically to insight the light on this disease with special regard to the prognosis after this approach.
Decomposition of abnormal free locomotor behavior in a rat model of Parkinson's disease
Benjamin Grieb,Constantin von Nicolai,Gerhard Engler,Andrew Sharott
Frontiers in Systems Neuroscience , 2013, DOI: 10.3389/fnsys.2013.00095
Abstract: Poverty of spontaneous movement, slowed execution and reduced amplitudes of movement (akinesia, brady- and hypokinesia) are cardinal motor manifestations of Parkinson's disease that can be modeled in experimental animals by brain lesions affecting midbrain dopaminergic neurons. Most behavioral investigations in experimental parkinsonism have employed short-term observation windows to assess motor impairments. We postulated that an analysis of longer-term free exploratory behavior could provide further insights into the complex fine structure of altered locomotor activity in parkinsonian animals. To this end, we video-monitored 23 h of free locomotor behavior and extracted several behavioral measures before and after the expression of a severe parkinsonian phenotype following bilateral 6-hydroxydopamine (6-OHDA) lesions of the rat dopaminergic substantia nigra. Unbiased stereological cell counting verified the degree of midbrain tyrosine hydroxylase positive cell loss in the substantia nigra and ventral tegmental area. In line with previous reports, overall covered distance and maximal motion speed of lesioned animals were found to be significantly reduced compared to controls. Before lesion surgery, exploratory rat behavior exhibited a bimodal distribution of maximal speed values obtained for single movement episodes, corresponding to a “first” and “second gear” of motion. 6-OHDA injections significantly reduced the incidence of second gear motion episodes and also resulted in an abnormal prolongation of these fast motion events. Likewise, the spatial spread of such episodes was increased in 6-OHDA rats. The increase in curvature of motion tracks was increased in both lesioned and control animals. We conclude that the discrimination of distinct modes of motion by statistical decomposition of longer-term spontaneous locomotion provides useful insights into the fine structure of fluctuating motor functions in a rat analog of Parkinson's disease.
Light Concentrators for Borexino and CTF
L. Oberauer,C. Grieb,F. von Feilitzsch,I. Manno
Physics , 2003, DOI: 10.1016/j.nima.2004.05.095
Abstract: Light concentrators for the solar neutrino experiment Borexino and the Counting Test Facility (CTF) have been developed and constructed. They increase the light yield of these detectors by a factor of 2.5 and 8.8, respectively. Technical challenges like long term stability in various media, high reflectivity and radiopurity have been addressed and the concepts to overcome these difficulties will be described. Gamma spectroscopy measurements of the concentrators show an upper limit of 12e-6 Bq/g for uranium and a value of 120e-6 Bq/g for thorium. Upper limits on other possible contaminations like 26Al are presented. The impact of these results on the performance of Borexino and the CTF are discussed and it is shown that the design goals of both experiments are fulfilled.
Letter of Intent for Double-CHOOZ: a Search for the Mixing Angle Theta13
F. Ardellier,I. Barabanov,J. C. Barriere,M. Bauer,L. Bezrukov,C. Buck,C. Cattadori,B. Courty,M. Cribier,F. Dalnoki-Veress,N. Danilov,H. de Kerret,A. Di Vacri,A. Etenko,M. Fallot,Ch. Grieb,M. Goeger,A. Guertin,T. Kirchner,Y. S. Krylov,D. Kryn,C. Hagner,W. Hampel,F. X. Hartmann,P. Huber,J. Jochum,T. Lachenmaier,Th. Lasserre,Ch. Lendvai,M. Lindner,F. Marie,J. Martino,G. Mention,A. Milsztajn,J. P. Meyer,D. Motta,L. Oberauer,M. Obolensky,L. Pandola,W. Potzel,S. Schoenert,U. Schwan,T. Schwetz,S. Scholl,L. Scola,M. Skorokhvatov,S. Sukhotin,A. Letourneau,D. Vignaud,F. von Feilitzsch,W. Winter,E. Yanovich
Physics , 2004,
Abstract: Tremendous progress has been achieved in neutrino oscillation physics during the last few years. However, the smallness of the $\t13$ neutrino mixing angle still remains enigmatic. The current best constraint comes from the CHOOZ reactor neutrino experiment $\s2t13 < 0.2$ (at 90% C.L., for $\adm2=2.0 10^{-3} \text{eV}^2$). We propose a new experiment on the same site, Double-CHOOZ, to explore the range of $\s2t13$ from 0.2 to 0.03, within three years of data taking. The improvement of the CHOOZ result requires an increase in the statistics, a reduction of the systematic error below one percent, and a careful control of the cosmic ray induced background. Therefore, Double-CHOOZ will use two identical detectors, one at $\sim$150 m and another at 1.05 km distance from the nuclear cores. The plan is to start data taking with two detectors in 2008, and to reach a sensitivity of 0.05 in 2009, and 0.03 in 2011.
Smoking, environmental tobacco smoke, and risk of renal cell cancer: a population-based case-control study
Ryan P Theis, Suzanne M Dolwick Grieb, Deborah Burr, Tariq Siddiqui, Nabih R Asal
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-387
Abstract: Incident cases (n = 335) were identified from hospital records and the Florida cancer registry, and population controls (n = 337) frequency-matched by age (+/- 5 years), gender, and race were identified through random-digit dialing. In-person interviews assessed smoking history and lifetime exposure to ETS at home, work, and public spaces. Home ETS was measured in both years and hours of exposure. Odds ratios and 95% confidence intervals were calculated using logistic regression, controlled for age, gender, race, and BMI.Cases were more likely to have smoked 20 or more pack-years, compared with never-smokers (OR: 1.35, 95% CI: 0.93 – 1.95). A protective effect was found for smoking cessation, beginning with 11–20 years of cessation (OR: 0.39, 95% CI: 0.18–0.85) and ending with 51 or more years of cessation (OR: 0.11, 95% CI: 0.03–0.39) in comparison with those having quit for 1–10 years. Among never-smokers, cases were more likely to report home ETS exposure of greater than 20 years, compared with those never exposed to home ETS (OR: 2.18; 95% CI: 1.14–4.18). Home ETS associations were comparable when measured in lifetime hours of exposure, with cases more likely to report 30,000 or more hours of home ETS exposure (OR: 2.37; 95% CI: 1.20–4.69). Highest quartiles of combined home/work ETS exposure among never-smokers, especially with public ETS exposure, increased RCC risk by 2 to 4 times.These findings confirm known associations between smoking and RCC and establish a potential etiologic role for ETS, particularly in the home. Differences in methods of retrospective measurement of lifetime smoking and ETS exposure may contribute to discrepancies in measures of associations across studies, and should be addressed in future research.Kidney and renal pelvis cancers account for nearly 4% of all new cancer cases in the United States, with 54,390 new cases estimated for the year 2008 [1,2]. Incidence rates have almost doubled over the past 30 years – from 7.1 per 100,000
Treatment of burns in the first 24 hours: simple and practical guide by answering 10 questions in a step-by-step form
Ziyad Alharbi, Andrzej Piatkowski, Rolf Dembinski, Sven Reckort, Gerrit Grieb, Jens Kauczok, Norbert Pallua
World Journal of Emergency Surgery , 2012, DOI: 10.1186/1749-7922-7-13
Mapping Cortical Thickness of the Patients with Unilateral End-Stage Open Angle Glaucoma on Planar Cerebral Cortex Maps
Piotr Bogorodzki, Ewa Pi?tkowska-Janko, Jerzy Szaflik, Jacek Pawe? Szaflik, Mira Gacek, Pawe? Grieb
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093682
Abstract: Purpose To estimate and compare cerebral cortex thickness in patients with unilateral end-stage glaucoma with that of age-matched individuals with unaffected vision. Methods 14 patients with unilateral end-stage primary open angle glaucoma (POAG) and 12 age-matched control individuals with no problems with vision were selected for the study based on detailed ophthalmic examination. For each participant 3D high-resolution structural brain T1-weighted magnetization prepared MR images were acquired on a 3.0 T scanner. Brain cortex thickness was estimated using the FreeSurfer image analysis environment. After warping of subjects' cortical surfaces to FreeSurfer common space, differences between POAG and control groups were inferred at the group analysis level with the General Linear Model. Results The analysis performed revealed local thinning in the visual cortex areas in the POAG group. Statistically significant differences form 600 mm2 clusters located in the Brodmann area BA19 in the left and right hemisphere. Conclusion Unilateral vision loss due to end-stage neuropathy from POAG is associated with significant thinning of cortical areas employed in vision.
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